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Article ; Online: Dicrotendipes sinicus Lin & Qi, sp. n. (Diptera

Xiaolong Lin / Xin Qi

CHIRONOMUS Journal of Chironomidae Research, Iss

Chironomidae)

2021 Volume 34

Abstract: The name Dicrotendipes sinicus was originally proposed in 2018, but the requirements of the International Code of Zoological Nomenclature were not fulfilled to make the name available. We here re-propose the name with full Code compliance and redescribe ... ...

Abstract	The name Dicrotendipes sinicus was originally proposed in 2018, but the requirements of the International Code of Zoological Nomenclature were not fulfilled to make the name available. We here re-propose the name with full Code compliance and redescribe and illustrate all life stages of the species to make the name available.
Keywords	Chironomidae ; Dicrotendipes ; new species ; nomenclature ; ICZN ; Science ; Q ; Zoology ; QL1-991
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	NTNU University Museum Norwegian University of Science and Technology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis.

Qu, Qian / Li, Shu-Peng / Dong, Qi / Du, Hong-Liang / Wang, Zhi-Hua / Ma, Yi-Mu / Gong, Xiao-Pei / Ding, Yi-Qing / Zhou, Jing / Chen, Jia-Yan / Liu, Meng-Jie / Lv, Wei-Jie / Guo, Shi-Ning

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 110, Page(s) 154645

Abstract: Background: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS), which has a long history of use in Traditional Chinese Medicine (TCM), has been widely used to treat ... ...

Abstract	Background: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS), which has a long history of use in Traditional Chinese Medicine (TCM), has been widely used to treat gastrointestinal diseases. The isolated fractions of TCM have also been proved to possess an important potential for treating diseases, which are due to their effective components. Purpose: In this study, we examined the possibility that SLBZS and its isolated active fractions may prevent DSS-induced colitis, and investigated the potential mechanisms by regulating genetic profile of colon. Methods: Colitis mice were induced by 2.5% DSS for 7 days, and then SLBZS and different SLBZS extracts were administrated to protect the mice for 7 days. Body weight, diarrhea, bleeding in stool, colon length, spleen weight, cytokines of serum and colon and pathology of colon were assessed. The level of Ginsenoside Rg1, Re and Rb1 in different SLBZS extracts and qualitative analysis of n-butanol extract of SLBZS (S-Nb) was performed by HPLC and LC-MS, respectively. And the effects of S-Nb on the transcriptome in colitis were investigated. Results: Our results showed that SLBZS and S-Nb significantly regained body weight, reduced DAI, splenomegaly and the length of colon and attenuated histological damage of the colon. Meanwhile, SLBZS and S-Nb markedly reduced the levels of TNF-α, IL-1β and IL-6 and increased the level of IL-10 in serum and colon. These effects may be associated with the high levels of Ginsenoside Rg1, Re and Rb1 and rich variety of compounds in S-Nb including 6 ginsenosides, glycyrrhizin, L-tryptophan, and so on. Transcriptome analysis revealed that S-Nb selectively regulated 103 differentially expressed genes (DEGs), 36 of which were changed in DSS-induced mice. And the genes of Per2, Per3, Npy and Serpina3m were closely related to colitis and also restored by S-Nb with different extent. Remarkably, these DEGs modulated the biological functions of colitis mice, including extracellular region, response to external stimulus, MAPK signaling pathway and arginine and proline metabolism. Conclusions: These data indicated that SLBZS and S-Nb blunted DSS-induced colitis by modulating differentially expression gene profile and biological functions based on their ginsenosides and rich compounds.
MeSH term(s)	Mice ; Animals ; Ginsenosides/pharmacology ; 1-Butanol/pharmacology ; Butanols/pharmacology ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/pathology ; Colon/pathology ; Chronic Disease ; Gene Expression Profiling ; Body Weight ; Dextran Sulfate ; Disease Models, Animal ; Mice, Inbred C57BL ; Cytokines
Chemical Substances	ginsenoside Rg1 (PJ788634QY) ; Ginsenosides ; 1-Butanol (8PJ61P6TS3) ; Butanols ; Dextran Sulfate (9042-14-2) ; Cytokines
Language	English
Publishing date	2023-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154645
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Article ; Online: Correction for Lin et al., "Protein Tyrosine Phosphatase-Like A Regulates Myoblast Proliferation and Differentiation through MyoG and the Cell Cycling Signaling Pathway".

Lin, Xi / Yang, Xiangsheng / Li, Qi / Ma, Yanlin / Cui, Shuang / He, Dacheng / Lin, Xia / Schwartz, Robert J / Chang, Jiang

Molecular and cellular biology

2017 Volume 37, Issue 16

Language	English
Publishing date	2017-07-28
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00236-17
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Article ; Online: Induction of breast cancer stem cells by M1 macrophages through Lin-28B-let-7-HMGA2 axis.

