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Article ; Online: SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1.

Jin, Xinxin / Sun, Xulei / Ma, Xiao / Qin, Zixuan / Gao, Xin / Kang, Xiaomin / Li, Huixia / Sun, Hongzhi

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 204

Abstract: The silent information regulator T1 (SIRT1) is linked to longevity and is a crucial mediator of osteoblast function. We investigated the direct role of Sirt1 during bone modeling and remodeling stages in vivo using Tamoxifen-inducible osteoblast-specific ...

Abstract	The silent information regulator T1 (SIRT1) is linked to longevity and is a crucial mediator of osteoblast function. We investigated the direct role of Sirt1 during bone modeling and remodeling stages in vivo using Tamoxifen-inducible osteoblast-specific Sirt1 conditional knockout (cKO) mice. cKO mice exhibited lower trabecular and cortical bone mass in the distal femur. These phenotypes were coupled with lower bone formation and bone resorption. Metabolomics analysis revealed that the metabolites involved in glycolysis were significantly decreased in cKO mice. Further analysis of the quantitative acetylome revealed 11 proteins with upregulated acetylation levels in both the femur and calvaria of cKO mice. Cross-analysis identified four proteins with the same upregulated lysine acetylation site in both the femur and calvaria of cKO mice. A combined analysis of the metabolome and acetylome, as well as immunoprecipitation, gene knockout, and site-mutation experiments, revealed that Sirt1 deletion inhibited glycolysis by directly binding to and increasing the acetylation level of Glutamine oxaloacetic transaminase 1 (GOT1). In conclusion, our study suggested that Sirt1 played a crucial role in regulating osteoblast metabolism to maintain bone homeostasis through its deacetylase activity on GOT1. These findings provided a novel insight into the potential targeting of osteoblast metabolism for the treatment of bone-related diseases.
MeSH term(s)	Animals ; Sirtuin 1/metabolism ; Sirtuin 1/genetics ; Osteoblasts/metabolism ; Glycolysis ; Mice, Knockout ; Homeostasis ; Mice ; Acetylation ; Bone and Bones/metabolism ; Osteogenesis ; Femur/metabolism
Chemical Substances	Sirtuin 1 (EC 3.5.1.-) ; Sirt1 protein, mouse (EC 3.5.1.-)
Language	English
Publishing date	2024-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-05043-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: a prospective observational study from the reaction study.

Su, Wanlu / Wang, Jie / Chen, Kang / Yan, Wenhua / Gao, Zhengnan / Tang, Xulei / Wan, Qin / Luo, Zuojie / Ning, Guang / Mu, Yiming

Diabetology & metabolic syndrome

2024 Volume 16, Issue 1, Page(s) 29

Abstract: Background: Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking the TyG index to the incidence of T2DM and HTN comorbidity remain unclear. This study aimed to to explore ...

Abstract	Background: Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking the TyG index to the incidence of T2DM and HTN comorbidity remain unclear. This study aimed to to explore the longitudinal association between TyG and new-onset T2DM with HTN. Methods: 4,434 subjects (1249 males and 3185 females) without initial T2DM and HTN were followed up for 7 years. This study was conducted from November 2011 to August 2018 in the Gucheng, Laoshan and Jinding communities of Beijing. The incidence of T2DM with HTN during the 7-year follow-up was identified as the endpoint. The TyG index was divided into four quartiles: the < 25% level, the 25-50% level, the 50-75% level and the ≥ 75% level. The relationships between the TyG index and T2DM with HTN were evaluated by Cox proportional hazards regression models. Results: During 7 years, the augmented trend of T2DM with HTN was observed in the participants. After adjusting for all confounding factors, compared with those in the lowest quartile of TyG index, the population in the highest quartile of TyG index had a higher risk of T2DM with HTN (hazard ratio (HR), 2.878; 95% confidence intervals (95% CI), 1.230-6.731, P = 0.015), however, the association remained significant only in the female population (HR 2.753, 95% CI, 1.061-7.139, p = 0.037). The TyG had superior predictive ability of increased risk of T2DM with HTN for the populations of older age (≥ 65 years) (HR 2.694, 95% CI 1.212-5.989, p = 0.015), higher eGFR (≥ 90 mL/(min·1.73 m Conclusion: A population with a higher TyG index level was more likely to have an enhanced incidence of T2DM and HTN comorbidity. TyG index could have the significance of clinical in early protection against T2DM with HTN.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-024-01258-3
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Article ; Online: Optimization and Accuracy Analysis of a Soil–Planter Model during the Sowing Period of Wheat after a Rice Stubble Based Discrete Element Method

