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  1. Book ; Thesis: Staphylococcus aureus pathogenesis

    Garcia-Moreno, Marina / Tuchscherr, Lorena / Löffler, Bettina / Zipfel, Peter F. / Ignatius, Anita

    the role of different host cell types during the passage from sepsis to chronic osteomyelitis

    2021  

    Institution Friedrich-Schiller-Universität Jena
    Author's details from M. Sc. Marina Garcia Moreno
    Keywords Staphylococcus aureus ; Osteomyelitis ; Osteozyt
    Subject Knochenzelle ; Knochenmarkentzündung ; Myelitis ; Knochenmark
    Language English ; German
    Size 81 Seiten, Illustrationen, Diagramme, 30 Seiten
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2021
    Note Tag der Verteidigung: 04.05.2021
    HBZ-ID HT021003374
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Die Rolle des Komplementsystems bei Nierenerkrankungen – Neue Aspekte.

    Zipfel, Peter F / Zipfel, Svante / Wiech, Thorsten

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 12, Page(s) 774–779

    Abstract: Complement is a central part of the immune system. In the human body, complement is responsible for recognition of infectious microbes, for coordinating the adaptive immune response, controlling homeotic reactions and for the non-inflammatory removal of ... ...

    Title translation Role of Complement in Kidney Diseases - New Aspects.
    Abstract Complement is a central part of the immune system. In the human body, complement is responsible for recognition of infectious microbes, for coordinating the adaptive immune response, controlling homeotic reactions and for the non-inflammatory removal of modified self-cells and infectious microbes. Complement is also closely linked to another proteolytic cascade, the coagulation system. Defective activation and altered complement regulation drives pathology of several severe human kidney diseases.This manuscript summarizes the latest developments on the role of complement in kidney diseases, on new complement inhibitors and on recent complement targeting therapies. In particular focusing on diseases (1) atypical Hemolytic Uremic Syndrome, (2) C3 Glomerulopathy, (3) Anti Neutrophil Cytoplasmic Antibody Mediated Vasculitis, (4) IgA Nephropathy, (5) Membranous Glomerulopathy, (6) Systemic Lupus Erythematosus, (7) Transplant rejection and (8) COVID 19 Infection-Triggered Kidney Diseases. More excitement is generated in this field, as more and more complement mediated diseases can be treated. Several complement targeting compounds are approved by the EMA and FDA and an increasing number of new candidates are in late phase clinical trials. In addition, clinical guidelines are developed for Diagnosis and Therapy of complement mediated diseases, new biomarkers are evaluated in clinical studies, and diagnostic guidelines are in development. The recent Covid infections showed a clear link of complement in thrombo inflammation, which ultimately results in kidney damage. These aspects have increased further the focus of complement inhibitors in COVID infections.
    MeSH term(s) Humans ; Complement Activation ; COVID-19 ; Complement System Proteins/therapeutic use ; Kidney Diseases/drug therapy ; Complement Inactivating Agents/therapeutic use ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; Kidney/pathology
    Chemical Substances Complement System Proteins (9007-36-7) ; Complement Inactivating Agents
    Language German
    Publishing date 2023-05-31
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1936-6697
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  3. Article ; Online: From magic bullets to modern therapeutics: Paul Ehrlich, the German immunobiologist and physician coined the term 'complement'.

    Zipfel, Peter F / Skerka, Christine

    Molecular immunology

    2022  Volume 150, Page(s) 90–98

    Abstract: Paul Ehrlich was a pioneering Immunobiologist and physician who coined the term 'complement' in the year 1899. He was a leading visionary scientist who worked in the late 19th and early 20th centuries in Berlin and Frankfurt. He received numerous awards ... ...

    Abstract Paul Ehrlich was a pioneering Immunobiologist and physician who coined the term 'complement' in the year 1899. He was a leading visionary scientist who worked in the late 19th and early 20th centuries in Berlin and Frankfurt. He received numerous awards and honors for his substantial contributions to immunobiology and medicine, including the identification of complement, and he received the Nobel Prize in Physiology or Medicine in 1908 in recognition of his work on immunity. During his clinical work, Paul Ehrlich treated a patient with paroxysmal hemoglobinuria and reported his diagnostic approaches, including those related to erythrocyte lysis and microscopic cell analysis, to the Verein für Innere Medicine/Society of Internal Medicine, Berlin. Paroxysmal nocturnal hemoglobinuria was shown to be a complement-mediated disease; treatment of this disease with the complement inhibitor Eculzimab/Soliris was approved by the European Medicines Agency in 2003 and by the United States Food and Drug Administration in 2007.
    MeSH term(s) Complement Inactivating Agents ; History, 20th Century ; Humans ; Male ; Nobel Prize ; Physicians ; United States
    Chemical Substances Complement Inactivating Agents
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2022.08.002
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  4. Book: Complement and kidney disease

    Zipfel, Peter F.

