LIVIVO - Search results -

Search results

Result 1 - 10 of total 2022

Search options

Article ; Online: Sialyl Lewis X Defines an Activated and Functional Regulatory T Cell Subpopulation in Mice.

Ohishi, Kanae / Ishikura, Asaki / Nishida, Shogo / Abo, Hirohito / Nakatsukasa, Hiroko / Kawashima, Hiroto

Journal of immunology (Baltimore, Md. : 1950)

2024

Abstract: Attempts have been made to elucidate the functional markers of regulatory T cells (Tregs ... CD4+Foxp3+ T cells with an immunosuppressive function. Sialyl Lewis X (sLex), a tetrasaccharide Ag, is ... naive CD4+ T cell proliferation than sLex- Tregs. In the murine contact hypersensitivity elicitation ...

Abstract	Attempts have been made to elucidate the functional markers of regulatory T cells (Tregs), CD4+Foxp3+ T cells with an immunosuppressive function. Sialyl Lewis X (sLex), a tetrasaccharide Ag, is involved in leukocyte trafficking as selectin ligands and is a marker of highly differentiated Tregs in humans. However, the importance of sLex in murine Tregs remains unknown. In this study, we report that sLex defines the activated and functional subset of murine Tregs. The contact hypersensitivity model showed that murine Tregs strongly express sLex upon activation, accompanied by functional Treg marker elevation, such as Foxp3, CD25, CD103, CD39, and granzyme B. RNA sequencing analysis revealed sLex-positive (sLex+) Tregs expressed genes involved in Treg function at a higher level than sLex-negative (sLex-) Tregs. Using an in vitro suppression assay, we found that sLex+ Tregs could more efficiently suppress naive CD4+ T cell proliferation than sLex- Tregs. In the murine contact hypersensitivity elicitation model, the topical sLex+ Treg injection into the ears suppressed ear inflammation more efficiently than that of sLex- Tregs. Our results indicate that sLex could serve as a unique surface marker of activated and functional Tregs with immunosuppressive functions in mice.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2300349
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Association of CD8 + T cells expressing nivolumab-free PD-1 with clinical status in a patient with relapsed refractory classical Hodgkin lymphoma.

Kowata, Shugo / Seki, Yuki / Tsukushi, Yasuhiko / Sato, Tsuyoshi / Asano, Kazuya / Maeta, Takahiro / Yashima-Abo, Akiko / Sasaki, Ryosei / Okano, Yoshiaki / Oyake, Tatsuo / Ito, Shigeki

International journal of hematology

2023 Volume 118, Issue 6, Page(s) 751–757

Abstract: ... of irAEs were associated with the proportion of CD8 + T cells expressing nivolumab-free PD-1 relative ... to the total number of CD8 + T cells. The findings in this nivolumab-sensitive patient highlight the clinical ...

Abstract	A 37-year-old man with refractory classical Hodgkin lymphoma (cHL) underwent PD-1 blockade therapy with nivolumab, which resulted in a partial response. However, treatment was discontinued due to immune-related adverse events (irAEs), including myasthenia gravis and myositis. Retreatment with nivolumab resulted in a complete metabolic response and hepatic irAE. Subsequently, nivolumab was administered at extended dosing intervals. Intermittent infusion of ten doses of nivolumab for a total dose of 2400 mg/body helped control the relapsed/refractory cHL over three years. During nivolumab treatment, disease progression and emergence of irAEs were associated with the proportion of CD8 + T cells expressing nivolumab-free PD-1 relative to the total number of CD8 + T cells. The findings in this nivolumab-sensitive patient highlight the clinical utility of monitoring immune cells expressing nivolumab-free PD-1 in patients with cHL who have been treated with nivolumab and have experienced irAEs.
MeSH term(s)	Male ; Humans ; Adult ; Nivolumab ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Programmed Cell Death 1 Receptor ; Neoplasm Recurrence, Local/drug therapy ; CD8-Positive T-Lymphocytes/pathology ; T-Lymphocytes/pathology
Chemical Substances	Nivolumab (31YO63LBSN) ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2023-07-24
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03644-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 269: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A multicentric and nationwide predictive study role of T cell sub-population in the prevalence and prognosis of cryoglobulinemia among genotype 4 chronic hepatitis C patients.