Luo, Weiwen / Chen, Xulei / Guo, Kai / Qin, Mingyang / Wu, Feng / Gu, Fengwei / Hu, Zhichao

Agriculture. 2023 Oct. 23, v. 13, no. 10

2023

Abstract: The soil during the sowing period of wheat after rice stubble cannot be accurately described by existing models and parameters with DEM because of its high moisture content and strong viscosity. The purpose of this study is to conduct an overall ... ...

Abstract	The soil during the sowing period of wheat after rice stubble cannot be accurately described by existing models and parameters with DEM because of its high moisture content and strong viscosity. The purpose of this study is to conduct an overall simulation of high-viscosity paddy soil and to analyze the accuracy of the model. Based on the results of an unconfined compression test and shear test, the range of bond parameters is preliminarily determined by a simulation test. Through the P-BD test and RSM test, the parameters with significant influence are determined to be normal stiffness per unit area (SN), shear stiffness per unit area (SS), and critical shear stress (CS), and an optimized combination of these parameters is obtained. Based on the optimized model, the error range and error generation mechanism of the model are analyzed under different operating parameters. The results show that the optimal parameter combination is SN of 1.07 × 10⁷ N/m³, SS of 0.70 × 10⁷ N/m³, and CS of 0.35 × 10⁵ Pa, corresponding to a compression force of 120.1 N and a shear force of 7.70 N. With an increase in forward speed or seeding quantity or a decrease in rotary plowing speed, the model accuracy tends to increase, and the range of relative errors was found to be from 8.8% to 28.4%. The results can provide a research basis for the study of the motion state of seeds under soil. It can also further enrich parameter data of soil discrete element simulation models and provide a reference for related research studies.
Keywords	agriculture ; models ; paddy soils ; rice ; shear stress ; stubble ; viscosity ; water content ; wheat
Language	English
Dates of publication	2023-1023
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13102036
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Design and Experiment of Uniform Seed Device for Wide-Width Seeder of Wheat after Rice Stubble

Luo, Weiwen / Chen, Xulei / Qin, Mingyang / Guo, Kai / Ling, Jie / Gu, Fengwei / Hu, Zhichao

Agriculture. 2023 Nov. 20, v. 13, no. 11

2023

Abstract: When wide-width sowing wheat after rice stubble (WRS) in a rice-wheat rotation area, there is a problem of poor uniform of seed distribution. To solve the problem, this study designed the seed distribution plate (SDP) structure and optimized its critical ...

