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  1. Article ; Online: Editorial - "Spine-in-spine": few considerations regarding the so-called "Spinal transplant".

    Gasbarrini, A

    European review for medical and pharmacological sciences

    2020  Volume 23, Issue 24, Page(s) 11062–11063

    MeSH term(s) Aged ; Bone Neoplasms/therapy ; Bone Transplantation ; Chordoma/therapy ; Humans ; Male ; Spinal Diseases/therapy ; Spinal Fusion
    Language English
    Publishing date 2020-01-06
    Publishing country Italy
    Document type Case Reports ; Editorial
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201912_19814
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    Zs.A 1887: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: A pharmacokinetic evaluation of tenapanor for the treatment of irritable bowel syndrome with constipation: an update of the literature.

    Currò, Diego / Ianiro, Gianluca / Gasbarrini, Antonio

    Expert opinion on drug metabolism & toxicology

    2024  Volume 19, Issue 12, Page(s) 889–894

    Abstract: Introduction: Tenapanor is the latest addition to the second-line pharmacotherapeutic options for the treatment of irritable bowel syndrome with constipation. It is a first-in-class inhibitor of type 3 sodium/hydrogen exchanger (NHE3), characterized by ... ...

    Abstract Introduction: Tenapanor is the latest addition to the second-line pharmacotherapeutic options for the treatment of irritable bowel syndrome with constipation. It is a first-in-class inhibitor of type 3 sodium/hydrogen exchanger (NHE3), characterized by very low oral absorption. Its pharmacological properties are discussed here based on the latest literature.
    Areas covered: A general description of tenapanor is provided, highlighting those pharmacokinetic and pharmacodynamic characteristics of the drug which may be of major importance for tolerability and safety. This description is associated with a summary and analysis of currently available toxicological data.
    Expert opinion: Plasma concentrations of free tenapanor after oral administration are well below the half maximal inhibitory concentration for NHE3, so that systemic effects of the drug are minimal. Therefore, the action of tenapanor is limited to NHE3 located on the apical membrane of enterocytes. The consequent reduction in intestinal sodium absorption increases the intraluminal content by osmosis, which in turn enhances the propulsive activity of the colon. Diarrhea is the most frequent adverse effect of tenapanor. Increased fecal sodium and water excretion do not appear to expose patients to short- and long-term hydro-electrolyte imbalances.
    MeSH term(s) Humans ; Irritable Bowel Syndrome/drug therapy ; Sodium-Hydrogen Exchanger 3 ; Constipation/drug therapy ; Constipation/complications ; Sodium/metabolism ; Sodium/therapeutic use ; Isoquinolines ; Sulfonamides
    Chemical Substances tenapanor (WYD79216A6) ; Sodium-Hydrogen Exchanger 3 ; Sodium (9NEZ333N27) ; Isoquinolines ; Sulfonamides
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2023.2294937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6264: Show issues Location:
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  3. Article ; Online: Letter: The multifaceted role of Escherichia coli in influencing disorders of industrial populations.

    Ingrosso, Maria Rosa / Gasbarrini, Antonio / Cammarota, Giovanni / Ianiro, Gianluca

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 5, Page(s) 717–718

    MeSH term(s) Humans ; Escherichia coli ; Escherichia coli Infections
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17865
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    Zs.A 2206: Show issues Location:
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  4. Article ; Online: GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS: FROM PROGNOSTIC ROLE TO THERAPEUTIC IMPLICATIONS.

    Maccauro, Valeria / Fianchi, Francesca / Gasbarrini, Antonio / Ponziani, Francesca Romana

    Digestive diseases (Basel, Switzerland)

    2024  

    Abstract: Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of unknown etiology characterized by biliary inflammation and periductal fibrosis. The gut microbiota plays a crucial role in the pathogenesis of PSC by regulating bile ... ...

    Abstract Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of unknown etiology characterized by biliary inflammation and periductal fibrosis. The gut microbiota plays a crucial role in the pathogenesis of PSC by regulating bile acids metabolism, inflammation and immune response. On the other hand, liver disease progression affects the composition of the gut microbiota, fostering these mechanisms in a mutual detrimental way.
    Summary: Recent evidences described a specific pro-inflammatory microbial signature in PSC patients, with an overall reduced bacterial diversity and the loss of beneficial metabolites such as short-chain fatty acids. As effective therapies for PSC are still lacking, targeting the gut microbiota offers a new perspective in the management of this disease. To date, antibiotics, fecal microbiota transplantation and probiotics are the most studied gut microbiota-targeted intervention in PSC, but new potential strategies such as vaccines and bacteriophages represent possible future therapeutic horizons.
    Key messages: In this review, we focus on the role of the gut microbiota in PSC, considering its pathogenetic and prognostic role, and the therapeutic implications.
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000538493
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    Zs.A 1853: Show issues Location:
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  5. Article: Vaccine Responses in Patients with Liver Cirrhosis: From the Immune System to the Gut Microbiota.

