Result 1 - 10 of total 15708
2015
| Author's details | Xijun Yan ed |
|---|---|
| Language | English |
| Dates of publication | 2015-9999 |
| Publisher | Springer |
| Publishing place | Dordrecht u.a. |
| Publishing country | Netherlands |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT018512143 |
| Database | Catalogue ZB MED Medicine, Health |
2015
| Author's details | Xijun Yan ed |
|---|---|
| Collection | Dan Shen (Salvia miltiorrhiza) in medicine |
| Language | English |
| Size | XXX, 212 S. : Ill., graph. Darst. |
| Publisher | Springer |
| Publishing place | Dordrecht u.a. |
| Publishing country | Netherlands |
| Document type | Book |
| HBZ-ID | HT018516372 |
| ISBN | 978-94-017-9468-8 ; 94-017-9468-5 ; 9789401794695 ; 9401794693 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2015 A 284 | available for loan (reading room) | Lesesaal EG |
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2015
| Author's details | Xijun Yan ed |
|---|---|
| Collection | Dan Shen (Salvia miltiorrhiza) in medicine |
| Language | English |
| Size | XXXVI, 592 S. : zahlr. Ill., graph. Darst. |
| Publisher | Springer |
| Publishing place | Dordrecht u.a. |
| Publishing country | Netherlands |
| Document type | Book |
| HBZ-ID | HT018512154 |
| ISBN | 978-94-017-9462-6 ; 94-017-9462-6 ; 9789401794633 ; 9401794634 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2015 A 147 | available for loan (reading room) | Lesesaal EG |
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2015
| Author's details | Xijun Yan ed |
|---|---|
| Collection | Dan Shen (Salvia miltiorrhiza) in medicine |
| Language | English |
| Size | XL, 296 S. : Ill., graph. Darst. |
| Publisher | Springer |
| Publishing place | Dordrecht u.a. |
| Publishing country | Netherlands |
| Document type | Book |
| HBZ-ID | HT018515608 |
| ISBN | 978-94-017-9465-7 ; 94-017-9465-0 ; 9789401794664 ; 9401794669 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2015 A 244 | available for loan (reading room) | Lesesaal EG |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Zhonghua wei zhong bing ji jiu yi xue
2023 Volume 35, Issue 12, Page(s) 1316–1320
Abstract: Objective: To observe the acute toxic reaction of the Li-Dan-He-Ji granules, and to evaluate ... was used to intragastric administration of Li-Dan-He-Ji granules 0.04 mL/g (42.8 g/kg), three times ... Conclusions: The Li-Dan-He-Ji granules have low oral toxicity, combined with clinical observation, can be ...
| Abstract | Objective: To observe the acute toxic reaction of the Li-Dan-He-Ji granules, and to evaluate its safety. Methods: Sixty C57BL6/J mice were randomly divided into normal control group, vehicle group and drug treatment group, with 10 females and 10 males in each group. According to the Technical guidelines for the study of toxicity of single drug administration, the maximum administration dosage (MAD) was used to intragastric administration of Li-Dan-He-Ji granules 0.04 mL/g (42.8 g/kg), three times within 24 hours, with an interval of 6 hours. The vehicle group was fed with the same pure water. The normal control group received no treatment. The mice were observed continuously for 14 days, and the appearance characteristics, behavioral activities, body weight changes and the number of deaths in each group were recorded. At the 14 days, blood samples were collected from the eyeballs, and routine blood tests such as white blood cell count (WBC), lymphocyte count (LYM), neutrophil count (NEU), lymphocyte percentage (LYM%), neutrophil percentage (NEU%), red blood cell count (RBC), hemoglobin (Hb), and platelet count (PLT) were performed. And alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr) and other biochemical indicators. The mice were then sacrificed, and the histopathological changes of liver and kidney were observed by hematoxylin-eosin (HE) staining. The organ indexes of heart, liver, spleen, lung, kidney and thymus were calculated. Results: The median lethal dose (LD Conclusions: The Li-Dan-He-Ji granules have low oral toxicity, combined with clinical observation, can be safely used in infants. |
|---|---|
| MeSH term(s) | Animals ; Female ; Humans ; Male ; Mice ; Body Weight ; Kidney ; Leukocyte Count ; Liver ; Toxicity Tests, Acute |
| Language | Chinese |
| Publishing date | 2023-12-19 |
| Publishing country | China |
| Document type | English Abstract ; Journal Article |
| ISSN | 2095-4352 |
| ISSN | 2095-4352 |
| DOI | 10.3760/cma.j.cn121430-20230812-00617 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Dual-Domain Adaptive-Scaling Non-local Network for CT Metal Artifact Reduction
2021
Abstract: ... performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR ... module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates ...
