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  1. Article ; Online: Authors' Reply.

    Bunnapradist, Suphamai / Tabriziani, Hossein

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 11, Page(s) 2973–2974

    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021081039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  2. Article ; Online: Adenovirus in a Kidney Transplant Recipient.

    Lum, Erik L / Zuckerman, Jonathan / Gaynor, Pryce / Bunnapradist, Suphamai

    Kidney medicine

    2023  Volume 5, Issue 4, Page(s) 100605

    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Editorial
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: BK Viremia Exacerbation With Adalimumab Coadministration.

    Lum, Erik L / Bunnapradist, Suphamai

    Transplantation direct

    2020  Volume 6, Issue 6, Page(s) e557

    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparing the pharmacokinetics of extended-release tacrolimus (LCP-TAC) to immediate-release formulations in kidney transplant patients.

    Tan, Teresa / Bunnapradist, Suphamai

    Expert opinion on drug metabolism & toxicology

    2021  Volume 17, Issue 10, Page(s) 1175–1186

    Abstract: Introduction: One of the most commonly used immunosuppressants in organ transplant, tacrolimus exhibits wide interpatient and intrapatient variability and narrow therapeutic index that necessitates routine concentration monitoring and dosage adjustments. ...

    Abstract Introduction: One of the most commonly used immunosuppressants in organ transplant, tacrolimus exhibits wide interpatient and intrapatient variability and narrow therapeutic index that necessitates routine concentration monitoring and dosage adjustments. Availability of modified -release tacrolimus products offer once-daily dosing options. The objective of this review is to highlight and compare available pharmacokinetic (PK) data of extended-release tacrolimus tablets (LCP-TAC) to immediate-release tacrolimus (IR-TAC) in kidney transplant recipients.
    Areas covered: A review of the literature was performed using PubMed and Embase search to identify relevant articles evaluating PK data for LCP-TAC compared to IR-TAC in kidney transplant patients including special populations.
    Expert opinion: LCP-TAC's unique PK profile may be more favorable than IR-TAC. While the clinical impact of these PK differences have not been established, several outcomes are being evaluated in ongoing studies. Results of these studies will add information incrementally to care for kidney transplant patients. Larger prospective studies evaluating kidney and patient survival differences are needed but it is unlikely that they will be conducted. Given that the patent exclusivity of LCP-TAC for the next several years and imminent loss of exclusivity of PR-TAC, our opinion is the use of LCP-TAC will be increasing, especially in Europe.
    MeSH term(s) Delayed-Action Preparations ; Drug Administration Schedule ; Drug Monitoring ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/pharmacokinetics ; Kidney Transplantation/methods ; Tacrolimus/administration & dosage ; Tacrolimus/pharmacokinetics
    Chemical Substances Delayed-Action Preparations ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2021.1974399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6264: Show issues Location:
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  5. Article ; Online: Association between ethnicity and kidney transplant waitlist outcomes beyond estimated post-transplant survival score.

    Homkrailas, Piyavadee / Bunnapradist, Suphamai

    Transplant international : official journal of the European Society for Organ Transplantation

    2021  Volume 34, Issue 10, Page(s) 1837–1844

    Abstract: White kidney transplant candidates have the highest pre-transplant mortality rate compared to other ethnicities. The reason for a higher mortality rate is not well-understood. Estimated post-transplant survival (EPTS) score has been used to predict ... ...

