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Article ; Online: Regarding "Is 16 Months of Specialized Nuclear Medicine Training Enough for Best Patient Care?"

Wing-Chuen Lam, Winnie

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2017 Volume 59, Issue 3, Page(s) 545

MeSH term(s)	Humans ; Nuclear Medicine ; Patient Care ; Radionuclide Imaging
Language	English
Publishing date	2017-10-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.117.203240
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article: Semi-quantitative indices of 2-[

Chen, Mingwei / Tang, Charlene Yu Lin / Fong, Warren Weng Seng / Lam, Winnie Wing-Chuen

EJNMMI research

2023 Volume 13, Issue 1, Page(s) 22

Abstract: Background: IgG4-related disease (IgG4-RD) is a heterogeneous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as 2-[: Methods: Patients diagnosed with IgG4-RD who underwent a 2-[: Results: Forty-six patients ... ...

Abstract	Background: IgG4-related disease (IgG4-RD) is a heterogeneous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as 2-[ Methods: Patients diagnosed with IgG4-RD who underwent a 2-[ Results: Forty-six patients identified were divided into an eight member subgroup of patients with cardiovascular manifestations, and a thirty-eight member subgroup of patients without. Patients with cardiovascular lesions were most frequently identified incidentally on imaging evaluation for other diseases (37.5%), with none presenting with chest pain or other cardiovascular symptoms. Ten patients with pre-treatment and post-treatment 2-[ Conclusion: 2-[
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-023-00972-9
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Article ; Online: The Curious Case of the Missing Limb on FDG PET Imaging.

Tay, Wan Jiun / Teh, Daniel Jing Wen / Qin, Yan / Lam, Winnie Wing-Chuen

Clinical nuclear medicine

2023 Volume 49, Issue 2, Page(s) 185–187

Abstract: Abstract: A 58-year-old woman with poorly controlled diabetes, peripheral vascular disease, and end-stage renal disease requiring hemodialysis was referred for 18 F-FDG PET/CT to evaluate for source of sepsis. She had history of prior left forefoot and ... ...

Abstract	Abstract: A 58-year-old woman with poorly controlled diabetes, peripheral vascular disease, and end-stage renal disease requiring hemodialysis was referred for 18 F-FDG PET/CT to evaluate for source of sepsis. She had history of prior left forefoot and right second toe amputation, as well as left lower-limb dry gangrene for which she declined surgical management. We present a case of a nonamputated lower limb demonstrating regions of absolute photopenia, consistent with dry gangrene.
MeSH term(s)	Female ; Humans ; Middle Aged ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Gangrene ; Positron-Emission Tomography ; Foot
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004999
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Zs.A 1276: Show issues

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Article ; Online: Safety and efficacy of peptide receptor radionuclide therapy in patients with advanced pheochromocytoma and paraganglioma: A single-institution experience and review of the literature.

Tang, Charlene Yu Lin / Chua, Wei Ming / Huang, Hian Liang / Lam, Winnie Wing-Chuen / Loh, Lih Ming / Tai, David / Ong, Simon Yew Kuang / Yan, Sean Xuexian / Loke, Kelvin S H / Ng, David Chee-Eng / Tham, Wei Ying

Journal of neuroendocrinology

2023 Volume 35, Issue 12, Page(s) e13349

Abstract: Introduction: Despite advances in diagnosis and management, patients with advanced pheochromocytomas and paragangliomas (PPGL) face limited treatment options. This study aims to evaluate the safety and efficacy of peptide receptor radionuclide therapy ( ... ...

Abstract	Introduction: Despite advances in diagnosis and management, patients with advanced pheochromocytomas and paragangliomas (PPGL) face limited treatment options. This study aims to evaluate the safety and efficacy of peptide receptor radionuclide therapy (PRRT) in patients with advanced PPGL, based on a single-institution experience and provide a comprehensive review of the literature. Methods: A retrospective analysis was conducted on patients with advanced pheochromocytoma and paraganglioma who received PRRT at a single institution from April 2012 to March 2022. Clinical characteristics, treatment response, adverse events, and survival outcomes were assessed. A systematic literature review was also performed. Results: A total of 15 patients with advanced PPGL were included, the majority of whom had both metastatic and functional disease. Most patients received four infusions of 177Lu-DOTATATE (73%). The median therapeutic 177Lu-DOTATATE radioactivity for each infusion was 7.4 GBq. Only one patient was treated with one infusion of 90Y-DOTATATE (4.2 GBq) in addition to three infusions of Lu-177 DOTATATE. Overall, PRRT suggests a promising efficacy with disease control rate of 63.6% by RECIST v1.1. The median overall survival (OS) was not reached and the median progression free survival (PFS) was 25.9 months. In terms of safety, PRRT was well tolerated. Review of the literature revealed consistent findings, supporting the efficacy and safety of PRRT in PPGL. Conclusion: This study suggests that PRRT is a safe and effective therapeutic option for patients with PPGL. Our findings align with the existing literature, providing additional evidence to support the use of PRRT in this challenging patient population.
MeSH term(s)	Humans ; Pheochromocytoma/radiotherapy ; Yttrium Radioisotopes ; Retrospective Studies ; Paraganglioma/radiotherapy ; Adrenal Gland Neoplasms/radiotherapy ; Receptors, Peptide
Chemical Substances	Yttrium-90 (1K8M7UR6O1) ; Yttrium Radioisotopes ; Receptors, Peptide
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.13349
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Zs.A 2634: Show issues

