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Article ; Online: Do all short stem types restore biomechanical parameters of the hip? Comparison according to femoral neck osteotomy levels.

Barça, Fatih / Demir, Ekin Barış / İbolar, Mithat / Atilla, Halis Atıl / Akdoğan, Mutlu

2024

Abstract: Purpose: There is no consensus on ideal short femoral stem design. A classification system proposed by Feyen and Shimmin divides short stems in two types according to femoral neck osteotomy levels: subcapital (IIIA) and standard (IIIB). The study aims ... ...

Abstract	Purpose: There is no consensus on ideal short femoral stem design. A classification system proposed by Feyen and Shimmin divides short stems in two types according to femoral neck osteotomy levels: subcapital (IIIA) and standard (IIIB). The study aims to determine which design type is more successful in restoring native biomechanical parameters and whether stem type has an impact on clinical results. Methods: In this retrospective comparative study, patients that have undergone short stem hip arthroplasty were evaluated according to stem types: type IIIA (n = 52, 66.7%) (Mathys Optimys) and IIIB (n = 26, 33.3%) (Implantcast Aida and Smith & Nephew SMF). Pelvis X-rays were assessed in terms of femoral neck length, horizontal and vertical hip centres of rotation, horizontal and vertical femoral offsets, abductor lever arm lengths, leg lengths, and stem-shaft angles. Improvement in Harris hip scores, differences between post-operative and pre-operative measurements, and stem-shaft angles were evaluated and compared between two groups. Results: Mean femoral neck resection (8.27 ± 6.68 mm in IIIA and 15 ± 6.33 mm in IIIB) was significantly different between both groups (p < 0.001). Harris hip scores were increased at post-operative six months in both groups with no difference (84.4 ± 6.4 and 84.6 ± 5.5, p = 0.4). The absolute values of differences between pre-operative and post-operative horizontal centres of rotation (p = 0.63), vertical centers of rotation (p = 0.75), horizontal femoral offsets (p = 0.78), vertical femoral offsets (p = 0.83), abductor lever arm distances (p = 0.63), and leg length (p = 0.21) measurements were not different between both groups. Stem positions were both varus with no statistically significant difference between groups (p = 0.14). Conclusion: We found no difference regarding restoration of biomechanical parameters between short stem designs with different levels of neck osteotomy. Additionally, short stem can mostly result in varus component positioning regardless of the level of neck osteotomy.
Language	English
Publishing date	2024-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-024-06176-7
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Zs.A 1324: Show issues

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Article ; Online: Use of tranexamic acid may reduce the need for routine tourniquet use in total knee arthroplasty.

Akdoğan, Mutlu / Öztürk, Alper / Çatma, Mehmet Faruk / Akdoğan, Burak Menderes / Gülsoy, Atakan / Atilla, Halis Atıl

Joint diseases and related surgery

2022 Volume 33, Issue 3, Page(s) 547–552

Abstract: Objectives: The aim of this study was to evaluate the effects of tranexamic acid (TXA) administration on bleeding control and to compare its utilization with and without simultaneous use of conventional pneumatic tourniquets during total knee ... ...

Abstract	Objectives: The aim of this study was to evaluate the effects of tranexamic acid (TXA) administration on bleeding control and to compare its utilization with and without simultaneous use of conventional pneumatic tourniquets during total knee arthroplasty (TKA). Patients and methods: Between January 2017 and December 2017, a total of 204 patients (23 males, 181 females; mean age: 66±6.9 years; range, 45 to 86 years) who underwent TKA for Stage 4 gonarthrosis were retrospectively analyzed. The patients were divided into two groups as those with (n=110) and without (n=94) pneumatic tourniquet use. Tranexamic acid (1 g) was administered intravenously to all patients in both study groups. Intra- and postoperative blood loss were calculated, and postoperative pain was evaluated by a Visual Analog Scale. Demographic and clinical data were compared between the study groups. Results: The amount of total blood loss and postoperative blood loss were significantly higher in the tourniquet group than that in the no-tourniquet group (589.4±69.5 mL vs. 490.8±55.2 mL and 326±56 mL vs. 164±35.5 mL, respectively; p<0.001 for both). Intraoperative blood loss was significantly higher in the no-tourniquet group (326.9±42.9 mL vs. 263.5±53.8 mL, respectively; p<0.001). The pain score at 24 h was significantly higher in the tourniquet group (p<0.001). Conclusion: Total blood loss and postoperative pain were significantly higher among patients in whom a tourniquet was used during TKA. Therefore, the routine use of tourniquets with TXA should be reconsidered.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Tranexamic Acid/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Antifibrinolytic Agents/therapeutic use ; Retrospective Studies ; Postoperative Hemorrhage/prevention & control ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control
Chemical Substances	Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents
Language	English
Publishing date	2022-10-06
Publishing country	Turkey
Document type	Journal Article
ISSN	2687-4792
ISSN (online)	2687-4792
DOI	10.52312/jdrs.2022.737
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Article ; Online: Are Behçet's disease patients with Budd-Chiari at increased risk for the development of pulmonary hypertension?

