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Article ; Online: Posterior Reversible Encephalopathy Syndrome With Visual Disturbances in an Adolescent After Overdose With Adderall XR: A Case Report.

Linton, Edward / Pak, Thomas / Halhouli, Oday / Field, Matthew G / Gunderson, Carissa / Chung, Sophia M

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2022 Volume 43, Issue 4, Page(s) e278–e279

MeSH term(s)	Humans ; Adolescent ; Posterior Leukoencephalopathy Syndrome/chemically induced ; Posterior Leukoencephalopathy Syndrome/diagnosis ; Amphetamines ; Drug Overdose/complications ; Drug Overdose/diagnosis
Chemical Substances	Adderall ; Amphetamines ; SLI381
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000001615
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Zs.A 1670: Show issues

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Article ; Online: Youth stress generation: an examination of the role of anxiety, anxiety symptoms and cognitive distortions.

Harrison, Thomas J / Ginsburg, Golda S / Smith, Isaac C / Orlando, Carissa M

Anxiety, stress, and coping

2022 Volume 36, Issue 3, Page(s) 304–319

Abstract: Introduction: Stress generation suggests a reciprocal relationship between depression and prospective stressful life events. However, the applicability of stress generation to anxiety disorders has been understudied, particularly among youth. We address ...

Abstract	Introduction: Stress generation suggests a reciprocal relationship between depression and prospective stressful life events. However, the applicability of stress generation to anxiety disorders has been understudied, particularly among youth. We address this gap by examining stress generation in youth at high-risk of developing anxiety disorders. Methods: Participants were one-hundred thirty-six at-risk youth ( Results: Anxiety symptoms and cognitive distortions were significant predictors of one-year total dependent stress. Anxiety diagnosis and anxiety symptoms were significant predictors of one-year dependent interpersonal stress. Anxiety diagnosis and anxiety symptoms were significant predictors of six-year independent stress. Conclusion: Support for the stress generation model was found in high-risk youth, but only over a one-year period. This suggests important effects of anxiety and cognitive distortions on stress generation, though their implications might be time-capped.
MeSH term(s)	Humans ; Female ; Adolescent ; Male ; Prospective Studies ; Depression/psychology ; Anxiety/psychology ; Anxiety Disorders ; Cognition
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1115932-7
ISSN	1477-2205 ; 1061-5806
ISSN (online)	1477-2205
ISSN	1061-5806
DOI	10.1080/10615806.2022.2076083
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Zs.A 2778: Show issues

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Article ; Online: Determination of Flap Survival Isolated From Wound Bed Vasculature Using a Murine Axial Flap Model.

Hicks, Melanie D / Ovaitt, Alyssa K / Morrison, Daniel R / Fleming, Jason C / Jeyarajan, Hari / Greene, Benjamin / Sorace, Anna G / Patel, Juhi / Kasten, Benjamin B / Hartman, Yolanda E / Rosenthal, Eben L / Warram, Jason M / Thomas, Carissa M

Ear, nose, & throat journal

2023 , Page(s) 1455613231183392

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613231183392
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Zs.B 107: Show issues

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Article ; Online: Panitumumab-IRDye800 Improves Laryngeal Tumor Mapping During Transoral Laser Microsurgery.

Bailey, Luke / Stone, Logan D / Gonzalez, Manuel L / Thomas, Carissa M / Jeyarajan, Hari / Warram, Jason M / Panuganti, Bharat

The Laryngoscope

2023 Volume 134, Issue 4, Page(s) 1837–1841

Abstract: Transoral laser microsurgery represents the primary surgical modality for early laryngeal cancers with oncologic outcomes equivalent to radiotherapy. Accurate tumor mapping and margin assessment can be difficult, however, particularly during piecemeal or ...

Abstract	Transoral laser microsurgery represents the primary surgical modality for early laryngeal cancers with oncologic outcomes equivalent to radiotherapy. Accurate tumor mapping and margin assessment can be difficult, however, particularly during piecemeal or ablative resections, and for tumors with a wider geographic footprint. Tumor-targeted fluorescence-guided surgery in patients with head and neck cancer has empirically improved tumor and margin identification; this case details, for the first time, a fluorescence-guided surgical resection of a T2N0M0 transglottic tumor using panitumumab-IRDye800, an epidermal growth factor receptor monoclonal antibody covalently linked to near-infrared (NIR) dye. Laryngoscope, 134:1837-1841, 2024.
MeSH term(s)	Humans ; Laryngeal Neoplasms/pathology ; Panitumumab ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Microsurgery ; Laser Therapy ; Lasers ; Glottis/surgery ; Retrospective Studies ; Neoplasm Staging ; Indoles
Chemical Substances	IRDye800 ; Panitumumab (6A901E312A) ; Indoles
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31078
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Ul II Zs.82: Show issues

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Article ; Online: Microvascular reconstruction of medication related osteonecrosis of the head and neck.

