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Article ; Online: [Nb@Ge

Huang, Ya-Shan / Xue, Yuan / Muñoz-Castro, Alvaro / Popov, Ivan A / Sun, Zhong-Ming

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 62, Page(s) e202202192

Abstract: During the past two decades, single-atom-centered medium-sized germanium clusters [M@Ge ...

Abstract	During the past two decades, single-atom-centered medium-sized germanium clusters [M@Ge
Language	English
Publishing date	2022-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202202192
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Article: [GE Signa HDxt 1.5 T MRI PAC Module Troubleshooting and Repair].

Chen, Kai / You, Haonan / Shan, Jiaqi / You, Wei

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2023 Volume 47, Issue 4, Page(s) 468–472

Abstract: Through the analysis of PAC module faults in two GE Signa HDxt 1.5 T MRI cases, the fault ...

Abstract	Through the analysis of PAC module faults in two GE Signa HDxt 1.5 T MRI cases, the fault performance was analyzed. According to the working principle of PAC module, the fault was analyzed and processed, and then the suspicious fault parts were located and repaired to make the equipment run normally. Finally, the operating principles of PAC module in terms of power supply, signal transmission and data transmission were summarized to facilitate the subsequent quickly and find out fault points for maintenance accurately.
Language	Chinese
Publishing date	2023-08-14
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.3969/j.issn.1671-7104.2023.04.023
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Article ; Online: Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane.

Chen, Xi / Yang, Jia-Bin / Cao, Hui-Hui / Fang, Xiao-Chuan / Liu, Shan-Hong / Zou, Li-Fang / Yu, Jian-Hai / Zuo, Jian-Ping / Zhao, Wei / Lu, Zi-Bin / Liu, Jun-Shan / Yu, Lin-Zhong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 119, Page(s) 154977

Abstract: ... therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently ...

Abstract	Background: Dengue virus (DENV) is a major public health threat. However, there are no specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently used in the virus-induced diseases. The antiviral effect of LGS has not been reported yet. Purpose: In this study, the effect of LGS on the inhibition of dengue virus serotype 2 (DENV-2) was investigated and the relevant mechanism was explored. Methods: High-performance liquid chromatography was applied to analyze the chemical characterization of LGS. The in vitro antiviral activities of LGS against DENV-2 were evaluated by time-of-drug-addition assay. The binding of heat shock protein 70 (Hsp70) and envelope (E) protein or caveolin1 (Cav1) were analyzed by immunofluorescence and immunoprecipitation assays. Then the role of Cav1 in the anti-DENV-2 effects of LGS was further examined. DENV-2 infected Institute of Cancer Research suckling mice (n = 10) and AG129 mice (n = 8) were used to examine the protective effects of LGS. Results: It was found that geniposide, liquiritin, forsythenside A, forsythin, baicalin, baicalein, rhein, and emodin maybe the characteristic components of LGS. LGS inhibited the early stage of DENV-2 infection, decreased the expression levels of viral E and non-structural protein 1 (NS1) proteins. LGS also reduced E protein and Hsp70 binding and attenuated the translocation of Hsp70 from cytoplasm to the cell membrane. Moreover, LGS decreased the binding of Hsp70 to Cav1. Further study showed that the overexpression of Cav1 reversed LGS-mediated E protein and Hsp70 inhibition in the plasma membrane. In the in vivo study, LGS was highly effective in prolonging the survival time, reducing viral loads. Conclusion: This work demonstrates for the first time that LGS exerts anti-DENV-2 activity in vitro and in vivo. LGS decreases DENV-2-stimulated cytoplasmic Hsp70 translocation into the plasma membrane by Cav1 inhibition, thereby inhibiting the early stage of virus infection. These findings indicate that LGS may be a candidate for the treatment of DENV.
MeSH term(s)	Animals ; Mice ; Dengue Virus ; Dengue/drug therapy ; HSP70 Heat-Shock Proteins ; Serogroup ; Cell Membrane ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytoplasm/metabolism
Chemical Substances	HSP70 Heat-Shock Proteins ; Antiviral Agents
Language	English
Publishing date	2023-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154977
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Article: Construction and Immunogenicity of a Recombinant Pseudorabies Virus Variant With TK/gI/gE/11k/28k Deletion.

