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  1. Article ; Online: Unraveling crime scenes strand by strand: the forensic odyssey of Bruce Budowle.

    Budowle, Bruce

    BioTechniques

    2023  Volume 75, Issue 3, Page(s) 85–89

    Abstract: Bruce Budowle speaks to Ashling Cannon, Journal Development Editor for ...

    Abstract Bruce Budowle speaks to Ashling Cannon, Journal Development Editor for
    MeSH term(s) Male ; Humans ; Forensic Medicine ; Forensic Sciences ; Crime ; Genetic Techniques ; Health Facilities
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Interview
    ZDB-ID 48453-2
    ISSN 1940-9818 ; 0736-6205
    ISSN (online) 1940-9818
    ISSN 0736-6205
    DOI 10.2144/btn-2023-0069
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  2. Book ; Online ; E-Book: Microbial forensics

    Budowle, Bruce / Schutzer, Steven / Morse, Stephen

    2020  

    Author's details edited by Bruce Budowle, Steven Schutzer, Stephen Morse
    Keywords Forensic genetics ; Forensic biology ; Forensic epidemiology
    Language English
    Size 1 Online-Ressource (xx, 506 Seiten), Illustrationen
    Edition Third edition
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020373129
    ISBN 978-0-12-815380-2 ; 9780128153796 ; 0-12-815380-6 ; 0128153792
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Unraveling crime scenes strand by strand

    Bruce Budowle

    BioTechniques, Vol 75, Iss 3, Pp 85-

    the forensic odyssey of Bruce Budowle

    2023  Volume 89

    Abstract: Bruce Budowle speaks to Ashling Cannon, Journal Development Editor for BioTechniques ... about advancements & challenges in forensic science. Budowle completed his doctorate in genetics at Virginia Tech (VA ... risk factors for acute lymphocytic leukemia, diabetes and melanoma. Budowle was early in his career and hadn't ...

    Abstract Bruce Budowle speaks to Ashling Cannon, Journal Development Editor for BioTechniques, about advancements & challenges in forensic science. Budowle completed his doctorate in genetics at Virginia Tech (VA, USA) formally known as Virginia Polytechnic Institute and State University. He then went on to complete a postdoctoral fellowship at the University of Alabama at Birmingham (AL, USA) to study genetic risk factors for acute lymphocytic leukemia, diabetes and melanoma. Budowle was early in his career and hadn't spent much time in forensics at this stage, but in 1982 an advert caught his eye for a job with the FBI to develop genetic marker systems to identify people who have left biological evidence at crime scenes. Budowle spent 26 years with the FBI and helped develop a plethora of genetic analysis methods. In 1985, it became a reality that DNA could be a signature for identifying people, and there were huge developments in DNA forensic analysis. In 2009, Budowle moved into academia and went to the University of North Texas Health Science Center (TX, USA), eventually becoming the Director of the Center for Human Identification, where he oversaw missing person and traditional crime cases, taught students and carried out fundamental and applied research. Budowle feels incredibly lucky to have had the resources, opportunities and academic infrastructure to learn and develop his knowledge. Budowle recently retired from academia and now spends his time building capacity for DNA forensics applications in Africa through the Department of Justice, with a well-established program known as the International Criminal Investigative Training Assistance Program (ICITAP) as well as with the non-government organization (NGO) DNAforAfrica.
    Keywords DNA analysis ; DNA sequencing ; forensic profiling ; genetic marker ; genetic profile ; next-generation sequencing ; Biology (General) ; QH301-705.5
    Subject code 360
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Short tandem repeats - how microsatellites became the currency of forensic genetics.

    Budowle, Bruce / Sajantila, Antti

    Nature reviews. Genetics

    2024  

    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-024-00721-1
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  5. Article ; Online: Revisiting informed consent in forensic genomics in light of current technologies and the times.

    Budowle, Bruce / Sajantila, Antti

    International journal of legal medicine

    2023  Volume 137, Issue 2, Page(s) 551–565

    Abstract: Informed consent is based on basic ethical principles that should be considered when conducting biomedical and behavioral research involving human subjects. These principles-respect, beneficence, and justice-form the foundations of informed consent which ...