Sweeny, Larissa / Long, Sallie M / Pipkorn, Patrik / Wax, Mark K / Thomas, Carissa M / Curry, Joseph M / Yang, Sara / Lander, Daniel / Chowdhury, Farshad / Amin, Dev / Kane, Anne C / Miles, Brett A / Salama, Andrew / Cannady, Steven B / Tasche, Kendall / Mann, Derek / Jackson, Ryan

Head & neck

2024

Abstract: Background: Medication related osteonecrosis of the jaw (MRONJ) requiring free flap (FF) reconstruction is uncommon with limited reported findings.: Methods: Multicenter, retrospective case series of 49 consecutive adult patients presenting with ... ...

Abstract	Background: Medication related osteonecrosis of the jaw (MRONJ) requiring free flap (FF) reconstruction is uncommon with limited reported findings. Methods: Multicenter, retrospective case series of 49 consecutive adult patients presenting with advanced MRONJ requiring FF reconstruction from 2010 to 2022. Perioperative complications and outcomes were analyzed. Results: Eighty-two percent (n = 40) of cases were of the mandible and 18% (n = 9) were of the maxilla. The mean follow-up was 15 months (±19.6). The majority of FF survived (96%, n = 47). FF reconstructions of the maxilla were more likely to require postoperative debridement (56%, 95% CI [27, 81%] vs. 15%, 95% CI [7, 25%], p = 0.008) or develop intraoral bone exposure (56%, 95% CI [27, 81%] vs. 18%, 95% CI [9, 27%], p = 0.02). Most patients (71%, n = 35) received preoperative antibiotics which was associated with a higher rate of FF survival (100% vs. 86%, 95% CI [60, 96%], p = 0.02) and fewer complications. Conclusions: Patients undergoing FF reconstruction for MRONJ do well with high rates of FF success. MRONJ of the maxilla have a higher rate of some complications. Preoperative antibiotics correlated with higher FF survival and fewer postoperative complications.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27653
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Zs.A 1493: Show issues

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Article: Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma.

Dong, Minh Phuong / Dharmaraj, Neeraja / Kaminagakura, Estela / Xue, Jianfei / Leach, David G / Hartgerink, Jeffrey D / Zhang, Michael / Hanks, Hana-Joy / Ye, Yi / Aouizerat, Bradley E / Vining, Kyle / Thomas, Carissa M / Dovat, Sinisa / Young, Simon / Viet, Chi T

Biomedicines

2024 Volume 12, Issue 4

Abstract: Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid tolerance. The ... ...

Abstract	Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid tolerance. The stimulator of interferon genes (STING) agonism has been investigated as an anti-cancer strategy. We have developed STINGel, an extended-release formulation that prolongs the availability of STING agonists, which has demonstrated an enhanced anti-tumor effect in OSCC compared to STING agonist injection. This study investigates the impact of intra-tumoral STINGel on OSCC-induced pain using two separate OSCC models and nociceptive behavioral assays. Intra-tumoral STINGel significantly reduced mechanical allodynia in the orofacial cancer model and alleviated thermal and mechanical hyperalgesia in the hind paw model. To determine the cellular signaling cascade contributing to the antinociceptive effect, we performed an in-depth analysis of immune cell populations via single-cell RNA-seq. We demonstrated an increase in M1-like macrophages and N1-like neutrophils after STINGel treatment. The identified regulatory pathways controlled immune response activation, myeloid cell differentiation, and cytoplasmic translation. Functional pathway analysis demonstrated the suppression of translation at neuron synapses and the negative regulation of neuron projection development in M2-like macrophages after STINGel treatment. Importantly, STINGel treatment upregulated TGF-β pathway signaling between various cell populations and peripheral nervous system (PNS) macrophages and enhanced TGF-β signaling within the PNS itself. Overall, this study sheds light on the mechanisms underlying STINGel-mediated antinociception and anti-tumorigenic impact.
Language	English
Publishing date	2024-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12040920
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Article ; Online: Effect of Perioperative Antithrombotics on Postoperative Transfusion and Hematoma in Head and Neck Free Flaps.