Guo, Liang / Cheng, Xiang / Chen, Hongyu / Chen, Changguo / Xie, Shuai / Zhao, Min / Liu, Dan / Deng, Que / Liu, Yanjun / Wang, Xiaomeng / Chen, Xintian / Wang, Jiangong / Yin, Zhaoyang / Qi, Siyong / Gao, Jiangping / Ma, Yuanfang / Guo, Ning / Shi, Ming

Cancer letters

2019 Volume 452, Page(s) 213–225

Abstract: Proinflammatory macrophage (M1) is now being suggested as a potential therapeutic strategy for cancer because of its tumoricidal capacity. However, few studies have been focused directly on the effects of M1 macrophages on cancer cells. Here, we found ... ...

Abstract	Proinflammatory macrophage (M1) is now being suggested as a potential therapeutic strategy for cancer because of its tumoricidal capacity. However, few studies have been focused directly on the effects of M1 macrophages on cancer cells. Here, we found that M1 induced a subpopulation of CD44
MeSH term(s)	Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Epithelial-Mesenchymal Transition/genetics ; Female ; HMGA2 Protein/genetics ; Humans ; MCF-7 Cells ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; NF-kappa B/metabolism ; Neoplastic Stem Cells/pathology ; RNA-Binding Proteins/genetics ; STAT3 Transcription Factor/metabolism
Chemical Substances	HMGA2 Protein ; HMGA2 protein, human ; Lin28A protein, human ; MicroRNAs ; NF-kappa B ; RNA-Binding Proteins ; STAT3 Transcription Factor ; STAT3 protein, human ; mirnlet7 microRNA, human
Language	English
Publishing date	2019-03-24
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2019.03.032
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Article: Characterization, Sources and Excessive Cancer Risk of PM2.5-Bound Polycyclic Aromatic Hydrocarbons in Different Green Spaces in Lin’an, Hangzhou, China

Huang, Fang / Zhang, Yinke / Lou, Yilei / Li, Xiaolu / Zhang, Tianran / Yu, Hui / Yuan, Chuyang / Tong, Qun / Qi, Feng / Shao, Feng

Bulletin of environmental contamination and toxicology. 2021 Sept., v. 107, no. 3

2021

Abstract: PM₂.₅ samples were collected from residential, commercial, plaza and public green spaces in Lin ...

Abstract	PM₂.₅ samples were collected from residential, commercial, plaza and public green spaces in Lin’an, Hangzhou, in spring (March and April) and winter (February and December) in 2017. PAHs were detected by gas chromatography-mass spectrometry (GC-MS), and their sources were identified using the diagnostic ratio (DR) and principal component analysis-multiple linear regression (PCA-MLR). The average PAH concentration in winter was 1.3 times that in spring (p < 0.01). The PAH concentrations in the green spaces decreased as commercial > residential > plaza > public green space (p < 0.05). The sources of PAHs were vehicle emissions and coal combustion pollution transported by northern Chinese air masses. Slightly higher excessive cancer risks were determined in the commercial and residential green spaces than in the plaza and public green spaces. Green coverage, pedestrian volume, traffic flow and building density greatly influenced the decrease in the PAH concentration in the green spaces. Among the 4 types of green spaces, public green space had the most ecological benefits and should be fully utilized in urban green space planning to improve public health in urban spaces.
Keywords	air ; coal ; combustion ; gas chromatography-mass spectrometry ; green infrastructure ; pollution ; public health ; regression analysis ; risk ; spring ; toxicology ; traffic ; winter ; China
Language	English
Dates of publication	2021-09
Size	p. 519-529.
Publishing place	Springer US
Document type	Article
ZDB-ID	6895-0
ISSN	1432-0800 ; 0007-4861
ISSN (online)	1432-0800
ISSN	0007-4861
DOI	10.1007/s00128-021-03304-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inhibition of Notch 1 receptor influenced the differentiation of Lin-CD45RA-dendritic cell precursors within ovarian carcinoma microenvironment.

Qian, Xue-Qian / Chen, Li-Li / Cheng, Qi / Tian, Yang / Luo, Xiao-Feng / Wan, Xiao-Yun

BMC immunology

2016 Volume 17, Issue 1, Page(s) 14

Abstract: Background: Previous evidence suggested that the differentiation of Lin-CD45RA-DC precursors were ... signal pathway in the differentiation of Lin-CD45RA-DC precursors.: Methods: The CD34+ ... hematopoietic stem cells were extracted from umbilical cord blood in term parturition, and Lin-CD45RA-DC precusors were ...