Ekici, Mustafa / İleri, Serez / Ünaldı, Erdinç / Bayram, Gözde Sevgi Kart / Kılıç, Levent / Akdoğan, Ali

Rheumatology (Oxford, England)

2024

Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae067
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: The potential of therapeutic hyperthermia to eradicate Staphylococcus aureus bacteria; an in vitro study.

Gazel, Deniz / Akdoğan, Hüseyin / Büyüktaş Manay, Ayşe / Erinmez, Mehmet / Zer, Yasemin

Journal of thermal biology

2024 Volume 120, Page(s) 103812

Abstract: Staphylococcus aureus is one of the most common infectious agents, causing morbidity and mortality worldwide. Most pathogenic bacteria are classified in the group of mesophilic bacteria and the optimal growth temperature of these bacteria changes between ...

Abstract	Staphylococcus aureus is one of the most common infectious agents, causing morbidity and mortality worldwide. Most pathogenic bacteria are classified in the group of mesophilic bacteria and the optimal growth temperature of these bacteria changes between 33 and 41 °C. Increased temperature can inhibit bacterial growth and mobility, which in turn, can trigger autolysis and cause cell wall damage. Hyperthermia treatment is defined as a heat-mediated treatment method applied using temperatures higher than body temperature. Nowadays, this treatment method is used especially in the treatment of tumours. Hyperthermia treatment is divided into two groups: mild hyperthermia and ablative or high-temperature hyperthermia. Mild hyperthermia is a therapeutic technique in which tumour tissue is heated above body temperature to produce a physiological or biological effect but is often not aimed at directly causing significant cell death. The goal of this method is to achieve temperatures of 40-45 °C in human tissues for up to 2 h. Hyperthermia can be used in the treatment of infections caused by such bacterial pathogens. In addition, using hyperthermia in combination with antimicrobial drugs may result in synergistic effects and reduce resistance issues. In our study, we used two different temperature levels (37 °C and 45 °C). We assessed growth inhibition, some virulence factors, alteration colony morphologies, and antimicrobial susceptibility for several antibiotics with three methods (Kirby-Bauer, E-test and broth microdilution) under hyperthermia. In the study, we observed that hyperthermia affected the urease enzyme, antibiotic sensitivity levels showed synergy with hyperthermia, and changes occurred in colony diameters and affected bacterial growth. We hypothesise that hyperthermia might be a new therapeutic option for infectious diseases as a sole agent or in combination with different antimicrobials.
MeSH term(s)	Humans ; Staphylococcus aureus ; Hyperthermia, Induced/methods ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Hot Temperature ; Staphylococcal Infections/therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2024.103812
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Article: Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biopolymer by recombinant Bacillus megaterium in fed-batch bioreactors

Akdoğan, Murat / Çelik, Eda

Bioprocess and biosystems engineering. 2021 Feb., v. 44, no. 2

2021

Abstract: Polyhydroxyalkanoates (PHAs) are biodegradable polyesters accumulated in a wide variety of microorganisms as intracellular carbon and energy storage compounds. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is one of the most valuable biopolymers ... ...