    Airola, Carlo / Andaloro, Silvia / Gasbarrini, Antonio / Ponziani, Francesca Romana

    Vaccines

    2024  Volume 12, Issue 4

    Abstract: Vaccines prevent a significant number of deaths annually. However, certain populations do not respond adequately to vaccination due to impaired immune systems. Cirrhosis, a condition marked by a profound disruption of immunity, impairs the normal ... ...

    Abstract Vaccines prevent a significant number of deaths annually. However, certain populations do not respond adequately to vaccination due to impaired immune systems. Cirrhosis, a condition marked by a profound disruption of immunity, impairs the normal immunization process. Critical vaccines for cirrhotic patients, such as the hepatitis A virus (HAV), hepatitis B virus (HBV), influenza, pneumococcal, and coronavirus disease 19 (COVID-19), often elicit suboptimal responses in these individuals. The humoral response, essential for immunization, is less effective in cirrhosis due to a decline in B memory cells and an increase in plasma blasts, which interfere with the creation of a long-lasting response to antigen vaccination. Additionally, some T cell subtypes exhibit reduced activation in cirrhosis. Nonetheless, the persistence of memory T cell activity, while not preventing infections, may help to attenuate the severity of diseases in these patients. Alongside that, the impairment of innate immunity, particularly in dendritic cells (DCs), prevents the normal priming of adaptive immunity, interrupting the immunization process at its onset. Furthermore, cirrhosis disrupts the gut-liver axis balance, causing dysbiosis, reduced production of short-chain fatty acids (SCFAs), increased intestinal permeability, and bacterial translocation. Undermining the physiological activity of the immune system, these alterations could impact the vaccine response. Enhancing the understanding of the molecular and cellular factors contributing to impaired vaccination responses in cirrhotic patients is crucial for improving vaccine efficacy in this population and developing better prevention strategies.
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12040349
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  6. Article ; Online: Reply to: Further advancing emergency department triage prediction.

    Covino, Marcello / Sandroni, Claudio / Gasbarrini, Antonio / Franceschi, Francesco

    Resuscitation

    2023  Volume 191, Page(s) 109952

    MeSH term(s) Humans ; Triage ; Emergency Service, Hospital ; ROC Curve
    Language English
    Publishing date 2023-08-28
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109952
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    Zs.A 1048: Show issues Location:
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  7. Article ; Online: An undetectable source of recurrent gastrointestinal bleeding: hemosuccus pancreaticus.

    Borriello, Raffaele / Massaro, Roberta / Abbate, Valeria / Gasbarrini, Antonio

    Internal and emergency medicine

    2023  Volume 18, Issue 4, Page(s) 1221–1223

    MeSH term(s) Humans ; Gastrointestinal Hemorrhage/etiology ; Chronic Disease
    Language English
    Publishing date 2023-03-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03242-7
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    Zs.A 6673: Show issues Location:
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  8. Article ; Online: The last step to achieve barrier damage control.

    Baglivo, Ilaria / Colantuono, Stefania / Lumaca, Arianna / Papa, Alfredo / Gasbarrini, Antonio / Caruso, Cristiano

    Frontiers in immunology

    2024  Volume 15, Page(s) 1354556

    Abstract: Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ... ...

    Abstract Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role triggering type 2 inflammation through the alarmins system, such as anti-Thymic Stromal Lymphopoietin (TSLP). Treatment with anti-TSLP monoclonal antibodies showed efficacy in severe asthma and clinical trials for other eosinophilic diseases are ongoing. The aim of this perspective review is to analyse current advances and future applications of TSLP inhibition to control barrier damage.
    MeSH term(s) Humans ; Cytokines ; Asthma ; Thymic Stromal Lymphopoietin ; Adaptive Immunity ; Inflammation
    Chemical Substances Cytokines ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1354556
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  9. Article ; Online: Editorial - COVID-19 pandemic outbreak and the Latin rule of Bernard de Clairvaux. Have we forgotten the past?

    Franceschi, F / Gasbarrini, G / Gasbarrini, A

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 12, Page(s) 7194–7195

    MeSH term(s) Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; History, Medieval ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Zoonoses/history ; Zoonoses/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-05-09
    Publishing country Italy
    Document type Editorial ; Historical Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202006_21715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  10. Article ; Online: Editorial - COVID-19 and the microbiota: new kids on the block.

    Gasbarrini, G / Dionisi, T / Franceschi, F / Gasbarrini, A

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 9, Page(s) 5189–5191

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Gastrointestinal Microbiome ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country Italy
    Document type Editorial
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202005_21218
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