    Abstract White kidney transplant candidates have the highest pre-transplant mortality rate compared to other ethnicities. The reason for a higher mortality rate is not well-understood. Estimated post-transplant survival (EPTS) score has been used to predict patient survival after transplant and may be associated with pre-transplant survival. First-time kidney transplant candidates listed between 2015 and 2018 were identified from the Organ Procurement Transplantation Network database. Individuals listed for multiple organs, at multiple centers, and age <18 years were excluded. We examined the impact of ethnicity on waitlist mortality and delisting. A total of 114 806 candidates were included. The study population was categorized into four groups which were 43% white, 28% Black, 19.2% Hispanic, and 9.8% "other ethnicities." At 5.2 years, the cumulative incidences of death and delist were 32%, 31%, 29%, and 26%, respectively. Compared to whites, adjusted subdistribution hazard ratio (aSHR) for death and delist among Black, Hispanics, and "other ethnicities" were 0.92 (95% CI 0.89-0.95), 0.89 (95% CI 0.85-0.91), and 0.76 (95% CI 0.72-0.80) after adjustment by EPTS along with other factors, respectively. After adjusting for EPTS score along with additional confounding factors and functional status at initial listing, white ethnicity was independently associated with an increased risk for death and delist.
    MeSH term(s) Adolescent ; Ethnic Groups ; Graft Survival ; Humans ; Kidney Transplantation ; Retrospective Studies ; Tissue and Organ Procurement ; Waiting Lists
    Language English
    Publishing date 2021-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13965
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    Zs.A 2358: Show issues Location:
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  6. Article ; Online: Novel indications for referral and care for simultaneous liver kidney transplant recipients.

    Lum, Erik L / Bunnapradist, Suphamai / Wiseman, Alexander C / Gurakar, Ahmet / Ferrey, Antoney / Reddy, Uttam / Al Ammary, Fawaz

    Current opinion in nephrology and hypertension

    2024  Volume 33, Issue 3, Page(s) 354–360

    Abstract: Purpose of review: Kidney dysfunction is challenging in liver transplant candidates to determine whether it is reversible or not. This review focuses on the pertinent data on how to best approach liver transplant candidates with kidney dysfunction in ... ...

    Abstract Purpose of review: Kidney dysfunction is challenging in liver transplant candidates to determine whether it is reversible or not. This review focuses on the pertinent data on how to best approach liver transplant candidates with kidney dysfunction in the current era after implementing the simultaneous liver kidney (SLK) allocation policy and safety net.
    Recent findings: The implementation of the SLK policy inverted the steady rise in SLK transplants and improved the utilization of high-quality kidneys. Access to kidney transplantation following liver transplant alone (LTA) increased with favorable outcomes. Estimating GFR in liver transplant candidates remains challenging, and innovative methods are needed. SLK provided superior patient and graft survival compared to LTA only for patients with advanced CKD and dialysis at least 3 months. SLK can provide immunological protection against kidney rejection in highly sensitized candidates. Post-SLK transplant care is complex, with an increased risk of complications and hospitalization.
    Summary: The SLK policy improved kidney access and utilization. Transplant centers are encouraged, under the safety net, to reserve SLK for liver transplant candidates with advanced CKD or dialysis at least 3 months while allowing lower thresholds for highly sensitized patients. Herein, we propose a practical approach to liver transplant candidates with kidney dysfunction.
    MeSH term(s) Humans ; Kidney Transplantation/methods ; Renal Dialysis/adverse effects ; Risk Factors ; Kidney ; Renal Insufficiency ; Graft Survival ; Liver ; Referral and Consultation ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/surgery
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  7. Article ; Online: Current opinions in nephrology and hypertension: kidney transplantation in patients with plasma cell dyscrasias.

    Lum, Erik L / Bunnapradist, Suphamai

    Current opinion in nephrology and hypertension

    2019  Volume 28, Issue 6, Page(s) 573–580

    Abstract: Purpose of review: Plasma cell dyscrasias encompass a group of hematological disorders characterized by increased production of immunoglobulins by clonal B cells. Kidney involvement is common. Significant advances in the treatment of plasma cell ... ...