Abstract	Polyhydroxyalkanoates (PHAs) are biodegradable polyesters accumulated in a wide variety of microorganisms as intracellular carbon and energy storage compounds. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is one of the most valuable biopolymers because of its superior mechanical properties. Here, we developed a bioprocess utilizing recombinant Bacillus megaterium strain for PHBV over-production from glucose, without any precursor addition. PHA production was performed in a controlled bioreactor by batch and fed-batch modes using wild-type B. megaterium and rec-B. megaterium cells overexpressing the native phaC gene. The effect of oxygen transfer rate on biomass formation and PHA accumulation was also investigated, under different dissolved oxygen levels. Structural and thermal properties of PHA were characterized by GC–FID, ¹H‐NMR, TGA and DSC analyses. Significantly, the copolymer produced from glucose as the carbon source in rec-B. megaterium was composed of 58 mol% of 3‐hydroxyvalerate monomers. After 66 h, rec-B. megaterium cells in fed-batch fermentation with a pre-determined growth rate µ₀ = 0.1 h⁻¹ produced the highest CDW (7.7 g L⁻¹) and PHA concentration (6.1 g L⁻¹). Moreover, an exponential glucose feeding profile resulted in 2.2-fold increase in PHA yield compared to batch cultivation. Overall, this study paves the way to an enhanced biopolymer production process in B. megaterium cells, where the highest product yield on cell was obtained as YP/X = 0.8 g g⁻¹.
Keywords	Bacillus megaterium ; batch fermentation ; biodegradability ; biomass ; bioprocessing ; bioreactors ; carbon ; composite polymers ; dissolved oxygen ; energy ; genes ; glucose ; oxygen ; polyhydroxyalkanoates
Language	English
Dates of publication	2021-02
Size	p. 403-416.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1476357-6
ISSN	1432-0797 ; 1615-7605 ; 1615-7591
ISSN (online)	1432-0797 ; 1615-7605
ISSN	1615-7591
DOI	10.1007/s00449-020-02452-z
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Article ; Online: Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biopolymer by recombinant Bacillus megaterium in fed-batch bioreactors.

Akdoğan, Murat / Çelik, Eda

Bioprocess and biosystems engineering

2020 Volume 44, Issue 2, Page(s) 403–416

Abstract	Polyhydroxyalkanoates (PHAs) are biodegradable polyesters accumulated in a wide variety of microorganisms as intracellular carbon and energy storage compounds. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is one of the most valuable biopolymers because of its superior mechanical properties. Here, we developed a bioprocess utilizing recombinant Bacillus megaterium strain for PHBV over-production from glucose, without any precursor addition. PHA production was performed in a controlled bioreactor by batch and fed-batch modes using wild-type B. megaterium and rec-B. megaterium cells overexpressing the native phaC gene. The effect of oxygen transfer rate on biomass formation and PHA accumulation was also investigated, under different dissolved oxygen levels. Structural and thermal properties of PHA were characterized by GC-FID,
MeSH term(s)	Bacillus megaterium/genetics ; Bacillus megaterium/growth & development ; Batch Cell Culture Techniques ; Bioreactors ; Microorganisms, Genetically-Modified/genetics ; Microorganisms, Genetically-Modified/growth & development ; Polyesters/metabolism
Chemical Substances	Polyesters ; poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476357-6
ISSN	1615-7605 ; 1432-0797 ; 1615-7591
ISSN (online)	1615-7605 ; 1432-0797
ISSN	1615-7591
DOI	10.1007/s00449-020-02452-z
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Article ; Online: Region-Based Semi-Two-Stream Convolutional Neural Networks for Pressure Ulcer Recognition.

Zalluhoğlu, Cemil / Akdoğan, Doğan / Karakaya, Derya / Güzel, Mehmet Serdar / Ülgü, M Mahir / Ardalı, Kemal / Boyalı, Atila Oğuz / Sezer, Ebru Akçapınar

Journal of imaging informatics in medicine

2024 Volume 37, Issue 2, Page(s) 801–813

Abstract: Pressure ulcers are a common, painful, costly, and often preventable complication associated with prolonged immobility in bedridden patients. It is a significant health problem worldwide because it is frequently seen in inpatients and has high treatment ... ...

