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  1. Article ; Online: Extubation of patients with COVID-19.

    D'Silva, David F / McCulloch, Timothy J / Lim, Jessica S / Smith, Sanchia S / Carayannis, Daniel

    British journal of anaesthesia

    2020  Volume 125, Issue 1, Page(s) e192–e195

    MeSH term(s) Aerosols ; Airway Extubation/methods ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extubation of patients with COVID-19

    D'Silva, David F. / McCulloch, Timothy J. / Lim, Jessica S. / Smith, Sanchia S. / Carayannis, Daniel

    2020  

    Keywords COVID-19 ; Coronavirus ; covid19
    Language English
    Publishing date 2020-01-01
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Extubation of patients with COVID-19

    D'Silva, David F. / McCulloch, Timothy J. / Lim, Jessica S. / Smith, Sanchia S. / Carayannis, Daniel

    British Journal of Anaesthesia

    2020  Volume 125, Issue 1, Page(s) e192–e195

    Keywords Anesthesiology and Pain Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.03.016
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Low Fat Yoghurts Produced with Different Protein Levels and Alternative Natural Sweeteners.

    Campos, Lara / Tuma, Paulina / Silva, Tânia / Gomes, David / Pereira, Carlos Dias / Henriques, Marta H F

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: The food industry is looking for substitutes for sucrose in food items due to the excessive consumption of products with added sugar and the demand for healthier products. Alternative natural sweeteners can help achieve this goal. Different types of low- ... ...

    Abstract The food industry is looking for substitutes for sucrose in food items due to the excessive consumption of products with added sugar and the demand for healthier products. Alternative natural sweeteners can help achieve this goal. Different types of low-fat yoghurts (1% fat), with low-protein and high-protein levels (3% and 4.5-6.5% protein, respectively), were produced using alternative natural sweeteners. The low-protein yoghurts were made with stevia (0.03%
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13020250
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  5. Article ; Online: Few-shot genes selection: subset of PAM50 genes for breast cancer subtypes classification.

    Okimoto, Leandro Y S / Mendonca-Neto, Rayol / Nakamura, Fabíola G / Nakamura, Eduardo F / Fenyö, David / Silva, Claudio T

    BMC bioinformatics

    2024  Volume 25, Issue 1, Page(s) 92

    Abstract: Background: In recent years, researchers have made significant strides in understanding the heterogeneity of breast cancer and its various subtypes. However, the wealth of genomic and proteomic data available today necessitates efficient frameworks, ... ...

    Abstract Background: In recent years, researchers have made significant strides in understanding the heterogeneity of breast cancer and its various subtypes. However, the wealth of genomic and proteomic data available today necessitates efficient frameworks, instruments, and computational tools for meaningful analysis. Despite its success as a prognostic tool, the PAM50 gene signature's reliance on many genes presents challenges in terms of cost and complexity. Consequently, there is a need for more efficient methods to classify breast cancer subtypes using a reduced gene set accurately.
    Results: This study explores the potential of achieving precise breast cancer subtype categorization using a reduced gene set derived from the PAM50 gene signature. By employing a "Few-Shot Genes Selection" method, we randomly select smaller subsets from PAM50 and evaluate their performance using metrics and a linear model, specifically the Support Vector Machine (SVM) classifier. In addition, we aim to assess whether a more compact gene set can maintain performance while simplifying the classification process. Our findings demonstrate that certain reduced gene subsets can perform comparable or superior to the full PAM50 gene signature.
    Conclusions: The identified gene subsets, with 36 genes, have the potential to contribute to the development of more cost-effective and streamlined diagnostic tools in breast cancer research and clinical settings.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/diagnosis ; Biomarkers, Tumor/genetics ; Proteomics ; Gene Expression Profiling/methods ; Genetic Techniques
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-024-05715-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unbalanced sex-ratio in the Neolithic individuals from the Escoural Cave (Montemor-o-Novo, Portugal) revealed by peptide analysis.

