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  1. Book ; Online ; E-Book: Cardiovascular Calcification and Bone Mineralization

    Aikawa, Elena / Hutcheson, Joshua D.

    (Contemporary Cardiology,)

    2020  

    Abstract: The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than ...

    Author's details edited by Elena Aikawa, Joshua D. Hutcheson
    Series title Contemporary Cardiology,
    Abstract The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.
    Keywords Cardiology ; Pathology ; Biomedical engineering ; Biomedical Engineering/Biotechnology ; Calcificació ; Biomineralització ; Malalties del cor ; Malalties dels ossos ; Cardiologia
    Subject code 616.1
    Language English
    Size 1 online resource (XXI, 563 p. 108 illus., 102 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Humana
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-46725-2 ; 3-030-46724-4 ; 978-3-030-46725-8 ; 978-3-030-46724-1
    DOI 10.1007/978-3-030-46725-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Exploring the Frontiers of Regenerative Cardiovascular Medicine

    Hutcheson, Joshua D. / Phillippi, Julie A. / Aikawa, Elena

    2019  

    Keywords Medicine ; cardiovascular ; regenerative medicine ; heart valves ; arterial remodeling ; myocardium ; cardiac regeneration
    Size 1 electronic resource (166 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231460
    ISBN 9782889458189 ; 2889458180
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: From Flow to Pharmaceuticals: Single-Cell Mechanobiology and Drug Efficacy.

    Hutcheson, Joshua D

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 12, Page(s) 2282–2284

    MeSH term(s) Humans ; Endothelial Cells ; Mechanotransduction, Cellular ; Biophysics ; Pharmaceutical Preparations ; Sequence Analysis, RNA
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.320117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease.

    Hutcheson, Joshua D / Goettsch, Claudia

    Circulation research

    2023  Volume 132, Issue 8, Page(s) 993–1012

    Abstract: Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for cardiovascular disease, particularly ischemic heart disease, due to premature vascular and cardiac aging and accelerated ectopic calcification. The presence of ... ...

    Abstract Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for cardiovascular disease, particularly ischemic heart disease, due to premature vascular and cardiac aging and accelerated ectopic calcification. The presence of cardiovascular calcification associates with increased risk in patients with CKD. Disturbed mineral homeostasis and diverse comorbidities in these patients drive increased systemic cardiovascular calcification in different manifestations with diverse clinical consequences, like plaque instability, vessel stiffening, and aortic stenosis. This review outlines the heterogeneity in calcification patterning, including mineral type and location and potential implications on clinical outcomes. The advent of therapeutics currently in clinical trials may reduce CKD-associated morbidity. Development of therapeutics for cardiovascular calcification begins with the premise that less mineral is better. While restoring diseased tissues to a noncalcified homeostasis remains the ultimate goal, in some cases, calcific mineral may play a protective role, such as in atherosclerotic plaques. Therefore, developing treatments for ectopic calcification may require a nuanced approach that considers individual patient risk factors. Here, we discuss the most common cardiac and vascular calcification pathologies observed in CKD, how mineral in these tissues affects function, and the potential outcomes and considerations for therapeutic strategies that seek to disrupt the nucleation and growth of mineral. Finally, we discuss future patient-specific considerations for treating cardiac and vascular calcification in patients with CKD-a population in need of anticalcification therapies.
    MeSH term(s) Humans ; Renal Insufficiency, Chronic/complications ; Vascular Calcification/etiology ; Cardiovascular Diseases/etiology ; Minerals ; Aging
    Chemical Substances Minerals
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.321760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Developmental Origin of Calcific Aortic Stenosis.

    Aikawa, Elena / Hutcheson, Joshua D

    The New England journal of medicine

    2022  Volume 386, Issue 14, Page(s) 1372–1374

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/etiology ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Humans
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr2200439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells.

    Shaver, Mohammad / Gomez, Kassandra / Kaiser, Katherine / Hutcheson, Joshua D

    BMC molecular and cell biology

    2024  Volume 25, Issue 1, Page(s) 8

    Abstract: Background: Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural component of plasma membrane ... ...

    Abstract Background: Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural component of plasma membrane invaginations, is a mechanosensitive protein that is required for the formation of calcifying extracellular vesicles (EVs). However, the role of mechanics in Cav-1-induced EV formation from VSMCs has not been reported.
    Results: Exposure of VSMCs to 10% mechanical stretch (0.5 Hz) for 72 h resulted in Cav-1 translocation into non-caveolar regions of the plasma membrane and subsequent redistribution of Cav-1 from the VSMCs into EVs. Inhibition of Rho-A kinase (ROCK) in mechanically-stimulated VSMCs exacerbated the liberation of Cav-1 positive EVs from the cells, suggesting a potential involvement of actin stress fibers in this process. The mineralization potential of EVs was measured by incubating the EVs in a high phosphate solution and measuring light scattered by the minerals at 340 nm. EVs released from stretched VSMCs showed higher mineralization potential than the EVs released from non-stretched VSMCs. Culturing VSMCs in pro-calcific media and exposure to mechanical stretch increased tissue non-specific alkaline phosphatase (ALP), an important enzyme in vascular calcification, activity in EVs released from the cells, with cyclic stretch further elevating EV ALP activity compared to non-stretched cells.
    Conclusion: Our data demonstrate that mechanical stretch alters Cav-1 trafficking and EV release, and the released EVs have elevated mineralization potential.
    MeSH term(s) Humans ; Muscle, Smooth, Vascular ; Caveolin 1/metabolism ; Extracellular Vesicles/metabolism ; Vascular Calcification/metabolism ; Cell Membrane/metabolism
    Chemical Substances Caveolin 1
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ISSN 2661-8850
    ISSN (online) 2661-8850
    DOI 10.1186/s12860-024-00504-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A surface-based calibration approach to enable dynamic and accurate quantification of colorimetric assay systems.

