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Article ; Online: A study on Chinese ancient jades with mercury alteration unearthed from Lizhou’ao Tomb

Yi Bao / Changqing Xu / Qinwen Zhu / Yuesheng Li

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 9

Abstract: ... from Lizhou’ao Tomb in Jiangxi Province, China. Structural analyses revealed the internal microstructure ...

Abstract	Abstract “Alteration” geologically refers to chemical composition and/or structural changes of minerals under the influences of hydrothermal fluids, surface water, seawater, or other environmental conditions. In this paper, we use the word “alteration” to refer to chemical component and structural changes in jade artifacts caused by human activity and natural weathering, which is different from the term in geology. “Mercury alteration”, a kind of black alteration related to Hg, is unique among the several types of alteration that occur in Chinese ancient jades. Mercury alteration often appears on ancient jade artifacts unearthed from high-grade tombs of the pre-Qin period (before 221 B.C.). Therefore, ancient jades with mercury alteration have attracted substantial attention from Chinese archaeologists. This paper reports the use of materials analytic techniques to study such ancient jade fragments. The studied jade samples date to the middle and late periods of the Spring and Autumn Period (~500 B.C.) and were unearthed from Lizhou’ao Tomb in Jiangxi Province, China. Structural analyses revealed the internal microstructure of the ancient jade fragments and the microdistribution of the mercury alteration. The jade fragments exhibit typical characteristics of round holes and structural hierarchy, which imply that the jades were heated before burial. The black alteration on these jade samples was found to be rich in Hg. The results of this study will be widely useful in the study of ancient jade artifacts and jade culture in Chinese archeology.
Keywords	Medicine ; R ; Science ; Q
Subject code	930
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modulation of Gut Microbial Metabolism by Cyanidin-3-

Chen, Wen / Zheng, Xiaodong / Yan, Fujie / Xu, Lizhou / Ye, Xiang

Journal of agricultural and food chemistry

2024 Volume 72, Issue 13, Page(s) 7140–7154

Abstract: Microplastics derived from plastic waste have emerged as a pervasive environmental pollutant with potential transfer and accumulation through the food chain, thus posing risks to both ecosystems and human health. The gut microbiota, tightly intertwined ... ...

Abstract	Microplastics derived from plastic waste have emerged as a pervasive environmental pollutant with potential transfer and accumulation through the food chain, thus posing risks to both ecosystems and human health. The gut microbiota, tightly intertwined with metabolic processes, exert substantial influences on host physiology by utilizing dietary compounds and generating bacterial metabolites such as tryptophan and bile acid. Our previous studies have demonstrated that exposure to microplastic polystyrene (PS) disrupts the gut microbiota and induces colonic inflammation. Meanwhile, intervention with cyanidin-3-
MeSH term(s)	Mice ; Animals ; Humans ; Interleukin-10 ; Anthocyanins/pharmacology ; RNA, Ribosomal, 16S ; Tumor Necrosis Factor-alpha/pharmacology ; Plastics/pharmacology ; Polystyrenes/pharmacology ; Interleukin-6/pharmacology ; Gastrointestinal Microbiome ; Interleukin-4 ; Ecosystem ; Tryptophan/pharmacology ; Mice, Inbred C57BL ; Cytokines/genetics ; Cytokines/metabolism ; Inflammation/drug therapy ; Inflammation/genetics ; Anti-Inflammatory Agents/pharmacology ; Glucosides/pharmacology ; Bile Acids and Salts/pharmacology ; RNA, Messenger
Chemical Substances	Interleukin-10 (130068-27-8) ; cyanidin (7732ZHU564) ; Anthocyanins ; RNA, Ribosomal, 16S ; Tumor Necrosis Factor-alpha ; Plastics ; Polystyrenes ; Interleukin-6 ; Interleukin-4 (207137-56-2) ; Tryptophan (8DUH1N11BX) ; Cytokines ; Anti-Inflammatory Agents ; Glucosides ; Bile Acids and Salts ; RNA, Messenger
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08454
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Article ; Online: Comparative peptidomics analysis of preeclamptic placenta and the identification of a novel bioactive SERPINA1 C-terminal peptide.

Jiang, Lingling / Zhu, Yuanyuan / Wu, Liuxin / Wang, Cong / Yang, Nana / Xu, Yetao / Sun, Lizhou

Reproductive biology

2024 Volume 24, Issue 1, Page(s) 100858

Abstract: Preeclampsia (PE) is a life-threatening disease that severely harms pregnant women and infants' health but has a poorly understood etiology. Peptidomics can supply important information about the occurrence of diseases. However, application of ... ...

