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  1. Article: Activation of the Hippo Pathway in

    Gupta, Aakriti / Storey, Kenneth B

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: Wood frogs ( ...

    Abstract Wood frogs (
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perspectives from the developing world on last-minute refusals among pediatric patients.

    Mathew, Preethy J / Gupta, Aakriti

    Paediatric anaesthesia

    2021  Volume 31, Issue 11, Page(s) 1261–1262

    MeSH term(s) Child ; Humans
    Language English
    Publishing date 2021-08-25
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14278
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3306: Show issues Location:
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  3. Article ; Online: Prevalence of parental fasting before pediatric surgery.

    Yaddanapudi, Sandhya / Jain, Aditi / Jain, Divya / Gupta, Aakriti

    Paediatric anaesthesia

    2022  Volume 32, Issue 7, Page(s) 880–882

    MeSH term(s) Child ; Fasting ; Humans ; Parents ; Preoperative Care ; Prevalence
    Language English
    Publishing date 2022-04-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14456
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3306: Show issues Location:
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  4. Article ; Online: A "notch" in the cellular communication network in response to anoxia by wood frog (Rana sylvatica).

    Gupta, Aakriti / Storey, Kenneth B

    Cellular signalling

    2022  Volume 93, Page(s) 110305

    Abstract: Wood frogs (Rana sylvatica) experience months of whole-body freezing during winter. Anoxia is one of the side stresses along with cell dehydration and hyperglycemia. Among multicellular organisms, communication and coordination is essential between ... ...

    Abstract Wood frogs (Rana sylvatica) experience months of whole-body freezing during winter. Anoxia is one of the side stresses along with cell dehydration and hyperglycemia. Among multicellular organisms, communication and coordination is essential between neighbouring cells, particularly under stress conditions. Notch signaling is an effective communication channel between cells and regulates multiple pro-survival pathways. Signaling initiates when membrane-bound ligands Delta-like (DLL) or Jagged (JAG) interact with notch receptors. Activated receptor undergoes cleavage to release intracellular domain (NICD) in the cytoplasm. NICD translocates to the nucleus and forms a transcriptional complex with MAML and RBPJ that interacts with promoter regions and activates stress-specific genes. The role of notch signaling in enduring anoxia was assessed by studying the pathway components using immunoblots, TF-ELISA, and qPCR on treated samples of liver and heart. Bioinformatics tool Pymol was used to prepare structures based on available protein sequences for ligands, NOTCH receptor and the transcriptional complex. The results showed an increase in the levels of both ligands and receptors but decreased levels of RBPJ, suggesting an effective transmission of stress signal but suppressed gene transcription that goes in accordance with lowering energy expense required in energy crisis during anoxia. The study suggests Notch-independent activation of HES1 and HES5. Tissue-specific response of HES1, HES5, and MAML implies energy conservation and myocardial protection. The current study is the first analysis of the regulation of notch signaling in amphibians on encountering anoxic conditions that present multiple future directions.
    MeSH term(s) Animals ; Communication ; Hypoxia ; Ligands ; Ranidae/metabolism ; Receptors, Notch/metabolism
    Chemical Substances Ligands ; Receptors, Notch
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2022.110305
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    Zs.A 2579: Show issues Location:
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  5. Article ; Online: Activation of the Hippo Pathway in Rana sylvatica

    Aakriti Gupta / Kenneth B. Storey

    Life, Vol 11, Iss 1422, p

    Yapping Stops in Response to Anoxia

    2021  Volume 1422

    Abstract: Wood frogs ( Rana sylvatica ) display well-developed anoxia tolerance as one component of their capacity to endure prolonged whole-body freezing during the winter months. Under anoxic conditions, multiple cellular responses are triggered to efficiently ... ...