    (Progress in inflammation research)

    2006  

    Author's details Peter F. Zipfel, ed
    Series title Progress in inflammation research
    Keywords Kidney Diseases / etiology ; Complement System Proteins / physiology ; Hemolytic-Uremic Syndrome ; Nierenkrankheit ; Komplement
    Subject Complement ; Komplementsystem ; Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie
    Language English
    Size XVI, 236 S. : Ill., graph. Darst., 24 cm
    Publisher Birkhäuser
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014594635
    ISBN 978-3-7643-7166-1 ; 3-7643-7166-8
    Database Catalogue ZB MED Medicine, Health

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  5. Article: From magic bullets to modern therapeutics: Paul Ehrlich, the German immunobiologist and physician coined the term ‘complement’

    Zipfel, Peter F. / Skerka, Christine

    Molecular immunology. 2022 Oct., v. 150

    2022  

    Abstract: Paul Ehrlich was a pioneering Immunobiologist and physician who coined the term ‘complement’ in the year 1899. He was a leading visionary scientist who worked in the late 19th and early 20th centuries in Berlin and Frankfurt. He received numerous awards ... ...

    Abstract Paul Ehrlich was a pioneering Immunobiologist and physician who coined the term ‘complement’ in the year 1899. He was a leading visionary scientist who worked in the late 19th and early 20th centuries in Berlin and Frankfurt. He received numerous awards and honors for his substantial contributions to immunobiology and medicine, including the identification of complement, and he received the Nobel Prize in Physiology or Medicine in 1908 in recognition of his work on immunity. During his clinical work, Paul Ehrlich treated a patient with paroxysmal hemoglobinuria and reported his diagnostic approaches, including those related to erythrocyte lysis and microscopic cell analysis, to the Verein für Innere Medicine/Society of Internal Medicine, Berlin. Paroxysmal nocturnal hemoglobinuria was shown to be a complement-mediated disease; treatment of this disease with the complement inhibitor Eculzimab/Soliris was approved by the European Medicines Agency in 2003 and by the United States Food and Drug Administration in 2007.
    Keywords Nobel Prize ; complement ; erythrocytes ; hemoglobinuria ; immunity ; medicine ; patients ; physiology ; scientists ; therapeutics
    Language English
    Dates of publication 2022-10
    Size p. 90-98.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2022.08.002
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Die Rolle des Komplementsystems bei Nierenerkrankungen – Neue Aspekte

    Zipfel, Peter F. / Zipfel, Svante / Wiech, Thorsten

    DMW - Deutsche Medizinische Wochenschrift

    2023  Volume 148, Issue 12, Page(s) 774–779

    Abstract: Genaue Darstellung von Komplement bei Nierenerkrankungen nachgewiesen : Eine fehlerhafte Komplementaktivierung bzw. eine defekte, unpräzise Regulation von einzelnen Reaktionen dieses Immunsystems sind in der Zwischenzeit bei mehreren unterschiedlichen ... ...

    Abstract Genaue Darstellung von Komplement bei Nierenerkrankungen nachgewiesen : Eine fehlerhafte Komplementaktivierung bzw. eine defekte, unpräzise Regulation von einzelnen Reaktionen dieses Immunsystems sind in der Zwischenzeit bei mehreren unterschiedlichen Nierenerkrankungen klar aufgezeigt worden.
    Komplementdefekte sind therapierbar : Die komplementvermittelten Pathophysiologien bei den einzelnen Erkrankungen zeigen häufig eine stetige Überaktivierung einzelner Reaktionsschritte. Das genaue Verständnis dieser Mechanismen, die oft einhergehen mit Entzündungsreaktionen, Zellrekrutierung und Zellschädigung, erlauben eine gezielte Target-Identifizierung und den Einsatz von neuen Wirkstoffen. Aktuell gibt es eine Reihe von therapeutischen Wirkstoffen, die in die Komplementkaskade eingreifen. Mehrere Wirkstoffe sind schon für den therapeutischen Einsatz zugelassen, andere befinden sich in fortgeschrittener klinischer Erprobung und sind auf dem Weg zu einer Zulassung. Bei den Wirkstoffklassen für Nierenerkrankungen handelt es sich um monoklonale Antikörper, Nanobodies, die von der variablen Domäne von einzelsträngigen Lama- oder Kameliden-Antikörpern abgeleitet sind, kleine chemische Verbindungen, RNA-basierte Moleküle, sowie rekombinante Proteine.
    Diagnostik von Komplement-Erkrankungen : Aktuell werden Leitlinien zu unterschiedlichen Aspekten der Rolle des Komplementsystems bei Nierenerkrankungen erstellt. Viele der für die Komplement-Diagnostik relevanten Untersuchungen werden häufig nur von Speziallaboren angeboten.
    Präzisierung von Biomarkern in klinischen Studien und Diagnostik-Leitfaden : Die Identifikation von selektiven krankheitsspezifischen Biomarkern ist hochrelevant. Sie sind für die präzise Diagnose und für das Monitoring nach einer (komplement-)gerichteten Therapie von größter Bedeutung.
    Komplement-Infektionen – Covid und Nierenerkrankung : Bei COVID-19-Infektionen hat sich gezeigt, dass das stark aktivierte Komplementsystem zur Thromboinflammation und Schädigung der Niere beiträgt und einen erheblichen Faktor bei dieser Infektion darstellt.
    Keywords Komplement-System ; Komplement-Therapie ; Nierenerkrankungen ; Komplement-Diagnostik ; Infektions-getriggerte Komplement-Aktivierung ; complement ; treatment of complement mediated diseases ; kidney diseases ; diagnosis of complement mediated diseases ; infection-induced complement acitvation
    Language German
    Publishing date 2023-05-31
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1936-6697
    Database Thieme publisher's database