Abstract	Preeclampsia (PE) is a life-threatening disease that severely harms pregnant women and infants' health but has a poorly understood etiology. Peptidomics can supply important information about the occurrence of diseases. However, application of peptidomics in preeclamptic placentas has never been reported. We conducted a comparative peptidomics analysis of PE placentas and performed bio-informatics analysis on differentially expressed peptides. Effects of differential peptide
MeSH term(s)	Animals ; Humans ; Pregnancy ; Female ; Zebrafish ; Pre-Eclampsia/metabolism ; Placenta/metabolism ; Trophoblasts/metabolism ; Peptides/metabolism ; Peptides/pharmacology ; Proteomics ; alpha 1-Antitrypsin/metabolism ; alpha 1-Antitrypsin/pharmacology
Chemical Substances	Peptides ; SERPINA1 protein, human ; alpha 1-Antitrypsin
Language	English
Publishing date	2024-01-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2189316-0
ISSN	2300-732X ; 1642-431X
ISSN (online)	2300-732X
ISSN	1642-431X
DOI	10.1016/j.repbio.2024.100858
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Article ; Online: Detection of Cancer-Derived Exosomes Using a Sensitive Colorimetric Aptasensor.

Xu, Lizhou / Al-Jamal, Khuloud T

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2504, Page(s) 21–30

Abstract: Exosomes are a type of extracellular vesicles that contain constituents including proteins, DNAs, and RNAs of the cells that secrete them. Cancerous exosomes are potential biomarkers for cancer diagnosis. Biosensors are useful analytical tools for ... ...

Abstract	Exosomes are a type of extracellular vesicles that contain constituents including proteins, DNAs, and RNAs of the cells that secrete them. Cancerous exosomes are potential biomarkers for cancer diagnosis. Biosensors are useful analytical tools for quantification of biomarkers and targeted molecules. An aptasensor uses the aptamer as the biorecognition element to bind to the target and is one main type of biosensors that is promising for exosomes analysis and clinical cancer detection. The assay described in this chapter allows for reliable, sensitive, and specific detection of cancer-derived exosomes using a colorimetric aptasensor that is promising for point-of-care testing.
MeSH term(s)	Aptamers, Nucleotide/metabolism ; Biosensing Techniques ; Colorimetry ; Exosomes/metabolism ; Humans ; Neoplasms/diagnosis ; Neoplasms/metabolism
Chemical Substances	Aptamers, Nucleotide
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2341-1_2
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Article ; Online: Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression.

Tang, Xiaotong / Cao, Yueying / Wu, Dan / Sun, Lizhou / Xu, Yetao

Reproductive biology and endocrinology : RB&E

2023 Volume 21, Issue 1, Page(s) 58

Abstract: Background: Preeclampsia (PE), a pregnancy complication characterized by new-onset hypertension and proteinuria during the second trimester, is the leading cause of neonatal and maternal morbidity and mortality. In the etiology of PE, failure of uterine ...

Abstract	Background: Preeclampsia (PE), a pregnancy complication characterized by new-onset hypertension and proteinuria during the second trimester, is the leading cause of neonatal and maternal morbidity and mortality. In the etiology of PE, failure of uterine spiral artery remodeling may be related to functioning abnormally of trophoblast cells, leading to the occurrence and progression of PE. Recently, long noncoding RNAs (lncRNAs) have been reported to play critical roles in PE nowadays. This study aimed to investigate the expression and functions of the TFPI2 pathway-related lncRNA DUXAP8. Methods: DUXAP8 expression in the placenta from pregnancies was examined using qPCR. Then, the in vitro functions of DUXAP8 were investigated through MTT, EdU, colony, transwell, and flow cytometry experiments. The downstream gene expression profiles were assessed using RNA transcriptome sequencing analysis and verified using qPCR and western blot. Furthermore, Immunoprecipitation (RIP), chromatin immunoprecipitation (CHIP) and fluorescence in situ hybridization (FISH) were used to detect the interaction between lncDUXAP8/EZH2/TFPI2. Results: The expression of lncRNA DUXAP8 in placenta of patients with eclampsia was significantly decreased. After knockout of DUXAP8, the proliferation and migration of trophoblasts were significantly decreased, and the percentage of apoptosis was increased. Flow cytometry showed that low expression of DUXAP8 increased the accumulation of cells in G2/M phase, while overexpression of DUXAP8 had the opposite effect. We also proved that DUXAP8 epigenetically inhibited TFPI2 expression by recruiting EZH2 and mediating H3K27me3 modification. Conclusion: Together, these resulting data clarify that aberrant expression of DUXAP8 is involved in the potential PE development and progress. Unraveling the role of DUXAP8 will provide novel insights into the pathogenesis of PE.
MeSH term(s)	Female ; Humans ; Pregnancy ; Cell Movement/genetics ; Cell Proliferation/genetics ; In Situ Hybridization, Fluorescence ; MicroRNAs/genetics ; Placenta/metabolism ; Pre-Eclampsia/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Trophoblasts/metabolism
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; long non-coding RNA DUXAP8, human
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2119215-7
ISSN	1477-7827 ; 1477-7827
ISSN (online)	1477-7827
ISSN	1477-7827
DOI	10.1186/s12958-023-01108-3
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Article ; Online: Protection of electroactive biofilms against hypersaline shock by quorum sensing.