Abstract	When wide-width sowing wheat after rice stubble (WRS) in a rice-wheat rotation area, there is a problem of poor uniform of seed distribution. To solve the problem, this study designed the seed distribution plate (SDP) structure and optimized its critical structure parameters. Firstly, combined with the operating principles of the wide-width seeder and the agricultural standards for WRS, the main structural parameters affecting seed movement were determined by a theoretical analysis of seed grain dynamics and SDP structure. Secondly, the operational performance of six different structures of SDP under different structural parameters was compared using discrete element simulation technology. The structure of SDP most suitable for WRS wide-width seeding and the value ranges of key structural parameters that have a significant impact on the coefficient of the variation of seed lateral uniformity (CVLU) were determined. Finally, the pattern and mechanism of the influence of key structural parameters of SDP on the CVLU were analyzed. The optimum parameter combination was obtained and a field validation test was conducted on this. The results showed that the anti-arc ridge and arc bottom structure (S6) is more suitable for the agronomy standards of WRS wide-width seeding. The chord length of ridge, installation inclination, angle between the chord and tangent of the end of ridge line (ACT), span, and bottom curve radius are determined as the key structural parameters affecting the CVLU, and there is a lower CVLU (42.8%) when the ACT is 13°. The primary and secondary order of the influence of each factor on CVLU is the chord length of the ridge, span, installation inclination, and bottom curve radius. The corresponding parameter values after optimization are 140 mm, 40°, 75 mm and 50 mm, respectively. A field test was conducted on the SDP after optimizing parameters, and the CVLU was 30.27%, which was significantly lower than the CVLU before optimization.
Keywords	agriculture ; agronomy ; rice ; sowing ; stubble ; wheat
Language	English
Dates of publication	2023-1120
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13112173
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Field measurement of local wind environment on the approach deck of a suspension bridge in mountain terrain.

Zhang, Mingjin / Jiang, Fanying / Zhang, Jingyu / Qin, Jingxi / Jiang, Xulei / Li, Yongle

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15659

Abstract: The local wind environment above the bridge deck affects the aerodynamic characteristics of vehicles, thus affecting the driving safety of the bridge deck. Influenced by the mountain topography and the bridge deck's ancillary facilities, the local wind ... ...

Abstract	The local wind environment above the bridge deck affects the aerodynamic characteristics of vehicles, thus affecting the driving safety of the bridge deck. Influenced by the mountain topography and the bridge deck's ancillary facilities, the local wind environment above the bridge deck is complex and changeable, and its impact on the bridge deck traffic can not be ignored. In order to accurately evaluate the local wind field parameters, a monitoring system of the local wind environment is developed. Utilizing the monitoring system, wind parameters above the approach deck of a long-span suspension bridge in a mountain area are measured. The relationship of wind characteristics between the incoming flow and the wind above the bridge deck is investigated. Results show the significant difference between the local wind environment above the bridge deck and the incoming flow's characteristics; the wind profile above the bridge deck does not follow the exponential distribution; the equivalent height of the wind load on the vehicle is higher than the vehicle's gravity centre. This study is relevant for studying the local wind environment, driving safety, and serviceability of long-span bridges in mountainous areas.
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-19849-3
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Article ; Online: Efficient and cold-tolerant moisture-enabled power generator combining ionic diode and ionic hydrogel.

Fang, Jiahao / Zhang, Xiang / Duan, Peng / Jiang, Zhongbao / Lu, Xulei / Fu, Chunqiao / Zhang, Yong / Yao, Yuming / Shang, Kedong / Qin, Jieyang / Liu, Yangfan / Yang, Tingting

Materials horizons

2024 Volume 11, Issue 5, Page(s) 1261–1271

Abstract: The ionic diode structure has become one of the attractive structures in the field of moisture-based power generation. However, existing devices still suffer from poor moisture trapping, low surface charge, and inefficient ion separation, resulting in ... ...

Abstract	The ionic diode structure has become one of the attractive structures in the field of moisture-based power generation. However, existing devices still suffer from poor moisture trapping, low surface charge, and inefficient ion separation, resulting in low output power. Moreover, water freezes at low temperatures (<0 °C), limiting the ionic diode structure to generate electricity in cold environments. In this paper, a moisture-enabled power generator has been designed and fabricated, which assembles a negatively charged ionic hydrogel film and a positively charged anodized aluminum oxide (AAO) film to construct a heterojunction. The hydrogel polymer network is modified with a large number of sulfonate groups that dissociate to provide nanoscale pores with high surface charge to improve the rectification ratio. And the lithium chloride (LiCl) salt with high hydration ability is added to the hydrogel as a moisture-trapping and anti-freezing component. Usually salt ions reduce the Debye length, so that the ion transport is finally not controlled by the electric double layer (EDL) and the rectification fails. Interestingly, due to the natural affinity of the hydrogel polymer network for LiCl, LiCl is locked on the hydrogel side and does not easily enter the AAO pores to change the distribution of EDL within the nanochannel. As a result, the device rectification ratio is almost independent of the amount of LiCl addition, demonstrating an excellent balance of high output power and high freeze resistance. Ultimately, the device exhibits excellent power generation performance in the -20 °C to 60 °C temperature range and 15% to 93% RH humidity range. Typically, under high humidity (93% RH) at room temperature (25 °C), it provides an open-circuit voltage of 1.25 V and a short-circuit current of 300 μA cm
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh01496g
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Article ; Online: Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis.