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  7. Article ; Online: The Binding of the SARS-CoV-2 Spike Protein to Platelet Factor 4: A Proposed Mechanism for the Generation of Pathogenic Antibodies.

    Nguyen, Thi-Huong / Chen, Li-Yu / Khan, Nida Zaman / Lindenbauer, Annerose / Bui, Van-Chien / Zipfel, Peter F / Heinrich, Doris

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Pathogenic platelet factor 4 (PF4) antibodies contributed to the abnormal coagulation profiles in COVID-19 and vaccinated patients. However, the mechanism of what triggers the body to produce these antibodies has not yet been clarified. Similar patterns ... ...

    Abstract Pathogenic platelet factor 4 (PF4) antibodies contributed to the abnormal coagulation profiles in COVID-19 and vaccinated patients. However, the mechanism of what triggers the body to produce these antibodies has not yet been clarified. Similar patterns and many comparable features between the COVID-19 virus and heparin-induced thrombocytopenia (HIT) have been reported. Previously, we identified a new mechanism of autoimmunity in HIT in which PF4-antibodies self-clustered PF4 and exposed binding epitopes for other pathogenic PF4/eparin antibodies. Here, we first proved that the SARS-CoV-2 spike protein (SP) also binds to PF4. The binding was evidenced by the increase in mass and optical intensity as observed through quartz crystal microbalance and immunosorbent assay, while the switching of the surface zeta potential caused by protein interactions and binding affinity of PF4-SP were evaluated by dynamic light scattering and isothermal spectral shift analysis. Based on our results, we proposed a mechanism for the generation of PF4 antibodies in COVID-19 patients. We further validated the changes in zeta potential and interaction affinity between PF4 and SP and found that their binding mechanism differs from ACE2-SP binding. Importantly, the PF4/SP complexes facilitate the binding of anti-PF4/Heparin antibodies. Our findings offer a fresh perspective on PF4 engagement with the SARS-CoV-2 SP, illuminating the role of PF4/SP complexes in severe thrombotic events.
    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized ; COVID-19 ; Immunologic Factors ; Platelet Factor 4/chemistry ; Platelet Factor 4/metabolism ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus ; Thrombocytopenia
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunologic Factors ; Platelet Factor 4 (37270-94-3) ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; PF4 protein, human
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030245
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  8. Article ; Online: The choline-binding proteins PspA, PspC, and LytA of

    Vilhena, Cláudia / Du, Shanshan / Battista, Miriana / Westermann, Martin / Kohler, Thomas / Hammerschmidt, Sven / Zipfel, Peter F

    Infection and immunity

    2023  Volume 91, Issue 9, Page(s) e0015423

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pneumoniae
    MeSH term(s) Humans ; Streptococcus pneumoniae ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Endothelial Cells/metabolism ; Choline/metabolism ; Bacterial Proteins/metabolism ; Pneumococcal Infections/microbiology ; Membrane Proteins/metabolism ; Erythrocytes
    Chemical Substances Carrier Proteins ; Choline (N91BDP6H0X) ; Bacterial Proteins ; Membrane Proteins
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00154-23
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  9. Book ; Online ; Thesis: human complement system

    Tille, Alexander [Verfasser] / Figge, Marc Thilo Günter [Gutachter] / Zipfel, Peter F. [Gutachter] / Kaderali, Lars [Gutachter]

    a mathematical analysis of its regulation

    2023  

    Author's details Alexander Tille ; Gutachter: Marc Thilo Günter Figge, Peter F. Zipfel, Lars Kaderali
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
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  10. Book ; Online ; Thesis: Candida albicans Tef1 bindet an Dektin-1 und Dektin-2 auf humanen Dendritischen Zellen und löst eine inflammatorische Immunantwort aus

    Reiher, Nadine [Verfasser] / Zipfel, Peter F. [Gutachter] / Slevogt, Hortense [Gutachter] / Würzner, Reinhard [Gutachter]

    2023  

    Author's details Nadine Reiher ; Gutachter: Peter F. Zipfel, Hortense Slevogt, Reinhard Würzner
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
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