| Abstract | Metal implants can heavily attenuate X-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details as a more informative input. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and nonlocal module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates performance competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects. Comment: 29 pages, 11 figures |
|---|---|
| Keywords | Physics - Medical Physics ; Computer Science - Computer Vision and Pattern Recognition |
| Subject code | 006 |
| Publishing date | 2021-02-16 |
| Publishing country | us |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Zhonghua wei zhong bing ji jiu yi xue
2023 Volume 35, Issue 7, Page(s) 741–745
Abstract: Objective: To explore the clinical effect of Li-Dan-He-Ji in the treatment of infantile ... randomized controlled trial. They were divided into the conventional treatment group and Li-Dan-He-Ji group according ... according to the guidelines. In the Li-Dan-He-Ji group, the self-made Chinese medicinal compound Li-Dan ...
| Abstract | Objective: To explore the clinical effect of Li-Dan-He-Ji in the treatment of infantile cholestatic hepatic fibrosis. Methods: Patients who met the diagnostic criteria of infantile cholestatic hepatic fibrosis in the department of integrated traditional Chinese and Western medicine and the department of gastroenterology of Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from January to December 2021 were included in the study by prospective randomized controlled trial. They were divided into the conventional treatment group and Li-Dan-He-Ji group according to the random number table. The patients in the conventional treatment group were given conventional treatment according to the guidelines. In the Li-Dan-He-Ji group, the self-made Chinese medicinal compound Li-Dan-He-Ji (prescription: Herba Artemisiae Scopariae, Fructus Forsythiae, Radix et Rhizoma Rhei preparata, Radix Polygoni Multiflori Preparata, Radix Paeoniae Rubra, Ramulus Cinnamomi, Fructus Aurantii, Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Carapax Trionycis, and Radix Glycyrrhizae) was given on the basis of the routine treatment, by oral, enema or nasal feeding, 60 mL each day, divided into 2 or 3 times, for 28 days. Outpatient follow-up was maintained for 4 weeks. Before and after treatment, serum liver fibrosis 4 items [type IV collagen (IV-C), hyaluronidase (HA), type III procollagen (PC III), laminin (LN)], liver function and cholestasis-related markers [total bilirubin (TBil), direct bilirubin (DBil), total bile acid (TBA), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST)], oxidative stress markers [superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH)], liver stiffness measurement (LSM) detected by transient elastography (TE), aspartate aminotransferase-to-platelet ratio index (APRI), and liver and spleen retraction time were recorded in the two groups. Results: During the observation period, a total of 40 cases of cholestatic hepatic fibrosis were treated, including 21 cases in the conventional treatment group and 19 cases in the Li-Dan-He-Ji group. Before treatment, the differences in serum liver fibrosis 4 items, serum liver function and cholestasis-related markers, oxidative stress indexes, LSM and APRI of the two groups were not statistically significant. After treatment, the liver fibrosis 4 items, liver function and cholestasis-related markers, LSM, and APRI were all significantly decreased in both groups, and the indexes in the Li-Dan-He-Ji group were significantly lower than those in the conventional treatment group [HA (ng/L): 165.81±21.57 vs. 203.87±25.88, PC III (μg/L): 69.86±9.32 vs. 81.82±7.39, IV-C (μg/L): 204.14±38.97 vs. 239.08±24.93, LN (μg/L): 162.40±17.39 vs. 190.86±15.97, TBil (μmol/L): 37.58±27.63 vs. 53.06±45.09, DBil (μmol/L): 20.55±19.34 vs. 30.08±27.39, ALP (U/L): 436.50±217.58 vs. 469.60±291.69, γ-GGT (U/L): 66.78±35.84 vs. 87.00±32.82, ALT (U/L): 64.75±50.53 vs. 75.20±50.19, AST (U/L): 77.25±54.23 vs. 96.80±59.77, TBA (μmol/L): 74.35±44.44 vs. 85.45±39.50, LSM (kPa): 5.24±0.39 vs. 7.53±3.16, APRI: 0.52±0.39 vs. 0.98±0.29, all P < 0.05]. After treatment, MDA in the two groups were significantly lower than those before treatment, and SOD and GSH were significantly higher than those before treatment. The level of SOD in the Li-Dan-He-Ji group was significantly higher than that in the conventional treatment group (kU/L: 64.56±6.69 vs. 51.58±5.98, P < 0.05). In addition, the liver retraction time (day: 20.13±10.97 vs. 24.33±13.46) and spleen retraction time (day: 25.93±13.01 vs. 29.14±14.52) in the Li-Dan-He-Ji group were significantly shorter than those in the conventional treatment group (both P < 0.05). Conclusions: The use of Li-Dan-He-Ji in the treatment of cholestatic hepatic fibrosis can effectively improve the indicators of cholestasis, hepatic fibrosis, oxidative stress and clinical symptoms in children. |
|---|---|
| MeSH term(s) | Child ; Humans ; Prospective Studies ; Cholestasis/drug therapy ; Cholestasis/metabolism ; Cholestasis/pathology ; Liver ; Liver Cirrhosis/drug therapy ; Bilirubin/metabolism ; Bilirubin/pharmacology ; Oxidative Stress ; Aspartate Aminotransferases/metabolism ; Superoxide Dismutase/metabolism |
| Chemical Substances | Bilirubin (RFM9X3LJ49) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Superoxide Dismutase (EC 1.15.1.1) |
| Language | Chinese |
| Publishing date | 2023-08-07 |
| Publishing country | China |
| Document type | English Abstract ; Journal Article |
| ISSN | 2095-4352 |
| ISSN | 2095-4352 |
| DOI | 10.3760/cma.j.cn121430-20230316-00186 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 318, Issue Pt B, Page(s) 116975
Abstract: Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known ... Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and ... 4: Conclusion: Ding-kun-dan is another available, effective and safe method for patients ...
