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Article ; Online: Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. "Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration." Kidney Int. 2022;101:541-550.

Zhang, Jie / Cai, Jing / Cui, Yu / Jiang, Shan / Wei, Jin / Kim, Young Chul / Chan, Jenna / Thalakola, Anish / Le, Thanh / Xu, Lan / Wang, Lei / Jiang, Kun / Wang, Ximing / Wang, Haibo / Cheng, Feng / Buggs, Jacentha / Koepsell, Hermann / Vallon, Volker / Liu, Ruisheng

Kidney international

2022 Volume 102, Issue 2, Page(s) 448

Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Published Erratum
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.05.011
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Article ; Online: Mercerizing Extraction and Physicochemical Characterizations of Lignocellulosic Fiber from the Leaf Waste of Mikania micrantha Kunth ex H.B.K

Chaw Jiang Lim / Mahashanon Arumugam / Chan Kiang Lim / Gwendoline Cheng Lian Ee

Journal of Natural Fibers, Vol 17, Iss 5, Pp 726-

2020 Volume 737

Abstract: ... from the leaf waste of a luxuriant invasive plant, Mikania micrantha Kunth-ex H.B.K. by mercerization process ...

Abstract	Invasive plants can grow rampantly and spread fast in large amount, which can be economically invoked for generating value-added products. In this study, lignocellulosic fiber was extracted from the leaf waste of a luxuriant invasive plant, Mikania micrantha Kunth-ex H.B.K. by mercerization process. After the alkaline treatment, the lignocellulosic biomass remained at 38.54% resulting from the large removal of extractive impurities. The lignocellulosic fraction in the mercerized leaf fiber was improved from 56.59% to 83.96%. The chemical composition analysis showed the cellulose fraction was increased by 11.17% while the hemicellulose and lignin fractions were found to be decreased by 4.89% and 6.28%, respectively. The FT-IR and TGA results further affirmed the change in chemical composition of the lignocellulosic fiber. Furthermore, an increase in cellulose fraction raised the fiber crystallinity index from 11.0% to 36.7%. The SEM study revealed that the surface morphology of lignocellulosic fiber changed from smooth surface into rough corrugated ridges, which affirmed the increase in crystallinity, resulting from the removal of wrapped cementing materials. In subsequent, the lignocellulosic fiber exhibited more pervious to water attack with an increase in moisture absorption from 119.22% to 410.19%.
Keywords	lignocellulosic fiber ; invasive plant ; mikania micrantha ; mercerization ; value-added products ; sustainable agricultural practices ; Science ; Q ; Textile bleaching ; dyeing ; printing ; etc ; TP890-933
Subject code	660
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Green water-dispersible coarse powder nano-formulation for allelopathic leaf extract of Mikania micrantha Kunth ex H.B.K. in controlling the rice weed Echinochloa colona (L.) Link

Lim, Chaw Jiang / Lim, Chan Kiang / Arumugam, Mahashanon / Ee, Gwendoline Cheng Lian / Omar, Dzolkhifli / Mahiran Basri

Industrial Crops & Products. 2022 Nov., v. 187 p.115468-

2022

Abstract: Plant extracts originated from an exotic species, Mikania micrantha Kunth ex H.B.K. have shown ...

