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Article: Brain Mitochondria as a Therapeutic Target for Carnosic Acid.

Infantino, Vittoria / Pappalardo, Ilaria / Santarsiero, Anna / Tripathi, Swapnil / Singh, Gyanendra / de Oliveira, Marcos Roberto

Journal of integrative neuroscience

2024 Volume 23, Issue 3, Page(s) 53

Abstract: Carnosic acid (CA), a diterpene obtained mainly ... ...

Abstract	Carnosic acid (CA), a diterpene obtained mainly from
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Oxidation-Reduction ; Mitochondria/metabolism ; Brain/metabolism ; Mammals/metabolism ; Abietanes
Chemical Substances	salvin (LI791SXT24) ; Antioxidants ; Abietanes
Language	English
Publishing date	2024-03-25
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2303053
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Article ; Online: Foreign body aspiration in children: our pediatric tertiary care experience.

Torsello, Miriam / Sicuranza, Luana / Meucci, Duino / Salvati, Antonio / Tropiano, Maria Luisa / Santarsiero, Sara / Calabrese, Cinzia / D'Onghia, Alessandra / Trozzi, Marilena

Pediatric surgery international

2024 Volume 40, Issue 1, Page(s) 93

Abstract: Purpose: Inhalation of a foreign body is a real emergency in pediatric age and requires prompt diagnosis and treatment to reduce mortality. The objective of this study is to analyze clinical and radiological details, types, and localization of foreign ... ...

Abstract	Purpose: Inhalation of a foreign body is a real emergency in pediatric age and requires prompt diagnosis and treatment to reduce mortality. The objective of this study is to analyze clinical and radiological details, types, and localization of foreign bodies in patients conducted or to our hospital with suspected inhalation. Methods: We conducted a retrospective analysis of all cases of foreign body inhalation admitted to our Pediatric Emergency Room between January 2009 and June 2022. Results: 171 patients were included in the study. In 83 patients, the FB was detected. The mean age of presentation was 2.3 years (SD: ± 2). Cough (73%) and unilateral reduced breath sound (51%) were the most common clinical symptom and clinical sign. The most frequent localization was the right main bronchus (43%). The foreign bodies retrieved were vegetable (83%), of which peanut was the most common. Chest radiographs were normal in 25%. The mean duration of hospitalization was 5 days (± 2.9). Complications such as pneumothorax were seen in two cases. Conclusions: Foreign body inhalation represents a true pediatric emergency and still a challenge in clinical practice. The best way to manage it is an early diagnosis and removal by fully trained staff.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Bronchoscopy ; Retrospective Studies ; Tertiary Healthcare ; Respiratory Aspiration/diagnosis ; Respiratory Aspiration/therapy ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery
Language	English
Publishing date	2024-03-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-024-05679-z
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Article: New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks.

Iacobazzi, Dominga / Convertini, Paolo / Todisco, Simona / Santarsiero, Anna / Iacobazzi, Vito / Infantino, Vittoria

Biology

2023 Volume 12, Issue 6

Abstract: The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways-canonical and non-canonical-are ... ...

Abstract	The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways-canonical and non-canonical-are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases.
Language	English
Publishing date	2023-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12060776
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Article ; Online: Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target.

Infantino, Vittoria / Santarsiero, Anna / Convertini, Paolo / Todisco, Simona / Iacobazzi, Vito

International journal of molecular sciences

2021 Volume 22, Issue 11

Abstract: In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics. Nevertheless, tumor microenvironment is ... ...

Abstract	In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics. Nevertheless, tumor microenvironment is frequently characterized by low-oxygen conditions. Hypoxia-inducible factor 1 (HIF-1) is a pivotal modulator of the metabolic reprogramming which takes place in hypoxic cancer cells. In the hub of cellular bioenergetics, mitochondria are key players in regulating cellular energy. Therefore, a close crosstalk between mitochondria and HIF-1 underlies the metabolic and functional changes of cancer cells. Noteworthy, HIF-1 represents a promising target for novel cancer therapeutics. In this review, we summarize the molecular mechanisms underlying the interplay between HIF-1 and energetic metabolism, with a focus on mitochondria, of hypoxic cancer cells.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Biomarkers, Tumor ; Citric Acid Cycle/drug effects ; Disease Management ; Disease Susceptibility ; Energy Metabolism/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hypoxia/drug therapy ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/chemistry ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction/drug effects
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2021-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22115703
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Article: Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis.

Pagliuca, Giulio / Clemenzi, Veronica / Martellucci, Salvatore / Gazia, Francesco / Santarsiero, Sara / Farina, Luigi / Stolfa, Andrea / Gallo, Andrea

International archives of otorhinolaryngology

2023 Volume 27, Issue 4, Page(s) e586–e592

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2023-03-03
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0042-1758219
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Article ; Online: ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis.

