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  1. Article ; Conference proceedings: Symposia Bone Quality: From Bench to Bedside

    Boskey, Adele L.

    Clinical orthopaedics and related research 469 ,8, S. 2087 - 2259 : Ill., graph. Darst.

    [circa 2011]

    2011  

    Title variant Bone quality: from bench to bedside
    Event/congress Symposium Bone Quality, From Bench to Bedside (2011)
    Author's details guest ed.: Adele L. Boskey
    Collection Clinical orthopaedics and related research
    Language English
    Publishing place New York, NY
    Publishing country United States
    Document type Article ; Conference proceedings
    HBZ-ID HT016928480
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs 188 -469- Location:
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  2. Article: Erratum: Bone composition: relationship to bone fragility and antiosteoporotic drug effects.

    Boskey, Adele L

    BoneKEy reports

    2015  Volume 4, Page(s) 710

    Abstract: This corrects the article DOI: 10.1038/bonekey.2013.181.]. ...

    Abstract [This corrects the article DOI: 10.1038/bonekey.2013.181.].
    Language English
    Publishing date 2015-06-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2015.79
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: Fifth International Conference on the Chemistry and Biology of Mineralized Tissues

    Boskey, Adele L.

    Kohler, Wisconsin, USA, October 22 - 27, 1995

    (Connective tissue research ; 34,4, 35,1/4)

    1996  

    Event/congress International Conference on Chemistry and Biology of Mineralized Tissues (5, 1995, KohlerWis.)
    Author's details organized and ed. by Adele L. Boskey
    Series title Connective tissue research ; 34,4, 35,1/4
    Keywords Calcification, Physiologic / congresses ; Calcinosis / congresses ; Minerals / congresses ; Connective Tissue / chemistry / congresses
    Language English
    Size XXVIII S., S. 239 - 292, S. 1 - 417 : Ill., graph. Darst.
    Publisher Gordon and Breach
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT007449449
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1093 -34-<> not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: CORR Insights®: fractures in geriatric mice show decreased callus expansion and bone volume.

    Boskey, Adele L

    Clinical orthopaedics and related research

    2014  Volume 472, Issue 11, Page(s) 3533–3535

    MeSH term(s) Aging/physiology ; Animals ; Bone and Bones/pathology ; Bony Callus/pathology ; Bony Callus/physiology ; Fracture Healing/physiology ; Humans ; Male
    Language English
    Publishing date 2014-08-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-014-3892-3
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  5. Article ; Online: Bone quality changes associated with aging and disease: a review.

    Boskey, Adele L / Imbert, Laurianne

    Annals of the New York Academy of Sciences

    2018  Volume 1410, Issue 1, Page(s) 93–106

    Abstract: Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral ... ...

    Abstract Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral composition, and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of microcracks, which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity, and carbonate content are contrasted with mineral content. Age-dependent changes in humans and rodents are discussed in relation to rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta (OI), and osteopetrosis in both humans and animal models. Each of these conditions, along with aging, is associated with increased fracture risk for distinct reasons.
    MeSH term(s) Aging ; Animals ; Bone Density ; Bone Diseases/metabolism ; Bone and Bones/metabolism ; Disease Models, Animal ; Fractures, Bone/metabolism ; Humans ; Minerals/metabolism ; Risk Factors
    Chemical Substances Minerals
    Language English
    Publishing date 2018-01-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.13572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Lipids and biomineralizations

    Goldberg, Michel / Boskey, Adele L.

    with 41 tables

    (Progress in histochemistry and cytochemistry ; 31,2)

    1996  

    Author's details M. Goldberg ; A. L. Boskey
    Series title Progress in histochemistry and cytochemistry ; 31,2
    Collection
    Keywords Lipids / metabolism ; Lipids / ultrastructure ; Knochenstoffwechsel ; Biomineralisation ; Lipide
    Subject Fettähnliche Stoffe ; Lipoide ; Biomineralisierung ; Knochen
    Language English
    Size X, 187 S. : zahlr. Ill., graph. Darst.
    Publisher Fischer
    Publishing place Stuttgart u.a.
    Document type Book
    HBZ-ID HT007297716
    ISBN 3-437-21038-6 ; 1-56081-451-9 ; 978-3-437-21038-9 ; 978-1-56081-451-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 23 -31,2- verfügbar in Königswinter Königswinter

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  7. Article: Bone composition: relationship to bone fragility and antiosteoporotic drug effects.