Abstract	Plant extracts originated from an exotic species, Mikania micrantha Kunth ex H.B.K. have shown appreciable phytoinhibitory activities against a rice weed, Echinocloa colona (L.) Link. In spite of that, the glutinous extracts exhibit poor physicochemical properties preventing it from delivering efficiently and for ease of application. This research study aimed to formulate the leaf extract of M. micrantha with pre-emulsions and lignocellulosic coarse powder for the sake of ameliorated bioefficacy of the extract via nano-delivery system and improved product handling. Three pre-emulsions were developed using rapeseed oil methyl esters (ROME) and disparate bisurfactant mixtures including polyalkoxylated fatty alcohol (PAFA)-alkyl sulfonate (AS), PAFA-cocamidopropyl betaine (CB) and PAFA-alkyl polyglucosides (APG). The pre-emulsions were incorporated with leaf extracts containing the phenolic allelochemicals. The pre-emulsified extracts were loaded onto mercerized lignocellulose by solvent percolation and evaporation (SPE) technique produced the formulated water-dispersible coarse powders, WDP-F1, WDP-F2 and WDP-F3. A non-formulated extract was prepared into water-dispersible powder, WDP-EX for quality control. The results show greater water absorption by the formulated powders in prolonged duration of 7 days exerted the release of higher total amount of phenolic compounds (63.66-86.52%) than the phenolics amount released from the non-formulated powder (41.98%). Transmission electron microscopy (TEM) revealed the formulated extracts exhibited particles release in regular patterns from three dimensional networks and gigantic vesicles, unlike the non-formulated extract liberated uneven particles from disordered aggregates. The particles released from the formulated powders displayed low mean sizes (87.56-103.27 nm) in monodisperse range (PDI = 0.180-0.203). In opposition, non-formulated particles indicated larger mean size (423.93 nm) and polydisperse (PDI = 0.550). In the glasshouse study, the formulated powders promoted significantly higher inhibitions of germination, shoot height, fresh weight and dry weight of E. colona than non-formulated powder and non-treated weedy control. Moreover, the paddy seedling growth and grain yield treated with the formulated powders were statistically equivalent (p = 0.05) to treated with a commercial formulation, Satunil® and weed-free non-treated control. These valuable outcomes genuinely reflected the inspirational use of green water-dispersible coarse powder in the formulation of natural products in fostering the sustainable development of crop protection products.
Keywords	Echinochloa colona ; Mikania micrantha ; allelochemicals ; betaine ; evaporation ; fatty alcohols ; germination ; glucosides ; grain yield ; greenhouse experimentation ; introduced species ; leaf extracts ; leaves ; lignocellulose ; mercerization ; paddies ; phenolic compounds ; plant protection ; quality control ; rapeseed oil ; rice ; seedling growth ; solvents ; sulfonates ; sustainable development ; transmission electron microscopy ; water uptake ; weeds ; Mikania micrantha Kunth ex H.B.K. ; Allelopathic leaf extract ; Water-dispersible coarse powder ; Eco-friendly nano-formulation ; Weed control ; Echinochloa colona (L.) Link
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2022.115468
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Scalar coupling across [C-H···F-C] interactions in (σ-aryl)-chelating post-metallocenes.

So, Loi-Chi / Liu, Cham-Chuen / Chan, Michael C W / Lo, Jerry C Y / Sze, Kong-Hung / Zhu, Nianyong

Chemistry (Weinheim an der Bergstrasse, Germany)

2012 Volume 18, Issue 2, Page(s) 565–573

Abstract: The nature and importance of C-H···F-C interactions is a topical yet controversial issue, and ... of the CF(3)-substituted Hf derivative features intramolecular C-H···F-C and Hf···F-C contacts ... All complexes have been characterized by multinuclear NMR spectroscopy. The (1)H and (13)C NMR spectra of [M(O,C ...

Abstract	The nature and importance of C-H···F-C interactions is a topical yet controversial issue, and the development of spectroscopic methods to probe such contacts is therefore warranted. A series of Group 4 bis(benzyl) complexes supported by (σ-aryl)-2-phenolate-6-pyridyl [O,C,N-R(1)] ligands bearing a fluorinated R(1) group (CF(3) or F) in the vicinity of the metal has been prepared. The X-ray crystal structure of the CF(3)-substituted Hf derivative features intramolecular C-H···F-C and Hf···F-C contacts. All complexes have been characterized by multinuclear NMR spectroscopy. The (1)H and (13)C NMR spectra of [M(O,C,N-CF(3))(CH(2)Ph)(2)] derivatives display coupling (assigned to (1h)J(HF) and (2h)J(CF) for Ti; (3)J(HF) and (2)J(CF) (through M···F) for Hf and Zr) between the benzyl CH(2) and CF(3) moieties. [(1)H,(19)F]-HMBC NMR experiments have been performed for the M-[O,C,N-R(1)] complexes and their [O,N,C] counterparts, revealing significant scalar coupling across the C-H···F-C interactions for Ti-[O,C,N] and [O,N,C] species.
MeSH term(s)	Carbon/chemistry ; Chelating Agents/chemistry ; Crystallography, X-Ray ; Fluorine/chemistry ; Hydrogen Bonding ; Ligands ; Models, Molecular ; Organometallic Compounds/chemistry
Chemical Substances	Chelating Agents ; Ligands ; Organometallic Compounds ; metallocene ; Fluorine (284SYP0193) ; Carbon (7440-44-0)
Language	English
Publishing date	2012-01-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1478547-x
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201102439
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Article ; Online: Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie(a, b, c): Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

