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  1. Article: Activity of pazopanib in

    Gouda, Mohamed A / Zarzour, Maria A / Vaporciyan, Ara A / Kairemo, Kalevi / Chuang, Hubert H / Subbiah, Vivek

    Oncoscience

    2023  Volume 10, Page(s) 44–53

    Abstract: Pazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with ... ...

    Abstract Pazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Case Reports
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.587
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  2. Article ; Online: FDG PET/CT in Diagnosing COVID-19 Infection in a Cancer Patient With Exposure History But Minimal Symptoms.

    Chuang, Hubert H / Emery, Dustin J / Campbell, Richelle Millican / Lu, Yang

    Clinical nuclear medicine

    2020  Volume 45, Issue 8, Page(s) 656–658

    Abstract: A 56-year-old woman with high-grade neuroendocrine small cell carcinoma had known contact history of COVID-19 about 16 days prior to the restaging PET/CT. The patient was instructed to self-quarantine for 14 days, and no COVID-19 test was performed. Upon ...

    Abstract A 56-year-old woman with high-grade neuroendocrine small cell carcinoma had known contact history of COVID-19 about 16 days prior to the restaging PET/CT. The patient was instructed to self-quarantine for 14 days, and no COVID-19 test was performed. Upon arrival, the patient had low-grade fever of 37.1°C, but did not meet infection control criteria for COVID-19 testing, and it was approved to proceed with PET/CT. The FDG PET/CT images revealed new multifocal hypermetabolic bilateral pulmonary ground-glass opacities that are suggestive of COVID-19 pneumonia. Meanwhile, the patient's symptoms worsened, and a blood test later confirmed COVID-19 infection.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Carcinoma, Neuroendocrine/complications ; Carcinoma, Small Cell/complications ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Female ; Fever/etiology ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003137
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    Zs.A 1276: Show issues Location:
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  3. Article ; Online: False-Positive Positron Emission Tomography After Combined-Modality Induction Therapy in a Patient With Newly Diagnosed Early-Stage Bulky Classic Hodgkin Lymphoma.

    Cramer, Frederick M / Chuang, Hubert H / Miranda, Roberto N / Lee, Hun Ju

    Journal of oncology practice

    2019  Volume 15, Issue 9, Page(s) 499–501

    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy/methods ; Hodgkin Disease/diagnosis ; Hodgkin Disease/therapy ; Humans ; Male ; Multimodal Imaging/methods ; Neoplasm Staging ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/standards ; Remission Induction ; Treatment Outcome
    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2236338-5
    ISSN 1935-469X ; 1554-7477
    ISSN (online) 1935-469X
    ISSN 1554-7477
    DOI 10.1200/JOP.19.00258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: PET/CT of Osteosarcoma and Ewing Sarcoma.

    Costelloe, Colleen M / Chuang, Hubert H / Daw, Najat C

    Seminars in roentgenology

    2017  Volume 52, Issue 4, Page(s) 255–268

    MeSH term(s) Bone Neoplasms/diagnostic imaging ; Bone and Bones/diagnostic imaging ; Humans ; Osteosarcoma/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods ; Sarcoma, Ewing/diagnostic imaging
    Language English
    Publishing date 2017-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80310-8
    ISSN 1558-4658 ; 0037-198X
    ISSN (online) 1558-4658
    ISSN 0037-198X
    DOI 10.1053/j.ro.2017.04.007
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  5. Article ; Online: FDG PET/CT in Diagnosing COVID-19 Infection in a Cancer Patient With Exposure History But Minimal Symptoms

    Chuang, Hubert H. / Emery, Dustin J. / Campbell, Richelle Millican / Lu, Yang

    Clinical Nuclear Medicine

    2020  Volume 45, Issue 8, Page(s) 656–658

    Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/rlu.0000000000003137
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Zs.A 1276: Show issues Location:
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  6. Article ; Online: Programmed Cell Death-One Inhibition Therapy in Classical Hodgkin Lymphoma.

