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  1. Book ; Online: Dementia, Frailty and Aging

    Lim, Wee Shiong / Cesari, Matteo / Canevelli, Marco

    2018  

    Abstract: The number of older subjects is rapidly increasingly worldwide. As a consequence, the nature of clinical conditions is also changing. Traditional medicine and models of care have been based on the evaluation and treatment of single and usually acute ... ...

    Abstract The number of older subjects is rapidly increasingly worldwide. As a consequence, the nature of clinical conditions is also changing. Traditional medicine and models of care have been based on the evaluation and treatment of single and usually acute conditions occurring in relatively young individuals. Today, the usual clinical manifestation of diseases is characterized by multiple and often chronic conditions affecting older people. In this scenario, frailty and dementia have been triggering special interest both in research and clinical settings due to their high prevalence, impact on the individual's quality of life, and consequences for public health worldwide. These conditions aptly reflect the complexity of age-related pathological conditions, finding as causal factor a myriad of heterogeneous, interacting, and often still unclear pathophysiological processes. Indeed, their study is strongly affected by the difficulty to differentiate the effects of a normal aging process from eventual pathological deviations of the underlying systems. Their occurrence and trajectories over time are strongly affected by a wide array of factors and determinants that can be hardly attributed to the deficit/involvement of single biological systems and/or health domains. Moreover, environment and social factors also play a key role in the determination of phenotypes.The present Research Topic is aimed at widening our understanding of the frailty and dementia phenomena occurring with aging, in order to improve the clinical and public health approaches to these burdening conditions
    Keywords Medicine (General)
    Size 1 electronic resource (121 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101837
    ISBN 9782889455232 ; 2889455238
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: How many frailties exist?

    Cesari, Matteo / Canevelli, Marco

    The Lancet. Healthy longevity

    2021  Volume 2, Issue 10, Page(s) e615

    MeSH term(s) Frailty/diagnosis ; Humans ; Multivariate Analysis ; Survival Analysis
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Letter ; Comment
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(21)00225-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to "Frailty in multiple sclerosis: A closer look at the deficit accumulation framework".

    Belvisi, Daniele / Canevelli, Marco / Marfia, Girolama Alessandra / Ferraro, Elisabetta / Centonze, Diego / Salvetti, Marco / Conte, Antonella

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2022  Volume 28, Issue 6, Page(s) 1001–1002

    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585211068150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The many faces of brain aging.

    Marsili, Luca / Canevelli, Marco / Rodriguez-Porcel, Federico

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 1018238

    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1018238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Translation of Research on Sarcopenia Into Clinical Practice.

    Cesari, Matteo / Calvani, Riccardo / Canevelli, Marco / Marzetti, Emanuele

    Journal of the American Medical Directors Association

    2022  Volume 23, Issue 5, Page(s) 705–706

    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/therapy ; Translations
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2022.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Migration and dementia in Europe: towards a culturally competent approach and provision of care. Editorial.

    Canevelli, Marco / Vanacore, Nicola

    Annali dell'Istituto superiore di sanita

    2020  Volume 56, Issue 3, Page(s) 260–262

    MeSH term(s) Attitude of Health Personnel ; Cultural Competency ; Culture ; Delivery of Health Care ; Dementia/epidemiology ; Dementia/therapy ; Europe ; Human Migration ; Humans
    Language English
    Publishing date 2020-07-06
    Publishing country Italy
    Document type Editorial
    ZDB-ID 950344-4
    ISSN 2384-8553 ; 0021-2571
    ISSN (online) 2384-8553
    ISSN 0021-2571
    DOI 10.4415/ANN_20_03_02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: How many frailties exist?

    Matteo Cesari / Marco Canevelli

    The Lancet. Healthy Longevity, Vol 2, Iss 10, Pp e615- (2021)

    2021  

    Keywords Geriatrics ; RC952-954.6 ; Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Shifting the Focus of Dementia Prevention: Ethical Considerations.

    Blasimme, Alessandro / Canevelli, Marco / Cesari, Matteo

    AJOB neuroscience

    2021  Volume 12, Issue 4, Page(s) 240–242

    MeSH term(s) Dementia/diagnosis ; Dementia/epidemiology ; Dementia/prevention & control ; Humans ; Morals
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2576262-X
    ISSN 2150-7759 ; 2150-7740
    ISSN (online) 2150-7759
    ISSN 2150-7740
    DOI 10.1080/21507740.2021.1941405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transcranial direct current stimulation as a therapeutic opportunity in PSP.

    Vanacore, Nicola / Canevelli, Marco

    Neurology

    2019  Volume 93, Issue 6, Page(s) 235–236

    MeSH term(s) Humans ; Language ; Research Design ; Supranuclear Palsy, Progressive ; Transcranial Direct Current Stimulation
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of mild and complex multimorbidity with structural brain changes in older adults: A population-based study.

    Valletta, Martina / Vetrano, Davide Liborio / Calderón-Larrañaga, Amaia / Kalpouzos, Grégoria / Canevelli, Marco / Marengoni, Alessandra / Laukka, Erika J / Grande, Giulia

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 3, Page(s) 1958–1965

    Abstract: Introduction: We quantified the association of mild (ie, involving one or two body systems) and complex (ie, involving ≥3 systems) multimorbidity with structural brain changes in older adults.: Methods: We included 390 dementia-free participants aged ...

    Abstract Introduction: We quantified the association of mild (ie, involving one or two body systems) and complex (ie, involving ≥3 systems) multimorbidity with structural brain changes in older adults.
    Methods: We included 390 dementia-free participants aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen who underwent brain magnetic resonance imaging at baseline and after 3 and/or 6 years. Using linear mixed models, we estimated the association between multimorbidity and changes in total brain tissue, ventricular, hippocampal, and white matter hyperintensities volumes.
    Results: Compared to non-multimorbid participants, those with complex multimorbidity showed the steepest reduction in total brain (β*time -0.03, 95% CI -0.05, -0.01) and hippocampal (β*time -0.05, 95% CI -0.08, -0.03) volumes, the greatest ventricular enlargement (β*time 0.03, 95% CI 0.01, 0.05), and the fastest white matter hyperintensities accumulation (β*time 0.04, 95% CI 0.01, 0.07).
    Discussion: Multimorbidity, particularly when involving multiple body systems, is associated with accelerated structural brain changes, involving both neurodegeneration and vascular pathology.
    Highlights: Multimorbidity accelerates structural brain changes in cognitively intact older adults These brain changes encompass both neurodegeneration and cerebrovascular pathology The complexity of multimorbidity is associated with the rate of brain changes' progression.
    MeSH term(s) Humans ; Aged ; Multimorbidity ; Brain/diagnostic imaging ; Brain/pathology ; Aging/pathology ; Magnetic Resonance Imaging ; Sweden/epidemiology
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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