Yan, Shijun / Huang, Baicheng / Bai, Xiaofei / Zhou, Ying / Guo, Linghua / Wang, Tongyan / Shan, Yihong / Wang, Yuzhou / Tan, Feifei / Tian, Kegong

Frontiers in veterinary science

2022 Volume 8, Page(s) 797611

Abstract: ... with TK/gI/gE/11k/28k deletion was constructed based on variant HN1201 strain isolated in 2012 ...

Abstract	In China, the re-emerging pseudorabies virus (PRV) variant has caused large-scale outbreaks of pseudorabies in swine herds with classical PRV vaccine immunization since late 2011. Here, a recombinant PRV with TK/gI/gE/11k/28k deletion was constructed based on variant HN1201 strain isolated in 2012, by the bacterial artificial chromosome infectious clones. Compared with the parental virus, the recombinant PRV rHN1201
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.797611
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Article: Threshold Voltage Adjustment by Varying Ge Content in SiGe p-Channel for Single Metal Shared Gate Complementary FET (CFET).

Sun, Chong-Jhe / Wu, Chen-Han / Yao, Yi-Ju / Lin, Shan-Wen / Yan, Siao-Cheng / Lin, Yi-Wen / Wu, Yung-Chun

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 20

Abstract: We have demonstrated the method of threshold voltage ( ... ...

Abstract	We have demonstrated the method of threshold voltage (V
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12203712
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Article ; Online: Influence of the Ge distribution on the first order magnetic transition of the MnFe(P,Ge) magnetocaloric material.

Zhang, Zhen-Lu / Liu, Dan-Min / Xiao, Wei-Qiang / Li, Hui / Wang, Shao-Bo / Liang, Yun-Tian / Zhang, Hong-Guo / Li, Shan-Lin / Fu, Jun-Jie / Yue, Ming

Physical chemistry chemical physics : PCCP

2018 Volume 20, Issue 26, Page(s) 18117–18126

Abstract: MnFe(P,Ge) is a promising magnetocaloric material for potential refrigeration applications near ... on determination of the Ge distribution in MnFeP1-xGex (0.10 < x < 0.50) materials. We find that all the samples ... crystallize in the Fe2P-type structure [P6[combining macron]2m (No. 189), Z = 3] and Ge displays a strong ...

Abstract	MnFe(P,Ge) is a promising magnetocaloric material for potential refrigeration applications near room temperature. However, its relatively large hysteresis and large temperature/field range of two-phase [paramagnetic (PM) and ferromagnetic (FM)] coexistence displayed in the cyclic first order magnetic transition (FOMT) cause energy losses and reduce the energy conversion efficiency. In this work, we explore the underlying causes of phase coexistence, hysteresis and structural transformation based on determination of the Ge distribution in MnFeP1-xGex (0.10 < x < 0.50) materials. We find that all the samples crystallize in the Fe2P-type structure [P6[combining macron]2m (No. 189), Z = 3] and Ge displays a strong preference for the 2c site. First principles total energy calculations confirm this site preference of Ge, and Ge entering the 2c site changes the electronic structures and enhances the Fe and Mn 3d exchange splitting across the Fermi level as well as the FM exchange interactions, consequently leading to a linear increase in the transition temperature with increasing Ge content. Scanning electron microscopy and energy-dispersive spectroscopy reveal the inhomogeneous distribution of Ge in grains, which makes the grains with larger Ge content transform from the PM to the FM phase first when cooling and thus causes the phase coexistence. Maximum entropy method electron-densities show that weakening the coplanar Fe-P/Ge(2c) and Mn-P(1b) bonding strengths across the PM to FM phase transition can release some 3d-electrons to enhance the Fe-Mn FM exchange interaction and result in coupling between the magnetic and structural degrees of freedom. This provides first direct evidence for the dominant role of Fe-Mn exchange interaction in the ferromagnetic ordering and may provide a method to observe the exchange interaction. Diminishing the variances in covalent bonding strengths across the FOMT gives rise to an exponential decay in the heat hysteresis when increasing the Ge occupancy at the 2c site. To the best of our knowledge, this is the first time a relationship between the variances in covalent bonding strengths and hysteresis is proposed. This material thus provides an example of a FOMT and hysteresis driven by reversible weakening and strengthening of covalent bonds. Based on these, a strategy of designing better magnetocaloric materials is suggested.
Language	English
Publishing date	2018-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c8cp01495g
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Article ; Online: A Ge/Carbon Atomic-Scale Hybrid Anode Material: A Micro-Nano Gradient Porous Structure with High Cycling Stability.