    Granja, Raquel / Araújo, Ana Cristina / Lugli, Federico / Silvestrini, Sara / Silva, Ana Maria / Gonçalves, David

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19902

    Abstract: ... estimation. The obtained sex ratio (0.5:1, M:F) is biased to female individuals, probably due ... to cultural factors since the natural sex ratio of the human population falls between 0.95:1 and 1.02:1 (M:F). A high ...

    Abstract The sex profile estimation of pre-historic communities is often complicated by the commingled and scattered nature of skeletal assemblages. Demographic profiles are usually lacking and provide very truncated representations of these populations but proteomic analysis of sex-specific amelogenin peptides in tooth enamel brings new promise to these studies. The main objective was to obtain the sex profile of the human assemblage recovered from the Neolithic cave-necropolis of Escoural (Montemor-o-Novo, southern Portugal) through liquid chromatography-mass spectrometry. The secondary objective was to analyse sex-specific linear enamel hypoplasias (LEH), and to test the reliability of canine odontometric sex estimation. Sex estimation through peptide analysis was carried out in 36 left permanent canines which were macroscopically examined for the presence of LEH. The canine buccolingual diameter was used for odontometric sex estimation. The obtained sex ratio (0.5:1, M:F) is biased to female individuals, probably due to cultural factors since the natural sex ratio of the human population falls between 0.95:1 and 1.02:1 (M:F). A high frequency of LEH was observed, but with no significant sexual differences (p = 0.554). The mean LEH age of onset occurred at 3 years of age, with no significant differences between the sexes (p = 0.116), and was possibly related to the weaning process. Odontometric sex estimation revealed a correct classification of 80%, with a high number of males mistakenly attributed to females. This study is one of the largest samples subjected to peptide analysis, and thus demonstrates its usefulness on the research of commingled and scattered skeletal assemblages.
    MeSH term(s) Male ; Humans ; Female ; Child, Preschool ; Portugal ; Sex Ratio ; Proteomics ; Reproducibility of Results ; Peptides
    Chemical Substances Peptides
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47037-4
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  7. Article ; Online: Monkeypox Virus Immune Evasion and Eye Manifestation: Beyond Eyelid Implications.

    Lucena-Neto, Francisco D / Falcão, Luiz F M / Vieira-Junior, Adolfo S / Moraes, Evelly C S / David, Joacy P F / Silva, Camilla C / Sousa, Jorge R / Duarte, Maria I S / Vasconcelos, Pedro F C / Quaresma, Juarez A S

    Viruses

    2023  Volume 15, Issue 12

    Abstract: Monkeypox virus (MPXV), belonging to ... ...

    Abstract Monkeypox virus (MPXV), belonging to the
    MeSH term(s) Child ; Humans ; Female ; Pregnancy ; Child, Preschool ; Aged ; Monkeypox virus ; Immune Evasion ; Vaccination ; Corneal Diseases ; Eyelids
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15122301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines.

    Silva-Reis, Sara C / Costa, Vera M / Correia da Silva, Daniela / Pereira, David M / Correia, Xavier Cruz / Costa-Almeida, Hugo F / García-Mera, Xerardo / Rodríguez-Borges, José E / Sampaio-Dias, Ivo E

    European journal of medicinal chemistry

    2024  Volume 267, Page(s) 116174

    Abstract: Neurodegenerative disorders of the central nervous system (CNS) such as Alzheimer's and Parkinson's diseases, afflict millions globally, posing a significant public health challenge. Despite extensive research, a critical hurdle in effectively treating ... ...

