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Article: Improving the Continuity of Care for People Living with HIV Experiencing Incarceration in North Carolina Jails: Stakeholder Perspectives.

Juengst, Eric / Buchbinder, Mara / Blue, Colleen / Rennie, Stuart / Brinkley-Rubinstein, Lauren / Rosen, David L

2023 Volume 83, Issue 5, Page(s) 382–388

Abstract: ... ...

Abstract	BACKGROUND
MeSH term(s)	Humans ; Prisons ; Jails ; Prisoners ; North Carolina ; HIV Infections/therapy ; HIV Infections/epidemiology ; Continuity of Patient Care
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	422795-5
ISSN	0029-2559
ISSN	0029-2559
DOI	10.18043/ncm.83.5.382
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Article ; Online: The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction.

Kloner, Robert A / Stanek, Eric / Desai, Karishma / Crowe, Christopher L / Paige Ball, Kathryn / Haynes, Aaron / Rosen, Raymond C

Clinical cardiology

2024 Volume 47, Issue 2, Page(s) e24234

Abstract: Background: Tadalafil is a long-acting phosphodiesterase-5 inhibitor (PDE-5i) indicated for erectile dysfunction (ED).: Hypothesis: Our hypothesis was that tadalafil will reduce the risk of major adverse cardiovascular events (MACE: composite of ... ...

Abstract	Background: Tadalafil is a long-acting phosphodiesterase-5 inhibitor (PDE-5i) indicated for erectile dysfunction (ED). Hypothesis: Our hypothesis was that tadalafil will reduce the risk of major adverse cardiovascular events (MACE: composite of cardiovascular death, myocardial infarction, coronary revascularization, unstable angina, heart failure, stroke) and all-cause death in men with ED. Methods: A retrospective observational cohort study was conducted in a large US commercial insurance claims database in men with a diagnosis of ED without prior MACE within 1 year. The exposed group (n = 8156) had ≥1 claim for tadalafil; the unexposed group (n = 21 012) had no claims for any PDE-5i. Results: Primary outcome was MACE; secondary outcome was all-cause death. Groups were matched for cardiovascular risk factors, including preventive therapy. Over a mean follow-up of 37 months for the exposed group and 29 months for the unexposed group, adjusted rates of MACE were 19% lower in men exposed to tadalafil versus those unexposed to any PDE-5i (hazard ratio [HR] = 0.81; 95% confidence intervals [CI] = 0.70-0.94; p = .007). Tadalafil exposure was associated with lower adjusted rates of coronary revascularization (HR = 0.69; 95% CI = 0.52-0.90; p = .006); unstable angina (HR = 0.55; 95% CI = 0.37-0.81; p = .003); and cardiovascular-related mortality (HR = 0.45; CI = 0.22-0.93; p = .032). Overall mortality rate was 44% lower in men exposed to tadalafil (HR = 0.56; CI = 0.43-0.74; p < .001). Men in the highest quartile of tadalafil exposure had the lowest rates of MACE (HR: 0.40; 95% CI: 0.28-0.58; p < .001) compared to lowest exposure quartile. Conclusion: In men with ED, exposure to tadalafil was associated with significant and clinically meaningful lower rates of MACE and overall mortality.
MeSH term(s)	Male ; Humans ; Tadalafil/therapeutic use ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/epidemiology ; Retrospective Studies ; Carbolines/adverse effects ; Phosphodiesterase 5 Inhibitors/adverse effects ; Myocardial Infarction/chemically induced ; Angina, Unstable
Chemical Substances	Tadalafil (742SXX0ICT) ; Carbolines ; Phosphodiesterase 5 Inhibitors
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24234
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Article ; Online: The Postoperative Breast: Imaging Findings and Diagnostic Pitfalls After Breast-Conserving Surgery and Oncoplastic Breast Surgery.

Pittman, Sarah M / Rosen, Eric L / DeMartini, Wendy B / Nguyen, Dung H / Poplack, Steven P / Ikeda, Debra M

Journal of breast imaging

2024 Volume 6, Issue 2, Page(s) 203–216

Abstract: Breast surgery is the cornerstone of treatment for early breast cancer. Historically, mastectomy and conventional breast-conserving surgery (BCS) were the main surgical techniques for treatment. Now, oncoplastic breast surgery (OBS), introduced in the ... ...