Abdel-Samiee, Mohamed / Youssef, Mohamed I / Elghamry, Fathy / Bazeed, Mahmoud / Al-Shorbagy, Mohamed / Shalaby, Helmy / Shabana, Hossam / Abdelsameea, Eman / Lashin, Hesham El Sayed / El Zamek, Hossam M Farid / Esam, Tarek / Alwaseef, Mohammad AbdElhameed Ahmed / Helmy, Housam Ahmed / Almarshad, Feras / Khalaf, Fatma A / Yossef, Badawy W AboBakr / Kassem, Arafat / Gabr, Basant Mostafa / Abdelfattah, Ahmed /

S AboShabaan, Hind / Aboufarrag, Galal Abdelhameed / Omar, Marwa M / Bakeer, Mohammed Saied / Imam, Mohammed S / Ibrahim, Essam S / Kamel, Shimaa Y / Allisy, Talaat / Mohammed, Omima Sayed / Farahat, Ali / El-Khayat, Mohsen M / Sekeen, Mohamed Abdelrafaa Hassan / Zaher, Eman Mohammed / Said, Ashraf / Abuamer, Ahmed / Elmahdi, Essam

Journal of medical virology

2023 Volume 95, Issue 12, Page(s) e29248

Abstract: ... In this study, we examined the predictive significance of T-cell subpopulations in relation to the occurrence ... in chronic HCV patients with MC. T-cell subpopulation serves as a reliable indicator for assessing ...

Abstract	The infection caused by the hepatitis C virus (HCV) is a significant global health concern. The prevailing genotype of HCV in Egypt is 4a, commonly referred to as GT-4a. A significant proportion exceeding 50% of patients infected with HCV experience extrahepatic manifestations (EHMs), encompassing a diverse range of clinical presentations. These manifestations, including essential mixed cryoglobulinemia (MC), can serve as initial and solitary indicators of the disease. The complete understanding of the pathogenesis of EHM remains unclear, with autoimmune phenomena being recognized as the primary causative factor. In this study, we examined the predictive significance of T-cell subpopulations in relation to the occurrence and prognosis of cryoglobulinemia in HCV patients. A total of 450 CHC genotype four treatment naïve patients were enrolled in this analytic cross-sectional study after thorough clinical, laboratory, and radiological examinations. All patients underwent laboratory investigations, including testing for cryoglobulin antibodies and measurements of CD4 and CD8 levels; two groups were described according to their test results: Group 1 consists of patients who have tested positive for cryoglobulin antibodies and Group 2 consists of patients who have tested negative for cryoglobulin antibodies. The exclusion criteria encompassed individuals with HIV infection or chronic HBV infection. Additionally, pelvi-abdominal ultrasonography was performed. Our study included 450 treatment naïve CHC patients (59% male, mean age 50.8 years). The patients were categorized according to their cryoglobulin antibodys test results into two groups: group A, CHC patients with cryoglobulin antibodies (Abs) negative (364 patients), and group B, CHC patients with cryoglobulin Ab positive (86 patients). Group B demonstrated a higher average age, elevated international normalized ratio, more prolonged duration of HCV infection, lower albumin, higher alanine aminotransferase, higher aspartate aminotransferase, higher bilirubin, lower CD8, lower CD4, and lower CD4:CD8 ratio. In contrast, 27 out of 86 (31.40%) patients in group B had symptoms; 85.8% had purpura and arthralgia, 74.3% had paresthesias, 86.7% had weakness, and 12.2% had non-Hodgkin's lymphoma. The levels of CD4 and CD8 were found to be decreased in chronic HCV patients with MC. T-cell subpopulation serves as a reliable indicator for assessing the prevalence and prognosis of MC in individuals with genotype 4 chronic hepatitis C. However, additional research is needed to further understand the development and spread of various emerging infectious diseases. Nevertheless, it is noteworthy that a critical threshold may exist beyond which EHM reaches a point of no return.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/epidemiology ; Cryoglobulinemia/epidemiology ; Prevalence ; Cross-Sectional Studies ; Cryoglobulins ; HIV Infections ; T-Lymphocytes ; Prognosis ; Hepatitis C ; Hepacivirus/genetics
Chemical Substances	Cryoglobulins
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29248
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Genetic variants of ALR (-106C → T /-12C → G) and serum PKC-δ are associated with peripheral neuropathy in Egyptian diabetic patients with impaired handwriting.