Convertini, Paolo / Santarsiero, Anna / Todisco, Simona / Gilio, Michele / Palazzo, Donatella / Pappalardo, Ilaria / Iacobazzi, Dominga / Frontuto, Maria / Infantino, Vittoria

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 568

Abstract: Background: Non-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its progression to Nonalcoholic Steatohepatitis (NASH), more recently referred to as Metabolic (Dysfunction)- ... ...

Abstract	Background: Non-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its progression to Nonalcoholic Steatohepatitis (NASH), more recently referred to as Metabolic (Dysfunction)-Associated Steatohepatitis (MASH) are the most common causes of liver failure and chronic liver damage. The new names emphasize the metabolic involvement both in relation to liver function and pathological features with extrahepatic manifestations. This study aims to explore the role of the immunometabolic enzyme ATP citrate lyase (ACLY), with a critical function in lipogenesis, carbohydrate metabolism, gene expression and inflammation. Methods: ACLY function was investigated in TNFα-triggered human hepatocytes and in PBMC-derived macrophages from MASH patients. Evaluation of expression levels was carried out by western blotting and/or RT-qPCR. In the presence or absence of ACLY inhibitors, ROS, lipid peroxidation and GSSG oxidative stress biomarkers were quantified. Chromatin immunoprecipitation (ChIP), transient transfections, immunocytochemistry, histone acetylation quantitation were used to investigate ACLY function in gene expression reprogramming. IL-6 and IL-1β were quantified by Lumit immunoassays. Results: Mechanistically, ACLY inhibition reverted lipid accumulation and oxidative damage while reduced secretion of inflammatory cytokines in TNFα-triggered human hepatocytes. These effects impacted not only on lipid metabolism but also on other crucial features of liver function such as redox status and production of inflammatory mediators. Moreover, ACLY mRNA levels together with those of malic enzyme 1 (ME1) increased in human PBMC-derived macrophages from MASH patients when compared to age-matched healthy controls. Remarkably, a combination of hydroxycitrate (HCA), the natural ACLY inhibitor, with red wine powder (RWP) significantly lowered ACLY and ME1 mRNA amount as well as IL-6 and IL-1β production in macrophages from subjects with MASH. Conclusion: Collectively, our findings for the first time highlight a broad spectrum of ACLY functions in liver as well as in the pathogenesis of MASH and its diagnostic and therapeutic potential value.
MeSH term(s)	Humans ; ATP Citrate (pro-S)-Lyase/genetics ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Leukocytes, Mononuclear ; Hepatocytes ; Non-alcoholic Fatty Liver Disease
Chemical Substances	ATP Citrate (pro-S)-Lyase (EC 2.3.3.8) ; Tumor Necrosis Factor-alpha ; Interleukin-6
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04431-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Extracts of Two Selected Strains of

Pappalardo, Ilaria / Santarsiero, Anna / Radice, Rosa Paola / Martelli, Giuseppe / Grassi, Giulia / de Oliveira, Marcos Roberto / Infantino, Vittoria / Todisco, Simona

Life (Basel, Switzerland)

2023 Volume 13, Issue 8

Abstract: Recently, microalgae are arousing considerable interest as a source of countless molecules with potential impacts in the nutraceutical and pharmaceutical fields. ...

Abstract	Recently, microalgae are arousing considerable interest as a source of countless molecules with potential impacts in the nutraceutical and pharmaceutical fields.
Language	English
Publishing date	2023-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13081737
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Article: Analysis of a Large Database of Concrete Core Tests with Emphasis on Within-Structure Variability.

Masi, Angelo / Digrisolo, Andrea / Santarsiero, Giuseppe

Materials (Basel, Switzerland)

2019 Volume 12, Issue 12

Abstract: In reinforced concrete (RC) structures, the compressive strength of concrete can play a crucial role in seismic performance and is usually difficult to estimate. Major seismic codes prescribe that concrete strength must be determined essentially from in ... ...

Abstract	In reinforced concrete (RC) structures, the compressive strength of concrete can play a crucial role in seismic performance and is usually difficult to estimate. Major seismic codes prescribe that concrete strength must be determined essentially from in situ and laboratory tests. Mean values obtained from such tests are the reference design values when assessing existing structures under seismic actions. The variability of concrete strength can also play an important role, generally requiring that various homogeneous domains are identified in a single structure, in each of which a specific mean value should be assumed as representative. This study analyzes the inter- and intra-variability of the concrete strength of existing buildings using a very large database made up of approximately 1600 core tests extracted from RC buildings located in the Basilicata region (Southern Italy). The analysis highlighted that concrete strength variability was dependent on the structures' dimensions as well as on the number of storeys. Moreover, the concrete strength of cores extracted from columns was found to be, on average, lower than that from beams, thus justifying the usual practice to extract cores mainly from columns, which results in a conservative approach as well as a more feasible one. Finally, some case studies were analyzed, specifically focusing on the effects of the within-storey variability. Conservative strength values, to be used especially in the case of vertical members subjected to high axial loads, are suggested.
Language	English
Publishing date	2019-06-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma12121985
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Book ; Online: FIRE PLANNING OF URBAN-RURAL INTERFACE IN OPEN SOURCE GIS ENVIRONMENT

Cillis, G. / Lanorte, A. / Nolè, G. / Santarsiero, V. / Ronco, F.

eISSN: 2194-9034

CASE STUDY OF THE APULIA REGION (SOUTHERN ITALY)

2022

Abstract: Fires represent one of main challenges of the last decades as global changes are causing an increase in economic and environmental damages. Indeed, just in 2017, more than 10,000 km 2 of land were burned in Europe, causing significant damage to both the ... ...