Abstract	Breast surgery is the cornerstone of treatment for early breast cancer. Historically, mastectomy and conventional breast-conserving surgery (BCS) were the main surgical techniques for treatment. Now, oncoplastic breast surgery (OBS), introduced in the 1990s, allows for a combination of BCS and reconstructive surgery to excise the cancer while preserving or enhancing the contour of the breast, leading to improved aesthetic results. Although imaging after conventional lumpectomy demonstrates typical postsurgical changes with known evolution patterns over time, OBS procedures show postsurgical changes/fat necrosis in locations other than the lumpectomy site. The purpose of this article is to familiarize radiologists with various types of surgical techniques for removal of breast cancer and to distinguish benign postoperative imaging findings from suspicious findings that warrant further work-up.
MeSH term(s)	Humans ; Female ; Mastectomy ; Mastectomy, Segmental/adverse effects ; Breast Neoplasms/diagnostic imaging ; Breast/diagnostic imaging ; Mammaplasty/adverse effects
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbad105
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Article ; Online: Advancing a Data Justice Framework for Public Health Surveillance.

Buchbinder, Mara / Juengst, Eric / Rennie, Stuart / Blue, Colleen / Rosen, David L

AJOB empirical bioethics

2022 Volume 13, Issue 3, Page(s) 205–213

Abstract: Background: Bioethical debates about privacy, big data, and public health surveillance have not sufficiently engaged the perspectives of those being surveilled. The data justice framework suggests that big data applications have the potential to create ... ...

Abstract	Background: Bioethical debates about privacy, big data, and public health surveillance have not sufficiently engaged the perspectives of those being surveilled. The data justice framework suggests that big data applications have the potential to create disproportionate harm for socially marginalized groups. Using examples from our research on HIV surveillance for individuals incarcerated in jails, we analyze ethical issues in deploying big data in public health surveillance. Methods: We conducted qualitative, semi-structured interviews with 24 people living with HIV who had been previously incarcerated in county jails about their perspectives on and experiences with HIV surveillance, as part of a larger study to characterize ethical considerations in leveraging big data techniques to enhance continuity of care for incarcerated people living with HIV. Results: Most participants expressed support for the state health department tracking HIV testing results and viral load data. Several viewed HIV surveillance as a violation of privacy, and several had actively avoided contact from state public health outreach workers. Participants were most likely to express reservations about surveillance when they viewed the state's motives as self-interested. Perspectives highlight the mistrust that structurally vulnerable people may have in the state's capacity to act as an agent of welfare. Findings suggest that adopting a nuanced, context-sensitive view on surveillance is essential. Conclusions: Establishing trustworthiness through interpersonal interactions with public health personnel is important to reversing historical legacies of harm to racial minorities and structurally vulnerable groups. Empowering stakeholders to participate in the design and implementation of data infrastructure and governance is critical for advancing a data justice agenda, and can offset privacy concerns. The next steps in advancing the data justice framework in public health surveillance will be to innovate ways to represent the voices of structurally vulnerable groups in the design and governance of big data initiatives.
MeSH term(s)	HIV Infections/epidemiology ; Humans ; Public Health ; Public Health Surveillance ; Social Justice
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2763190-4
ISSN	2329-4523 ; 2329-4515
ISSN (online)	2329-4523
ISSN	2329-4515
DOI	10.1080/23294515.2022.2063997
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Article ; Online: Lessons Learned from an Academic Partnership to Review Pennsylvania Network for Student Assistance Services' Annual Survey.

Sekhar, Deepa L / Schaefer, Eric W / Hoke, Alicia M / Rosen, Perri / Chuzie, Roberta A / Milakovic, Dana M

The Journal of school health

2023 Volume 94, Issue 3, Page(s) 228–234

Abstract: Introduction: Pennsylvania's Student Assistance Program (SAP) began in the mid-1980s to address student barriers to academic success. SAP teams, groups of trained school and community professionals, review referrals, and connect students to services. ... ...

Abstract	Introduction: Pennsylvania's Student Assistance Program (SAP) began in the mid-1980s to address student barriers to academic success. SAP teams, groups of trained school and community professionals, review referrals, and connect students to services. State leadership conducts an annual SAP team survey, but capacity to evaluate data and affect change is limited. In 2020, leadership partnered with [institution name] to collaboratively review the survey data. Methods: Frequencies and percentages were calculated. Open responses were coded. Logistic regression models evaluated the association between SAP team size, team meeting frequency, and team maintenance. Results: The 2019 to 2020 survey had 1003 respondents. Median number of SAP team members was 8 (range 1-21). The majority (54%) indicated their SAP team met once per week/cycle for 30 to 90+ minutes. Larger teams met more often. Annual team maintenance occurred for 38% of teams, and was more common for larger teams. SAP team members identified mental health (68%), trauma (44%), and parent engagement (36%) as top training needs. Conclusions: An academic partnership successfully provided the capacity to review SAP survey responses, and informed evidenced-based discussion of best practice guidelines and realignment of staff professional development opportunities.
MeSH term(s)	Humans ; Pennsylvania ; Students ; School Health Services ; Surveys and Questionnaires ; Academic Success
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	952835-0
ISSN	1746-1561 ; 0022-4391
ISSN (online)	1746-1561
ISSN	0022-4391
DOI	10.1111/josh.13389
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Article ; Online: Public Health Research, Practice, and Ethics for Justice-Involved Persons in the Big Data Era.

