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  1. Article ; Online: Cystoseira myrica

    Manel Dhahri

    Frontiers in Marine Science, Vol

    from beach-cast seaweed to fucoidan with antioxidant and anticoagulant capacity

    2023  Volume 10

    Abstract: This study highlights the potential of the brown algae Cystoseira myrica, collected from raw beach seaweed wastes, as a reliable source of bioactive fucoidan. Fucoidans are natural bioactive sulfated polysaccharides that are gaining popularity worldwide ... ...

    Abstract This study highlights the potential of the brown algae Cystoseira myrica, collected from raw beach seaweed wastes, as a reliable source of bioactive fucoidan. Fucoidans are natural bioactive sulfated polysaccharides that are gaining popularity worldwide due to their diverse biochemical composition, attractive physical properties, and functional pharmacological activities. The aim of this work is to valorize the beach-Accumulated brown algae C. myrica by fucoidan extraction and to investigate its anticoagulant and antioxidant activity. Fucoidan was extracted using several steps of papain digestion followed by cetyltrimethylammonium bromide (CTAB) precipitation and calcium chloride treatment to avoid the coextraction of other polysaccharides. Structural features of the extracted fucoidan were investigated by Fourier transform infrared spectroscopy (FT-IR), solid-state nuclear magnetic resonance (NMR) and high-resolution mass spectroscopy. Agarose gel electrophoresis was used to confirm the purity of the isolated fucoidan from C. myrica. Anticoagulant properties were studied in vitro by activated partial thromboplastin time (aPTT) and prothrombin time (PT) assays. Furthermore, the antioxidant activity was investigated by 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and Fe chelating ability. Our results indicate that the approach used was effective in extracting fucoidan with a yield of 3.07%, a high amount of sulfate (27.79%), and fucose was found to be the major monosaccharide component. The extracted fucoidan showed an interesting anticoagulant activity. It prolonged aPTT significantly at a concentration of 10 µg/ml and prolonged PT at high doses. This demonstrated that fucoidan from C. myrica may affect intrinsic pathways while having little impact on the extrinsic mechanism of coagulation. However, the extracted fucoidan significantly exhibited an interesting antioxidant capacity as shown by the higher ABTS radical scavenging activity and Ferrous ion-chelating effect. The current findings ...
    Keywords marine waste ; brown algae ; fucoidan ; sulfate ; antioxidant ; anticoagulant ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 540
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Multifunctional Ag

    Zagloul, Hayat / Dhahri, Manel / Bashal, Ali H / Khaleil, Mona M / Habeeb, Talaat H / Khalil, Khaled D

    International journal of biological macromolecules

    2024  Volume 264, Issue Pt 1, Page(s) 129990

    Abstract: In this study, a single step in situ sol-gel method was used to syntheses nanocomposite films using chitosan (CS) as the basis material, with the addition of silver oxide nanoparticles ( ... ...

    Abstract In this study, a single step in situ sol-gel method was used to syntheses nanocomposite films using chitosan (CS) as the basis material, with the addition of silver oxide nanoparticles (Ag
    MeSH term(s) Chitosan/chemistry ; Antioxidants/pharmacology ; Food Packaging ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Metal Nanoparticles/chemistry ; Nanocomposites/chemistry ; Oxides ; Silver Compounds
    Chemical Substances Chitosan (9012-76-4) ; disilver oxide (897WUN6G6T) ; Antioxidants ; Anti-Infective Agents ; Anti-Bacterial Agents ; Oxides ; Silver Compounds
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129990
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  3. Article ; Online: Magnetocaloric effect and critical behavior of the La

    Bouzidi, Souhir / Hsini, Mohamed / Soltani, Sonia / Essid, Manel / Albedah, M A / Belmabrouk, Hafedh / Dhahri, J

    RSC advances

    2023  Volume 13, Issue 24, Page(s) 16529–16535

    Abstract: In this paper, we have studied the critical behavior and the magnetocaloric effect (MCE) simulation for the ... ...

    Abstract In this paper, we have studied the critical behavior and the magnetocaloric effect (MCE) simulation for the La
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra02443a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhanced detection of low concentration volatile organic compounds using advanced doped zinc oxide sensors.

