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Article ; Online: Downgrade from CRT-D to CRT-P at time of generator replacement: a true clinical conundrum or just an academic debate?

Clarke, John-Ross D / Friedman, Daniel J

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2023 Volume 66, Issue 6, Page(s) 1315–1316

MeSH term(s)	Humans ; Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Defibrillators, Implantable ; Heart Failure/surgery ; Treatment Outcome
Language	English
Publishing date	2023-02-16
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-023-01506-y
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Zs.A 5214: Show issues

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Article ; Online: Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics.

Himburg, Heather A / Grzybowski, Deborah M / Hazel, Andrew L / LaMack, Jeffrey A / Friedman, Morton H

Journal of biomechanical engineering

2016 Volume 138, Issue 9

Abstract: The biological response of living arteries to mechanical forces is an important component of the atherosclerotic process and is responsible, at least in part, for the well-recognized spatial variation in atherosusceptibility in man. Experiments to ... ...

Abstract	The biological response of living arteries to mechanical forces is an important component of the atherosclerotic process and is responsible, at least in part, for the well-recognized spatial variation in atherosusceptibility in man. Experiments to elucidate this response often generate maps of force and response variables over the arterial surface, from which the force-response relationship is sought. Rowland et al. discussed several statistical approaches to the spatial autocorrelation that confounds the analysis of such maps and applied them to maps of hemodynamic stress and vascular response obtained by averaging these variables in multiple animals. Here, we point out an alternative approach, in which discrete surface regions are defined by the hemodynamic stress levels they experience, and the stress and response in each animal are treated separately. This approach, applied properly, is insensitive to autocorrelation and less sensitive to the effect of confounding hemodynamic variables. The analysis suggests an inverse relation between permeability and shear that differs from that in Rowland et al. Possible sources of this difference are suggested.
MeSH term(s)	Animals ; Arteries ; Hemodynamics ; Spatial Analysis
Language	English
Publishing date	2016-06-29
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	243094-0
ISSN	1528-8951 ; 0148-0731
ISSN (online)	1528-8951
ISSN	0148-0731
DOI	10.1115/1.4034217
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Zs.B 2672: Show issues

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Book ; Online ; E-Book: Clinical tuberculosis

Friedman, Lloyd N. / Dedicoat, Martin / Davies, Peter D.O.

2020

Author's details	edited by Lloyd N. Friedman, Martin Dedicoat, Peter D. O. Davies
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (xix, 447 Seiten), Illustrationen, Diagramme
Edition	Sixth edition
Publisher	CRC Press, Taylor & Francis Group
Publishing place	Boca Raton
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020566343
ISBN	978-1-351-24996-6 ; 9780815370239 ; 1-351-24996-7 ; 0815370237
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A New Look at Gray Matter Decreases in Chronic Pain.

Wager, Tor D / Zorina-Lichtenwalter, Katerina / Friedman, Naomi P

Biological psychiatry

2024 Volume 95, Issue 5, Page(s) 387–388

MeSH term(s)	Humans ; Chronic Pain ; Gray Matter/diagnostic imaging ; Brain ; Cerebral Cortex ; Magnetic Resonance Imaging
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2023.12.009
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Zs.A 720: Show issues

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Article ; Online: Acute lymphoblastic leukemia of the central nervous system presenting with rapid weight gain.

Hall, Connor P / Friedman, Alan D

Pediatric blood & cancer

2022 Volume 70, Issue 3, Page(s) e30022

MeSH term(s)	Humans ; Central Nervous System ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
Language	English
Publishing date	2022-09-24
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30022
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Zs.A 1131: Show issues

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Article ; Online: Familial effects account for association between chronic pain and past month smoking.

Rader, L / Reineberg, A E / Petre, B / Wager, T D / Friedman, N P

European journal of pain (London, England)

2024

Abstract: ... significantly correlated phenotypically (r = 0.21, p = 0.001) and genetically (r: Conclusions: Pain and ...