    Abstract Wood frogs ( Rana sylvatica ) display well-developed anoxia tolerance as one component of their capacity to endure prolonged whole-body freezing during the winter months. Under anoxic conditions, multiple cellular responses are triggered to efficiently cope with stress by suppressing gene transcription and promoting activation of mechanisms that support cell survival. Activation of the Hippo signaling pathway initiates a cascade of protein kinase reactions that end with phosphorylation of YAP protein. Multiple pathway components of the Hippo pathway were analyzed via immunoblotting, qPCR or DNA-binding ELISAs to assess the effects of 24 h anoxia and 4 h aerobic recovery, compared with controls, on liver and heart metabolism of wood frogs. Immunoblot results showed significant increases in the relative levels of multiple proteins of the Hippo pathway representing an overall activation of the pathway in both organs under anoxia stress. Upregulation of transcript levels further confirmed this. A decrease in YAP and TEAD protein levels in the nuclear fraction also indicated reduced translocation of these proteins. Decreased DNA-binding activity of TEAD at the promoter region also suggested repression of gene transcription of its downstream targets such as SOX2 and OCT4. Furthermore, changes in the protein levels of two downstream targets of TEAD, OCT4 and SOX2, established regulated transcriptional activity and could possibly be associated with the activation of the Hippo pathway. Increased levels of TAZ in anoxic hearts also suggested its involvement in the repair mechanism for damage caused to cardiac muscles during anoxia. In summary, this study provides the first insights into the role of the Hippo pathway in maintaining cellular homeostasis in response to anoxia in amphibians.
    Keywords Hippo pathway ; MST ; SAV ; LATS1/2 ; MOB ; YAP ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Invasive Coronary Assessment in Myocardial Ischemia with No Obstructive Coronary Arteries.

    Takahashi, Tatsunori / Gupta, Aakriti / Samuels, Bruce A / Wei, Janet

    Current atherosclerosis reports

    2023  Volume 25, Issue 10, Page(s) 729–740

    Abstract: Purpose of review: The purpose of this review is threefold: (i) to give an overview of well-established invasive methods for assessing patients with ischemia with no obstructive coronary arteries (INOCA) in the cardiac catheterization laboratory; (ii) ... ...

    Abstract Purpose of review: The purpose of this review is threefold: (i) to give an overview of well-established invasive methods for assessing patients with ischemia with no obstructive coronary arteries (INOCA) in the cardiac catheterization laboratory; (ii) to describe the prognostic and treatment implications based on these findings, and (iii) to discuss current knowledge gaps and future perspectives.
    Recent findings: Recent studies have demonstrated that invasive coronary function testing not only allows for risk stratification of patients with INOCA but also guides medical therapy with improvement in symptoms and quality of life. Based on these findings, invasive coronary function assessment is now a class 2a recommendation in the 2021 ACC/AHA chest pain guideline to improve the diagnosis of coronary microvascular dysfunction and to enhance risk stratification. Invasive functional testing for patients with INOCA is well established and easily performed in the catheterization laboratory. Comprehensive invasive assessment is a key to differentiating INOCA endotypes and optimizing both medical therapy and preventive strategies including lifestyle modification.
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-023-01144-9
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    Zs.A 5534: Show issues Location:
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  7. Article ; Online: Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion.

    Challagundla, Naveen / Phadnis, Deepti / Gupta, Aakriti / Agrawal-Rajput, Reena

    The Journal of membrane biology

    2023  Volume 256, Issue 4-6, Page(s) 393–411

    Abstract: Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly found in membranes, thus playing an important role in membrane trafficking and protecting the cell from external dangers. Based on ... ...

    Abstract Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly found in membranes, thus playing an important role in membrane trafficking and protecting the cell from external dangers. Based on the composition of the lipids, their fluidity and charge, their interaction with embedded proteins vary greatly. Bacteria can hijack host lipids to satisfy their energy needs or to conceal themselves from host cells. Intracellular bacteria continuously exploit host, from their entry into host cells utilizing host lipid machinery to exiting through the cells. This acquisition of lipids from host cells helps in their disguise mechanism. The current review explores various mechanisms employed by the intracellular bacteria to manipulate and acquire host lipids. It discusses their role in manipulating host membranes and the subsequence impact on the host cells. Modulating these lipids in macrophages not only serve the purpose of the pathogen but also modulates the macrophage energy metabolism and functional state. Additionally, we have explored the intricate pathogenic relationship and the potential prospects of using this knowledge in lipid-based therapeutics to disrupt pathogen dominance.
    MeSH term(s) Immune Evasion ; Bacteria/metabolism ; Protein Transport ; Lipids ; Lipid Metabolism
    Chemical Substances Lipids
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3082-x
    ISSN 1432-1424 ; 0022-2631
    ISSN (online) 1432-1424
    ISSN 0022-2631
    DOI 10.1007/s00232-023-00296-8
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    Zs.A 613: Show issues Location:
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  8. Article ; Online: Time to Reperfusion in ST-Segment Elevation Acute Myocardial Infarction: When Does the Clock Start?