Fattah, Shaimaa A / Elmadani, Moshira / Abo-Elmatty, Dina M / Awadallah, Mohamed / Mehanna, Eman T

Journal of diabetes and metabolic disorders

2022 Volume 21, Issue 1, Page(s) 557–565

Abstract: ... association between the ALR polymorphisms (-106C → T/-12C → G) and elevated serum PKC-δ levels ... compared with 100 DP and 100 healthy volunteers. ALR -106C → T/-12C → G variants were studied using the PCR ... diabetic neuropathy than individuals with -106C → T and -12C → G genotypes (: Conclusion: The genetic variants ALR ...

Abstract	Purpose: Diabetic peripheral neuropathy can injure the hand median nerve and cause extensive nerve damage. PKC and ALR are associated with progression of diabetic complications. We hypothesized a genetic association between the ALR polymorphisms (-106C → T/-12C → G) and elevated serum PKC-δ levels in diabetic neuropathy and its adverse effects on handwriting in Egyptian population. Methods: One hundred DPN were compared with 100 DP and 100 healthy volunteers. ALR -106C → T/-12C → G variants were studied using the PCR-RFLP method. A routine set of standard laboratory markers was determined. Serum PKC-δ concentration was determined by ELISA. Logistic regression analysis and areas under the receiver characteristic curves (AUCs) were evaluated to investigate the predictors of diabetic neuropathy. Arabic handwriting was analyzed based on the recognition of functional features, word shape, and ascending/descending parts of letters. Results: Individuals carrying ALR-106C → C and -12G → G had a significantly higher risk of developing diabetic neuropathy than individuals with -106C → T and -12C → G genotypes ( Conclusion: The genetic variants ALR-106C → C / -12G → G and PKC-δ in serum may help in the detection and treatment of diabetic neuropathy in Egyptian population before writing performance is affected.
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-022-01008-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Upregulation of Cytotoxic T-cells in pediatric patients with Gaucher disease.

Zahran, Asmaa M / Saad, Khaled / Elsayh, Khalid I / Abdou, Madleen Adel A / Abo-Elgheet, Amir M / Eloseily, Esraa M / Khalaf, Shaimaa M / Sror, Shabaan / Ahmad, Faisal-Alkhateeb / Elhoufey, Amira / Ghandour, Aliaa / Osman, Naglaa S

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4977

Abstract: Cytotoxic (CD8) T-cells and natural killer (NK) cells have a significant immune function role ... at the proportion of cytotoxic CD8 T-cells and their subsets in children with GD. A prospective case-control study ... before the study. Complete blood count and flow cytometric analyses of CD8 T, Tc1, Tc2, NK, and NK T-cells were ...

Abstract	Cytotoxic (CD8) T-cells and natural killer (NK) cells have a significant immune function role. The ongoing stimulation of immunity and the excessive release of proinflammatory cytokines observed in pediatric patients with Gaucher disease (GD) can affect immune cells. Few studies have looked at the proportion of cytotoxic CD8 T-cells and their subsets in children with GD. A prospective case-control study was performed involving twenty pediatric patients with type 1 GD and twenty healthy age-matched controls. All patients received regular enzyme replacement therapy (ERT) for at least 6 months before the study. Complete blood count and flow cytometric analyses of CD8 T, Tc1, Tc2, NK, and NK T-cells were performed. GD patients showed significantly increased of CD8 T, Tc1 and significantly decreased NK cells frequencies when compared to healthy controls. However, no significant difference in Tc2 and NK T-cells was found between the studied groups. GD patients on regular ERT have increased CD8+ T-cell frequencies, predominantly Tc1, together with a reduction in NK cells than in healthy controls. These crucial immunological changes may contribute to some extent to the pathogenesis and the progression of GD.
MeSH term(s)	CD8-Positive T-Lymphocytes ; Case-Control Studies ; Child ; Gaucher Disease ; Humans ; T-Lymphocytes, Cytotoxic ; Up-Regulation
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08843-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: A biochemical, theoretical and immunohistochemical study comparing the therapeutic efficacy of curcumin and taurine on T-2 toxin induced hepatotoxicity in rats.

Al-Zahrani, Maryam H / Balgoon, Maha J / El-Sawi, Nagwa M / Alshubaily, Fawzia A / Jambi, Ebtihaj J / Khojah, Sohair M / Baljoon, Raghad S / Alkhattabi, Nuha A / Baz, Lina A / Alharbi, Asmaa A / Ahmed, Amira M / Abo Elkhair, Ayat M / Ismael, Mohamed / Gebril, Sahar M

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1172403

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1172403
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.