Yang, Zhiwei / Chen, Ting / Chen, Dequan / Shi, Xinyu / Yang, Shan / Zhong, Yanjun / Liu, Yuxia / Wang, Gongke / Zhong, Benhe / Song, Yang / Wu, Zhenguo / Guo, Xiaodong

Angewandte Chemie (International ed. in English)

2021 Volume 60, Issue 22, Page(s) 12539–12546

Abstract: ... the fundamental issues that hinder the application of Ge anodes in lithium-ion batteries. Solving Ge deformation ... methods. Due to the chemical stability and high melting point of carbon (3500 °C), Ge/carbon hybridization ... we have achieved the Ge/carbon doping at the atom-level, and this Ge/carbon anode shows excellent ...

Abstract	The continuous growth of the solid-electrolyte interface (SEI) and material crushing are the fundamental issues that hinder the application of Ge anodes in lithium-ion batteries. Solving Ge deformation crushing during discharge/charge cycles is challenging using conventional carbon coating modification methods. Due to the chemical stability and high melting point of carbon (3500 °C), Ge/carbon hybridization at the atomic level is challenging. By selecting a suitable carbon source and introducing an active medium, we have achieved the Ge/carbon doping at the atom-level, and this Ge/carbon anode shows excellent electrochemical performance. The reversible capacity is maintained at 1127 mAh g
Language	English
Publishing date	2021-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202102048
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Article ; Online: Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing Caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane

Chen, Xi / Yang, Jia-bin / Cao, Hui-hui / Fang, Xiao-chuan / Liu, Shan-hong / Zou, Li-fang / Yu, Jian-hai / Zuo, Jian-ping / Zhao, Wei / Lu, Zi-bin / Liu, Jun-shan / Yu, Lin-zhong

Phytomedicine. 2023 July 18, p.154977-

2023 , Page(s) 154977–

Abstract: ... therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently ...

Abstract	Dengue virus (DENV) is a major public health threat. However, there are no specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently used in the virus-induced diseases. The antiviral effect of LGS has not been reported yet. In this study, the effect of LGS on the inhibition of dengue virus serotype 2 (DENV-2) was investigated and the relevant mechanism was explored. High-performance liquid chromatography was applied to analyze the chemical characterization of LGS. The in vitro antiviral activities of LGS against DENV-2 were evaluated by time-of-drug-addition assay. The binding of heat shock protein 70 (Hsp70) and envelope (E) protein or caveolin1 (Cav1) were analyzed by immunofluorescence and immunoprecipitation assays. Then the role of Cav1 in the anti-DENV-2 effects of LGS was further examined. DENV-2 infected Institute of Cancer Research suckling mice (n=10) and AG129 mice (n=8) were used to examine the protective effects of LGS. It was found that geniposide, liquiritin, forsythenside A, forsythin, baicalin, baicalein, rhein, and emodin maybe the characteristic components of LGS. LGS inhibited the early stage of DENV-2 infection, decreased the expression levels of viral E and non-structural protein 1 (NS1) proteins. LGS also reduced E protein and Hsp70 binding and attenuated the translocation of Hsp70 from cytoplasm to the cell membrane. Moreover, LGS decreased the binding of Hsp70 to Cav1. Further study showed that the overexpression of Cav1 reversed LGS-mediated E protein and Hsp70 inhibition in the plasma membrane. In the in vivo study, LGS was highly effective in prolonging the survival time, reducing viral loads. This work demonstrates for the first time that LGS exerts anti-DENV-2 activity in vitro and in vivo. LGS decreases DENV-2-stimulated cytoplasmic Hsp70 translocation into the plasma membrane by Cav1 inhibition, thereby inhibiting the early stage of virus infection. These findings indicate that LGS may be a candidate for the treatment of DENV.
Keywords	Dengue virus ; antiviral properties ; baicalin ; cytoplasm ; emodin ; fluorescent antibody technique ; heat-shock protein 70 ; high performance liquid chromatography ; plasma membrane ; precipitin tests ; public health ; therapeutics ; viral nonstructural proteins ; viruses ; Liang-Ge-San ; Dengue virus serotype 2 ; Heat shock protein 70 ; Caveolin1 ; Envelope protein ; :ALT ; Cav1 ; CCK8 ; CPE ; DENV ; DENV-2 ; DHF ; DSS ; DAPI ; dpi ; E ; ECL ; FBS ; Hsp70 ; HPLC ; ICR ; LGS ; MTT ; MβCD ; NS1 ; PBS ; PFU ; PFA ; PVDF ; PLT ; Q-PCR ; WTO
Language	English
Dates of publication	2023-0718
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154977
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 4115: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Extrinsic Photoconduction Induced Short-Wavelength Infrared Photodetectors Based on Ge-Based Chalcogenides.