Hicks, Melanie D / Vasudev, Milind / Bishop, Jessica L / Garcia, Natalie / Chowdhury, Farshad / Pham, Tiffany T / Heslop, Gabriela / Greene, Benjamin / Jeyarajan, Hari / Grayson, Jessica W / Goddard, Julie A / Tjoa, Tjoson / Haidar, Yarah / Thomas, Carissa M

OTO open

2023 Volume 7, Issue 4, Page(s) e86

Abstract: Objective: To explore if antiplatelet or anticoagulant therapy increases the risk of transfusion requirement or postoperative hematoma formation in patients undergoing microvascular reconstruction for head and neck defects.: Study design: ... ...

Abstract	Objective: To explore if antiplatelet or anticoagulant therapy increases the risk of transfusion requirement or postoperative hematoma formation in patients undergoing microvascular reconstruction for head and neck defects. Study design: Retrospective cohort study. Setting: Departments of Otolaryngology-Head and Neck Surgery at the University of Alabama at Birmingham, the University of Colorado, and the University of California Irvine. Methods: A multi-institutional, retrospective review on microvascular reconstruction of the head and neck between August 2013 to July 2021. Perioperative antithrombotic data were collected to examine predictors of postoperative transfusion and hematoma. Results: A total of 843 free flaps were performed. Preoperative hemoglobin, hematocrit, operative time, and flap type were positive predictors of postoperative transfusion in both bivariate ( Conclusion: Antithrombotic regimens do not increase the risk of postoperative transfusion or hematoma in head and neck microvascular reconstruction. Based on this limited data, perioperative antithrombotic regimens can be considered in patients who may otherwise be at risk for these postoperative complications.
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ISSN	2473-974X
ISSN (online)	2473-974X
DOI	10.1002/oto2.86
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Article ; Online: Outcomes of Head and Neck Free Tissue Transfer in Renal Failure Patients.

Oglesby, Kacie R / Jefferson, Gina D / Thomas, Carissa M / Tomblin, Caitlyn / Alnemri, Angela / Curry, Joseph M / Bonaventure, Caroline / Sweeny, Larissa / Richards, Holden W / Wax, Mark / Kane, Anne C

The Laryngoscope

2023 Volume 134, Issue 2, Page(s) 688–694

Abstract: Objective: To assess if there is increased risk of free flap failure in renal failure patients undergoing head and neck reconstruction. We seek to primarily assess free flap outcomes based on stages of chronic kidney disease (CKD) and secondarily ... ...

Abstract	Objective: To assess if there is increased risk of free flap failure in renal failure patients undergoing head and neck reconstruction. We seek to primarily assess free flap outcomes based on stages of chronic kidney disease (CKD) and secondarily determine increased risk for postoperative complications. Methods: Retrospective chart review was performed at five tertiary care centers. Patients were identified that had undergone microvascular free flap reconstruction of the head and neck with diagnosis of renal failure, classified as Stage 3 CKD or higher. Demographic data was collected. Outcomes in the postoperative period were examined. Results: Seventy-three patients met inclusion criteria. The average patient age was 69 years with a male predominance (n = 48). The majority of patients had CKD Stage 3 (n = 52). Overall flap failure rate was 12.33% (n = 9, CKD stage 3 = 7.69%, CKD stage 4 = 30%, CKD stage 5 = 18%). There was an increased risk of flap failure on multivariate analysis for CKD stage 4/5 patients when compared to CKD 3 patients (p = 0.0095). When compared to matched controls, there was an increased risk of flap failure in CKD patients (p = 0.01) as well as an increased risk of overall complications (p < 0.0001). Conclusions: Patients with CKD undergoing head and neck reconstruction are at a higher risk of flap failure and overall complications. When comparing CKD stages there may be increased risk of flap failure in later stages of CKD compared to CKD 3. Appropriate patient counseling is recommended pre-operatively in this patient population with consideration for regional flaps in the appropriate patient. Level of evidence: 3 Laryngoscope, 134:688-694, 2024.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Retrospective Studies ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/surgery ; Neck/surgery ; Free Tissue Flaps/blood supply ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Renal Insufficiency/complications ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30862
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Article ; Online: Effect of Perioperative Antithrombotics on Head and Neck Microvascular Free Flap Survival After Anastomotic Revision.