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Article ; Online: Outcomes and prognostic predictors of Lu-177 PSMA radioligand therapy in metastatic castration-resistant prostate cancer (Asian Population Study).

Chua, Wei Ming / Lam, Winnie Wing-Chuen / Tong, Aaron Kian-Ti / Sultana, Rehena / Kua, Sandra Mei Yu / Kanesvaran, Ravindran / Wong, Alvin Seng Cheong / Tay, Kae Jack / Cheng, Tai Jit Lenith / Ng, David Chee Eng / Thang, Sue Ping

Asia-Pacific journal of clinical oncology

2023

Abstract: Aim: Lutetium-177 (Lu-177) prostate-specific membrane antigen radioligand therapy (PSMA-RLT) is a promising therapy for metastatic castration-resistant prostate cancer (mCRPC), but there is limited data of its efficacy and safety in Asian population. We ...

Abstract	Aim: Lutetium-177 (Lu-177) prostate-specific membrane antigen radioligand therapy (PSMA-RLT) is a promising therapy for metastatic castration-resistant prostate cancer (mCRPC), but there is limited data of its efficacy and safety in Asian population. We aim to explore the clinical outcomes of Lu-177 PSMA-RLT in this population. Methods: We evaluated 84 patients with progressive mCRPC receiving Lu-177 PSMA-RLT between 9 May 2018 and 21 February 2022. Lu-177-PSMA-I&T was administered at 6-8-week intervals. Primary end point was overall survival (OS), and secondary end points included prostate-specific antigen (PSA) progression-free survival (PFS), PSA response rate, clinical response, toxicity assessment, and prognostic indicators. Results: The median OS and PSA PFS were 12.2 and 5.2 months, respectively. PSA decline of ≥50% was observed in 51.8% of patients. Patients achieving PSA response had longer median OS (15.0 vs. 9.5 months, p = .03) and PSA PFS (6.5 vs. 2.9 months, p < .001). Pain score improvement was seen in 19 out of 34 patients. A hematotoxicity of ≥grade 3 was observed in 13 out of 78 patients. Multivariable analyses showed that PSA velocity, alkaline phosphatase, hemoglobin (Hb), and the number of treatment cycles were independent prognostic indicators for OS. The retrospective design was the main limitation of the study. Conclusions: Our study demonstrated a similar safety and efficacy of Lu-177 PSMA-RLT in Asian mCRPC patients compared to the existing literature. A PSA decline ≥50% was associated with longer OS and PSA PFS. Several prognostic indicators for patient outcomes were also identified.
Language	English
Publishing date	2023-03-31
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.13944
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Article ; Online: Facing a disruptive threat: how can a nuclear medicine service be prepared for the coronavirus outbreak 2020?

Lam, Winnie Wing-Chuen / Loke, Kelvin Siu-Hoong / Wong, Wai Yin / Ng, David Chee-Eng

European journal of nuclear medicine and molecular imaging

2020 Volume 47, Issue 7, Page(s) 1645–1648

Abstract: Purpose: The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore.: Methods: We describe the key considerations of policies and processes that ... ...

Abstract	Purpose: The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore. Methods: We describe the key considerations of policies and processes that have been implemented in our nuclear medicine service since the first case of COVID-19 was confirmed in Singapore General Hospital on 23 January 2020, up to the present time. Results: Infection control, screening of patients and visitors, segregation of risk groups, segregation of staff and service continuity plans, communication and staff welfare, using electronic platforms for multi-disciplinary meetings and tele-reporting are discussed. Conclusion: Since our hospital received the first patient with COVID-19 in Singapore, our centre has managed 16 COVID-19 cases to date. There has not been any healthcare worker in our institution who has contracted COVID-19 through patient contact. We have highlighted for discussion some of the policies and processes to prepare a nuclear medicine service for the COVID-19 threat.
MeSH term(s)	COVID-19 ; Communication ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks ; Humans ; Nuclear Medicine ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Research Report ; Risk ; Safety
Keywords	covid19
Language	English
Publishing date	2020-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-020-04790-2
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Zs.A 1227: Show issues