| Abstract | Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. Materials and method: 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF Results: Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4 Conclusion: Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents. |
|---|---|
| MeSH term(s) | Female ; Humans ; Desogestrel/therapeutic use ; Dinoprostone ; Double-Blind Method ; Dysmenorrhea/drug therapy ; Dysmenorrhea/diagnosis ; Endometriosis ; Medicine, Chinese Traditional ; Prospective Studies |
| Chemical Substances | Desogestrel (81K9V7M3A3) ; Dinoprostone (K7Q1JQR04M) |
| Language | English |
| Publishing date | 2023-07-29 |
| Publishing country | Ireland |
| Document type | Journal Article ; Multicenter Study ; Randomized Controlled Trial |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2023.116975 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1494: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Industrial Crops & Products. 2023 Sept., v. 200 p.116808-
2023
Abstract: Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is ...
| Abstract | Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is an emerging oilseed crop widely cultivated in China. As a byproduct, its stamens showed promising anti-neuroinflammation potential in our previous study. In this work, an in-depth phytochemical investigation was firstly conducted through comprehensive spectra to elucidate the neuroprotective components. Two new compounds (+)-oxylactiflorin (1), (+)-3′′-methoxy-oxylactiflorin (2), and twenty-two known compounds were isolated and identified. In lipopolysaccharides-induced BV-2 cells, compound 2 exhibited excellent inhibitory property in inhibiting nitric oxide (NO) production with the lowest EC₅₀ value of 3.02 ± 1.60 µM among all tested compounds. Western blotting and molecular docking results demonstrated the feasible mechanism that 2 exerted anti-inflammatory activity mainly by binding with the key protein cyclooxygenase-2 (COX-2). Additionally, compound 2 showed potent protective effects on the oxidative damages of H₂O₂ or 6-Hydroxydopamine (6-OHDA)-treated PC12 cells. This work provides a theoretical basis of P. ostii stamens for developing into a promising functional tea or neuroprotective drug. |
|---|---|
| Keywords | Paeonia ostii ; anti-inflammatory activity ; byproducts ; drugs ; neuroprotective effect ; nitric oxide ; oilseed crops ; ornamental plants ; phytochemicals ; prostaglandin synthase ; tea ; China ; Paeonia ostii stamen ; Anti-neuroinflammation ; Cyclooxygenase-2 ; Neuroprotection |
| Language | English |
| Dates of publication | 2023-09 |
| Publishing place | Elsevier B.V. |
| Document type | Article ; Online |
| ZDB-ID | 1132158-1 |
| ISSN | 1872-633X ; 0926-6690 |
| ISSN (online) | 1872-633X |
| ISSN | 0926-6690 |
| DOI | 10.1016/j.indcrop.2023.116808 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 5577: Show issues |
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Journal of Ethnopharmacology. 2024 Jan., v. 318 p.116975-
2024
Abstract: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered ... dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients ... kun-dan is another available, effective and safe method for patients with primary dysmenorrhea ...
| Abstract | Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO during the 12 weeks intervention. Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4ᵗʰ week, 8ᵗʰ week and 12ᵗʰ week). Although Marvelon was significantly superior to DKD in reducing VAS scores, the total CMSS, CMSS severity and duration scores at each posttreatment follow-up (P < 0.01), VAS scores in the DKD group decreased significantly over time while scores in the COC group only dropped rapidly after the first two months of treatment. Efficacy gap between two interventions continuously narrowed over time and the efficacy of DKD became non-inferior at the 12ᵗʰ week compared to that of Marvelon (the difference between groups, – 0.78%; 95% confidence interval (CI), −13.67%–12.75%; non-inferiority margin, 15%). DKD group had better efficacy on mild pain compared to that of the COC group with no statistical difference (75% VS 61.9%, P > 0.05). DKD and Marvelon could effectively reduce PGF₂ₐ, PGE₂ and higher PGF₂ₐ/PGE₂ in patients with PD. There was no statistical difference in the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO between DKD and Marvelon group at each follow-up. No serious adverse effect was observed. Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents. |
|---|---|
| Keywords | Oriental traditional medicine ; adverse effects ; animals ; blood serum ; confidence interval ; endometriosis ; immunity ; insulin resistance ; menstruation ; metabolism ; pain ; polycystic ovary syndrome ; therapeutics ; Primary dysmenorrhea ; Ding-kun-dan ; Marvelon ; VAS ; CMSS ; PGF2a ; PGE2 ; PGF2a/PGE2 |
| Language | English |
| Dates of publication | 2024-01 |
| Publishing place | Elsevier B.V. |
| Document type | Article ; Online |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2023.116975 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 90/710: Show issues |
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