    Boskey, Adele L

    BoneKEy reports

    2013  Volume 2, Page(s) 447

    Abstract: The composition of a bone can be described in terms of the mineral phase, hydroxyapatite, the organic phase, which consists of collagen type I, noncollagenous proteins, other components and water. The relative proportions of these various components vary ...

    Abstract The composition of a bone can be described in terms of the mineral phase, hydroxyapatite, the organic phase, which consists of collagen type I, noncollagenous proteins, other components and water. The relative proportions of these various components vary with age, site, gender, disease and treatment. Any drug therapy could change the composition of a bone. This review, however, will only address those pharmaceuticals used to treat or prevent diseases of bone: fragility fractures in particular, and the way they can alter the composition. As bone is a heterogeneous tissue, its composition must be discussed in terms of the chemical makeup, properties of its chemical constituents and their distributions in the ever-changing bone matrix. Emphasis, in this review, is placed on changes in composition as a function of age and various diseases of bone, particularly osteoporosis. It is suggested that while some of the antiosteoporotic drugs can and do modify composition, their positive effects on bone strength may be balanced by negative ones.
    Language English
    Publishing date 2013-12-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2013.181
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  8. Article: Signaling in response to hypoxia and normoxia in the intervertebral disc.

    Boskey, Adele L

    Arthritis and rheumatism

    2008  Volume 58, Issue 12, Page(s) 3637–3639

    MeSH term(s) Animals ; Humans ; Hypoxia/metabolism ; Intervertebral Disc/metabolism ; Intervertebral Disc Displacement/metabolism ; Oxygen/metabolism ; Signal Transduction/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2008-11-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.24071
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  9. Article ; Online: The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data.

    Raggio, Cathleen L / Pleshko, Nancy / Boskey, Adele L

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2016  Volume 31, Issue 11, Page(s) 2065

    MeSH term(s) Bone Density Conservation Agents ; Diphosphonates ; Fracture Fixation ; Humans ; Osteogenesis Imperfecta
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2016-09-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.2976
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  10. Article ; Online: Biomolecular regulation, composition and nanoarchitecture of bone mineral.

    Poundarik, Atharva A / Boskey, Adele / Gundberg, Caren / Vashishth, Deepak

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 1191

    Abstract: Tough natural nanocomposites like bone, nacre and sea sponges contain within their hierarchy, a mineral (phosphate, silicate or carbonate) phase that interacts with an organic phase. In bone, the role of mineral ultrastructure (organization, morphology, ... ...

    Abstract Tough natural nanocomposites like bone, nacre and sea sponges contain within their hierarchy, a mineral (phosphate, silicate or carbonate) phase that interacts with an organic phase. In bone, the role of mineral ultrastructure (organization, morphology, composition) is crucial to the mechanical and biological properties of the tissue. Better understanding of mineral interaction with the organic matrix, in particular non-collagenous proteins, osteocalcin (OC) and osteopontin (OPN), can lead to better design of biomimetic materials. Using small angle x-ray scattering (SAXS) and wavelength dispersive spectroscopy (WDS) on single (OC
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Bone and Bones/ultrastructure ; Calcification, Physiologic ; Genotype ; Mice ; Mice, Knockout ; Minerals/metabolism ; Models, Biological ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Osteopontin/genetics ; Osteopontin/metabolism ; Scattering, Small Angle ; Trace Elements/metabolism ; X-Ray Diffraction
    Chemical Substances Minerals ; Trace Elements ; Osteocalcin (104982-03-8) ; Osteopontin (106441-73-0)
    Language English
    Publishing date 2018-01-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-19253-w
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