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  1. Article: Facing challenges with the novel coronavirus SARS-CoV-2 outbreak

    van der Werf, Sylvie / Peltekian, Cécile

    Virologie (Montrouge, France)

    2020  Volume 24, Issue S1, Page(s) e12–15

    Title translation Facing challenges with the novel coronavirus SARS-CoV-2 outbreak.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/prevention & control ; Communicable Diseases, Emerging/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Global Health/trends ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2020.0826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 Omicron emergence urges for reinforced One-Health surveillance.

    Montagutelli, Xavier / van der Werf, Sylvie / Rey, Felix A / Simon-Loriere, Etienne

    EMBO molecular medicine

    2022  Volume 14, Issue 3, Page(s) e15558

    Abstract: SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents. Wild animal reservoirs could favor the emergence of new variants with risks of spillback to humans and should be ... ...

    Abstract SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents. Wild animal reservoirs could favor the emergence of new variants with risks of spillback to humans and should be closely monitored.
    MeSH term(s) Animals ; COVID-19/epidemiology ; COVID-19/virology ; Humans ; One Health ; Population Surveillance ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202115558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Influenza B Virus Infection Is Enhanced Upon Heterotypic Co-infection With Influenza A Virus.

    Malausse, Nicolas / van der Werf, Sylvie / Naffakh, Nadia / Munier, Sandie

    Frontiers in microbiology

    2021  Volume 12, Page(s) 631346

    Abstract: Homotypic co-infections with influenza viruses are described to increase genetic population diversity, to drive viral evolution and to allow genetic complementation. Less is known about heterotypic co-infections between influenza A (IAV) and influenza B ( ...

    Abstract Homotypic co-infections with influenza viruses are described to increase genetic population diversity, to drive viral evolution and to allow genetic complementation. Less is known about heterotypic co-infections between influenza A (IAV) and influenza B (IBV) viruses. Previous publications showed that IAV replication was suppressed upon co-infection with IBV. However, the effect of heterotypic co-infections on IBV replication was not investigated. To do so, we produced by reverse genetics a pair of replication-competent recombinant IAV (A/WSN/33) and IBV (B/Brisbane/60/2008) expressing a GFP and mCherry fluorescent reporter, respectively. A549 cells were infected simultaneously or 1 h apart at a high MOI with IAV-GFP or IBV-mCherry and the fluorescence was measured at 6 h post-infection by flow cytometry. Unexpectedly, we observed that IBV-mCherry infection was enhanced upon co-infection with IAV-GFP, and more strongly so when IAV was added 1 h prior to IBV. The same effect was observed with wild-type viruses and with various strains of IAV. Using UV-inactivated IAV or type-specific antiviral compounds, we showed that the enhancing effect of IAV infection on IBV infection was dependent on transcription/replication of the IAV genome. Our results, taken with available data in the literature, support the hypothesis that the presence of IAV proteins can enhance IBV genome expression and/or complement IBV defective particles.
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.631346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options.

    Znaidia, Mariem / Demeret, Caroline / van der Werf, Sylvie / Komarova, Anastassia V

    Viruses

    2022  Volume 14, Issue 6

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to circumvent the innate immune response. The early interferon (IFN) response is necessary ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to circumvent the innate immune response. The early interferon (IFN) response is necessary to establish a robust antiviral state. However, this response is weak and delayed in COVID-19 patients, along with massive pro-inflammatory cytokine production. This dysregulated innate immune response contributes to pathogenicity and in some individuals leads to a critical state. Characterizing the interplay between viral factors and host innate immunity is crucial to better understand how to manage the disease. Moreover, the constant emergence of new SARS-CoV-2 variants challenges the efficacy of existing vaccines. Thus, to control this virus and readjust the antiviral therapy currently used to treat COVID-19, studies should constantly be re-evaluated to further decipher the mechanisms leading to SARS-CoV-2 pathogenesis. Regarding the role of the IFN response in SARS-CoV-2 infection, in this review we summarize the mechanisms by which SARS-CoV-2 evades innate immune recognition. More specifically, we explain how this virus inhibits IFN signaling pathways (IFN-I/IFN-III) and controls interferon-stimulated gene (ISG) expression. We also discuss the development and use of IFNs and potential drugs controlling the innate immune response to SARS-CoV-2, helping to clear the infection.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Immune Evasion ; Immunity, Innate ; Interferon Type I ; Interferons/therapeutic use ; Pandemics ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Interferon Type I ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14061247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Detection of

