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  1. Article ; Online: Nachruf Prof. Dr. Volker Bay.

    Engel, U / Brinkmann, H

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2014  Volume 85, Issue 7, Page(s) 599–600

    Title translation Obituary prof. Dr. Volker Bay.
    MeSH term(s) General Surgery/history ; Germany ; History, 20th Century ; History, 21st Century ; Pediatrics/history
    Language German
    Publishing date 2014-07
    Publishing country Germany
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-014-2825-8
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  2. Article ; Online: Entering the neutrophil trap.

    Brinkmann, Volker / Zychlinsky, Arturo

    Nature reviews. Immunology

    2021  Volume 21, Issue 10, Page(s) 615

    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00614-y
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  3. Article ; Online: Neutrophil Extracellular Traps in the Second Decade.

    Brinkmann, Volker

    Journal of innate immunity

    2018  Volume 10, Issue 5-6, Page(s) 414–421

    Abstract: Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our knowledge concerning this structure has expanded considerably. Initially, NETs were considered solely an elaborate function of the innate immune system to combat ... ...

    Abstract Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our knowledge concerning this structure has expanded considerably. Initially, NETs were considered solely an elaborate function of the innate immune system to combat invading microorganisms. Successively it became clear that NETs have farther-reaching capabilities. They are involved in a series of pathophysiological mechanisms ranging from inflammation to thrombosis where they fulfill essential functions when produced at the right site and the right time but can have a serious impact when generation or clearance of NETs is inadequately controlled. This review provides a concise overview on the far-reaching functions of NETs in health and disease.
    MeSH term(s) Animals ; Autoimmunity ; Bacterial Infections/immunology ; Blood Coagulation ; Extracellular Traps/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Neutrophils/immunology ; Thrombosis/immunology
    Language English
    Publishing date 2018-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000489829
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  4. Article: Neutrophil Extracellular Traps in the Second Decade

    Brinkmann, Volker

    Journal of Innate Immunity

    2018  Volume 10, Issue 5-6, Page(s) 414–421

    Abstract: Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our knowledge concerning this structure has expanded considerably. Initially, NETs were considered solely an elaborate function of the innate immune system to combat ... ...

    Institution Max Planck Institute for Infection Biology, Berlin, Germany
    Abstract Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our knowledge concerning this structure has expanded considerably. Initially, NETs were considered solely an elaborate function of the innate immune system to combat invading microorganisms. Successively it became clear that NETs have farther-reaching capabilities. They are involved in a series of pathophysiological mechanisms ranging from inflammation to thrombosis where they fulfill essential functions when produced at the right site and the right time but can have a serious impact when generation or clearance of NETs is inadequately controlled. This review provides a concise overview on the far-reaching functions of NETs in health and disease.
    Keywords Autoimmunity ; Bacterial infection ; Cancer ; Coagulation ; Extracellular traps ; Inflammation
    Language English
    Publishing date 2018-06-15
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Review Article
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000489829
    Database Karger publisher's database

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  5. Article ; Online: Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.

    Buijze, Hellen / Brinkmann, Volker / Hurwitz, Robert / Dorhoi, Anca / Kaufmann, Stefan H E / Pei, Gang

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Mouse guanylate-binding proteins (mGBPs) are recruited to various invasive pathogens, thereby conferring cell-autonomous immunity against these pathogens. However, whether and how human GBPs (hGBPs) ... ...

    Abstract Mouse guanylate-binding proteins (mGBPs) are recruited to various invasive pathogens, thereby conferring cell-autonomous immunity against these pathogens. However, whether and how human GBPs (hGBPs) target
    MeSH term(s) Humans ; Animals ; Mice ; GTP-Binding Proteins/metabolism ; Phagosomes/metabolism ; Interferons/metabolism ; Endosomes/metabolism
    Chemical Substances GTP-Binding Proteins (EC 3.6.1.-) ; Interferons (9008-11-1) ; GBP1 protein, human
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119701
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  6. Article ; Online: Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in

    Arias-Rojas, Aranzazu / Frahm, Dagmar / Hurwitz, Robert / Brinkmann, Volker / Iatsenko, Igor

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 36, Page(s) e2305649120

    Abstract: Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here, we show ... ...

    Abstract Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here, we show that
    MeSH term(s) Animals ; Drosophila ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides/genetics ; Aging ; Inflammation
    Chemical Substances Antimicrobial Peptides ; Antimicrobial Cationic Peptides
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2305649120
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  7. Article ; Online: Immunofluorescent Detection of NET Components in Paraffin-Embedded Tissue.

    Abu-Abed, Ulrike / Brinkmann, Volker

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2087, Page(s) 415–424

    Abstract: Neutrophil extracellular traps (NETs) consist of decondensed chromatin fibers studded with granular and cytoplasmic proteins and peptides that are released by stimulated neutrophil granulocytes. If present in abundance (e.g., in large thrombi), NETs are ... ...