    Abstract Informed consent is based on basic ethical principles that should be considered when conducting biomedical and behavioral research involving human subjects. These principles-respect, beneficence, and justice-form the foundations of informed consent which in itself is grounded on three fundamental elements: information, comprehension, and voluntary participation. While informed consent has focused on human subjects and research, the practice has been adopted willingly in the forensic science arena primarily to acquire reference samples from family members to assist in identifying missing persons. With advances in molecular biology technologies, data mining, and access to metadata, it is important to assess whether the past informed consent process and in particular associated risks are concomitant with these increased capabilities. Given the state-of-the-art, areas in which informed consent may need to be modified and augmented are as follows: reference samples from family members in missing persons or unidentified human remains cases; targeted analysis of an individual(s) during forensic genetic genealogy cases to reduce an investigative burden; donors who provide their samples for validation studies (to include population studies and entry into databases that would be applied to forensic statistical calculations) to support implementation of procedures and operations of the forensic laboratory; family members that may contribute samples or obtain genetic information from a molecular autopsy; and use of medical and other acquired samples that could be informative for identification purposes. The informed consent process should cover (1) purpose for collection of samples; (2) process to analyze the samples (to include type of data); (3) benefits (to donor, target, family, community, etc. as applicable); (4) risks (to donor, target, family, community, etc. as applicable); (5) access to data/reports by the donor; (6) sample disposition; (7) removal of data process (i.e., expungement); (8) process to ask questions/assessment of comprehension; (9) follow-up processes; and (10) voluntary, signed, and dated consent. Issues surrounding these topics are discussed with an emphasis on addressing risk factors. Addressing informed consent will allow human subjects to make decisions voluntarily and with autonomy as well as secure the use of samples for intended use.
    MeSH term(s) Humans ; Informed Consent ; Comprehension ; Research Design
    Language English
    Publishing date 2023-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-023-02947-w
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  6. Book: DNA typing protocols

    Budowle, Bruce

    molecular biology and forensic analysis

    (BioForensic science series ; BioTechniques books)

    2000  

    Author's details Bruce Budowle
    Series title BioForensic science series
    BioTechniques books
    Language English
    Size VII, 304 S. : Ill., graph. Darst.
    Publisher Eaton
    Publishing place Natick, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT012928479
    ISBN 1-881299-23-6 ; 978-1-881299-23-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 972 order for loan Magazin

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  7. Article: Wildfire smoke exposure and cardiovascular disease-should statins be recommended to prevent cardiovascular events?

    Vuorio, Alpo / Budowle, Bruce / Raal, Frederick / Kovanen, Petri T

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1259162

    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1259162
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  8. Article: Current Healthcare Systems in Light of Hyperendemic NCDs and the COVID-19 Pandemic: Time to Change.

    Buhmeida, Abdelbaset / Assidi, Mourad / Budowle, Bruce

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 10

    Abstract: Despite the significant achievements of current healthcare systems (CHCSs) in curing or treating several acute conditions, there has been far less success coping with noncommunicable diseases (NCDs), which have complex roots and nonconventional ... ...

    Abstract Despite the significant achievements of current healthcare systems (CHCSs) in curing or treating several acute conditions, there has been far less success coping with noncommunicable diseases (NCDs), which have complex roots and nonconventional transmission vectors. Owing to the impact of the invisible hyperendemic NCDs and the COVID-19 pandemic, the limitations of CHCSs have been exposed. In contrast, the advent of omics-based technologies and big data science has raised global hope of curing or treating NCDs and improving overall healthcare outcomes. However, challenges related to their use and effectiveness must be addressed. Additionally, while such advancements intend to improve quality of life, they can also contribute the ever-increasing health disparity among vulnerable populations, such as low/middle-income populations, poorly educated people, gender-based violence victims, and minority and indigenous peoples, to name a few. Among five health determinants, the contribution of medical care to individual health does not exceed 11%. Therefore, it is time to implement a new well-being-oriented system complementary or parallel to CHCSs that incorporates all five health determinants to tackle NCDs and unforeseen diseases of the future, as well as to promote cost-effective, accessible, and sustainable healthy lifestyle choices that can reduce the current level of healthcare inequity.
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11101382
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  9. Article: TRcaller: a novel tool for precise and ultrafast tandem repeat variant genotyping in massively parallel sequencing reads.