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Article ; Online: 18

Tang, Charlene Yu Lin / Chua, Wei Ming / Cheng, Lenith Tai Jit / Fong, Warren / Zaheer, Sumbul / Lam, Winnie Wing-Chuen

The British journal of radiology

2021 Volume 94, Issue 1124, Page(s) 20210105

Abstract: Immunoglobulin G4-related disease (IgG4-RD) was not recognised as a systemic condition until 2003, when extra pancreatic manifestations were identified in patients with autoimmune pancreatitis. Since then, IgG4-RD has been described to involve virtually ... ...

Abstract	Immunoglobulin G4-related disease (IgG4-RD) was not recognised as a systemic condition until 2003, when extra pancreatic manifestations were identified in patients with autoimmune pancreatitis. Since then, IgG4-RD has been described to involve virtually every organ system. It is highly responsive to immunosuppressants but can have detrimental effects if left untreated. Early recognition of the disease is, therefore, critical. The diagnosis of IgG4-RD is frequently challenging owing to its non-specific clinical manifestations, indolent nature and broad differential diagnoses. Although histopathological examination remains the cornerstone of diagnosis, imaging plays an important role in establishing extent of disease and identifying areas suitable for biopsy.
MeSH term(s)	Adult ; Aged ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunoglobulin G4-Related Disease/diagnostic imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20210105
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Article ; Online: Myoepithelial hyperplasia: A rare mimic of breast cancer on

Tang, Charlene Yu Lin / Lam, Winnie Wing-Chuen / Tan, Puay Hoon / Xie, Wanying / Peh, Wee Ming / Tan, Veronique Kiak-Mien / Leong, Lester Chee Hao

The breast journal

2019 Volume 26, Issue 4, Page(s) 775–777

MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Hyperplasia/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2019-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13643
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Zs.A 4483: Show issues

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Article ; Online: Radiolabeled Liposomes for Nuclear Imaging Probes.

Low, Ho Ying / Yang, Chang-Tong / Xia, Bin / He, Tao / Lam, Winnie Wing Chuen / Ng, David Chee Eng

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 9

Abstract: Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide. Current preclinical ... ...

Abstract	Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide. Current preclinical and clinical radiotracers, so-called nuclear imaging probes, are radioisotope-labeled small molecules. Liposomal radiotracers have been rapidly developing as novel nuclear imaging probes. The physicochemical properties and structural characteristics of liposomes have been elucidated to address their long circulation and stability as radiopharmaceuticals. Various radiolabeling methods for synthesizing radionuclides onto liposomes and synthesis strategies have been summarized to render them biocompatible and enable specific targeting. Through a variety of radionuclide labeling methods, radiolabeled liposomes for use as nuclear imaging probes can be obtained for in vivo biodistribution and specific targeting studies. The advantages of radiolabeled liposomes including their use as potential clinical nuclear imaging probes have been highlighted. This review is a comprehensive overview of all recently published liposomal SPECT and PET imaging probes.
MeSH term(s)	Liposomes/chemistry ; Tissue Distribution ; Radioisotopes ; Tomography, Emission-Computed, Single-Photon/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/chemistry
Chemical Substances	Liposomes ; Radioisotopes ; Radiopharmaceuticals
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28093798
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Zs.MO 81: Show issues

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Article: Facing a disruptive threat: how can a nuclear medicine service be prepared for the coronavirus outbreak 2020?

Lam, Winnie Wing-Chuen / Loke, Kelvin Siu-Hoong / Wong, Wai Yin / Ng, David Chee-Eng

Eur J Nucl Med Mol Imaging

Abstract: PURPOSE: The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore. METHODS: We describe the key considerations of policies and processes that have ... ...

Abstract	PURPOSE: The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore. METHODS: We describe the key considerations of policies and processes that have been implemented in our nuclear medicine service since the first case of COVID-19 was confirmed in Singapore General Hospital on 23 January 2020, up to the present time. RESULTS: Infection control, screening of patients and visitors, segregation of risk groups, segregation of staff and service continuity plans, communication and staff welfare, using electronic platforms for multi-disciplinary meetings and tele-reporting are discussed. CONCLUSION: Since our hospital received the first patient with COVID-19 in Singapore, our centre has managed 16 COVID-19 cases to date. There has not been any healthcare worker in our institution who has contracted COVID-19 through patient contact. We have highlighted for discussion some of the policies and processes to prepare a nuclear medicine service for the COVID-19 threat.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #19581
Database	COVID19

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