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  1. Article: Vacunación con B.C.G. en el Ecuador.

    HIGGINS JARAMILLO, J

    Revista ecuatoriana de higiene y medicina tropical

    1956  Volume 13, Issue 1, Page(s) 27–44

    Title translation Vaccination with B.C.G. in Ecuador.
    MeSH term(s) BCG Vaccine/statistics & numerical data ; Ecuador ; Humans ; Mycobacterium bovis ; Vaccination
    Chemical Substances BCG Vaccine
    Language Spanish
    Publishing date 1956-01
    Publishing country Ecuador
    Document type Journal Article
    ZDB-ID 732057-7
    ISSN 0013-0745 ; 0048-7775
    ISSN 0013-0745 ; 0048-7775
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 681: Show issues Location:
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  2. Article ; Online: Peripheral nerve regeneration: The resolution revolution.

    Higgins, G C / Thomson, S E

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 74, Issue 1, Page(s) 223–243

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Nerve Regeneration/genetics ; Peripheral Nerve Injuries/genetics ; Sequence Analysis, DNA
    Language English
    Publishing date 2020-09-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.08.118
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Vacunación con B.C.G. en la República del Ecuador.

    PEREZ, J A / HIGGINS, J A / CASTANEDA, V A

    Hoja tisiologica

    1950  Volume 10, Issue 2, Page(s) 159–168

    Title translation BCG vaccination in the Republic of Ecuador.
    MeSH term(s) Ecuador ; Humans ; Mycobacterium bovis ; Tuberculosis ; Vaccination
    Language Undetermined
    Publishing date 1950-06
    Publishing country Uruguay
    Document type Journal Article
    ISSN 0018-3326
    ISSN 0018-3326
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  4. Article ; Online: Risk Assessment of Industrial Microbes Using a Terrestrial Mesocosm Platform.

    Arnolds, Kathleen L / Higgins, Riley C / Crandall, Jennifer / Li, Gabriella / Linger, Jeffrey G / Guarnieri, Michael T

    Microbial ecology

    2023  Volume 87, Issue 1, Page(s) 12

    Abstract: Industrial microbes and bio-derived products have emerged as an integral component of the bioeconomy, with an array of agricultural, bioenergy, and biomedical applications. However, the rapid development of microbial biotechnology raises concerns related ...

    Abstract Industrial microbes and bio-derived products have emerged as an integral component of the bioeconomy, with an array of agricultural, bioenergy, and biomedical applications. However, the rapid development of microbial biotechnology raises concerns related to environmental escape of laboratory microbes, detection and tracking thereof, and resultant impact upon native ecosystems. Indeed, though wild-type and genetically modified microbes are actively deployed in industrial bioprocesses, an understanding of microbial interactivity and impact upon the environment is severely lacking. In particular, the persistence and sustained ecosystem impact of industrial microbes following laboratory release or unintentional laboratory escape remains largely unexplored. Herein, we investigate the applicability of soil-sorghum mesocosms for the ecological risk assessment of the industrial microbe, Saccharomyces cerevisiae. We developed and applied a suite of diagnostic and bioinformatic analyses, including digital droplet PCR, microscopy, and phylogenomic analyses to assess the impacts of a terrestrial ecosystem perturbation event over a 30-day time course. The platform enables reproducible, high-sensitivity tracking of S. cerevisiae in a complex soil microbiome and analysis of the impact upon abiotic soil characteristics and soil microbiome population dynamics and diversity. The resultant data indicate that even though S. cerevisiae is relatively short-lived in the soil, a single perturbation event can have sustained impact upon mesocosm soil composition and underlying microbial populations in our system, underscoring the necessity for more comprehensive risk assessment and development of mitigation and biocontainment strategies in industrial bioprocesses.
    MeSH term(s) Ecosystem ; Saccharomyces cerevisiae/genetics ; Soil Microbiology ; Microbiota ; Soil ; Risk Assessment
    Chemical Substances Soil
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1462065-0
    ISSN 1432-184X ; 0095-3628
    ISSN (online) 1432-184X
    ISSN 0095-3628
    DOI 10.1007/s00248-023-02321-8
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  5. Article ; Online: Mapping QTL for vernalization requirement identified adaptive divergence of the candidate gene Flowering Locus C in polyploid Camelina sativa.

    Chaudhary, Raju / Higgins, Erin E / Eynck, Christina / Sharpe, Andrew G / Parkin, Isobel A P

    The plant genome

    2023  Volume 16, Issue 4, Page(s) e20397

    Abstract: ... three QTLs associated with vernalization requirement in C. sativa; two from the interspecific ... mapped to different homologous regions of the hexaploid C. sativa genome. All three QTLs were found ... in proximity to Flowering Locus C (FLC), variants of which have been reported to affect the vernalization ...

    Abstract Vernalization requirement is an integral component of flowering in winter-type plants. The availability of winter ecotypes among Camelina species facilitated the mapping of quantitative trait loci (QTL) for vernalization requirement in Camelina sativa. An inter and intraspecific crossing scheme between related Camelina species, where one spring and two different sources of winter-type habit were used, resulted in the development of two segregating populations. Linkage maps generated with sequence-based markers identified three QTLs associated with vernalization requirement in C. sativa; two from the interspecific (chromosomes 13 and 20) and one from the intraspecific cross (chromosome 8). Notably, the three loci were mapped to different homologous regions of the hexaploid C. sativa genome. All three QTLs were found in proximity to Flowering Locus C (FLC), variants of which have been reported to affect the vernalization requirement in plants. Temporal transcriptome analysis for winter-type Camelina alyssum demonstrated reduction in expression of FLC on chromosomes 13 and 20 during cold treatment, which would trigger flowering, since FLC would be expected to suppress floral initiation. FLC on chromosome 8 also showed reduced expression in the C. sativa ssp. pilosa winter parent upon cold treatment, but was expressed at very high levels across all time points in the spring-type C. sativa. The chromosome 8 copy carried a deletion in the spring-type line, which could impact its functionality. Contrary to previous reports, all three FLC loci can contribute to controlling the vernalization response in C. sativa and provide opportunities for manipulating this requirement in the crop.
    MeSH term(s) Quantitative Trait Loci ; Vernalization ; Flowers ; Chromosome Mapping ; Arabidopsis/genetics
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375444-8
    ISSN 1940-3372 ; 0011-183X
    ISSN (online) 1940-3372
    ISSN 0011-183X
    DOI 10.1002/tpg2.20397
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    In stock of ZB MED Bonn / Germany