He, Ting / Wang, Zhen / Cao, Ruyue / Li, Qing / Peng, Meng / Xie, Runzhang / Huang, Yan / Wang, Yang / Ye, Jiafu / Wu, Peisong / Zhong, Fang / Xu, Tengfei / Wang, Hailu / Cui, Zhuangzhuang / Zhang, Qinghua / Gu, Lin / Deng, Hui-Xiong / Zhu, He / Shan, Chongxin /

Wei, Zhongming / Hu, Weida

Small (Weinheim an der Bergstrasse, Germany)

2020 Volume 17, Issue 4, Page(s) e2006765

Abstract: ... on Ge-based chalcogenides are reported for the first time and the effectiveness of intrinsic point ... with the assistance of Ge vacancies is broadened to 1.6 µm. Extrinsic GeSe photodetectors have an excellent external ...

Abstract	2D layered photodetectors have been widely researched for intriguing optoelectronic properties but their application fields are limited by the bandgap. Extending the detection waveband can significantly enrich functionalities and applications of photodetectors. For example, after breaking through bandgap limitation, extrinsic Si photodetectors are used for short-wavelength infrared or even long-wavelength infrared detection. Utilizing extrinsic photoconduction to extend the detection waveband of 2D layered photodetectors is attractive and desirable. However, extrinsic photoconduction has yet not been observed in 2D layered materials. Here, extrinsic photoconduction-induced short-wavelength infrared photodetectors based on Ge-based chalcogenides are reported for the first time and the effectiveness of intrinsic point defects are demonstrated. The detection waveband of room-temperature extrinsic GeSe photodetectors with the assistance of Ge vacancies is broadened to 1.6 µm. Extrinsic GeSe photodetectors have an excellent external quantum efficiency (0.5%) at the communication band of 1.31 µm and polarization-resolved capability to subwaveband radiation. Moreover, room-temperature extrinsic GeS photodetectors with a detection waveband to the communication band of 1.55 µm further verify the versatility of intrinsic point defects. This approach provides design strategies to enrich the functionalities of 2D layered photodetectors.
Language	English
Publishing date	2020-12-20
Publishing country	Germany
Document type	Journal Article
ISSN	1613-6829
ISSN (online)	1613-6829
DOI	10.1002/smll.202006765
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Article ; Online: How Graphene Islands Are Unidirectionally Aligned on the Ge(110) Surface.

Dai, Jiayun / Wang, Danxia / Zhang, Miao / Niu, Tianchao / Li, Ang / Ye, Mao / Qiao, Shan / Ding, Guqiao / Xie, Xiaoming / Wang, Yongqiang / Chu, Paul K / Yuan, Qinghong / Di, Zengfeng / Wang, Xi / Ding, Feng / Yakobson, Boris I

Nano letters

2016 Volume 16, Issue 5, Page(s) 3160–3165

Abstract: ... single-crystal graphene on Ge(110) surface, but the underlying mechanism is not well-understood. Here ... we report that the necessary coalignment of the nucleating graphene islands on Ge(110) surface is caused ... by the presence of step-pattern; we show that on the preannealed Ge(110) textureless surface the graphene islands ...

Abstract	The unidirectional alignment of graphene islands is essential to the synthesis of wafer-scale single-crystal graphene on Ge(110) surface, but the underlying mechanism is not well-understood. Here we report that the necessary coalignment of the nucleating graphene islands on Ge(110) surface is caused by the presence of step-pattern; we show that on the preannealed Ge(110) textureless surface the graphene islands appear nonpreferentially orientated, while on the Ge(110) surfaces with natural step pattern, all graphene islands emerge coaligned. First-principles calculations and theoretical analysis reveal this different alignment behaviors originate from the strong chemical binding formed between the graphene island edges and the atomic steps on the Ge(110) surface, and the lattice matching at edge-step interface dictates the alignment of graphene islands with the armchair direction of graphene along the [-110] direction of the Ge(110) substrate.
Language	English
Publishing date	2016-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.6b00486
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