Mansour, Adel Abo / Raucci, Federica / Sevim, Mustafa / Saviano, Anella / Begum, Jenefa / Zhi, Zhaogong / Pezhman, Laleh / Tull, Samantha / Maione, Francesco / Iqbal, Asif Jilani

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 151, Page(s) 113171

Abstract: Adaptive immunity relies on the efficient recruitment of T cells from the blood into peripheral ... leukocyte adhesion and transmigration. However, very little is known about its function in T cell migration ...

Abstract	Adaptive immunity relies on the efficient recruitment of T cells from the blood into peripheral tissues. However, the current understanding of factor(s) coordinating these events is incomplete. Previous studies on galectin-9 (Gal-9), have proposed a functionally significant role for this lectin in mediating leukocyte adhesion and transmigration. However, very little is known about its function in T cell migration. Here, we have investigated the role of the Gal-9 on the migration behaviour of both human primary CD4
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes ; Galectins ; Integrins ; Mice ; Polysaccharides ; Transendothelial and Transepithelial Migration
Chemical Substances	Galectins ; Integrins ; Polysaccharides
Language	English
Publishing date	2022-05-25
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113171
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors.

Almulla, Abbas F / Abbas Abo Algon, Ali / Tunvirachaisakul, Chavit / Al-Hakeim, Hussein K / Maes, Michael

Journal of advanced research

2023

Abstract: ... cytokines/chemokines/growth factors, classical M1, alternative M2, T helper (Th)-1, Th-2, and Th-17 ... MDMD is accompanied by positive regulation of the IRS mainly driven by Th-1 polarization and T cell ...

Abstract	Background: Immune-inflammatory pathways in major depressive disorder are confined to the major dysmood disorder (MDMD) phenotype (Maes et al., 2022). No studies have addressed the immune profile of first episode MDMD (FE-MDMD). Methods: This study investigated the immune profiles of 71 patients with the acute phase of first-episode major depressive disorder (FE-MDMD) and 40 healthy controls. We measured 48 cytokines/chemokines/growth factors, classical M1, alternative M2, T helper (Th)-1, Th-2, and Th-17 phenotypes, immune-inflammatory response system (IRS), compensatory immunoregulatory system (CIRS), and neuro-immunotoxicity profiles. Results: FE-MDMD patients show significantly activated M1, M2, Th-1, IRS, CIRS, and neurotoxicity, but not Th-2 or Th-17, profiles compared to controls. FE-MDMD is accompanied by Th-1 polarization, while there are no changes in M1/M2 or IRS/CIRS ratios. The top single indicator of FE-MDMD was by far interleukin (IL)-16, followed at a distance by TRAIL, IL-2R, tumor necrosis factor (TNF)-β. The severity of depression and anxiety was strongly associated with IRS (positively) and Th-2 (inversely) profiles, whereas suicidal behavior was associated with M1 activation. Around 56-60% of the variance in depression, anxiety, and suicidal behavior scores was explained by IL-16, platelet-derived growth factor (PDGF) (both positively), and IL-1 receptor antagonist (inversely). Increased neurotoxicity is mainly driven by IL-16, TNF-α, TRAIL, IL-6, and chemokine (CCL2, CCL11, CXCL1, CXCL10) signaling. Antidepressant-treated patients show an increased IRS/CIRS ratio as compared with drug-naïve FE-MDMD patients. Conclusions: FE-MDMD is accompanied by positive regulation of the IRS mainly driven by Th-1 polarization and T cell activation (via binding of IL-16 to CD4), and TNF, chemokine, and growth factor signaling.
Language	English
Publishing date	2023-11-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2023.11.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Upregulation of Cytotoxic T-cells in pediatric patients with Gaucher disease

Asmaa M. Zahran / Khaled Saad / Khalid I. Elsayh / Madleen Adel A. Abdou / Amir M. Abo-Elgheet / Esraa M. Eloseily / Shaimaa M. Khalaf / Shabaan Sror / Faisal-Alkhateeb Ahmad / Amira Elhoufey / Aliaa Ghandour / Naglaa S. Osman

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 7

Abstract: Abstract Cytotoxic (CD8) T-cells and natural killer (NK) cells have a significant immune function ... at the proportion of cytotoxic CD8 T-cells and their subsets in children with GD. A prospective case–control study ... before the study. Complete blood count and flow cytometric analyses of CD8 T, Tc1, Tc2, NK, and NK T-cells were ...