    Tong, Lin / Hutcheson, Joshua D

    Analytical methods : advancing methods and applications

    2021  Volume 13, Issue 37, Page(s) 4290–4297

    Abstract: Colorimetry is widely used in assay systems for its low-cost, ease-of-use, rapidity, moderate storage requirements and intuitively visible effects. However, the application is limited due to its relatively low sensitivity. Conventional colorimetric ... ...

    Abstract Colorimetry is widely used in assay systems for its low-cost, ease-of-use, rapidity, moderate storage requirements and intuitively visible effects. However, the application is limited due to its relatively low sensitivity. Conventional colorimetric calibration methods often use a fixed incubation time that can limit the detection range, system robustness and sensitivity. In this paper, we used color saturation to measure the accumulation of product (correlation coefficient
    MeSH term(s) Biological Assay ; Calibration ; Colorimetry ; Physical Phenomena
    Language English
    Publishing date 2021-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d1ay01130h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models.

    Ashbrook, Sophie K / Valentin Cabrera, Ana M / Shaver, Mohammad / Hutcheson, Joshua D

    Journal of visualized experiments : JoVE

    2023  , Issue 191

    Abstract: Cardiovascular disease is the leading cause of death in the world, and vascular calcification is the most significant predictor of cardiovascular events; however, there are currently no treatment or therapeutic options for vascular calcification. ... ...

    Abstract Cardiovascular disease is the leading cause of death in the world, and vascular calcification is the most significant predictor of cardiovascular events; however, there are currently no treatment or therapeutic options for vascular calcification. Calcification begins within specialized extracellular vesicles (EVs), which serve as nucleating foci by aggregating calcium and phosphate ions. This protocol describes methods for obtaining and assessing calcification in murine aortas and analyzing the associated extracted EVs. First, gross dissection of the mouse is performed to collect any relevant organs, such as the kidneys, liver, and lungs. Then, the murine aorta is isolated and excised from the aortic root to the femoral artery. Two to three aortas are then pooled and incubated in a digestive solution before undergoing ultracentrifugation to isolate the EVs of interest. Next, the mineralization potential of the EVs is determined through incubation in a high-phosphate solution and measuring the light absorbance at a wavelength of 340 nm. Finally, collagen hydrogels are used to observe the calcified mineral formation and maturation produced by the EVs in vitro.
    MeSH term(s) Mice ; Animals ; Vascular Calcification ; Aorta ; Calcium ; Phosphates ; Extracellular Vesicles
    Chemical Substances Calcium (SY7Q814VUP) ; Phosphates
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.

    Krohn, Jona B / Aikawa, Elena / Aikawa, Masanori / Hutcheson, Joshua D / Sahoo, Susmita / Fish, Jason E

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 1077124

    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1077124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Altered Caveolin-1 Dynamics Result in Divergent Mineralization Responses in Bone and Vascular Calcification.

    Bakhshian Nik, Amirala / Kaiser, Katherine / Sun, Patrick / Khomtchouk, Bohdan B / Hutcheson, Joshua D

    Cellular and molecular bioengineering

    2023  Volume 16, Issue 4, Page(s) 299–308

    Abstract: Introduction: Though vascular smooth muscle cells adopt an osteogenic phenotype during pathological vascular calcification, clinical studies note an inverse correlation between bone mineral density and arterial mineral-also known as the calcification ... ...

    Abstract Introduction: Though vascular smooth muscle cells adopt an osteogenic phenotype during pathological vascular calcification, clinical studies note an inverse correlation between bone mineral density and arterial mineral-also known as the calcification paradox. Both processes are mediated by extracellular vesicles (EVs) that sequester calcium and phosphate. Calcifying EV formation in the vasculature requires caveolin-1 (CAV1), a membrane scaffolding protein that resides in membrane invaginations (caveolae). Of note, caveolin-1-deficient mice, however, have increased bone mineral density. We hypothesized that caveolin-1 may play divergent roles in calcifying EV formation from vascular smooth muscle cells (VSMCs) and osteoblasts (HOBs).
    Methods: Primary human coronary artery VSMCs and osteoblasts were cultured for up to 28 days in an osteogenic media. CAV1 expression was knocked down using siRNA. Methyl β-cyclodextrin (MβCD) and a calpain inhibitor were used, respectively, to disrupt and stabilize the caveolar domains in VSMCs and HOBs.
    Results: CAV1 genetic variation demonstrates significant inverse relationships between bone-mineral density (BMD) and coronary artery calcification (CAC) across two independent epidemiological cohorts. Culture in osteogenic (OS) media increased calcification in HOBs and VSMCs. siRNA knockdown of CAV1 abrogated VSMC calcification with no effect on osteoblast mineralization. MβCD-mediated caveolae disruption led to a 3-fold increase of calcification in VSMCs treated with osteogenic media (
    Conclusion: Our data indicate fundamental cellular-level differences in physiological and pathophysiological mineralization mediated by CAV1 dynamics. This is the first study to suggest that divergent mechanisms in calcifying EV formation may play a role in the calcification paradox.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12195-023-00779-7.
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-023-00779-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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