Article ; Online: Palladium-Catalyzed Branch- and Z-Selective Allylic C-H Amination with Aromatic Amines.
Angewandte Chemie (International ed. in English)
2022 Volume 62, Issue 4, Page(s) e202211631
Abstract: ... coupling of allylic C-H bonds and commonly available amines is a major synthetic challenge. An allylic C-H ... allylic aminations are favored to generate thermodynamically unstable Z-allylamines. In addition, more basic ...
Abstract | Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C-H bonds and commonly available amines is a major synthetic challenge. An allylic C-H amination of 1,4-dienes has been accomplished by palladium catalysis. With aromatic amines, branch-selective allylic aminations are favored to generate thermodynamically unstable Z-allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products. |
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MeSH term(s) | Amination ; Palladium/chemistry ; Allyl Compounds/chemistry ; Amines/chemistry ; Allylamine ; Catalysis |
Chemical Substances | Palladium (5TWQ1V240M) ; Allyl Compounds ; Amines ; Allylamine (48G762T011) |
Language | English |
Publishing date | 2022-12-19 |
Publishing country | Germany |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2011836-3 |
ISSN | 1521-3773 ; 1433-7851 |
ISSN (online) | 1521-3773 |
ISSN | 1433-7851 |
DOI | 10.1002/anie.202211631 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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