LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 7815

Search options

  1. Article ; Online: Fundamental and Applied Reviews in Analytical Chemistry: 2023.

    Ren, Bin

    Analytical chemistry

    2023  Volume 95, Issue 1, Page(s) 1–2

    MeSH term(s) Chemistry, Analytic ; Chemistry Techniques, Analytical
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c05717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Fundamental and Applied Reviews in Analytical Chemistry.

    Ren, Bin

    Analytical chemistry

    2022  Volume 94, Issue 1, Page(s) 1–2

    MeSH term(s) Chemistry Techniques, Analytical ; Chemistry, Analytic ; Humans ; Review Literature as Topic
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.1c05291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Targeting methionine metabolism in cancer: opportunities and challenges.

    Bin, Peng / Wang, Chuanlong / Zhang, Hangchao / Yan, Yuqi / Ren, Wenkai

    Trends in pharmacological sciences

    2024  Volume 45, Issue 5, Page(s) 395–405

    Abstract: Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis. Recent studies have revealed mechanisms regulating methionine metabolism within the tumor microenvironment (TME) that drive both cancer development and antitumor immunity ... ...

    Abstract Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis. Recent studies have revealed mechanisms regulating methionine metabolism within the tumor microenvironment (TME) that drive both cancer development and antitumor immunity evasion. In this review article we summarize advancements in our understanding of tumor regulation of methionine metabolism and therapies in development that target tumor methionine metabolism. We also delineate the challenges of methionine blockade therapies in cancer and discuss emerging strategies to address them.
    MeSH term(s) Humans ; Methionine/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Tumor Microenvironment ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Methionine (AE28F7PNPL) ; Antineoplastic Agents
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Assessing Passengers' Motion Sickness Levels Based on Cerebral Blood Oxygen Signals and Simulation of Actual Ride Sensation.

    Ren, Bin / Zhou, Qinyu

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: 1) Background: After motion sickness occurs in the ride process, this can easily cause passengers to have a poor mental state, cold sweats, nausea, and even vomiting symptoms. This study proposes to establish an association model between motion sickness ...

    Abstract (1) Background: After motion sickness occurs in the ride process, this can easily cause passengers to have a poor mental state, cold sweats, nausea, and even vomiting symptoms. This study proposes to establish an association model between motion sickness level (MSL) and cerebral blood oxygen signals during a ride. (2) Methods: A riding simulation platform and the functional near-infrared spectroscopy (fNIRS) technology are utilized to monitor the cerebral blood oxygen signals of subjects in a riding simulation experiment. The subjects' scores on the Fast Motion sickness Scale (FMS) are determined every minute during the experiment as the dependent variable to manifest the change in MSL. The Bayesian ridge regression (BRR) algorithm is applied to construct an assessment model of MSL during riding. The score of the Graybiel scale is adopted to preliminarily verify the effectiveness of the MSL evaluation model. Finally, a real vehicle test is developed, and two driving modes are selected in random road conditions to carry out a control test. (3) Results: The predicted MSL in the comfortable mode is significantly less than the MSL value in the normal mode, which is in line with expectations. (4) Conclusions: Changes in cerebral blood oxygen signals have a huge correlation with MSL. The MSL evaluation model proposed in this study has a guiding significance for the early warning and prevention of motion sickness.
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13081403
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Zero-Sum Differential Game-Based Fault-Tolerant Control for a Class of Affine Nonlinear Systems.

    Ren, Hao / Jiang, Bin / Ma, Yajie

    IEEE transactions on cybernetics

    2024  Volume 54, Issue 2, Page(s) 1272–1282

    Abstract: This article proposes a zero-sum differential game-based control scheme for a class of affine nonlinear control systems with actuator faults, including loss of control, loss of effectiveness, and bias faults. In the control design, the bias faults and ... ...

    Abstract This article proposes a zero-sum differential game-based control scheme for a class of affine nonlinear control systems with actuator faults, including loss of control, loss of effectiveness, and bias faults. In the control design, the bias faults and the control signal are chosen as the two opposite sides. The Nash equilibrium is achieved while the optimal control signal and the upper bound of bias faults can be derived from the Hamilton-Jacobi-Isaacs (HJI) equation. An adaptive dynamic programming (ADP) method is employed to estimate the weight of the critic network. The developed zero-sum differential game-based control scheme can ensure the system stability and optimal performance. Two simulation results on a numerical system and a rigid spacecraft model illustrate the effectiveness of the proposed control scheme.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2022.3215716
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Differential Analysis of Blood Routine Examination Parameters in Patients with Upper Gastrointestinal Bleeding and Lower Gastrointestinal Bleeding.

    Wang, Jun / Ren, Houwei / Gu, Bin / Zhang, Yuezhan

    Alternative therapies in health and medicine

    2024  

    Abstract: Background: This study addresses the critical need for differentiating between upper and lower gastrointestinal bleeding by focusing on blood routine parameters to enhance diagnostic precision.: Objective: This study aims to identify and compare ... ...