Wu, Joseph C / Qin, Xulei / Neofytou, Evgenios

JACC. Cardiovascular imaging

2018 Volume 11, Issue 12, Page(s) 1834–1836

MeSH term(s)	Apoptosis ; Bacteriocins ; Humans ; Molecular Imaging ; Peptides ; Phosphatidylethanolamines ; Reperfusion Injury
Chemical Substances	Bacteriocins ; Peptides ; Phosphatidylethanolamines ; duramycin (1391-36-2)
Language	English
Publishing date	2018-02-14
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2017.12.009
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Article ; Online: Image-level supervised segmentation for human organs with confidence cues.

Chen, Zhang / Tian, Zhiqiang / Zheng, Yaoyue / Si, Xiangyu / Qin, Xulei / Shi, Zhong / Zheng, Shuai

Physics in medicine and biology

2021 Volume 66, Issue 6, Page(s) 65018

Abstract: Image segmentation for human organs is an important task for the diagnosis and treatment of diseases. Current deep learning-based methods are fully supervised and need pixel-level labels. Since the medical images are highly specialized and complex, the ... ...

Abstract	Image segmentation for human organs is an important task for the diagnosis and treatment of diseases. Current deep learning-based methods are fully supervised and need pixel-level labels. Since the medical images are highly specialized and complex, the work of delineating pixel-level segmentation masks is very time-consuming. Weakly supervised methods are then chosen to lighten the workload, which only needs physicians to determine whether an image contains the organ regions of interest. These weakly supervised methods have a common drawback, in that they do not incorporate prior knowledge that alleviates the lack of pixel-level information for segmentation. In this work, we propose a weakly supervised method based on prior knowledge for the segmentation of human organs. The proposed method was validated on three data sets of human organ segmentation. Experimental results show that the proposed image-level supervised segmentation method outperforms several state-of-the-art methods.
MeSH term(s)	Algorithms ; Computer Simulation ; Cues ; Deep Learning ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Prostate/diagnostic imaging ; Prostatic Neoplasms/diagnostic imaging ; Radiology ; Supervised Machine Learning
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/abde98
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Article: Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study.

Zhang, Yue / Gao, Wenxing / Ren, Rui / Liu, Yang / Li, Binqi / Wang, Anping / Tang, Xulei / Yan, Li / Luo, Zuojie / Qin, Guijun / Chen, Lulu / Wan, Qin / Gao, Zhengnan / Wang, Weiqing / Ning, Guang / Mu, Yiming

Frontiers in endocrinology

2023 Volume 14, Page(s) 1148662

Abstract: Background: Kidney disease is related to visceral obesity. As a new indicator of obesity, body roundness index (BRI) has not been fully revealed with kidney disease. This study's objective is to assess the relationship between estimated glomerular ... ...