    Abstract Purpose of review: Plasma cell dyscrasias encompass a group of hematological disorders characterized by increased production of immunoglobulins by clonal B cells. Kidney involvement is common. Significant advances in the treatment of plasma cell dyscrasias have resulted in improved survival and may permit kidney transplantation in candidates previously denied transplantation. Treatments may also have effects on kidney transplant recipients who develop plasma cell dyscrasias post transplantation.
    Recent finding: The available evidence suggests that transplantation of candidates with nonmultiple myeloma plasma cell dyscrasias provides good outcome with low recurrence rates, so long as the disease has been treated with a complete or good partial response prior to transplantation. Candidates with a history untreated MGRS or a history of multiple myeloma have a high rate of recurrence posttransplant. Kidney transplant recipients who develop plasma cell dyscrasias post transplantation have an increased risk of death and thalidomide-based regimens may increase the risk of rejection.
    Summary: Transplant candidates with a history of plasma cell dyscrasia who are in remission should not be excluded from transplantation. Individuals with multiple myeloma have a high rate of recurrence and myeloma post kidney transplant must be managed carefully.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Monoclonal Gammopathy of Undetermined Significance/complications ; Multiple Myeloma/complications ; Paraproteinemias/complications ; Paraproteinemias/therapy
    Language English
    Publishing date 2019-10-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  8. Article ; Online: Reduction in Maintenance Immunosuppression in Kidney Transplant Recipients With Stable Donor-Derived Cell-Free DNA Measurements: A Case Series.

    Lum, Erik L / Towns, Arta / Basuli, Debargha / Pham, Phuong-Thu / Sarkar, Mrinalini / Bunnapradist, Suphamai

    Transplantation proceedings

    2022  Volume 55, Issue 1, Page(s) 93–97

    Abstract: Personalization of maintenance immunosuppression in kidney transplant recipients has long remained a goal in the transplant community. The recent addition of donor-derived cell-free DNA assays to detect allograft rejection and monitor allograft health ... ...

    Abstract Personalization of maintenance immunosuppression in kidney transplant recipients has long remained a goal in the transplant community. The recent addition of donor-derived cell-free DNA assays to detect allograft rejection and monitor allograft health may permit for reductions in maintenance immunosuppression in recipients with stable levels. Herein, we described 5 patients with stable donor-derived cell-free DNA levels who underwent reduction in maintenance immunosuppression without precipitation of clinical rejection, proteinuria, or de novo donor specific antibody formation.
    MeSH term(s) Humans ; Immunosuppressive Agents ; Kidney Transplantation ; Immunosuppression Therapy ; Tissue Donors ; Transplantation, Homologous ; Graft Rejection ; Transplant Recipients
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.12.003
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    Zs.A 835: Show issues Location:
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  9. Article ; Online: Marginal quality kidneys for simultaneous liver-kidney transplantation: To pass or double down?

    Bunnapradist, Suphamai / Danovitch, Gabriel M

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2017  Volume 23, Issue 1, Page(s) 7–8

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.24669
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    Zs.A 4702: Show issues Location:
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  10. Article ; Online: Evaluation of Renal Disease in Patients With Cirrhosis.

    Lum, Erik L / Homkrailas, Piyavadee / Bunnapradist, Suphamai

    Journal of clinical gastroenterology

    2020  Volume 54, Issue 4, Page(s) 314–321

    Abstract: Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, approach, and evaluation of renal disease in this group of ... ...

    Abstract Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, approach, and evaluation of renal disease in this group of patients is similar to the noncirrhosis patient, with a few specific caveats. Renal disease may be unrelated to the cause of cirrhosis (eg, prerenal acute kidney injury, acute tubular necrosis), occur as a manifestation of the same systemic disease responsible for the liver disease (eg, chronic viral hepatitis B and C infection) or as a consequence of cirrhosis (hepatorenal syndrome). Kidney impairment may be underrecognized in patients with cirrhosis due to over-reliance on creatinine-based glomerular filtration rate equations used in clinical practice. The first steps of evaluation for the renal disease include a thorough medical history to identify the underlying cause of cirrhosis and any potential trigger for renal dysfunction, physical examination, and review of prior laboratory records for baseline renal function. Renal imaging and urinalysis should be performed on all cirrhotic patients with renal dysfunction to establish the presence of urinary obstruction, chronicity and intrinsic renal disease.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Creatinine ; Hepatorenal Syndrome ; Humans ; Kidney ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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