    Z 7758: Show issues

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  6. Article ; Online: Male pattern hair loss: Can developmental origins explain the pattern?

    Redmond, Leah C / Limbu, Summik / Farjo, Bessam / Messenger, Andrew G / Higgins, Claire A

    Experimental dermatology

    2023  Volume 32, Issue 7, Page(s) 1174–1181

    Abstract: Male pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non-scarring progressive hair loss, with 80% of men suffering from this condition in their lifetime. In MPHL, the hair line recedes to a ... ...

    Abstract Male pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non-scarring progressive hair loss, with 80% of men suffering from this condition in their lifetime. In MPHL, the hair line recedes to a specific part of the scalp which cannot be accurately predicted. Hair is lost from the front, vertex, and the crown, yet temporal and occipital follicles remain. The visual effect of hair loss is due to hair follicle miniaturisation, where terminal hair follicles become dimensionally smaller. Miniaturisation is also characterised by a shortening of the growth phase of the hair cycle (anagen), and a prolongation of the dormant phase (kenogen). Together, these changes result in the production of thinner and shorter hair fibres, referred to as miniaturised or vellus hairs. It remains unclear why miniaturisation occurs in this specific pattern, with frontal follicles being susceptible while occipital follicles remain in a terminal state. One main factor we believe to be at play, which will be discussed in this viewpoint, is the developmental origin of the skin and hair follicle dermis on different regions of the scalp.
    MeSH term(s) Male ; Humans ; Alopecia/etiology ; Hair ; Hair Follicle ; Scalp ; Skin
    Language English
    Publishing date 2023-05-26
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14839
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
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  7. Article ; Online: Exploring the relationship between contraceptive medication use and concussion recovery in female collegiate athletes: a LIMBIC MATARS consortium investigation.

    Bouchard, Heather C / Kelshaw, Patricia M / Bowman, Thomas G / Beidler, Erica / Resch, Jacob E / Cifu, David X / Higgins, Kate L

    Brain injury

    2024  , Page(s) 1–7

    Abstract: Objective: While recovery from concussion is variable, women are more likely to report symptoms, experience worse outcomes, and have longer recovery trajectories following concussion than men. Preliminary data suggest that hormonal fluctuations, ... ...

    Abstract Objective: While recovery from concussion is variable, women are more likely to report symptoms, experience worse outcomes, and have longer recovery trajectories following concussion than men. Preliminary data suggest that hormonal fluctuations, specifically progesterone, may be associated with this variability. This study aimed to understand the effect of contraceptive medication on concussion recovery.
    Methods: A retrospective chart review using consensus-based common data elements was conducted at 11 NCAA institutions as part of the LIMBIC MATARS consortium. Participants included female collegiate athletes diagnosed with a concussion who did (
    Results: The proportions of participants who did or did not take contraceptive medication were similar across covariates. Female athletes regardless of contraceptive medication use recovered similarly following a concussion.
    Conclusions: Our findings suggest that contraceptive medication use did not significantly impact concussion recovery. Future prospective investigations should examine documentation practices and operationalize terminology for hormonal contraceptive medication to better understand their role on recovery from sport-related concussion in female collegiate athletes.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2024.2310780
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2242: Show issues Location:
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  8. Article: [Besprechung von:] Dualistic economic development. Theory and history. By Allen C. Kelley; Jeffrey G. Williamson and Russel J. Cheetham. Chicago, London 1972

    Higgins, Benjamin / Cheetham, Russel J / Kelley, Allen C / Williamson, Jeffrey G

    Journal of economic literature Vol. 11, No. 4 , p. 1378-1380

    1973  Volume 11, Issue 4, Page(s) 1378–1380

    Author's details Benjamin Higgins
    Publisher Assoc.
    Publishing place Nashville, Tenn.
    Document type Article
    ZDB-ID 3076-4
    Database ECONomics Information System

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  9. Article ; Online: Freestyle superficial femoral artery perforator (SFAp) free flap combined with a free periosteal medial condyle flap in Gustillo IIb fracture: Overkill or ideal treatment?

    di Summa, P G / Sapino, G / Higgins, G C / Guillier, D

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 73, Issue 7, Page(s) 1253–1254

    MeSH term(s) Adult ; Femoral Artery ; Fractures, Open/classification ; Fractures, Open/surgery ; Free Tissue Flaps ; Humans ; Leg Bones/injuries ; Perforator Flap/blood supply ; Periosteum/transplantation ; Soft Tissue Injuries/surgery
    Language English
    Publishing date 2020-03-17
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.02.047
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  10. Article ; Online: Diffusion of hydrophilic to hydrophobic forms of Nile red in aqueous C

    Shafiee, Omid / Jenkins, Samantha G / Ito, Takashi / Higgins, Daniel A

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 4, Page(s) 2853–2861

    Abstract: ... decaethylene glycol monododecyl ether (C ...

    Abstract Solute diffusion within lyotropic liquid crystal gels prepared from a series of water and decaethylene glycol monododecyl ether (C
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp05578c
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