Zhou, Shaofeng / An, Wenwen / Zhao, Kexin / Lin, Lizhou / Yang, Shan / Zhang, Yifeng / Xu, Meiying

Water research

2023 Volume 233, Page(s) 119823

Abstract: Quorum sensing (QS) is an ideal strategy for boosting the operating performance of electroactive biofilms (EABs), but its potential effects on the protection of electroactive biofilms against environmental shocks (e.g., hypersaline shock) have been ... ...

Abstract	Quorum sensing (QS) is an ideal strategy for boosting the operating performance of electroactive biofilms (EABs), but its potential effects on the protection of electroactive biofilms against environmental shocks (e.g., hypersaline shock) have been rarely revealed. In this study, a QS signaling molecule, the N-(3-oxo-dodecanoyl)-L-homoserine lactone, was employed to promote the anti-shock property of the EABs against extreme saline shock. The maximum current density of the QS-regulated biofilm recovered to 0.17 mA/cm
MeSH term(s)	Quorum Sensing ; Biofilms ; Lactones ; Bacteria ; Pseudomonas
Chemical Substances	Lactones
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.119823
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Article ; Online: Multicolor melting curve analysis discloses high carrier frequency of hearing loss-associated variants among neonates in Jiangsu province.

Liu, Yi / Zhang, Yuanyuan / Wang, Jue / Song, Shengnan / Wang, Huiyan / Meng, Qian / Zhan, Yuan / Xu, Yetao / Sun, Lizhou

Molecular genetics & genomic medicine

2024 Volume 12, Issue 2, Page(s) e2384

Abstract: Background: Genetic disorders ascribe to half of cases of congenital hearing loss. Hearing screening is significant in detecting hearing loss (HL) but weak at diagnosis, which can be complemented by genetic screening.: Methods: To find a feasible ... ...

Abstract	Background: Genetic disorders ascribe to half of cases of congenital hearing loss. Hearing screening is significant in detecting hearing loss (HL) but weak at diagnosis, which can be complemented by genetic screening. Methods: To find a feasible method to accomplish genetic screening and evaluate its advantage when combined with hearing screening, between 1 January 2022, and 10 December 2023, we performed an observational cohort study based on 2488 neonates from the Han population at three hospitals in Jiangsu province. Genetic screening for 20 variants in four common HL-associated genes by multicolor melting curve analysis (MMCA) and hearing screening were offered concurrently to all participants. Results: In total, 170 (6.8%) of 2488 eligible neonates were detected at least one variant and among them, the proportion of referral was higher (p < 0.05). Genetic screening combined with hearing screening was associated with a 25.0% increase (2 of 8) in discovering cases of diagnosed hearing loss that were missed by hearing screening. Conclusion: This study suggests that genetic screening combined with hearing screening by MMCA is effective at finding potential HL cases and practical to be validated in other places.
MeSH term(s)	Infant, Newborn ; Humans ; Hearing Loss/genetics ; Deafness ; Hearing ; Referral and Consultation
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.2384
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Article ; Online: Non-Covalent Functionalization of Graphene Oxide with POSS to Improve the Mechanical Properties of Epoxy Composites

Ting Xu / Yumin Jiao / Zhenglian Su / Qin Yin / Lizhou An / Yefa Tan

Polymers, Vol 15, Iss 24, p

2023 Volume 4726

Abstract: Phenyl polyhedral oligomeric silsesquioxane (POSS) is modified onto the GO surface by using the strong π–π coupling between a large number of benzene rings at the end of the phenyl POSS structure and the graphite structure in the GO sheet, realizing the ... ...