Abstract	Background: Smoking is associated with chronic pain, but it is not established whether smoking causes pain or if the link is due to familial effects. One proposed mechanism is that smoking strengthens maladaptive cortico-striatal connectivity, which contributes to pain chronification. We leveraged a twin design to assess direct effects of smoking on pain controlling for familial confounds, and whether cortico-striatal connectivity mediates this association. Methods: In a population-based sample of 692 twins (age = 28.83 years), we assessed past-month smoking frequency (n = 132 used in the past month), presence and severity of a current pain episode (n = 179 yes), and resting-state functional connectivity of the nucleus accumbens and medial prefrontal cortex (NAc-mPFC). Results: Smoking was significantly associated with pain, but the association was not significantly mediated by NAc-mPFC connectivity. In a co-twin control model, smoking predicted which families had more pain but could not distinguish pain between family members. Pain risk was 43% due to additive genetic (A) and 57% due to non-shared environmental (E) influences. Past-month smoking frequency was 71% genetic and 29% non-shared environmental. Smoking and pain significantly correlated phenotypically (r = 0.21, p = 0.001) and genetically (r Conclusions: Pain and smoking are associated; however, the association appears to reflect shared familial risk factors, such as genetic risk, rather than being causal in nature. The connectivity strength of the reward pathway was not related to concurrent pain and smoking in this sample. Significance: Smoking does not appear to directly cause chronic pain; rather, there may be shared biopsychosocial risk factors, including genetic influences, that explain their association. These findings can be integrated into future research to identify shared biological pathways of both chronic pain and smoking behaviours as a way to conceptualize pain chronification.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.2247
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Zs.A 5194: Show issues

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Article ; Online: Disentangling differing relationships between internalizing disorders and alcohol use.

Brasher, Maizy S / Grotzinger, Andrew D / Friedman, Naomi P / Smolker, Harry R / Evans, Luke M

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

2024 , Page(s) e32975

Abstract: Both internalizing disorders and alcohol use have dramatic, wide-spread implications for global health. Previous work has established common phenotypic comorbidity among these disorders, as well as shared genetic variation underlying them both. We used ... ...

Abstract	Both internalizing disorders and alcohol use have dramatic, wide-spread implications for global health. Previous work has established common phenotypic comorbidity among these disorders, as well as shared genetic variation underlying them both. We used genomic structural equation modeling to investigate the shared genetics of internalizing, externalizing, and alcohol use traits, as well as to explore whether specific domains of internalizing symptoms mediate the contrasting relationships with problematic alcohol use compared to alcohol consumption. We also examined patterns of genetic correlations between similar traits within additional Finnish and East Asian ancestry groups. When the shared genetic influence of externalizing psychopathology was accounted for, the genetic effect of internalizing traits on alcohol use was reduced, suggesting the important role of common genetic factors underlying multiple psychiatric disorders and their genetic influences on comorbidity of internalizing and alcohol use traits. Individual internalizing domains had contrasting effects on frequency of alcohol consumption, which demonstrate the complex system of pleiotropy that exists, even within similar disorders, and can be missed when evaluating only relationships among formal diagnoses. Future work must consider the broad effects of shared psychopathology along with the fine-scale effects of heterogeneity within disorders to more fully understand the biology underlying complex traits.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108616-3
ISSN	1552-485X ; 1552-4841 ; 0148-7299
ISSN (online)	1552-485X
ISSN	1552-4841 ; 0148-7299
DOI	10.1002/ajmg.b.32975
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Zs.A 1376/B: Show issues

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Article ; Online: Repeat catheter ablation for atrial fibrillation.

Brahier, Mark S / Friedman, Daniel J / Bahnson, Tristram D / Piccini, Jonathan P

Heart rhythm

2023 Volume 21, Issue 4, Page(s) 471–483

Abstract: Catheter ablation of atrial fibrillation (AF) is an established therapy that reduces AF burden, improves quality of life, and reduces the risks of cardiovascular outcomes. Although there are clear guidelines for the application of de novo catheter ... ...

Abstract	Catheter ablation of atrial fibrillation (AF) is an established therapy that reduces AF burden, improves quality of life, and reduces the risks of cardiovascular outcomes. Although there are clear guidelines for the application of de novo catheter ablation, there is less evidence to guide recommendations for repeat catheter ablation in patients who experience recurrent AF. In this review, we examine the rationale for repeat ablation, mechanisms of recurrence, patient selection, optimal timing, and procedural strategies. We discuss additional important considerations, including treatment of comorbidities and risk factors, risk of complications, and effectiveness. Mechanisms of recurrent AF are often due to non-pulmonary vein (non-PV) triggers; however, there is insufficient evidence supporting the routine use of empiric lesion sets during repeat ablation. The emergence of pulsed field ablation may alter the safety and effectiveness of de novo and repeat ablation. Extrapolation of data from randomized trials of de novo ablation does not optimally inform efficacy in cases of redo ablation. Additional large, randomized controlled trials are needed to address important clinical questions regarding procedural strategies and timing of repeat ablation.
MeSH term(s)	Humans ; Atrial Fibrillation ; Quality of Life ; Treatment Outcome ; Pulmonary Veins/surgery ; Catheter Ablation/adverse effects ; Recurrence
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2023.12.003
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Article ; Online: How I diagnose and treat thrombocytopenia in geriatric patients.