Bishop, Jessica L / Vasudev, Milind / Garcia, Natalie / Heslop, Gabriela / Pham, Tiffany T / Hicks, Melanie D / Chowdhury, Farshad / Grayson, Jessica W / Goddard, Julie A / Tjoa, Tjoson / Haidar, Yarah / Thomas, Carissa M

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2023 Volume 168, Issue 6, Page(s) 1353–1361

Abstract: Objective: To determine if antithrombotic therapy improves head and neck microvascular free flap survival following anastomotic revision.: Study design: A retrospective review of all patients with microvascular free tissue transfer to the head and ... ...

Abstract	Objective: To determine if antithrombotic therapy improves head and neck microvascular free flap survival following anastomotic revision. Study design: A retrospective review of all patients with microvascular free tissue transfer to the head and neck between August 2013 and July 2021. Setting: Otolaryngology-Head and Neck Surgery Departments at University of Alabama at Birmingham, University of Colorado, and University of California Irvine. Methods: Perioperative use of anticoagulation, antiplatelets, intraoperative heparin bolus, tissue plasminogen activator (tPA) and vasopressor use, and leech therapy were collected plus microvascular free flap outcomes. The primary endpoint was free flap failure. Analyses of free flaps that underwent anastomotic revision with or without thrombectomy were performed. Results: A total of 843 microvascular free flaps were included. The overall rate of flap failure was 4.0% (n = 34). The overall rate of pedicle anastomosis revision (artery, vein, or both) was 5.0% (n = 42) with a failure rate of 47.6% (n = 20) after revision. Anastomotic revision significantly increased the risk of flap failure (odds ratio [OR] 52.68, 95% confidence interval [CI] [23.90, 121.1], p < .0001) especially when both the artery and vein were revised (OR 9.425, 95% CI [2.117, 52.33], p = .005). Free flap failure after the anastomotic revision was not affected by postoperative antiplatelet therapy, postoperative prophylactic anticoagulation, intraoperative heparin bolus, tPA, and therapeutic anticoagulation regardless of which vessels were revised and if a thrombus was identified. Conclusion: In cases of microvascular free tissue transfer pedicle anastomotic revision, the use of antithrombotic therapy does not appear to significantly change free flap survival outcomes.
MeSH term(s)	Humans ; Free Tissue Flaps/blood supply ; Fibrinolytic Agents/therapeutic use ; Tissue Plasminogen Activator ; Heparin ; Postoperative Complications/prevention & control ; Retrospective Studies ; Anticoagulants/therapeutic use ; Anastomosis, Surgical ; Head and Neck Neoplasms/drug therapy
Chemical Substances	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Heparin (9005-49-6) ; Anticoagulants
Language	English
Publishing date	2023-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.295
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Article: Reconstructing Discontinuous Facial Defects with Simultaneous Ulnar Perforator Free Flaps.

Thomas, Carissa M / Sokoya, Mofiyinfolu / Deleyiannis, Frederic W-B

Plastic and reconstructive surgery. Global open

2017 Volume 5, Issue 4, Page(s) e1291

Abstract: Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e., separate sites of the face) with simultaneous ulnar perforator flaps. The distinct innovations of this ... ...

Abstract	Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e., separate sites of the face) with simultaneous ulnar perforator flaps. The distinct innovations of this multiple flap design are the ability to restrict the harvest site to one extremity, to obtain vein and arterial grafts from the same extremity, and to create multiple flaps with minimal hirsutism and bulk. We present a case of a 57-year-old male with multiple basal cell carcinomas who underwent wide local excisions of the right upper lip and cheek and of the left lower eyelid and infraorbital cheek. Two left-sided ulnar perforator free flaps were used for reconstruction with the outcome of normal oral competence and eyelid function. When faced with discontinuous facial defects, reconstruction with simultaneous ulnar perforator flaps is a useful option because of the advantages of matching the thinness and pliability of the resected skin, reducing the number of harvest sites and preventing the distortion and contraction that can be seen with local advancement flaps or skin grafts.
Language	English
Publishing date	2017-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000001291
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