Rosen, David L / Buchbinder, Mara / Juengst, Eric / Rennie, Stuart

American journal of public health

2020 Volume 110, Issue S1, Page(s) S37–S38

MeSH term(s)	Big Data ; Biomedical Research/ethics ; Criminal Law/ethics ; Humans ; Internet ; Population Surveillance ; Public Health/ethics
Language	English
Publishing date	2020-01-22
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2019.305456
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Article ; Online: Effect of phosphodiesterase type 5 inhibitors on major adverse cardiovascular events and overall mortality in a large nationwide cohort of men with erectile dysfunction and cardiovascular risk factors: A retrospective, observational study based on healthcare claims and national death index data.

Kloner, Robert A / Stanek, Eric / Crowe, Christopher L / Singhal, Mukul / Pepe, Rebecca S / Bradsher, Julia / Rosen, Raymond C

The journal of sexual medicine

2023 Volume 20, Issue 1, Page(s) 38–48

Abstract: Background: Treatment with phosphodiesterase type 5 inhibitors (PDE-5is) is effective in treating erectile dysfunction (ED).: Aim: The objective of this study was to determine the effect of PDE-5is on the incidence of major adverse cardiovascular (CV) ...

Abstract	Background: Treatment with phosphodiesterase type 5 inhibitors (PDE-5is) is effective in treating erectile dysfunction (ED). Aim: The objective of this study was to determine the effect of PDE-5is on the incidence of major adverse cardiovascular (CV) events (MACE; composite outcome of CV death, hospitalization for myocardial infarction, coronary revascularization, stroke, heart failure, and unstable angina pectoris) and overall mortality. Methods: A retrospective observational cohort study was conducted in a large US claims database in men with ≥1 diagnosis of ED without prior MACE within 1 year, from January 1, 2006, to October 31, 2020. The exposed group had ≥1 claim for PDE-5i and the unexposed group had no claims for PDE-5i, and the groups were matched up to 1:4 on baseline risk variables. Outcome: The primary outcome was MACE and the secondary outcomes were overall mortality and individual components of MACE, determined by multivariable Cox proportional hazard modeling. Results: Matched plus multivariable analyses showed that MACE was lower by 13% in men exposed (n = 23 816) to PDE-5is (hazard ratio [HR] 0.87; 95% CI 0.79-0.95; P = .001) vs nonexposure (n = 48 682) over mean follow-up periods of 37 and 29 months, respectively, with lower incidence of coronary revascularization (HR 0.85; 95% CI 0.73-0.98; P = .029), heart failure (HR 0.83; 95% CI 0.72-0.97; P = .016), unstable angina (HR 0.78; 95% CI 0.64-0.96; P = .021), and CV death (HR 0.61; 95% CI 0.41-0.90; P = .014) with PDE-5i exposure. Phosphodiesterase type 5 inhibitor-exposed men had a 25% lower incidence of overall mortality (HR 0.75; 95% CI 0.65-0.87; P < .001). Men without coronary artery disease (CAD) but with CV risk factors at baseline showed a similar pattern. In the main study cohort, men in the highest quartile of PDE-5i exposure had the lowest incidence of MACE (HR 0.45; 95% CI 0.37-0.54; P < .001) and overall mortality (HR 0.51; 95% CI 0.37-0.71; P < .001) vs the lowest exposure quartile. In a subgroup with baseline type 2 diabetes (n = 6503), PDE-5i exposure was associated with a lower MACE risk (HR 0.79; 95% CI 0.64-0.97; P = .022). Clinical implications: PDE-5is may have cardioprotective effects. Strengths and limitations: Strengths are the large numbers of participants and consistency of the data; limitations include the retrospective nature of the study and unknown confounders. Conclusions: In a large population of US men with ED, PDE-5i exposure was associated with lower incidence of MACE, CV death, and overall mortality risk compared to non-exposure. Risk reduction correlated with PDE-5i exposure level.
MeSH term(s)	Male ; Humans ; Erectile Dysfunction ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Retrospective Studies ; Risk Factors ; Coronary Artery Disease ; Heart Failure/complications ; Delivery of Health Care
Chemical Substances	Phosphodiesterase 5 Inhibitors
Language	English
Publishing date	2023-03-10
Publishing country	Netherlands
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1093/jsxmed/qdac005
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Article: Corrigendum: Scraping the Web for Public Health Gains: Ethical Considerations from a 'Big Data' Research Project on HIV and Incarceration.