    Wang, Xuewen / Huang, Meng / Budowle, Bruce / Ge, Jianye

    Frontiers in genetics

    2023  Volume 14, Page(s) 1227176

    Abstract: Calling tandem repeat (TR) variants from DNA sequences is of both theoretical and practical significance. Some bioinformatics tools have been developed for detecting or genotyping TRs. However, little study has been done to genotyping TR alleles from ... ...

    Abstract Calling tandem repeat (TR) variants from DNA sequences is of both theoretical and practical significance. Some bioinformatics tools have been developed for detecting or genotyping TRs. However, little study has been done to genotyping TR alleles from long-read sequencing data, and the accuracy of genotyping TR alleles from next-generation sequencing data still needs to be improved. Herein, a novel algorithm is described to retrieve TR regions from sequence alignment, and a software program TRcaller has been developed and integrated into a web portal to call TR alleles from both short- and long-read sequences, both whole genome and targeted sequences generated from multiple sequencing platforms. All TR alleles are genotyped as haplotypes and the robust alleles will be reported, even multiple alleles in a DNA mixture. TRcaller could provide substantially higher accuracy (>99% in 289 human individuals) in detecting TR alleles with magnitudes faster (e.g., ∼2 s for 300x human sequence data) than the mainstream software tools. The web portal preselected 119 TR loci from forensics, genealogy, and disease related TR loci. TRcaller is validated to be scalable in various applications, such as DNA forensics and disease diagnosis, which can be expanded into other fields like breeding programs. Availability: TRcaller is available at https://www.trcaller.com/SignIn.aspx.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1227176
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  10. Article ; Online: A cost-benefit analysis for use of large SNP panels and high throughput typing for forensic investigative genetic genealogy.

    Budowle, Bruce / Arnette, Andrew / Sajantila, Antti

    International journal of legal medicine

    2023  Volume 137, Issue 5, Page(s) 1595–1614

    Abstract: Next-generation sequencing (NGS), also known as massively sequencing, enables large dense SNP panel analyses which generate the genetic component of forensic investigative genetic genealogy (FIGG). While the costs of implementing large SNP panel analyses ...

    Abstract Next-generation sequencing (NGS), also known as massively sequencing, enables large dense SNP panel analyses which generate the genetic component of forensic investigative genetic genealogy (FIGG). While the costs of implementing large SNP panel analyses into the laboratory system may seem high and daunting, the benefits of the technology may more than justify the investment. To determine if an infrastructural investment in public laboratories and using large SNP panel analyses would reap substantial benefits to society, a cost-benefit analysis (CBA) was performed. This CBA applied the logic that an increase of DNA profile uploads to a DNA database due to a sheer increase in number of markers and a greater sensitivity of detection afforded with NGS and a higher hit/association rate due to large SNP/kinship resolution and genealogy will increase investigative leads, will be more effective for identifying recidivists which in turn reduces future victims of crime, and will bring greater safety and security to communities. Analyses were performed for worst case/best case scenarios as well as by simulation sampling the range spaces with multiple input values simultaneously to generate best estimate summary statistics. This study shows that the benefits, both tangible and intangible, over the lifetime of an advanced database system would be huge and can be projected to be for less than $1 billion per year (over a 10-year period) investment can reap on average > $4.8 billion in tangible and intangible cost-benefits per year. More importantly, on average > 50,000 individuals need not become victims if FIGG were employed, assuming investigative associations generated were acted upon. The benefit to society is immense making the laboratory investment a nominal cost. The benefits likely are underestimated herein. There is latitude in the estimated costs, and even if they were doubled or tripled, there would still be substantial benefits gained with a FIGG-based approach. While the data used in this CBA are US centric (primarily because data were readily accessible), the model is generalizable and could be used by other jurisdictions to perform relevant and representative CBAs.
    MeSH term(s) Humans ; Cost-Benefit Analysis ; DNA Fingerprinting ; DNA/analysis ; High-Throughput Nucleotide Sequencing ; Crime ; Polymorphism, Single Nucleotide
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-023-03029-7
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