Foy, Patrick / Friedman, Kenneth D / Michaelis, Laura C

Blood

2023 Volume 143, Issue 3, Page(s) 214–223

Abstract: Abstract: Thrombocytopenia in older individuals is a common but diagnostically challenging condition that has variable clinical impact to those who are affected. Diagnostic approach requires evaluation of the preexisting clinical conditions, detailed ... ...

Abstract	Abstract: Thrombocytopenia in older individuals is a common but diagnostically challenging condition that has variable clinical impact to those who are affected. Diagnostic approach requires evaluation of the preexisting clinical conditions, detailed review of medications, and assessment for disorders that warrant urgent treatment. In this article, we describe a systematic approach to diagnosis of thrombocytopenia and present a schematic review for management strategies. Three clinical scenarios are presented that are relevant for their prevalence and management challenges in an older adult population. The first scenario addresses primary immune thrombocytopenia (ITP) and reviews different treatment options. The second one addresses complications of thrombocytopenia in management of the myelodysplastic syndrome. The last one reviews diagnostic challenges of drug-induced ITP.
MeSH term(s)	Humans ; Aged ; Thrombocytopenia/diagnosis ; Thrombocytopenia/therapy ; Thrombocytopenia/chemically induced ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Myelodysplastic Syndromes/complications ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Purpura, Thrombocytopenic, Idiopathic/complications
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022017634
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Article ; Online: Patient-Reported Outcomes on Subjective Nipple Sensation After Double-Incision and Periareolar Mastectomy for Chest Masculinization: Subjective Nipple Sensation After Chest Masculinization.

Chen, Amy / Garvey, Shannon R / Nanda, Asha D / Friedman, Rosie / Jia, Emmeline / Morgenstern, Monica / Barron, Sivana / Tobias, Adam / Cauley, Ryan P

Annals of plastic surgery

2024 Volume 92, Issue 4, Page(s) 383–388

Abstract: ... toward significance (P = 0.0719). There was a stepwise increase in proportion of patients reporting sensation ... with greater recovery time until response to survey 1. Obesity (P = 0.0080) and greater tissue removed (P = 0 ... significantly higher for patients reporting improved nipple sensation (P = 0.0235). Responders to survey 2 ...

Abstract	Abstract: We evaluated patient-reported outcomes to assess for patient and procedural factors associated with postchest masculinization subjective nipple sensation. Patients who underwent double-incision or periareolar mastectomies for chest masculinization by a single senior surgeon (2015-2019) were surveyed at 2 time points regarding postoperative nipple sensation and satisfaction, including patient-reported outcomes using BODY-Q modules (Q-Portfolio.org). Demographic, operative, and postoperative variables were obtained from medical records. Patients were stratified according to survey responses. Univariate and multivariate analyses were performed.Response rate was 42% for survey 1 and 22% for survey 2. Of the 151 survey 1 responders, 138 (91.4%) received double-incision mastectomies and 13 (8.6%) received periareolar mastectomies. Among Survey 1 responders, 84.6% periareolar patients and 69.6% double-incision patients reported "completely" or "a little" nipple sensation preservation, and the difference trended toward significance (P = 0.0719). There was a stepwise increase in proportion of patients reporting sensation with greater recovery time until response to survey 1. Obesity (P = 0.0080) and greater tissue removed (P = 0.0247) were significantly associated with decreased nipple sensation. Nipple satisfaction scores were significantly higher for patients reporting improved nipple sensation (P = 0.0235). Responders to survey 2 who reported greater satisfaction with nipple sensation were significantly more likely to report preserved sensitivity to light touch (P = 0.0277), pressure (P = 0.0046), and temperature (P = 0.0031). Preserved erogenous sensation was also significantly associated with greater satisfaction (P = 0.0018).In conclusion, we found that nipple sensation may be associated with postoperative nipple satisfaction. Operative techniques to optimize nipple sensation preservation may improve this population's postoperative satisfaction.
MeSH term(s)	Humans ; Female ; Mastectomy/methods ; Nipples/surgery ; Mammaplasty/methods ; Treatment Outcome ; Breast Neoplasms/surgery ; Sensation ; Patient Reported Outcome Measures ; Surgical Wound/surgery ; Retrospective Studies
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003821
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