    Al-Hadidi, Samer A / Chuang, Hubert H / Miranda, Roberto N / Lee, Hun Ju

    Clinical lymphoma, myeloma & leukemia

    2020  Volume 21, Issue 2, Page(s) e105–e111

    Abstract: The majority of patients with classical Hodgkin lymphoma (cHL) may be cured, but for patients with relapsed or refractory (R/R) cHL, the prognosis is unfavorable. Immune dysfunction is a significant contributor of relapse and a hallmark of cHL; in ... ...

    Abstract The majority of patients with classical Hodgkin lymphoma (cHL) may be cured, but for patients with relapsed or refractory (R/R) cHL, the prognosis is unfavorable. Immune dysfunction is a significant contributor of relapse and a hallmark of cHL; in particular, the immune system is unable to eradicate lymphoma cells that overexpress immune checkpoint proteins. The blocking of this mechanism used by lymphoma cells to evade the immune system has resulted in clinical benefits. Use of checkpoint inhibitors (CPIs) in R/R cHL is associated with high response rates and an acceptable adverse effects profile. There is growing interest in combining chemotherapy with CPIs in frontline therapy of cHL treatment to improve relapse rates without significant additive toxicity. In this review, we discuss the current evidence supporting CPI use in R/R cHL and maintenance therapy. We present emerging CPI data in frontline adult cHL and assess its role in the elderly. In addition, we discuss critical immune-related toxicities and their management, and elaborate on the challenges of monitoring response and minimal residual disease as tools for maximizing efficacy by limiting toxicity.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Resistance, Neoplasm ; Hodgkin Disease/drug therapy ; Hodgkin Disease/immunology ; Hodgkin Disease/mortality ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Maintenance Chemotherapy/methods ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/mortality ; Neoplasm, Residual ; Prognosis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Progression-Free Survival ; Randomized Controlled Trials as Topic
    Chemical Substances Immune Checkpoint Inhibitors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2020.08.031
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    Zs.A 5903: Show issues Location:
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  7. Article ; Online: Chimeric antigen receptor T-cell therapy's role in antiphospholipid syndrome: a case report.

    Schmelz, Jacob L / Navsaria, Lucy / Goswamy, Rohit / Chuang, Hubert H / Miranda, Roberto N / Lee, Hun Ju

    British journal of haematology

    2019  Volume 188, Issue 3, Page(s) e5–e8

    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnostic imaging ; Antiphospholipid Syndrome/therapy ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Facial Neoplasms/diagnostic imaging ; Facial Neoplasms/therapy ; Female ; Humans ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/therapy ; Prednisone/administration & dosage ; Rituximab/administration & dosage ; Vincristine/administration & dosage
    Chemical Substances Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-11-13
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16266
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  8. Article: FDG PET/CT in Diagnosing COVID-19 Infection in a Cancer Patient With Exposure History But Minimal Symptoms

    Chuang, Hubert H / Emery, Dustin J / Campbell, Richelle Millican / Lu, Yang

    Clin Nucl Med

    Abstract: A 56-year-old woman with high-grade neuroendocrine small cell carcinoma had known contact history of COVID-19 about 16 days prior to the restaging PET/CT. The patient was instructed to self-quarantine for 14 days, and no COVID-19 test was performed. Upon ...

    Abstract A 56-year-old woman with high-grade neuroendocrine small cell carcinoma had known contact history of COVID-19 about 16 days prior to the restaging PET/CT. The patient was instructed to self-quarantine for 14 days, and no COVID-19 test was performed. Upon arrival, the patient had low-grade fever of 37.1°C, but did not meet infection control criteria for COVID-19 testing, and it was approved to proceed with PET/CT. The FDG PET/CT images revealed new multifocal hypermetabolic bilateral pulmonary ground-glass opacities that are suggestive of COVID-19 pneumonia. Meanwhile, the patient's symptoms worsened, and a blood test later confirmed COVID-19 infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #325587
    Database COVID19

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  9. Article ; Online: Correlation of fluorine 18-labeled sodium fluoride uptake and arterial calcification on whole-body PET/CT in cancer patients.