    Murugiah, Karthik / Gupta, Aakriti / Krumholz, Harlan M

    Circulation. Cardiovascular interventions

    2021  Volume 14, Issue 2, Page(s) e010459

    MeSH term(s) Humans ; Myocardial Reperfusion/adverse effects ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/therapy
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.121.010459
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    Zs.A 6746: Show issues Location:
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  9. Article ; Online: Coordinated expression of Jumonji and AHCY under OCT transcription factor control to regulate gene methylation in wood frogs during anoxia.

    Gupta, Aakriti / Storey, Kenneth B

    Gene

    2021  Volume 788, Page(s) 145671

    Abstract: Wood frogs (Rana sylvatica) can survive extended periods of whole body freezing. Freezing imparts multiple stresses on cells that include anoxia and dehydration, but these can also be experienced as independent stresses. Under anoxia stress, energy ... ...

    Abstract Wood frogs (Rana sylvatica) can survive extended periods of whole body freezing. Freezing imparts multiple stresses on cells that include anoxia and dehydration, but these can also be experienced as independent stresses. Under anoxia stress, energy metabolism is suppressed, and pro-survival pathways are prioritized to differentially regulate some transcription factors including OCT1 and OCT4. Jumonji C domain proteins (JMJD1A and JMJD2C) are hypoxia responsive demethylases whose expression is accelerated by OCT1 and OCT4 which act to demethylate genes related to the methionine cycle. The responses by these factors to 24 h anoxia exposure and 4 h aerobic recovery was analyzed in liver and skeletal muscle of wood frogs to assess their involvement in metabolic adaptation to oxygen limitation. Immunoblot results showed a decrease in JMJD1A levels under anoxia in liver and muscle, but an increase was observed in JMJD2C demethylase protein in anoxic skeletal muscle. Protein levels of adenosylhomocysteinase (AHCY) and methionine adenosyl transferase (MAT), enzymes of the methionine cycle, also showed an increase in the reoxygenated liver, whereas the levels decreased in muscle. A transcription factor ELISA showed a decrease in DNA binding by OCT1 in the reoxygenated liver and anoxic skeletal muscle, and transcript levels also showed tissue specific gene expression. The present study provides the first analysis of the role of the OCT1 transcription factor, associated proteins, and lysine demethylases in mediating responses to anoxia by wood frog tissues.
    MeSH term(s) Adenosylhomocysteinase/genetics ; Adenosylhomocysteinase/metabolism ; Animals ; Cell Hypoxia ; Energy Metabolism ; Epigenesis, Genetic ; Gene Expression Regulation ; Histones/metabolism ; Liver/metabolism ; Male ; Methylation ; Muscle, Skeletal/metabolism ; Octamer Transcription Factors/genetics ; Octamer Transcription Factors/metabolism ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Ranidae/physiology
    Chemical Substances Histones ; Octamer Transcription Factors ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Adenosylhomocysteinase (EC 3.3.1.1)
    Language English
    Publishing date 2021-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.145671
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    Zs.A 1357: Show issues Location:
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  10. Article ; Online: The regulation of m

    Rehman, Saif / Varma, Anchal / Gupta, Aakriti / Storey, Kenneth B

    Biochemistry and cell biology = Biochimie et biologie cellulaire

    2022  Volume 101, Issue 1, Page(s) 77–86

    Abstract: ... Rana ... ...

    Abstract Rana sylvatica
    MeSH term(s) Animals ; Freezing ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Methylation ; Ranidae/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Liver/metabolism
    Chemical Substances RNA, Messenger ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2022-12-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 54104-7
    ISSN 1208-6002 ; 0829-8211
    ISSN (online) 1208-6002
    ISSN 0829-8211
    DOI 10.1139/bcb-2022-0164
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