Abstract	Background: Kidney disease is related to visceral obesity. As a new indicator of obesity, body roundness index (BRI) has not been fully revealed with kidney disease. This study's objective is to assess the relationship between estimated glomerular filtration rate (eGFR) and BRI among the Chinese population. Methods: This study enrolled 36,784 members over the age of 40, they were from 7 centers in China by using a random sampling method. BRI was computed using height and waist circumference, eGFR ≤ 90 mL/min/1.73 m Results: The age, diabetes and coronary heart disease rates, fasting blood glucose, and triglycerides were all greater in participants with low eGFR. The BRI quartile was still positively connected with low eGFR after controlling for confounding variables, according to multivariate logistic regression analysis. (OR [95%CI] Q2:1.052 [1.021-1.091], OR [95%CI] Q3:1.189 [1.062-1.284], OR [95%CI] Q4:1.283 [1.181-1.394], P trend < 0.001). Stratified research revealed that the elders, women, habitual smokers, and those with a history of diabetes or hypertension experienced the connection between BRI level and low eGFR. According to ROC, BRI was able to detect low eGFR more accurately. Conclusion: Low eGFR in the Chinese community is positively connected with BRI, which has the potential to be used as an effective indicator for screening kidney disease to identify high-risk groups and take appropriate measures to prevent subsequent complications.
MeSH term(s)	Aged ; Female ; Humans ; Cross-Sectional Studies ; Diabetes Mellitus ; East Asian People ; Glomerular Filtration Rate ; Obesity/complications ; Adiposity ; Somatotypes
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1148662
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Article ; Online: Remnant cholesterol is independently associated with diabetes, even if the traditional lipid is at the appropriate level: A report from the REACTION study.

Li, Binqi / Zhou, Xin / Wang, Weiqing / Gao, Zhengnan / Yan, Li / Qin, Guijun / Tang, Xulei / Wan, Qin / Chen, Lulu / Luo, Zuojie / Ning, Guang / Mu, Yiming

Journal of diabetes

2023 Volume 15, Issue 3, Page(s) 204–214

Abstract: Background: The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study and data. This study attempted to explore the association between RC and diabetes in a large sample, multicenter general population.: ... ...

Abstract	Background: The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study and data. This study attempted to explore the association between RC and diabetes in a large sample, multicenter general population. Methods: The current study included 36 684 participants from eight provinces across China. Subjects were quartered according to the RC quartile. Logistic regression analysis was used to evaluate the association between RC and diabetes. Results: After adjusting for potential confounding factors, RC was still significantly associated with diabetes (Q4: odds ratio [OR]:1.147, 95% confidence interval [CI]: 1.049-1.254, p = .003). In addition, RC and diabetes were still significantly associated when triglycerides (TG) were <1.7 mmol/L (Q4: OR: 1.155, 95% CI: 1.005-1.327, p = .042), low-density lipoprotein cholesterol (LDL-C) <3.4 mmol/L (Q4: OR: 1.130, 95% CI: 1.011-1.264, p = .032), or HDL-C (high-density lipoprotein cholesterol) ≥1.0 mmol/L (Q4: OR: 1.116, 95% CI: 1.007-1.237, p = .037). In the stratification analysis, elevated RC was significantly associated with diabetes in subjects with systolic blood pressure (SBP) <140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg, 60 ≤ estimated glomerular filtration rate (eGFR) ≤90 ml/min per 1.73 m Conclusion: In the Chinese community, RC is significantly correlated with diabetes, even when TG, LDL-C, or HDL-C were controlled within the appropriate range recommended by the guidelines.
MeSH term(s)	Humans ; Female ; Middle Aged ; Cholesterol, LDL ; Cholesterol ; Triglycerides ; Diabetes Mellitus/epidemiology ; Cholesterol, HDL ; Risk Factors
Chemical Substances	Cholesterol, LDL ; lipid I ; Cholesterol (97C5T2UQ7J) ; Triglycerides ; Cholesterol, HDL
Language	English
Publishing date	2023-02-05
Publishing country	Australia
Document type	Multicenter Study ; Journal Article
ZDB-ID	2503337-2
ISSN	1753-0407 ; 1753-0393
ISSN (online)	1753-0407
ISSN	1753-0393
DOI	10.1111/1753-0407.13362
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