    Benamara, Majdi / Ly, Ahmadou / Soltani, Sonia / Essid, Manel / Dahman, Hassen / Dhahri, Ramzi / El Mir, Lassaad / Debliquy, Marc / Lahem, Driss

    RSC advances

    2023  Volume 13, Issue 43, Page(s) 30230–30242

    Abstract: Pure zinc oxide nanoparticles, as well as those doped with 3% calcium, aluminum, and gallium, were synthesized using a sol-gel method and then deposited onto an alumina substrate for sensing tests. The resulting nanoparticles were characterized using a ... ...

    Abstract Pure zinc oxide nanoparticles, as well as those doped with 3% calcium, aluminum, and gallium, were synthesized using a sol-gel method and then deposited onto an alumina substrate for sensing tests. The resulting nanoparticles were characterized using a variety of techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM) equipped with energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), UV-VIS-NIR absorption spectroscopy, and photoluminescence (PL) measurements, to examine their structural, morphological, and optical properties. The prepared nanoparticles were found to have the hexagonal wurtzite structure of ZnO with a
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03143h
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  5. Article: Synthesis, DFT Molecular Geometry and Anticancer Activity of Symmetrical 2,2'-(2-Oxo-1

    Dhahri, Manel / Khan, Firdos Alam / Emwas, Abdul-Hamid / Alnoman, Rua B / Jaremko, Mariusz / Rezki, Nadjet / Aouad, Mohamed Reda / Hagar, Mohamed

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 7

    Abstract: To identify new candidate anticancer compounds, we here report the synthesis of benzimidazole derivatives: diethyl 2,2'-(2-oxo- ... ...

    Abstract To identify new candidate anticancer compounds, we here report the synthesis of benzimidazole derivatives: diethyl 2,2'-(2-oxo-1
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15072544
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  6. Article: Untargeted metabolomics analysis of four date palm (Phoenix dactylifera L.) cultivars using MS and NMR.

    Alsuhaymi, Shuruq / Singh, Upendra / Al-Younis, Inas / Kharbatia, Najeh M / Haneef, Ali / Chandra, Kousik / Dhahri, Manel / Assiri, Mohammed A / Emwas, Abdul-Hamid / Jaremko, Mariusz

    Natural products and bioprospecting

    2023  Volume 13, Issue 1, Page(s) 44

    Abstract: Since ancient times, the inhabitants of dry areas have depended on the date palm (Phoenix dactylifera L.) as a staple food and means of economic security. For example, dates have been a staple diet for the inhabitants of the Arabian Peninsula and Sahara ... ...

    Abstract Since ancient times, the inhabitants of dry areas have depended on the date palm (Phoenix dactylifera L.) as a staple food and means of economic security. For example, dates have been a staple diet for the inhabitants of the Arabian Peninsula and Sahara Desert in North Africa for millennia and the local culture is rich in knowledge and experience with the benefits of dates, suggesting that dates contain many substances essential for the human body. Madinah dates are considered one of the most important types of dates in the Arabian Peninsula, with Ajwa being one of the most famous types and grown only in Madinah, Saudi Arabia. Date seeds are traditionally used for animal feed, seed oil production, cosmetics, and as a coffee substitute. Phytochemical compounds that have been detected in date fruits and date seeds include phenolic acids, carotenoids, and flavonoids. Phenolic acids are the most prevalent bioactive constituents that contribute to the antioxidant activity of date fruits. The bioactive properties of these phytochemicals are believed to promote human health by reducing the risk of diseases such as chronic inflammation. Ajwa dates especially are thought to have superior bioactivity properties. To investigate these claims, in this study, we compare the metabolic profiles of Ajwa with different types of dates collected from Saudi Arabia and Tunisia. We show by UHPLC-MS that date seeds contain several classes of flavonoids, phenolic acids, and amino acid derivatives, including citric acid, malic acid, lactic acid, and hydroxyadipic acid. Additionally, GC-MS profiling showed that date seeds are richer in metabolite classes, such as hydrocinnamic acids (caffeic, ferulic and sinapic acids), than flesh samples. Deglet N fruit extract (minimum inhibitory concentration: 27 MIC/μM) and Sukkari fruit extract (IC
    Language English
    Publishing date 2023-10-23
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-2195
    ISSN 2192-2195
    DOI 10.1007/s13659-023-00406-y
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  7. Article ; Online: Living with the enemy: from protein-misfolding pathologies we know, to those we want to know.