    Abstract Neutrophil extracellular traps (NETs) consist of decondensed chromatin fibers studded with granular and cytoplasmic proteins and peptides that are released by stimulated neutrophil granulocytes. If present in abundance (e.g., in large thrombi), NETs are depicted in H&E-stained tissue sections as pale bluish areas. Since no NET-specific antibodies exist, to unambiguously identify even small amounts of NETs in tissue, it is essential to demonstrate colocalization of nuclear and granular/cytoplasmic NET components which in unstimulated neutrophils are clearly separated. This requires good tissue preservation and a very defined immunolocalization, which can be achieved by using 2-3 μm thick sections of paraffin-embedded tissue. It provides sufficiently good tissue preservation for subcellular localization of two or more NET components, thereby allow to differentiate stimulated from unstimulated neutrophils and to clearly identify NETs. In this chapter, we will provide protocols for antigen retrieval and immunofluorescent labeling of NET components in paraffin-embedded tissue with commercially available antibodies.
    MeSH term(s) Extracellular Traps/immunology ; Fluorescent Antibody Technique/methods ; Humans ; Immunohistochemistry/methods ; Microscopy, Confocal/methods ; Microscopy, Fluorescence/methods ; Neutrophils/immunology ; Neutrophils/metabolism ; Paraffin Embedding
    Language English
    Publishing date 2019-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0154-9_24
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  8. Article ; Online: Immunofluorescence Labelling of Human and Murine Neutrophil Extracellular Traps in Paraffin-Embedded Tissue.

    Abu Abed, Ulrike / Brinkmann, Volker

    Journal of visualized experiments : JoVE

    2019  , Issue 151

    Abstract: Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMN) due to their lobulated nucleus, are the most abundant type of leukocytes. They mature in the bone marrow and are released into the peripheral blood, where they circulate for about 6- ... ...

    Abstract Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMN) due to their lobulated nucleus, are the most abundant type of leukocytes. They mature in the bone marrow and are released into the peripheral blood, where they circulate for about 6-8 h; however, in tissue, they can survive for days. By diapedesis through the endothelium, they leave the blood stream, enter tissues, and migrate towards the site of an infection following chemotactic gradients. Neutrophils can combat invading microorganisms by phagocytosis, degranulation, and generation of neutrophil extracellular traps (NETs). This protocol will help to detect NETs in paraffin-embedded tissue. NETs are the result of a process called NETosis, which leads to the release of nuclear, granular, and cytoplasmic components either from living (vital NETosis) or dying (suicidal NETosis) neutrophils. In vitro, NETs form cloud-like structures, which occupy a space several times larger than that of the cells from which they descended. The backbone of NETs is chromatin, to which a selection of proteins and peptides originating from granules and cytoplasm are bound. Thereby, a high local concentration of toxic compounds is maintained so that NETs can capture and inactivate a variety of pathogens including bacteria, fungi, viruses, and parasites, while diffusion of the highly active NET components leading to damage in neighboring tissue is limited. Nevertheless, in recent years it has become apparent that NETs, if generated in abundance or cleared insufficiently, do have pathological potential ranging from autoimmune diseases to cancer. Thus, detection of NETs in tissue samples may have diagnostic significance, and the detection of NETs in diseased tissue can influence the treatment of patients. Since paraffin-embedded tissue samples are the standard specimen used for pathological analysis, it was sought to establish a protocol for fluorescent staining of NET components in paraffin-embedded tissue using commercially available antibodies.
    MeSH term(s) Animals ; Extracellular Traps/metabolism ; Fluorescent Antibody Technique/methods ; Humans ; Mice ; Neutrophils/metabolism ; Paraffin Embedding
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/60115
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  9. Article ; Online: Fabrication and function of polymer membranes

    Abetz Volker / Brinkmann Torsten / Sözbilir Mustafa

    Chemistry Teacher International, Vol 3, Iss 2, Pp 141-

    2021  Volume 154

    Abstract: The paper gives an introduction to membrane science and technology, an area of research of high significance for the development of a sustainable life for human beings. It is therefore intended to be a guide for teachers in the areas of chemistry, ... ...

    Abstract The paper gives an introduction to membrane science and technology, an area of research of high significance for the development of a sustainable life for human beings. It is therefore intended to be a guide for teachers in the areas of chemistry, physics, or biology, who can incorporate the presented materials in their respective courses. The paper gives some insights into the different types of membranes, their functions, production and use in some selected areas.
    Keywords filtration ; permeation ; polymer membrane ; selectivity ; separation ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Case Management und seine ökonomischen Potentiale

    Brinkmann, Volker

    Case Management

    2015  Volume 12, Issue 3, Page(s) 152

    Language German
    Document type Article
    ZDB-ID 2204426-7
    ISSN 1861-0102
    Database Current Contents Medicine

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