Rennie, Stuart / Buchbinder, Mara / Juengst, Eric / Brinkley-Rubinstein, Lauren / Rosen, Colleen Blue And David L

Public health ethics

2020 Volume 13, Issue 3, Page(s) 314

Abstract: This corrects the article DOI: 10.1093/phe/phaa006.][This corrects the article DOI: 10.1093/phe/phaa006.]. ...

Abstract	[This corrects the article DOI: 10.1093/phe/phaa006.][This corrects the article DOI: 10.1093/phe/phaa006.].
Language	English
Publishing date	2020-05-04
Publishing country	England
Document type	Published Erratum
ZDB-ID	2438463-X
ISSN	1754-9981 ; 1754-9973
ISSN (online)	1754-9981
ISSN	1754-9973
DOI	10.1093/phe/phaa018
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Article ; Online: Trends in nitrogen, phosphorus, and sediment concentrations and loads in streams draining to Lake Tahoe, California, Nevada, USA.

Domagalski, Joseph L / Morway, Eric / Alvarez, Nancy L / Hutchins, Juliet / Rosen, Michael R / Coats, Robert

The Science of the total environment

2020 Volume 752, Page(s) 141815

Abstract: Lake Tahoe, a large freshwater lake of the eastern Sierra Nevada in California and Nevada, has 63 tributaries that are sources of nutrients and sediment to the lake. The Tahoe watershed is relatively small, and the surface area of the lake occupies about ...

Abstract	Lake Tahoe, a large freshwater lake of the eastern Sierra Nevada in California and Nevada, has 63 tributaries that are sources of nutrients and sediment to the lake. The Tahoe watershed is relatively small, and the surface area of the lake occupies about 38% of the watershed area (1313 km
Language	English
Publishing date	2020-08-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.141815
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Article ; Online: Using Item-Response Theory to Improve Interpretation of the Trans Woman Voice Questionnaire.

Zhao, Nina W / Mason, James M / Blum, Alexander M / Kim, Eric K / Young, VyVy N / Rosen, Clark A / Schneider, Sarah L

The Laryngoscope

2022 Volume 133, Issue 5, Page(s) 1197–1204

Abstract: Objective: The Trans Woman Voice Questionnaire (TWVQ) is commonly used to quantify self-perceptions of voice for trans women seeking gender-affirming voice care, but the interpretation of TWVQ scores remains challenging. The objective of this study was ... ...

Abstract	Objective: The Trans Woman Voice Questionnaire (TWVQ) is commonly used to quantify self-perceptions of voice for trans women seeking gender-affirming voice care, but the interpretation of TWVQ scores remains challenging. The objective of this study was to use item-response theory (IRT) to evaluate the relationship between TWVQ items and persons on a common scale and identify improvements to increase the meaningfulness of TWVQ scores. Methods: A retrospective review of TWVQ scores from trans women patients between 2018-2020 was performed. Rasch-family models were used to generate item-person maps positioning respondent location and item difficulty estimates on a logit scale, which was then converted into a scaled score using linear transformations. Results: TWVQ responses from 86 patients were analyzed. Initial item-person maps demonstrated that the middle response categories ("sometimes" and "often") performed inconsistently across items (poor threshold banding); interpretability improved when these ratings were scored as one category. The models were rerun using revised scoring, which retained high reliability (0.93) and supported a unidimensional construct. Updated item-person maps revealed four scaled score zones (≤54, >54 to ≤101, >101 to ≤140, and >140) that each corresponded to an increasing pattern of item thresholds (probability of selecting one response category vs. others). These ranges can be interpreted as minimal, low, moderate, and high, respectively. Conclusions: Empiric data from Rasch analysis supports new interval scoring for the TWVQ that advances the clinical and research utility of the instrument and lays the foundation for future improvements in clinical care and outcomes assessment. Level of evidence: NA Laryngoscope, 133:1197-1204, 2023.
MeSH term(s)	Humans ; Female ; Reproducibility of Results ; Psychometrics/methods ; Surveys and Questionnaires ; Outcome Assessment, Health Care ; Self Concept
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30360
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