    Abstract Background: This study addresses the critical need for differentiating between upper and lower gastrointestinal bleeding by focusing on blood routine parameters to enhance diagnostic precision.
    Objective: This study aims to identify and compare specific blood routine parameters to determine their efficacy in distinguishing between upper and lower gastrointestinal bleeding for improved clinical decision-making.
    Methods: This retrospective study analyzed 119 patients with gastrointestinal bleeding (GIB) admitted to our hospital between January 2017 and June 2020. Among them, 86 were diagnosed with upper GIB (UGIB) and 33 with lower GIB (LGIB). After admission, peripheral blood samples were collected for a comprehensive blood routine examination, including white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), platelet count (PLT), blood urea nitrogen (BUN), creatinine (Cr), and BUN to Cr ratio (BUN/Cr ratio). Differences in blood routine parameters were compared between the UGIB and LGIB groups. Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the efficacy of blood routine examinations in differentiating between UGIB and LGIB.
    Results: The study revealed no significant differences in WBC and Cr levels between LGIB and UGIB patients (P > .05). However, UGIB patients exhibited statistically lower levels of RBC, Hb, and PLT, along with higher BUN and BUN/Cr ratio levels compared to LGIB patients (P < .05). Pearson correlation coefficient analysis indicated an inverse correlation of BUN/Cr with RBC, Hb, and PLT in GIB patients and a positive association between BUN/Cr and BUN (P < .05). ROC analysis demonstrated that RBC, Hb, PLT, BUN, and BUN/Cr ratios were effective in distinguishing UGIB from LGIB (P < .05).
    Conclusions: Blood routine parameters, including RBC, Hb, PLT, BUN, and BUN/Cr ratio, are valuable in differentiating between UGIB and LGIB. These parameters can serve as early evaluation indexes for GIB, facilitating timely intervention and treatment to enhance therapeutic outcomes.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Bacterial diversity and metabolites: Exploring correlations with preservative properties in soybean pastes.

    Ren, Fei / Liu, Ming / Tan, Bin

    Journal of food science

    2024  Volume 89, Issue 4, Page(s) 2397–2409

    Abstract: Soybean paste, a traditional fermented condiment, exhibits distinct quality attributes by its microbial communities. This study employed Illumina sequencing and LC-MS to scrutinize the bacterial biota and metabolome of highly preserved (HP) and easily ... ...

    Abstract Soybean paste, a traditional fermented condiment, exhibits distinct quality attributes by its microbial communities. This study employed Illumina sequencing and LC-MS to scrutinize the bacterial biota and metabolome of highly preserved (HP) and easily spoiled (ES) soybean pastes. Firmicutes were prevalent in both pastes, with HP showcasing greater microbial α-diversity compared to ES pastes. Bacillus predominated in HP pastes, whereas Lactobacillus was most abundant in ES pastes. Significant metabolic differences were observed between HP and ES samples in lipids, peptides, nucleic acids, secondary metabolite biosynthesis, protein digestion, amino acid metabolism, inflammatory mediator regulation, and neomycin, kanamycin, and gentamicin biosynthesis. Lactobacillus exhibited positive associations with daidzein and 3,4,5-trihydroxypentanoylcarnitine, whereas Bacillus showed negative correlations with 1,n6-ethenoadenosine, 2-deoxy-2,3-dehydro-n-acetyl-neuraminic acid, 3,4,5-trihydroxypentanoyl carnitine, and fructosyl valine. These findings highlight the collaborative impact of bacterial communities and metabolites on soybean paste quality attributes. This research enhances our comprehension of preservation mechanisms in fermented foods, particularly soybean pastes. PRACTICAL APPLICATION: The investigation would provide insights into the soybean pastes fermentation, safe and quality control methods, bio-preservative development strategies, and so on of soybean pastes for related studies and the consumers. Bacteria and their metabolites could be used to optimize the fermentation processes for the preservative and safe regulations.
    MeSH term(s) Glycine max ; Bacteria/genetics ; Fermented Foods ; Bacillus ; Fermentation
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.16982
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Effect of electroacupuncture on neuronal programmed necrosis by regulating RIP1/RIP3/MLKL pathway in rats with cerebral ischemia reperfusion injury.

    Chen, Jing / Ren, Bin-Bin / Ma, Su-Na / Wei, Hui-Lin / Yang, Yue-Yue / Wu, Song

    Zhen ci yan jiu = Acupuncture research

    2024  Volume 49, Issue 2, Page(s) 127–134

    Abstract: Objectives: To investigate the neuroprotective effect of electroacupuncture (EA) at "Quchi"(LI11) and "Zusanli"(ST36) in the rats with cerebral ischemia reperfusion injury and its influence on programmed necrosis of cerebral cortical neurons.: Methods! ...