Abstract	Pressure ulcers are a common, painful, costly, and often preventable complication associated with prolonged immobility in bedridden patients. It is a significant health problem worldwide because it is frequently seen in inpatients and has high treatment costs. For the treatment to be effective and to ensure an international standardization for all patients, it is essential that the diagnosis of pressure ulcers is made in the early stages and correctly. Since invasive methods of obtaining information can be painful for patients, different methods are used to make a correct diagnosis. Image-based diagnosis method is one of them. By using images obtained from patients, it will be possible to obtain successful results by keeping patients away from such painful situations. At this stage, disposable wound rulers are used in clinical practice to measure the length, width, and depth of patients' wounds. The information obtained is then entered into tools such as the Braden Scale, the Norton Scale, and the Waterlow Scale to provide a formal assessment of risk for pressure ulcers. This paper presents a novel benchmark dataset containing pressure ulcer images and a semi-two-stream approach that uses the original images and the cropped wound areas together for diagnosing the stage of pressure ulcers. Various state-of-the-art convolutional neural network (CNN) architectures are evaluated on this dataset. Our experimental results (test accuracy of 93%, the precision of 93%, the recall of 92%, and the F1-score of 93%) show that the proposed semi-two-stream method improves recognition results compared to the base CNN architectures.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-023-00960-4
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Article ; Online: The Effects of Systemic Coenzyme Q10 Treatment on Corneal Histology in Streptozocin-Induced Diabetic Rats.

Karaca, Çiğdem / Akdoğan, Müberra / Demirel, Hasan Hüseyin / Ünal, Canan

Ocular immunology and inflammation

2022 , Page(s) 1–7

Abstract: Objective: This study investigate the histopathological changes and VEGF, IL-1β, and IL-6 immunoreactivities in cornea treated with Coenzyme Q10 (CoQ10) in a Streptozocin (STZ) induced diabetic rat model.: Methods: A total of 20 male Wistar Albino ... ...

Abstract	Objective: This study investigate the histopathological changes and VEGF, IL-1β, and IL-6 immunoreactivities in cornea treated with Coenzyme Q10 (CoQ10) in a Streptozocin (STZ) induced diabetic rat model. Methods: A total of 20 male Wistar Albino rats including a group of STZ diabetic rats, diabetic rats treated with CoQ10, rats were given CoQ10 without being diabetic and a Control group were included the study. The groups were followed up for 2 months. Eye tissues were stained with Hematoxylin-Eosin (HE), Periodic Acid-Schiff (PAS), and immunohistochemical staining (IHC). Findings: The mean corneal thickness was found to be lower in the group with DM (126,62 ± 18,1) compared to the other groups. However, this decrease was found to be significant only in comparison with the control group (181,75 ± 13,87) (p = 0.000). In diabetic corneas, PAS positivity was observed in in Descemet's membrane (p = 0.021). Staining with VEGF, IL-1β, IL-6antibodies was found to be lower in the DM+CoQ10 group compared to the group with DM (p < 0.001, p < 0.001, p < 0.001). Results: We observed that diabetes increases inflammation and tendency to angiogenesis in the corneal tissue, and CoQ10 treatment reduces the corneal thickness, inflammation, and tendency to angiogenesis caused by diabetes.
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2022.2140298
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Zs.A 4004: Show issues

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Article ; Online: Which knee replacement do the patients forget? Unicondylar or total knee arthroplasty.

Ateş, Yalım / Akdoğan, Mutlu / Atilla, Halis Atil

Acta orthopaedica et traumatologica turcica

2021 Volume 55, Issue 5, Page(s) 417–421

Abstract: Objective: The aim of this study was to determine which type of knee arthroplasty is easier to forget by comparing levels of joint awareness evaluated with the Forgotten Joint Score (FJS-12) after unicondylar versus total knee arthroplasty.: Methods: ...