    Bratuleanu, Bianca Elena / Temmam, Sarah / Munier, Sandie / Chrétien, Delphine / Bigot, Thomas / van der Werf, Sylvie / Savuta, Gheorghe / Eloit, Marc

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 863814

    Abstract: Ticks are involved in the transmission of various pathogens and several tick-borne diseases cause significant problems for the health of humans and livestock. The members of ... ...

    Abstract Ticks are involved in the transmission of various pathogens and several tick-borne diseases cause significant problems for the health of humans and livestock. The members of the
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.863814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance

    Xavier Montagutelli / Sylvie van der Werf / Felix A Rey / Etienne Simon‐Loriere

    EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)

    2022  

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Facing challenges with the novel coronavirus SARS-CoV-2 outbreak./ Facing challenges with the novel coronavirus SARS-CoV-2 outbreak

    van der Werf, Sylvie / Peltekian, Cécile

    Virologie (Montrouge)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #9648
    Database COVID19

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  8. Article ; Online: Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages.

    Touret, Franck / Giraud, Emilie / Bourret, Jérôme / Donati, Flora / Tran-Rajau, Jaouen / Chiaravalli, Jeanne / Lemoine, Frédéric / Agou, Fabrice / Simon-Lorière, Etienne / van der Werf, Sylvie / de Lamballerie, Xavier

    iScience

    2023  Volume 26, Issue 4, Page(s) 106413

    Abstract: The landscape of SARS-CoV-2 variants dramatically diversified with the simultaneous appearance of multiple subvariants originating from BA.2, BA.4, and BA.5 Omicron sub-lineages. They harbor a specific set of mutations in the spike that can make them ... ...

    Abstract The landscape of SARS-CoV-2 variants dramatically diversified with the simultaneous appearance of multiple subvariants originating from BA.2, BA.4, and BA.5 Omicron sub-lineages. They harbor a specific set of mutations in the spike that can make them more evasive to therapeutic monoclonal antibodies. In this study, we compared the neutralizing potential of monoclonal antibodies against the Omicron BA.2.75.2, BQ.1, BQ.1.1, and XBB variants, with a pre-Omicron Delta variant as a reference. Sotrovimab retains some activity against BA.2.75.2, BQ.1, and XBB as it did against BA.2/BA.5, but is less active against BQ.1.1. Within the Evusheld/AZD7442 cocktail, Cilgavimab lost all activity against all subvariants studied, resulting in loss of Evusheld activity. Finally, Bebtelovimab, while still active against BA.2.75, also lost all neutralizing activity against BQ.1, BQ.1.1, and XBB variants.
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Beta SARS-CoV-2 variant and BNT162b2 vaccine effectiveness in long-term care facilities in France.

    Lefèvre, Benjamin / Tondeur, Laura / Madec, Yoann / Grant, Rebecca / Lina, Bruno / van der Werf, Sylvie / Rabaud, Christian / Fontanet, Arnaud

    The Lancet. Healthy longevity

    2021  Volume 2, Issue 11, Page(s) e685–e687

    MeSH term(s) BNT162 Vaccine ; COVID-19 ; Humans ; Long-Term Care ; SARS-CoV-2 ; Vaccine Efficacy
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(21)00230-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.

    Hérate, Cécile / Marlin, Romain / Touret, Franck / Dereuddre-Bosquet, Nathalie / Donati, Flora / Relouzat, Francis / Junges, Laura / Galhaut, Mathilde / Dehan, Océane / Sconosciuti, Quentin / Nougairède, Antoine / de Lamballerie, Xavier / van der Werf, Sylvie / Le Grand, Roger

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16664

    Abstract: The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19. Recently, ... ...

    Abstract The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19. Recently, both
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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