Klimek, Ludger / Pfaar, Oliver / Worm, Margitta / Eiwegger, Thomas / Hagemann, Jan / Ollert, Markus / Untersmayr, Eva / Hoffmann-Sommergruber, Karin / Vultaggio, Alessandra / Agache, Ioana / Bavbek, Sevim / Bossios, Apostolos / Casper, Ingrid / Chan, Susan / Chatzipetrou, Alexia / Vogelberg, Christian / Firinu, Davide / Kauppi, Paula / Kolios, Antonios /

Kothari, Akash / Matucci, Andrea / Palomares, Oscar / Szépfalusi, Zsolt / Pohl, Wolfgang / Hötzenecker, Wolfram / Rosenkranz, Alexander / Bergmann, Karl-Christian / Bieber, Thomas / Buhl, Roland / Buters, Jeroen / Darsow, Ulf / Keil, Thomas / Kleine-Tebbe, Jörg / Lau, Susanne / Maurer, Marcus / Merk, Hans / Mösges, Ralph / Saloga, Joachim / Staubach, Petra / Jappe, Uta / Rabe, Claus / Rabe, Uta / Vogelmeier, Claus / Biedermann, Tilo / Jung, Kirsten / Schlenter, Wolfgang / Ring, Johannes / Chaker, Adam / Wehrmann, Wolfgang / Becker, Sven / Freudelsperger, Laura / Mülleneisen, Norbert / Nemat, Katja / Czech, Wolfgang / Wrede, Holger / Brehler, Randolf / Fuchs, Thomas / Tomazic, Peter-Valentin / Aberer, Werner / Fink Wagner, Antje / Horak, Fritz / Wöhrl, Stefan / Niederberger-Leppin, Verena / Pali-Schöll, Isabella / Roller-Wirnsberger, Regina / Spranger, Otto / Valenta, Rudolf / Akdis, Mübecell / Matricardi, Paolo M. / Spertini, François / Khaltaev, Nikolai / Michel, Jean-Pierre / Nicod, Larent / Schmid-Grendelmeier, Peter / Idzko, Marco / Hamelmann, Eckard / Jakob, Thilo / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Jensen-Jarolim, Erika / Korn, Stephanie / Hentges, Francois / Schwarze, Jürgen / O´Mahony, Liam / Knol, Edward / del Giacco, Stefano / Chivato, Tomás / Bousquet, Jean / Zuberbier, Torsten / Akdis, Cezmi / Jutel, Marek

Allergo J

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s15007-020-2553-y
Database	COVID19

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Article ; Online: Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemiea, b, c ; Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H

Allergo Journal

2020 Volume 29, Issue 4, Page(s) 14–27

Keywords	Immunology and Allergy ; covid19
Language	German
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	1136943-7
ISSN	0941-8849
ISSN	0941-8849
DOI	10.1007/s15007-020-2553-y
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anaplastic large cell Ki-1 lymphoma. Delineation of two morphological types. J. K. C. Chan, C. S. Ng, P. K. Hui, T. W. Leung, E. S. F. Lo, W. H. Lau, L. J. McGuire. Histopathology 1989; 15; 11-34.

Chan, J K C

Histopathology

2002 Volume 41, Issue 3A, Page(s) 124–5, discussion 125–6

MeSH term(s)	B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Diagnosis, Differential ; Humans ; Ki-1 Antigen/metabolism ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/pathology ; Protein-Tyrosine Kinases/metabolism ; Receptor Protein-Tyrosine Kinases
Chemical Substances	Ki-1 Antigen ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; anaplastic lymphoma kinase (EC 2.7.10.1)
Language	English
Publishing date	2002-09
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
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Article ; Online: Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins.

Chan, Albert H / Simanshu, Dhirendra K

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2797, Page(s) 47–65

Abstract: RAS proteins play a vital role in regulating downstream signaling and essential cellular processes, positioning them as key players in normal cellular physiology and disease development. Among the various isoforms of RAS, KRAS stands out as one of the ... ...