    Title translation 电针调节RIP1/RIP3/MLKL通路对脑缺血再灌注损伤大鼠神经元程序性坏死的影响.
    Abstract Objectives: To investigate the neuroprotective effect of electroacupuncture (EA) at "Quchi"(LI11) and "Zusanli"(ST36) in the rats with cerebral ischemia reperfusion injury and its influence on programmed necrosis of cerebral cortical neurons.
    Methods: Sixty male SD rats were randomly divided into sham-operation group, model group, EA group and inhibitor group, with 15 rats in each group. Left middle cerebral artery occlusion model was established using the modified thread embolism method. In the sham-operation group, the carotid artery was exposed and dissociated in each rat. EA was applied to "Quchi"(LI11) and "Zusanli"(ST36) on the right side for 30 min each time, once daily for 7 days in the rats of the EA group. The rats in the inhibitor group were intraperitoneally injected with norstatin-1 (0.6 mg/kg) for consecutive 7 days. The neurological deficit score of rats in each group was observed. HE staining was adopted to detect the degree of pathological damage of the cerebral cortex in the infarction area. Using TUNEL staining, the apoptosis of cortical neurons in the infarction area was determined;the contents of tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 were detected by ELISA;the mRNA and protein expression of the receptor interacting protein-1 (RIP1), the receptor interacting protein-3 (RIP3) and the substrate mixed lineage kinase like protein (MLKL) were detected by fluorescence quantitative PCR and Western blot, respectively.
    Results: In comparison with the sham-operation group, the neurological deficit score in the model group was higher(
    Conclusions: EA can attenuate cerebral ischemia reperfusion injury and display its neuroprotective effect probably through inhibiting programmed necrosis of cerebral cortical neurons in the rats.
    MeSH term(s) Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/genetics ; Brain Ischemia/genetics ; Brain Ischemia/therapy ; Electroacupuncture ; Interleukin-6 ; Neuroprotective Agents ; Reperfusion Injury/genetics ; Reperfusion Injury/therapy ; Neurons/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Necrosis ; Apoptosis ; Infarction ; RNA, Messenger ; Protein Kinases
    Chemical Substances Tumor Necrosis Factor-alpha ; Interleukin-6 ; Neuroprotective Agents ; Interleukin-1beta ; RNA, Messenger ; MLKL protein, rat (EC 2.7.-) ; Protein Kinases (EC 2.7.-)
    Language Chinese
    Publishing date 2024-02-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    DOI 10.13702/j.1000-0607.20221295
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Diversified Chemical Structures and Bioactivities of the Chemical Constituents Found in the Brown Algae Family Sargassaceae.

    Peng, Yan / Yang, Xianwen / Huang, Riming / Ren, Bin / Chen, Bin / Liu, Yonghong / Zhang, Hongjie

    Marine drugs

    2024  Volume 22, Issue 2

    Abstract: Sargassaceae, the most abundant family in Fucales, was recently formed through the merging of the two former families Sargassaceae and Cystoseiraceae. It is widely distributed in the world's oceans, notably in tropical coastal regions, with the exception ...

    Abstract Sargassaceae, the most abundant family in Fucales, was recently formed through the merging of the two former families Sargassaceae and Cystoseiraceae. It is widely distributed in the world's oceans, notably in tropical coastal regions, with the exception of the coasts of Antarctica and South America. Numerous bioactivities have been discovered through investigations of the chemical diversity of the Sargassaceae family. The secondary metabolites with unique structures found in this family have been classified as terpenoids, phlorotannins, and steroids, among others. These compounds have exhibited potent pharmacological activities. This review describes the new discovered compounds from Sargassaceae species and their associated bioactivities, citing 136 references covering from March 1975 to August 2023.
    MeSH term(s) Humans ; Phaeophyceae ; Oceans and Seas ; Antarctic Regions
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22020059
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: FoxO1 transcriptional activities in VEGF expression and beyond: a key regulator in functional angiogenesis?

    Ren, Bin

    The Journal of pathology

    2018  Volume 245, Issue 3, Page(s) 255–257

    Abstract: FoxO1 has emerged as an important regulator of angiogenesis. Recent work published in this Journal shows that FoxO1 regulates VEGF expression in keratinocytes and is required for angiogenesis in wound healing. Since FoxO1 also regulates CD36 ... ...

    Abstract FoxO1 has emerged as an important regulator of angiogenesis. Recent work published in this Journal shows that FoxO1 regulates VEGF expression in keratinocytes and is required for angiogenesis in wound healing. Since FoxO1 also regulates CD36 transcription, and endothelial cell differentiation and vascular maturation, this transcription factor may be essential for the formation of functional vascular networks via coupling the regulation of CD36 in vascular endothelial cells under physiological and pathological conditions. Although many outstanding questions remain to be answered, the mechanisms by which FoxO1 regulates VEGF in keratinocytes provide insight into the development of functional angiogenesis and further our understanding of vascular biology. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) Endothelial Cells ; Forkhead Box Protein O1 ; Humans ; Neovascularization, Pathologic ; United Kingdom ; Vascular Endothelial Growth Factor A ; Wound Healing
    Chemical Substances FOXO1 protein, human ; Forkhead Box Protein O1 ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2018-05-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5088
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top