Abstract	Phenyl polyhedral oligomeric silsesquioxane (POSS) is modified onto the GO surface by using the strong π–π coupling between a large number of benzene rings at the end of the phenyl POSS structure and the graphite structure in the GO sheet, realizing the non-covalent functionalization of GO (POSS-GO). The POSS-GO-reinforced EP (POSS-GO/EP) composite material is prepared using the casting molding process. The surface morphology of GO before and after modification and its peel dispersion in EP are examined. Furthermore, the mechanical properties, cross-sectional morphology, and reinforcement mechanism of POSS-GO/EP are thoroughly examined. The results show that the cage-like skeleton structure of POSS is embedded between the GO layers, increasing the spacing between the GO layers and leading to a steric hindrance effect, which effectively prevents their stacking and aggregation and improves the dispersion performance of GO. In particular, the 0.4 phr POSS-GO/EP sample shows the best mechanical properties. This is because, on the one hand, POSS-GO is uniformly dispersed in the EP matrix, which can more efficiently induce crack deflection and bifurcation and can also cause certain plastic deformations in the EP matrix. On the other hand, the POSS-GO/EP fracture cross-section with a stepped morphology of interlaced “canine teeth” shape is rougher and more uneven, leading to more complex crack propagation paths and greater energy consumption. Moreover, the mechanical meshing effect between the rough POSS-GO surface and the EP matrix is stronger, which is conducive to the transfer of interfacial stress and the strengthening and toughening effects of POSS-GO.
Keywords	polyhedral oligomeric silsesquioxane ; graphene oxide ; non-covalent functionalization ; epoxy resin ; mechanical properties ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Study on the Construction of Dopamine/Poly(ethyleneimine)/Aminoated Carbon Nanotube Multilayer Films on Aramid Fiber Surfaces to Improve the Mechanical Properties of Aramid Fibers/Epoxy Composites.

Xu, Ting / Tian, Jin / An, Lizhou / Jiao, Yumin / Yin, Qin / Tan, Yefa

ACS omega

2022 Volume 7, Issue 40, Page(s) 35610–35625

Abstract: To improve the mechanical properties of aramid fiber (AF) reinforced epoxy resin (EP) composites without damaging the strength of the AF body, in this paper, poly(ethyleneimine) (PEI) and aminoated carbon nanotubes ( ... ...

Abstract	To improve the mechanical properties of aramid fiber (AF) reinforced epoxy resin (EP) composites without damaging the strength of the AF body, in this paper, poly(ethyleneimine) (PEI) and aminoated carbon nanotubes (NH
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03390
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Article ; Online: TET3-mediated novel regulatory mechanism affecting trophoblast invasion and migration: Implications for preeclampsia development.

Wang, Cong / Ju, Huihui / Zhou, Lihong / Zhu, Yuanyuan / Wu, Liuxin / Deng, Xiaokang / Jiang, Lingling / Sun, Lizhou / Xu, Yetao

Placenta

2024 Volume 147, Page(s) 31–41

Abstract: Introduction: Aberrant expression of genes has been demonstrated to be related to the abnormal function of trophoblasts and lead to the occurrence and progression of Preeclampsia (PE). However, the underlying mechanism of PE has not been elucidated.: ... ...

Abstract	Introduction: Aberrant expression of genes has been demonstrated to be related to the abnormal function of trophoblasts and lead to the occurrence and progression of Preeclampsia (PE). However, the underlying mechanism of PE has not been elucidated. Methods: We performed PCR analysis to investigate TET3 expression in PE placental tissues. Cell assays were performed in HTR-8/SVneo and JAR. Cell invasion and migration events were investigated by transwell assays in vitro. ChIP-PCR and Targeted bisulfite sequencing were conducted to detect the demethylation of related CpG sites in the KLF13 promoter after inhibition of TET3. In conjunction with bioinformatics analysis, luciferase reporter assays were performed to elucidate the mechanism by which miR-544 binds to TET3/KLF13 mRNA. Results: In this study, we identified genes associated with human extravillous trophoblasts by conducting sc-seq analysis from the GEO. Then, we measured the expression of TET3 in a larger clinical sample. The results showed that TET3, a DNA demethylase, was found to be expressed at much higher levels in the preeclamptic placenta compared to the control. Then, the inhibition of TET3 significantly promoted trophoblast cell migration and invasion. Conversely, TET3 overexpression suppressed cell migration and invasion in vitro. Further RNA sequencing and mechanism analysis indicated that the inhibition of TET3 suppressed the activation of KLF13 by reducing the demethylation of related CpG sites in the KLF13 promoter, thereby transcriptionally inactivating KLF13 expression. Moreover, luciferase reporter assay indicate that TET3 and KLF13 were direct targets of miR-544. Discussion: This study uncovers a TET3-mediated regulatory mechanism in PE progression and suggests that targeting the placental miR-544-TET3-KLF13-axis might provide new diagnostic and therapeutic strategies for PE.
MeSH term(s)	Humans ; Pregnancy ; Female ; Placenta/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pre-Eclampsia/metabolism ; Trophoblasts/metabolism ; Cell Movement/genetics ; Luciferases/metabolism ; Cell Proliferation ; Dioxygenases/metabolism
Chemical Substances	MicroRNAs ; Luciferases (EC 1.13.12.-) ; TET3 protein, human (EC 1.-) ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2024.01.010
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