Abstract	Fires represent one of main challenges of the last decades as global changes are causing an increase in economic and environmental damages. Indeed, just in 2017, more than 10,000 km 2 of land were burned in Europe, causing significant damage to both the natural heritage (25% of burned areas were part of Natura 2000 protected areas) and the economy with estimated losses around 10 billion euros. In addition, every year there are losses of human life that make even more necessary new strategies of action and monitoring. Therefore, an efficient management of forecasting, prevention, active fight and post fire phases, is essential to make the territories less vulnerable and reduce the impacts on human lives. But these steps require an integrated approach of different tools in order to make faster and more efficient the different operations. In this context, the study illustrates the expeditious and standardized methodologies in open source GIS environment proposed in a research project with the Civil Protection of Apulia Region in order to implement a vulnerability index to improve operations in forecasting, emergency management in real-near time and post-event analysis in urban-rural interface. All the techniques and methodologies proposed were based on the use of QGIS software as it is a highly user friendly software that can be easily used even by non-specialized technicians. Moreover, the methodologies have been validated through a direct comparison with the tools currently in use in Civil Protection Department of Apulia Region.
Subject code	710
Language	English
Publishing date	2022-08-09
Publishing country	de
Document type	Book ; Online
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Article ; Online: Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: Clinical and Radiological Results of a Prospective Randomized Controlled Trial Study at 10-Year Follow-Up.

Randelli, Pietro Simone / Stoppani, Carlo Alberto / Santarsiero, Gianvito / Nocerino, Elisabetta / Menon, Alessandra

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2021 Volume 38, Issue 1, Page(s) 51–61

Abstract: Purpose: The aim of the study is to compare, at 10-year follow-up, the clinical and radiological outcomes of arthroscopic rotator cuff repair with or without the addition of platelet-rich plasma (PRP) over the tendon-bone interface at the end of the ... ...

Abstract	Purpose: The aim of the study is to compare, at 10-year follow-up, the clinical and radiological outcomes of arthroscopic rotator cuff repair with or without the addition of platelet-rich plasma (PRP) over the tendon-bone interface at the end of the surgical procedure. Methods: Of 53 patients recruited in the study, and randomly divided into 2 groups (PRP = 26; control = 27), 38 were re-evaluated at least 10 years after the index procedure. The clinical evaluation was carried out through: University of California at Los Angeles (UCLA) Shoulder Score, Visual Analogue Scale (VAS), Simple Shoulder Test, Constant-Murley Score (CMS), Single Assessment Numerical Evaluation (SANE), American Shoulder and Elbow Surgeons (ASES) and isometric strength in abduction, forward flexion and external rotation. Musculoskeletal ultrasonography had been used to evaluate the integrity of the repaired cuff. Results: A number of 38 (71%) patients (PRP = 17; control = 21) with a median age of 71 [64.75-76.50] years have been evaluated. Satisfaction at follow-up is high (90%), without statistically significant difference between the two groups. We report good and excellent clinical results in both groups (PRP vs control): CMS (81.62 [72.47-85.75] vs 77.97 [69.52-82.55] points), UCLA (34 [29.00-35.00] vs 33 [29.00-35.00] points), VAS (0.34 [0.00-1.85] vs 0.70 [0.00-2.45] cm). It was not possible to find a statistically significant difference for the variables analyzed, except for ASES and SANE. On average, 37% of the operated patients had a re-rupture at the ultrasound examination, regardless of the treatment group (P = 1.00). Compared with the previous radiological control at the 2-year follow-up, new retears occurred in 6% of the patients who received PRP treatment, whereas in the control group the percentage raises to 14% (P = .61). Conclusion: The clinical and radiological outcomes at the 10-year follow-up show a substantial uniformity of results between the 2 groups. The minor differences that had been observed at 2-year follow-up disappeared at long term. Patients' satisfaction is still high 10 years after surgical treatment. Level of evidence: Level II, randomized controlled trial, treatment study.
MeSH term(s)	Aged ; Arthroscopy ; Follow-Up Studies ; Humans ; Middle Aged ; Platelet-Rich Plasma ; Prospective Studies ; Range of Motion, Articular ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/surgery ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/surgery ; Treatment Outcome
Language	English
Publishing date	2021-05-27
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2021.05.017
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