Abstract	Abstract Cytotoxic (CD8) T-cells and natural killer (NK) cells have a significant immune function role. The ongoing stimulation of immunity and the excessive release of proinflammatory cytokines observed in pediatric patients with Gaucher disease (GD) can affect immune cells. Few studies have looked at the proportion of cytotoxic CD8 T-cells and their subsets in children with GD. A prospective case–control study was performed involving twenty pediatric patients with type 1 GD and twenty healthy age-matched controls. All patients received regular enzyme replacement therapy (ERT) for at least 6 months before the study. Complete blood count and flow cytometric analyses of CD8 T, Tc1, Tc2, NK, and NK T-cells were performed. GD patients showed significantly increased of CD8 T, Tc1 and significantly decreased NK cells frequencies when compared to healthy controls. However, no significant difference in Tc2 and NK T-cells was found between the studied groups. GD patients on regular ERT have increased CD8+ T-cell frequencies, predominantly Tc1, together with a reduction in NK cells than in healthy controls. These crucial immunological changes may contribute to some extent to the pathogenesis and the progression of GD.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Thymoglobulin-Resistant T-Cell-Mediated Acute Rejection in a Pregnant Renal Transplant Recipient: Case Report and Review of the Literature.

Balaha, Mohamed / Al-Otaibi, Torki / Gheith, Osama A / Halim, Medhat A / Shaker, Mohamed / Fayyad, Zohair / Nair, Prasad / Zakaria, Zakaria / Abo-Atya, Hasaneen / Makkeyia, Yahya

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2019 Volume 17, Issue Suppl 1, Page(s) 159–163

Abstract: ... She received empirical pulse steroids with partial response, and her graft biopsy showed acute T-cell-mediated ...

Abstract	To avoid graft rejection during pregnancy, frequent monitoring of serum drug levels is recommended. Pregnancy induces hyperfiltration in transplanted kidneys, as in native kidneys; therefore, detection of rejection can be difficult when monitoring by serum creatinine. If rejection is suspected, ultrasonographguided graft biopsy can be done; once proven, it can be treated with pulse steroids, but data are scarce regarding other agents. Here, we present a 28-year-old pregnant female patient with resistant acute rejection but with successful pregnancy outcome. Our patient had end-stage kidney disease secondary to lupus nephropathy and underwent living-donor renal transplant in May 2013 after hemodialysis support for 1 year. She received thymoglobulin as induction therapy and was maintained on prednisolone, mycophenolate mofetil, and tacrolimus. She had normal renal graft function without proteinuria. After she received counseling, she became pregnant in February 2015. In June 2015, she presented with acute graft dysfunction with serum creatinine level of 365 μmol/L. Her abdominal ultrasonography showed mild hydronephrosis and viable fetus. She received empirical pulse steroids with partial response, and her graft biopsy showed acute T-cell-mediated rejection and negative C4d. Intravenous immunoglobulins and minipulse steroids were administered but without response. After gynecologic counseling and informed consent, she received 5 doses of thymoglobulin. She was dialysis dependent until premature vaginal labor, which resulted in birth of a viable 2-kg boy. We suggest that successful pregnancy outcomes could occur with close monitoring and daily dialysis in female kidney transplant patients with resistant rejection.
MeSH term(s)	Acute Disease ; Adult ; Antilymphocyte Serum/adverse effects ; Antilymphocyte Serum/therapeutic use ; Drug Resistance ; Drug Substitution ; Drug Therapy, Combination ; Female ; Graft Rejection/immunology ; Graft Rejection/therapy ; Humans ; Immunity, Cellular/drug effects ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Live Birth ; Living Donors ; Lupus Nephritis/complications ; Mycophenolic Acid/therapeutic use ; Prednisolone/therapeutic use ; Pregnancy ; Pregnancy, Unplanned ; Renal Dialysis ; Risk Factors ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Tacrolimus/therapeutic use ; Treatment Outcome
Chemical Substances	Antilymphocyte Serum ; Immunosuppressive Agents ; Prednisolone (9PHQ9Y1OLM) ; thymoglobulin (D7RD81HE4W) ; Mycophenolic Acid (HU9DX48N0T) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2019-02-19
Publishing country	Turkey
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.MESOT2018.P38
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6632: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito