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Article ; Online: Municipal solid waste management: Dynamics, risk assessment, ecological influence, advancements, constraints and perspectives.

Vyas, Shaili / Prajapati, Priya / Shah, Anil V / Varjani, Sunita

2022 Volume 814, Page(s) 152802

Abstract: Global energy consumption has been increasing in tandem with economic growth, putting pressure on the world's supply of renewable energy sources. Municipal Solid waste (MSW) has been reported contributing immensely to the improvement of a secure ... ...

Abstract	Global energy consumption has been increasing in tandem with economic growth, putting pressure on the world's supply of renewable energy sources. Municipal Solid waste (MSW) has been reported contributing immensely to the improvement of a secure environment and renewable sources. Energy scarcity and conventional MSW disposal methods in developing countries lead towards many environmental and economic issues. Scientists have been able to experiment with various waste-to-energy conversion technologies in light of this situation. This communication highlights and reviews WtE technologies to convert MSW and other feedstocks into electricity, hydrogen gas, bioethanol along with other value added products like fertilizer(s), platform chemicals as an environmentally friendly products. This review comprehensively summarized the dynamics, risk assessment, ecological influence, advancements, constraints and perspectives altogether in field of municipal solid waste management and treatment. Stare-of-the-art information on ecological influence and risk assessment in handling and transportation of municipal solid waste has been provided. Advanced trends involved in remediation of emerging pollutants and resources obtained from municipal solid wastes have been uncovered. Lastly, this paper comprises constraints and perspectives for uncovering MSW based circular bioeconomy aspects.
MeSH term(s)	Environmental Pollutants ; Refuse Disposal ; Risk Assessment ; Solid Waste/analysis ; Waste Management
Chemical Substances	Environmental Pollutants ; Solid Waste
Language	English
Publishing date	2022-01-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.152802
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Article ; Online: Assessment of retinal manifestations of Parkinson's disease using spectral domain optical coherence tomography: A study in Indian eyes.

Verghese, Shishir / Berkowitz, Sean T / Shah, Virna M / Shah, Parag / Priya, S / Saravanan, Veerappan R / Narendran, Venkatapathy / Selvan, V A

Indian journal of ophthalmology

2022 Volume 70, Issue 2, Page(s) 448–452

Abstract: Purpose: To assess the retinal manifestations of Parkinson's disease using optical coherence tomography.: Methods: A prospective case-control study comparing 30 eyes from 15 patients with Parkinson's disease and 22 eyes from 11 healthy age-matched ... ...

Abstract	Purpose: To assess the retinal manifestations of Parkinson's disease using optical coherence tomography. Methods: A prospective case-control study comparing 30 eyes from 15 patients with Parkinson's disease and 22 eyes from 11 healthy age-matched controls. Total macular subfield thickness and the thickness of the ganglion cell layer, nerve fiber layer, and peripapillary retinal nerve fiber layer were measured with spectral-domain optical coherence tomography (SD-OCT). Results: The mean age of PD patients was 68.4 years ± 10.64 (range: 46-82) and in the control group was 66.36 ± 5.22 (range: 64-68). The average disease duration in patients with PD was 6.7 ± 2.8 years (range: 2-10 years). The mean best-corrected visual acuity in PD was 20/26 and 20/20 in controls, with P = 0.0059, which was significant. Significant difference was also found in the contrast sensitivity between both groups. Structural differences in the central macular thickness (P = 0.0001), subfield thicknesses in the superior (P = 0.003), inferior (P = 0.001), nasal (P = 0.004), and temporal subfields (P = 0.017) was seen. Severe thinning of the ganglion cell layer was seen in PD patients (P = 0.000) as well as of the nerve fiber layer (P = 0.004). Peripapillary retinal nerve fiber thickness measured showed significant thinning in superotemporal (P = 0.000), superonasal (P = 0.04), inferonasal (P = 0.000), inferotemporal (P = 0.000), nasal (P = 0.000), and temporal quadrants (P = 0.000). Conclusion: Visual dysfunction was observed in patients with PD along with structural alterations on OCT, which included macular volumes, ganglion cell layer, and peripapillary retinal nerve fiber layer.
MeSH term(s)	Aged ; Case-Control Studies ; Humans ; Nerve Fibers ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Retinal Ganglion Cells ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2022-01-27
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_1409_21
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Article ; Online: Proteomics, Human Environmental Exposure, and Cardiometabolic Risk.

Perry, Andrew S / Zhang, Kai / Murthy, Venkatesh L / Choi, Bina / Zhao, Shilin / Gajjar, Priya / Colangelo, Laura A / Hou, Lifang / Rice, Mary / Carr, John Jeffrey / Carson, April P / Nigra, Anne E / Vasan, Ramachandran S / Gerszten, Robert E / Khan, Sadiya S / Kalhan, Ravi / Nayor, Matthew / Shah, Ravi V

Circulation research

2024

Abstract: Rationale: ...

Abstract	Rationale:
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.124.324559
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Article: Comparing Simvastatin Monotherapy V/S Simvastatin-Ezetimibe Combination Therapy for the Treatment of Hyperlipidemia: A Meta-Analysis and Review.

Chauhan, Dhruva / Memon, Farzana / Patwardhan, Vaibhav / Kotwani, Priya / Shah, Parth / Samala Venkata, Vikramaditya

Cureus

2022 Volume 14, Issue 11, Page(s) e31007

Abstract: Longstanding hyperlipidemia can increase the risk of cardiovascular disease. Statins are currently the mainstay of treatment in hyperlipidemia. Combination therapy of statin with ezetimibe is only indicated for severe hypercholesterolemia and very high- ... ...

Abstract	Longstanding hyperlipidemia can increase the risk of cardiovascular disease. Statins are currently the mainstay of treatment in hyperlipidemia. Combination therapy of statin with ezetimibe is only indicated for severe hypercholesterolemia and very high-risk atherosclerotic cardiovascular disease (ASCVD) population. There is a paucity of studies comparing statin monotherapy vs combination therapy with ezetimibe. This study aims to perform a meta-analysis of the existing literature and compare the effectiveness of statin monotherapy with statin-ezetimibe combination therapy in the management of hyperlipidemia. A systematic electronic search of the scientific literature was performed in PubMed, EMBASE, and Scopus. Only randomized controlled trials comparing simvastatin monotherapy vs simvastatin-ezetimibe combination therapy between the years 2000 and 2021 and published in English language were included. Fifteen studies were included in the final analysis. The main outcomes that were compared were a reduction in low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Our study showed that combination therapy led to a higher reduction of LDL-C (Mean difference: -20.22(-26.38, -14.07); P<0.0001) compared to monotherapy with a statin alone. There was no significant difference in the reduction of HDL-C values (Mean difference: -0.07(-0.45,0.32); P-0.04) between the two groups. Our study indicates that the combination therapy of simvastatin and ezetimibe is more effective in reduction of LDL-C levels compared to simvastatin monotherapy alone. Currently, guidelines recommend combination therapy only for severe hypercholesterolemia and high-risk ASCVD patients, more studies are needed to study the effectiveness of simvastatin-ezetimibe combination therapy in low-risk ASCVD population.
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.31007
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Article ; Online: Facile Synthesis of Chitosan Capped Mesoporous Silica Nanoparticles: A pH Responsive Smart Delivery Platform for Raloxifene Hydrochloride.

Shah, Priya V / Rajput, Sadhana J

AAPS PharmSciTech

2018 Volume 19, Issue 3, Page(s) 1344–1357

Abstract: An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous ... ...

Abstract	An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive drug delivery system. A silanol skeleton of MSN has been productively modified to amine intermediate which served as a firm platform to adapt chitosan grafted assembly and systematically evaluated. RAL incorporation inside the featured mesopores was performed employing novel immersion solvent evaporation methodology and evaluated further. The pH responsive behavior of formulated nano framework was studied at three different pH of a phosphate buffer saline individually. The in vitro cell viability assay on MCF-7 breast carcinoma cells was performed in time and concentration dependent manner. Finally, the hemolysis assay of designed nanoparticle was accomplished to envisage the hemocompatibility. The outcome of characterization details unveiled a perfect 2D hexagonal spherical structure gifted with higher surface area and optimum pore size for designed nanoparticles. The higher percentage grafting of amine and chitosan residue, i.e., 4.01 and 28.51% respectively along with 31.89 and 33.57% RAL loading efficiency made MSNs more attractive and applicable. Eventually, in vitro release study exhibited higher RAL release in acidic media for extended time periods confirming successful formation of pH responsive nanoparticle having controlled release property. Conclusively potential of designed nanosystem to serve efficient anti-cancer remedy was confirmed by superior behaviour of chitosan grafted MSN towards MCF-7 cells with supreme hemocompatibility.
MeSH term(s)	Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/chemical synthesis ; Cell Survival/drug effects ; Cell Survival/physiology ; Chitosan/administration & dosage ; Chitosan/chemical synthesis ; Dose-Response Relationship, Drug ; Drug Delivery Systems/methods ; Humans ; Hydrogen-Ion Concentration ; MCF-7 Cells ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Porosity ; Raloxifene Hydrochloride/administration & dosage ; Raloxifene Hydrochloride/chemical synthesis ; Silicon Dioxide/administration & dosage ; Silicon Dioxide/chemical synthesis
Chemical Substances	Bone Density Conservation Agents ; Raloxifene Hydrochloride (4F86W47BR6) ; Silicon Dioxide (7631-86-9) ; Chitosan (9012-76-4)
Language	English
Publishing date	2018-04
Publishing country	United States
Document type	Journal Article
ISSN	1530-9932
ISSN (online)	1530-9932
DOI	10.1208/s12249-017-0949-0
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Article ; Online: Direct benefit transfer for nutritional support of patients with TB in India-analysis of national TB program data of 3.7 million patients, 2018-2022.

BMC public health

2024 Volume 24, Issue 1, Page(s) 299

Abstract: Background: Patients with TB have additional nutritional requirements and thus additional costs to the household. Ni-kshay Poshan Yojana(NPY) is a Direct Benefit Transfer (DBT) scheme under the National Tuberculosis Elimination Programme(NTEP) in India ... ...

Abstract	Background: Patients with TB have additional nutritional requirements and thus additional costs to the household. Ni-kshay Poshan Yojana(NPY) is a Direct Benefit Transfer (DBT) scheme under the National Tuberculosis Elimination Programme(NTEP) in India which offers INR 500 monthly to all notified patients with TB for nutritional support during the period of anti-TB treatment. Five years after its implementation, we conducted the first nationwide evaluation of NPY. Methods: In our retrospective cohort study using programmatic data of patients notified with TB in nine randomly selected Indian states between 2018 and 2022, we estimated the proportion of patients who received at least one NPY instalment and the median time to receive the first instalment. We determined the factors associated (i) with non-receipt of NPY using a generalised linear model with Poisson family and log link and (ii) with time taken to receive first NPY benefit in 2022 using quantile regression at 50th percentile. Results: Overall, 3,712,551 patients were notified between 2018 and 2022. During this period, the proportion who received at least one NPY instalment had increased from 56.9% to 76.1%. Non-receipt was significantly higher among patients notified by private sector (aRR 2.10;2.08,2.12), reactive for HIV (aRR 1.69;1.64,1.74) and with missing/undetermined diabetic status (aRR 2.02;1.98,2.05). The median(IQR) time to receive the first instalment had reduced from 200(109,331) days in 2018 to 91(51,149) days in 2022. Patients from private sector(106.9;106.3,107.4days), those with HIV-reactive (103.7;101.8,105.7days), DRTB(104.6;102.6,106.7days) and missing/undetermined diabetic status (115.3;114,116.6days) experienced longer delays. Conclusions: The coverage of NPY among patients with TB had increased and the time to receipt of benefit had halved in the past five years. Three-fourths of the patients received at least one NPY instalment, more than half of whom had waited over three months to receive the first instalment. NTEP has to focus on timely transfer of benefits to enable patients to meet their additional nutritional demands, experience treatment success and avoid catastrophic expenditure.
MeSH term(s)	Humans ; Retrospective Studies ; Nutritional Support ; HIV Seropositivity ; India/epidemiology ; Diabetes Mellitus
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17777-7
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Article: Municipal solid waste management: Dynamics, risk assessment, ecological influence, advancements, constraints and perspectives

Vyas, Shaili / Prajapati, Priya / Shah, Anil V. / Varjani, Sunita

Science of the total environment. 2022 Mar. 25, v. 814

2022

Abstract	Global energy consumption has been increasing in tandem with economic growth, putting pressure on the world's supply of renewable energy sources. Municipal Solid waste (MSW) has been reported contributing immensely to the improvement of a secure environment and renewable sources. Energy scarcity and conventional MSW disposal methods in developing countries lead towards many environmental and economic issues. Scientists have been able to experiment with various waste-to-energy conversion technologies in light of this situation. This communication highlights and reviews WtE technologies to convert MSW and other feedstocks into electricity, hydrogen gas, bioethanol along with other value added products like fertilizer(s), platform chemicals as an environmentally friendly products. This review comprehensively summarized the dynamics, risk assessment, ecological influence, advancements, constraints and perspectives altogether in field of municipal solid waste management and treatment. Stare-of-the-art information on ecological influence and risk assessment in handling and transportation of municipal solid waste has been provided. Advanced trends involved in remediation of emerging pollutants and resources obtained from municipal solid wastes have been uncovered. Lastly, this paper comprises constraints and perspectives for uncovering MSW based circular bioeconomy aspects.
Keywords	bioeconomics ; bioethanol ; electricity ; energy ; environment ; feedstocks ; fertilizers ; hydrogen ; municipal solid waste ; remediation ; risk assessment ; transportation ; waste management
Language	English
Dates of publication	2022-0325
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.152802
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Article ; Online: Genome sequences of

Bansal, Devansh / Fazilat, Alexander Z / Genchev, Matthew V / Han, Sanguk / Ho, David Y / Kumar, Amisha / Lam, Brian J / Le, Noah Q / Lin, Ryan P / Lopez, Amanda J / Lu, Nicole Y / Marroquin, Marco / Neemuchwala, Zainab H / Seng, William J / Shah, Priya T / Toliao, Jason M / Bancroft, Christa T

Microbiology resource announcements

2023 Volume 12, Issue 12, Page(s) e0093623

Abstract: Phages MidnightRain and Gusanita, with siphovirus morphology, were isolated ... ...

Abstract	Phages MidnightRain and Gusanita, with siphovirus morphology, were isolated on
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00936-23
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Article ; Online: Hepcidin Signaling in Health and Disease: Ironing Out the Details.

Kowdley, Kris V / Gochanour, Eric M / Sundaram, Vinay / Shah, Raj A / Handa, Priya

Hepatology communications

2021 Volume 5, Issue 5, Page(s) 723–735

Abstract: Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export ... ...

Abstract	Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels. Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection. Erythropoietic drive and hypoxia suppress hepcidin expression and promote red cell production. In contrast, inflammation and infection are associated with increased hepcidin production to sequester iron intracellularly as a means of depriving microorganisms of iron. Chronic inflammation may up-regulate hepcidin expression through the interleukin-6 (IL-6)-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway. The bone morphogenetic protein (BMP)-mothers against decapentaplegic homolog (SMAD) pathway is a major positive driver of hepcidin expression in response to either increased circulating iron in the form of transferrin or iron loading in organs. Hereditary hemochromatosis (HH) consists of several inherited disorders that cause inappropriately reduced hepcidin expression in response to body iron stores, leading to increased iron absorption from a normal diet. The most common form of HH is due to a mutation in the
Language	English
Publishing date	2021-03-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1002/hep4.1717
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Article: Association of Healthy Dietary Patterns and Cardiorespiratory Fitness in the Community.

Mi, Michael Y / Gajjar, Priya / Walker, Maura E / Miller, Patricia / Xanthakis, Vanessa / Murthy, Venkatesh L / Larson, Martin G / Vasan, Ramachandran S / Shah, Ravi V / Lewis, Gregory D / Nayor, Matthew

medRxiv : the preprint server for health sciences

2023

Abstract: Aims: To evaluate the associations of dietary indices and quantitative CRF measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology.: Methods: Framingham Heart Study (FHS) participants underwent ... ...

Abstract	Aims: To evaluate the associations of dietary indices and quantitative CRF measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology. Methods: Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO Results: In 2380 FHS participants (54±9 years, 54% female, BMI 28±5 kg/m Conclusion: Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favorable effects on health.
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.09.23285714
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