    Dai, Dong / Chuang, Hubert H / Macapinlac, Homer A / Li, Tengfei / Pan, Tinsu

    Nuclear medicine communications

    2019  Volume 40, Issue 6, Page(s) 604–610

    Abstract: Background: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with ... ...

    Abstract Background: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT). The aim of this study was to determine the extent to which F-NaF uptake is correlated with calcification at arterial plaques in cancer patients undergoing whole-body PET/CT imaging.
    Patients and methods: Image data from 179 patients who underwent F-NaF PET/CT were evaluated retrospectively. Plaques were categorized into four groups by calcium score (CS) on CT: CS1 (≥1000); CS2 (400-999); CS3 (100-399), and CS4 (<100) and into three groups by F-NaF target-to-background ratio (TBR) on PET: TBRlow (≤1.0), TBRmedium (1.0-1.5), and TBRhigh (>1.5). Correlations between F-NaF uptake and CS were evaluated.
    Results: Plaques with F-NaF uptake or arterial calcification were observed in 122 (76%) of the 179 patients. We found a weak but statistically significant positive correlation between CS and F-NaF uptake. The TBR in CS1 plaques was higher than those in CS3 and CS4 plaques, and the TBR in CS2 plaques was higher than that in CS3 plaques (P<0.05). Compared with patients whose plaques were with F-NaF uptake (TBR>1.5) or arterial calcification (CS>0), patients without plaques of F-NaF uptake or calcification were significantly younger (P=0.00) or with significantly more women (P=0.02).
    Conclusion: Our finding of a weak but significant positive correlation between F-NaF uptake and arterial calcification suggests that F-NaF PET/CT could provide complementary information of active microcalcification for atherosclerosis evaluation in cancer patients.
    MeSH term(s) Aged ; Arteries/diagnostic imaging ; Arteries/metabolism ; Biological Transport ; Calcinosis/complications ; Calcinosis/diagnostic imaging ; Calcinosis/metabolism ; Calcium/metabolism ; Female ; Fluorine Radioisotopes ; Humans ; Male ; Neoplasms/complications ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Sodium Fluoride/metabolism ; Whole Body Imaging
    Chemical Substances Fluorine Radioisotopes ; Sodium Fluoride (8ZYQ1474W7) ; Fluorine-18 (GZ5I74KB8G) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000000986
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    Zs.A 1577: Show issues Location:
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  10. Article ; Online: HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: New and future perspectives for parathyroid carcinoma.

    Perrier, Nancy D / Arnold, Andrew / Costa-Guda, Jessica / Busaidy, Naifa L / Nguyen, Ha / Chuang, Hubert H / Brandi, Maria Luisa

    Endocrine-related cancer

    2020  Volume 27, Issue 8, Page(s) T53–T63

    Abstract: This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27-29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was ... ...

    Abstract This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27-29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was constituted by the Steering Committee to address key questions in the field. The objectives were to recap open forum discussion of interested parties from multiple disciplines. The expert panel met in a closed session to consult on the data to be highlighted on the evidence-based results and on the future directions. Preceding the Conference, members of the expert panel conducted an extensive literature search. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. Questions were developed by the expert panel on parathyroid carcinoma. A comprehensive literature search for relevant studies was undertaken. This report represents the expert panel's synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of parathyroid carcinoma. This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of parathyroid carcinoma.
    MeSH term(s) Humans ; Multiple Endocrine Neoplasia/complications ; Parathyroid Neoplasms/etiology ; Parathyroid Neoplasms/pathology
    Language English
    Publishing date 2020-05-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-20-0018
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    Zs.A 4192: Show issues Location:
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