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  1. Article: Asthma Exacerbations: Patient Features and Potential Long-Term Implications.

    Akuthota, Praveen

    Advances in experimental medicine and biology

    2023  Volume 1426, Page(s) 253–263

    Abstract: Asthma exacerbations occur in the context of a complex interplay between external exposures and host factors. Respiratory tract viral infections, in particular rhinovirus, are dominant initiators of exacerbations, with allergens and other inhalation ... ...

    Abstract Asthma exacerbations occur in the context of a complex interplay between external exposures and host factors. Respiratory tract viral infections, in particular rhinovirus, are dominant initiators of exacerbations, with allergens and other inhalation exposures as additional key contributors. The presence of underlying type II inflammation, with associated biomarker elevations, is a major driver of exacerbation risk and mechanism, as evidenced by the consistent reduction of exacerbations seen with biologics targeting these pathways. Several genetic polymorphisms are associated with exacerbations, and while they may individually have small effects, they are cumulatively important and magnified by environmental exposures. A history of exacerbations predicts future exacerbations with potentially negative implications on long-term lung health.
    MeSH term(s) Humans ; Asthma/genetics ; Asthma/complications ; Lung ; Virus Diseases/complications ; Allergens ; Inflammation/complications ; Rhinovirus/genetics ; Picornaviridae Infections/complications
    Chemical Substances Allergens
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-32259-4_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online: Severe Eosinophilic Disorders: Mechanisms and Clinical Management

    Ueki, Shigeharu / Akuthota, Praveen / Sabbadini Neves, Josiane

    2019  

    Keywords Medicine ; Immunology ; Asthma ; Eosinophils ; Eosinophilic disorders ; Extracellular traps ; Hypereosinophilia ; IL-5 ; Degranulation ; Rhinitis
    Size 1 electronic resource (138 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230812
    ISBN 9782889631797 ; 2889631796
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Corticosteroid-sparing effect of biologics in patients with allergic bronchopulmonary aspergillosis.

    Darragh, Keara / Akuthota, Praveen

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.01.010
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  4. Article ; Online: Approach to non-type 2 asthma.

    Adrish, Muhammad / Akuthota, Praveen

    Respiratory medicine

    2023  Volume 216, Page(s) 107327

    MeSH term(s) Humans ; Asthma ; Neutrophils ; Inflammation ; Phenotype ; Sputum ; Eosinophils
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107327
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  5. Article ; Online: Bronchial Epithelial Cell CC16 mRNA: Novel Asthma Biomarker or the Same Book with a New Cover?

    Desai, Brinda / Akuthota, Praveen

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 4, Page(s) 385–386

    MeSH term(s) Humans ; RNA, Messenger/metabolism ; Asthma/diagnosis ; Asthma/genetics ; Asthma/metabolism ; Biomarkers/metabolism ; Epithelial Cells/metabolism
    Chemical Substances RNA, Messenger ; Biomarkers
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202209-1768ED
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  6. Article ; Online: Type 2 Biomarkers in Asthma: Yet Another Reflection of Heterogeneity.

    Lugogo, Njira L / Akuthota, Praveen

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 3, Page(s) 1276–1277

    MeSH term(s) Asthma/diagnosis ; Biomarkers/metabolism ; Humans ; Inflammation ; Prevalence
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.12.032
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  7. Article ; Online: How Sex and Age of Asthma Onset Influence Difficult Asthma Heterogeneity.

    Akuthota, Praveen / Busse, William W

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 10, Page(s) 3407–3408

    MeSH term(s) Asthma/epidemiology ; Humans ; Phenotype
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.07.041
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  8. Article ; Online: Estimated Ventricular Size: A New Predictor of Asthma Severity and Exacerbation Rate?

    Barry, Jeffrey R / Akuthota, Praveen

    Chest

    2020  Volume 157, Issue 2, Page(s) 243–244

    MeSH term(s) Asthma ; Cohort Studies ; Humans
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.10.019
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  9. Article ; Online: Eosinophils and eosinophilic immune dysfunction in health and disease.

    Jackson, David J / Akuthota, Praveen / Roufosse, Florence

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood ... ...

    Abstract The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood and/or tissue. The ability to induce eosinophil depletion either experimentally in animal models or through targeted therapies in humans has extended our understanding of the roles played by eosinophils in health and homeostasis as well as in disease pathogenesis. When associated with human disease aetiology, the eosinophil takes on a pathogenic rather than a protective role. This maladaptive response, called "eosinophilic immune dysfunction" herein, appears central to exacerbation pathogenesis and disease control in severe asthma and may be involved in the aetiology of other eosinophil-related conditions ranging from organ-system-limited diseases such as phenotypic subsets of chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyposis to more broadly systemic diseases such as eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. In this review, we describe the evidence supporting eosinophilic functions related to health and homeostasis and explore the contribution of eosinophilic immune dysfunction to human disease.
    MeSH term(s) Animals ; Asthma ; Churg-Strauss Syndrome ; Eosinophilia ; Eosinophils ; Granulomatosis with Polyangiitis ; Humans
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0150-2021
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  10. Article ; Online: Introducing the Severe Asthma Series of Invited Reviews.

    Akuthota, Praveen / Jackson, David J / Wechsler, Michael E

    Chest

    2021  Volume 160, Issue 4, Page(s) 1151–1152

    MeSH term(s) Asthma/epidemiology ; Humans
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.08.056
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