Abstract	RAS proteins play a vital role in regulating downstream signaling and essential cellular processes, positioning them as key players in normal cellular physiology and disease development. Among the various isoforms of RAS, KRAS stands out as one of the most frequently mutated genes in human cancer. The prevalence of RAS mutations in cancer often involves single amino acid substitutions at codons 12, 13, or 61. These mutations disrupt the RAS protein's inherent ability to transition between its active and inactive states, resulting in a constant activation signal and driving uncontrolled cell growth. Crystallization and structural analysis of KRAS with inhibitors and RAS-binding proteins play a pivotal role in unraveling the structural and mechanistic details of KRAS function, aiding in drug discovery efforts, and advancing our understanding of KRAS-driven diseases. Here, we present our experimental methodology for crystallizing KRAS in the presence of covalent or non-covalent small molecules and proteins acting as effectors or regulators of RAS. We detail the techniques for successful crystallization and the subsequent optimization of crystallization conditions. The resulting crystals and their structures will provide valuable insights into the key interactions between KRAS and its partner proteins or potential inhibitors, offering a foundation for developing targeted therapies that are more potent and selective against KRAS-driven cancers.
MeSH term(s)	Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Carrier Proteins/metabolism ; ras Proteins/genetics ; ras Proteins/metabolism ; Signal Transduction ; Neoplasms/genetics ; Mutation
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Carrier Proteins ; ras Proteins (EC 3.6.5.2) ; KRAS protein, human
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3822-4_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The ethics of wicked problems: an exegesis.

Chan, Jeffrey K H

Socio-ecological practice research

2023 Volume 5, Issue 1, Page(s) 35–47

Abstract: For nearly all the most urgent issues confronting humanity today, there is neither consensus about how to address them nor clarity on how tackling them might further compound existing inequality, erode democratic capacities and accelerate environmental ... ...

Abstract	For nearly all the most urgent issues confronting humanity today, there is neither consensus about how to address them nor clarity on how tackling them might further compound existing inequality, erode democratic capacities and accelerate environmental decline. Urgent issues of climate change, rapid urbanization and public health are teeming with wicked problems. Even so, their prospective solutions may nevertheless exacerbate these problems and bring about new ones. Taming any one of these wicked problems with planning and public policy tools presumes making decisions on ethical questions such as what to tame and what to ignore, who or what to prioritize in the solution, or conversely, who or what should bear the costs and risks, and how to strike a balance between uncertain benefits and probable harms. Despite the saliency of ethics in the formulation of wicked problems and how they are tamed, the ethics of wicked problems has remained woefully under-developed ever since (Rittel and Webber, Policy Sci 4:155-169, 1973) publication nearly five decades ago. In this article, each of the ten properties of the wicked problem, following their original sequence, will be examined in relation to ethics. What is the moral significance of each of these properties? How does explicating their moral content advance present understanding of wicked problems? And how might this study of ten properties in relation to ethics enable planners to avoid moral blindspots and pitfalls that often accompany wicked problems? Finally, how can the ethics of wicked problems aspire new planning ideals?
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2947249-0
ISSN	2524-5287 ; 2524-5279
ISSN (online)	2524-5287
ISSN	2524-5279
DOI	10.1007/s42532-022-00137-3
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Article ; Online: A sub-analysis of multi-center planning radiosurgery for intracranial metastases through automation (MC-PRIMA) comparing UK and international centers.

Chan, Mark K H

Medical engineering & physics

2023 Volume 117, Page(s) 103996

Abstract: Objectives: A sub-analysis of the MC-PRIMA study was performed to compare the plan quality of stereotactic radiosurgery (SRS) to multiple brain metastases (MBM) between UK and other international centres.: Methods and materials: Six centres from the ... ...

Abstract	Objectives: A sub-analysis of the MC-PRIMA study was performed to compare the plan quality of stereotactic radiosurgery (SRS) to multiple brain metastases (MBM) between UK and other international centres. Methods and materials: Six centres from the UK and nineteen from other international centres autoplanned using Multiple Brain Mets™ (AutoMBM; Brainlab, Munich, Germany) software for a five MBM study case from a prior planning competition that was originally organized by the Trans-Tasmania Radiation Oncology Group (TROG). Twenty-three dosimetric metrics and the resulting composite plan score per the TROG planning competition were compared between the UK and other international centres. Planning experience and planning time from each planner were recorded and statistically compared. Results: Planning experiences between two groups are equal. Except for mean dose to the hippocampus, all other 22 dosimetric metrics were comparable between two groups. The inter-planner variations in these 23 dosimetric metrics and the composite plan score were also statistically equivalent. Planning time is slightly longer in the UK group (mean = 86.8 min) with a mean difference of 50.3 min. Conclusions: AutoMBM effectively achieves standardization of the plan quality of SRS to MBM within UK and further against the other international centres. Significant planning efficiency gain by AutoMBM both among the UK and other international centres may help to increase the capacity of SRS service by alleviating the clinical and technical loadings.
MeSH term(s)	Radiosurgery/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Automation ; United Kingdom
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2023.103996
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