    Emwas, Abdul-Hamid / Alghrably, Mawadda / Dhahri, Manel / Sharfalddin, Abeer / Alsiary, Rawiah / Jaremko, Mariusz / Faa, Gavino / Campagna, Marcello / Congiu, Terenzio / Piras, Monica / Piludu, Marco / Pichiri, Giuseppina / Coni, Pierpaolo / Lachowicz, Joanna Izabela

    Ageing research reviews

    2021  Volume 70, Page(s) 101391

    Abstract: Conformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with ... ...

    Abstract Conformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and previously unconsidered biological effect as an endogenous metal ion chelator that plays a significant role in essential metal ion homeostasis. In this respect, AAT polymorphism may cause an imbalance of metal ions, which could be correlated with the aggregation of amylin, tau, amyloid beta, and alpha synuclein proteins in type 2 diabetes mellitus (T2DM), Alzheimer's and Parkinson's diseases, respectively.
    MeSH term(s) Amyloid beta-Peptides ; Diabetes Mellitus, Type 2 ; Humans ; Islet Amyloid Polypeptide ; Parkinson Disease ; alpha 1-Antitrypsin Deficiency
    Chemical Substances Amyloid beta-Peptides ; Islet Amyloid Polypeptide
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2021.101391
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  8. Article: Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases.

    Dhahri, Manel / Alghrably, Mawadda / Mohammed, Hamdoon A / Badshah, Syed Lal / Noreen, Noreen / Mouffouk, Fouzi / Rayyan, Saleh / Qureshi, Kamal A / Mahmood, Danish / Lachowicz, Joanna Izabela / Jaremko, Mariusz / Emwas, Abdul-Hamid

    Pharmaceutics

    2021  Volume 14, Issue 1

    Abstract: Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. ... ...

    Abstract Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural compounds including polysaccharides have demonstrated neuroprotective and even therapeutic effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and fungal species, and have received considerable attention for their wide-ranging bioactivity, including their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In this review, we summarize different mechanisms involved in neurodegenerative diseases and the neuroprotective effects of natural polysaccharides, highlighting their potential role in the prevention and therapy of neurodegenerative disease.
    Language English
    Publishing date 2021-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14010001
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  9. Article ; Online: Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from

    Dhahri, Manel / Sioud, Salim / Dridi, Rihab / Hassine, Mohsen / Boughattas, Naceur A / Almulhim, Fatimah / Al Talla, Zeyad / Jaremko, Mariusz / Emwas, Abdul-Hamid M

    ACS omega

    2020  Volume 5, Issue 24, Page(s) 14786–14795

    Abstract: Bioactive compounds for drug discovery are increasingly extracted and purified from natural sources including marine organisms. Heparin is a therapeutic agent that has been used for several decades as an anticoagulant. However, heparin is known to cause ... ...

    Abstract Bioactive compounds for drug discovery are increasingly extracted and purified from natural sources including marine organisms. Heparin is a therapeutic agent that has been used for several decades as an anticoagulant. However, heparin is known to cause many undesirable complications such as thrombocytopenia and risk of hemorrhage. Hence, there is a need to find alternatives to current widely used anticoagulant drugs. Here, we extract a sulfated polysaccharide from sea hare, that is,
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c01724
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  10. Article ; Online: Access to new anticoagulant by sulfation of pectin-like polysaccharides isolated from Opuntia ficus indica cladodes.

    Chaouch, Mohamed Aymen / Hammi, Khaoula Mkhadmini / Dhahri, Manel / Mansour, Mohamed Ben / Maaroufi, Mounir Raoui / Le Cerf, Didier / Majdoub, Hatem

    International journal of biological macromolecules

    2018  Volume 120, Issue Pt B, Page(s) 1794–1800

    Abstract: In order to develop new and low cost anticoagulants as potential heparin alternatives, sulfation of a pectin-like polysaccharide from Opuntia ficus indica cladodes using ... ...

    Abstract In order to develop new and low cost anticoagulants as potential heparin alternatives, sulfation of a pectin-like polysaccharide from Opuntia ficus indica cladodes using SO
    MeSH term(s) Anticoagulants/chemistry ; Anticoagulants/pharmacology ; Opuntia/chemistry ; Pectins/chemistry ; Pectins/pharmacology ; Sulfates/chemistry ; Thrombin Time
    Chemical Substances Anticoagulants ; Sulfates ; Pectins (89NA02M4RX)
    Language English
    Publishing date 2018-09-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2018.09.130
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