Abstract	Objective: The aim of this study was to determine which type of knee arthroplasty is easier to forget by comparing levels of joint awareness evaluated with the Forgotten Joint Score (FJS-12) after unicondylar versus total knee arthroplasty. Methods: Patients who underwent either unicondylar or total knee arthroplasty due to primary gonarthrosis were retrospectively identified and then divided into 2 groups: the TKA group (218 patients; mean age = 68.93 ± 7.14 years) and the UKA group (131 patients; mean age = 60.39 ± 7.03 years). The status of joint awareness after knee replacement surgery was assessed using the Turkish version of the FJS-12 at the final follow-up by telephone interview. Also, The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and The EuroQol five-dimensional (EQ-5D) scores were obtained to assess the clinical status of the patients. Results: The mean follow-up was 2.8 years (range = 24-49 months) in the TKA group and 3.2 years (range = 24-50 months) in the UKA group. The FJS-12 was significantly higher in the UKA group (73.60 ± 9.95) than in the TKA group (64.88 ± 9.47) (P = .001). The WOMAC score was significantly better in the UKA group (81.39 ± 9.84) than in the TKA group (74.92 ± 9.99) (P = .001). No significant difference in EQ-5D existed between the groups (0.76 ± 0.14 for the TKA group, 0.79 ± 0.17 for the UKA group; P = .441). In terms of gender, the FJS-12 showed no differences between the groups; however, more favorable scores were recorded in younger patients with UKA. Conclusion: The results of this study have demonstrated that UKA may be better than TKA in terms of the patient perception of pain, stiffness, and physical functioning. Level of evidence: Level IV, Therapeutic Study.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Knee Joint/surgery ; Middle Aged ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-11-03
Publishing country	Turkey
Document type	Journal Article
ISSN	2589-1294
ISSN (online)	2589-1294
DOI	10.5152/j.aott.2021.20173
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Article ; Online: Multidrug-Resistant Infections After Liver Transplantation, Etiology and Risk Factors: A Single-Center Experience.

Tezcan, Hatice / Altunsoy, Adalet / Turan Gökçe, Dilara / Gökcan, Hale / Arı, Derya / Aydın, Osman / Bostancı, Erdal Birol / Akdoğan Kayhan, Meral

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2024 Volume 21, Issue 12, Page(s) 952–960

Abstract: Objectives: Patients undergoing liver transplant are at an increased risk of morbidity and mortality due to the development of infections. We aimed to evaluate the risk factors affecting the incidence of infectious diseases after liver transplant and to ...

Abstract	Objectives: Patients undergoing liver transplant are at an increased risk of morbidity and mortality due to the development of infections. We aimed to evaluate the risk factors affecting the incidence of infectious diseases after liver transplant and to present the epidemiological data. Materials and methods: We investigated patients aged ≥18 years who underwent liver transplant between 2012 and 2020 at our center. We collected infections, causative microorganisms, and antibacterial resistance patterns seen during the first 6 months posttransplant. Risk factors affecting the development of infectious diseases were also analyzed and evaluated. Results: Of 112 patients included in our study, 76 (67.9%) were men, and the median age was 50 years (range, 20-66 years). Within month 1 and month 6 after transplant, at least 1 episode of infection occurred in 67 (59.8%) and 80 (71.4%) patients, respectively. Bacterial infections were the most common type (n = 78, 95.1%), followed by fungal (n = 2, 2.4%) and viral (n = 2, 2.4%) infections. The rate of multidrug resistance in bacterial infections was high (n = 38, 52.7%) and was also a risk factor for mortality in the first 6 months after transplant (P < .001). Pretransplant values of international normalized ratio, creatinine, bilirubin, and posttransplant intensive care unit stay, as well as the presence of encephalopathy, were shown to increase the risk of infection after transplant. Conclusions: Multidrug-resistant bacterial infections are a significant risk factor for mortality in liver transplant patients. Many risk factors that contribute to the development of infections aftertransplant have been included in prognostic scoring systems of liver failure. Consequently, the severity of end-stage liver failure is directly related to the risk of posttransplant infections.
MeSH term(s)	Male ; Humans ; Adolescent ; Adult ; Middle Aged ; Female ; Liver Transplantation ; Risk Factors ; End Stage Liver Disease ; Bacterial Infections ; Communicable Diseases
Language	English
Publishing date	2024-01-24
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2023.0081
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