    Abstract Neurodegenerative disorders of the central nervous system (CNS) such as Alzheimer's and Parkinson's diseases, afflict millions globally, posing a significant public health challenge. Despite extensive research, a critical hurdle in effectively treating neurodegenerative diseases is the lack of neuroprotective drugs that can halt or reverse the underlying disease processes. In this work, we took advantage of the neuroprotective properties of the neuropeptide glycyl-l-prolyl-l-glutamic acid (Glypromate) for the development of new peptidomimetics using l-pipecolic acid as a proline surrogate and exploring their chemical conjugation with relevant active pharmaceutical ingredients (API) via a peptide bond. Together with prolyl-based Glypromate conjugates, a total of 36 conjugates were toxicologically and biologically evaluated. In this series, the results obtained showed that a constrained ring (l-proline) at the central position of the peptide motif accounts for enhanced toxicological profiles and biological effects using undifferentiated and differentiated human neuroblastoma SH-SY5Y cells. Additionally, it was shown that biased biological responses are API-dependent. Conjugation with (R)-1-aminoindane led to a 38-43% reduction of protein aggregation induced by Aβ
    MeSH term(s) Humans ; Neuroprotection ; Cell Line, Tumor ; Neuroblastoma/drug therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxidopamine/toxicity ; Oligopeptides/pharmacology ; Oligopeptides/therapeutic use ; Neurodegenerative Diseases ; Neuropeptides/pharmacology ; Apoptosis
    Chemical Substances glycyl-prolyl-glutamic acid (ZYK4RVV5LS) ; Neuroprotective Agents ; Oxidopamine (8HW4YBZ748) ; Oligopeptides ; Neuropeptides
    Language English
    Publishing date 2024-01-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116174
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  9. Article ; Online: Septicemic salmonellosis in suckling piglets resulting from improper intramuscular administration of an oral vaccine.

    Menegatt, Jean C O / Almeida, Bruno A / Perosa, Fernanda F / Castro, Lucas T / Gris, Anderson H / Piva, Manoela M / Silva, Emanoelly M S / Pavarini, Saulo P / Driemeier, David

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2024  Volume 36, Issue 2, Page(s) 278–282

    Abstract: We describe an unusual outbreak of mortality in suckling piglets following the misadministration of an oral vaccine ... ...

    Abstract We describe an unusual outbreak of mortality in suckling piglets following the misadministration of an oral vaccine against
    MeSH term(s) Swine ; Animals ; Salmonella Infections, Animal/microbiology ; Swine Diseases/microbiology ; Salmonella typhimurium ; Vaccines, Attenuated ; Edema/veterinary ; Administration, Oral ; Salmonella
    Chemical Substances Vaccines, Attenuated
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387231221115
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  10. Article ; Online: Human mesenchymal stromal cells inhibit

    Shaw, Timothy D / Krasnodembskaya, Anna D / Schroeder, Gunnar N / Doherty, Declan F / Silva, Johnatas Dutra / Tandel, Shikha M / Su, Yue / Butler, David / Ingram, Rebecca J / O'Kane, Cecilia M

    Thorax

    2024  

    Abstract: Introduction: Novel therapeutic strategies are urgently needed for : Methods: Human monocyte-derived macrophages (MDMs) were infected with : Results: MSCs reduced intracellular bacteria in MDMs over 72 hours (median 35% reduction, p=0.027). MSC ... ...

    Abstract Introduction: Novel therapeutic strategies are urgently needed for
    Methods: Human monocyte-derived macrophages (MDMs) were infected with
    Results: MSCs reduced intracellular bacteria in MDMs over 72 hours (median 35% reduction, p=0.027). MSC treatment increased extracellular concentrations of prostaglandin E2 (PGE2) (median 10.1-fold rise, p=0.002) and reduced tumour necrosis factor-α (median 28% reduction, p=0.025). Blocking MSC PGE2 production by cyclo-oxygenase-2 (COX-2) inhibition with celecoxib abrogated the antimicrobial effect, while this was restored by adding exogenous PGE2. MSC-treated mice had lower pulmonary CFUs (median 18% reduction, p=0.012), but no significant change in spleen or liver CFUs compared with controls.
    Conclusion: MSCs can modulate inflammation and reduce intracellular
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220819
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