Abstract	Background: Previous evidence suggested that the differentiation of Lin-CD45RA-DC precursors were prior to plasmcytoid dendritic cells (pDCs) than myeloid dendritic cells (mDCs) within ovarian cancer microenvironment. However, the mechanism is still unclear. Therefore, we investigated the function of Notch 1 signal pathway in the differentiation of Lin-CD45RA-DC precursors. Methods: The CD34+ hematopoietic stem cells were extracted from umbilical cord blood in term parturition, and Lin-CD45RA-DC precusors were separated and induced mature. Expression of Notch1 receptor and ligands in Lin-CD45RA-DC precusors was detected by Real-time PCR and was down-regulated by shRNA or γ-secretase inhibitor (GSI). Flow cytometry was used to analyze the subset of DCs with or without SKOV3 culture supernatants. IL-12 level was detected by ELISA. Results: Expression of Notch1 receptors and ligands were detected in Lin-CD45RA-DC precursor cells. The Notch1 mRNA in Lin-CD45RA-DC precursors can be down-regulated by shRNA-Notch1 lentivirus transfection and GSI. ShRNA mediated Notch 1 knock-down significantly differentiated less plasmcytoid dendritic cells (pDCs), but generated more myeloid dendritic cells (mDCs), and this would not be influenced by the supernatant of the ovarian carcinoma cell line. GSI had the same effect in the differentiation of pDC. The secretion of IL-12 significantly increased after Notch1 knock-down with or without SKOV3 culture supernatants. Conclusions: Notch1 is an important signaling pathway in the differentiation of Lin-CD45RA-DC precursor cells to plasmcytoid dendritic cells (pDCs). And this would not be affected by the supernatant of the ovarian carcinoma cell line.
MeSH term(s)	Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Cell Differentiation ; Cell Line, Tumor ; Cell Lineage ; Dendritic Cells/immunology ; Female ; Fetal Blood/cytology ; Gene Expression Regulation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/immunology ; Humans ; Interleukin-12/metabolism ; Leukocyte Common Antigens/metabolism ; Oligopeptides/pharmacology ; Ovarian Neoplasms/immunology ; RNA, Small Interfering/genetics ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Tumor Microenvironment
Chemical Substances	NOTCH1 protein, human ; Oligopeptides ; RNA, Small Interfering ; Receptor, Notch1 ; benzyloxycarbonyl-leucyl-leucyl-norleucinal ; Interleukin-12 (187348-17-0) ; Leukocyte Common Antigens (EC 3.1.3.48) ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2016-06-04
Publishing country	England
Document type	Journal Article
ISSN	1471-2172
ISSN (online)	1471-2172
DOI	10.1186/s12865-016-0150-3
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Article: Threatened fishes of the world: Tanichthys albonubes Lin 1932 (Cyprinidae)

Liang, Xu-Fang / Chen, Guo-Zhu / Chen, Xiang-Lin / Yue, Pei-Qi

Environmental biology of fishes. 2008 June, v. 82, no. 2

2008

Abstract: The white cloud mountain minnow Tanichthys albonubes Lin is an endemic species to southern China ... and the genus has two species, Tanichthys albonubes Lin and Tanichthys micagemmae Freyhof et Herder ... The distribution range of T. albonubes Lin and T. micagemmae is very narrow and only found in the mountain brooks ...

Abstract	The white cloud mountain minnow Tanichthys albonubes Lin is an endemic species to southern China and the genus has two species, Tanichthys albonubes Lin and Tanichthys micagemmae Freyhof et Herder. The distribution range of T. albonubes Lin and T. micagemmae is very narrow and only found in the mountain brooks of Baiyunshan Mountain (White Cloud Mountain), Huaxian Country and the vicinity of Guangzhou in Guangdong Province and Halong, Quang Ninh Province, Vietnam respectively. The wild populations of this fish had already been on the verge of extinction when Shu-Yan Lin first discovered it in 1932 at the Baiyunshan Mountain. It was believed to be extinct in the wild because there were no reports of this fish in the wild since 1980. In September 2003, a small and isolated population of the fish was discovered in a mountain puddle in the north vicinity of Guangzhou. Additional studies are needed to determine the survival and propagation of the released fish. The protection of their natural habitat should be implemented.
Keywords	reproduction
Language	English
Dates of publication	2008-06
Size	p. 177-178.
Publisher	Springer Netherlands
Publishing place	Dordrecht
Document type	Article
ZDB-ID	196790-3
ISSN	1573-5133 ; 0378-1909
ISSN (online)	1573-5133
ISSN	0378-1909
DOI	10.1007/s10641-007-9286-6
Database	NAL-Catalogue (AGRICOLA)

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Article: [Study on a downstream signal molecule of human CASK/LIN-2].

Qi, J / Luo, X / Luo, Q

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2000 Volume 17, Issue 6, Page(s) 404–408

Abstract: Objective: To elucidate the function of human CASK/LIN-2, a novel member ...

Abstract	Objective: To elucidate the function of human CASK/LIN-2, a novel member of membrane-associated guanylate kinase homologs family (MAGUK), by using the yeast two-hybrid system(LexA) to screen the protein interacting with the guanylate kinase-like domain(GK) of hCASK and identify possible protein that might involve downstream signal transduction of hCASK. Methods: PCR strategy was used to amplify GK domain cDNA fragment of hCASK. The DNA was subcloned into pLexA to construct bait vector pLexA-GK. The pLexA-GK was transformed into yeast host strain EGY48; through testing the bait protein and a repression assay, it was demonstrated that the bait protein did not have transcription activation for leu and lacZ reporter genes, however it could enter nucleus, bind LexA operator. Human fetus brain cDNA library plasmids were transformed into EGY48 containing pLexA-GK and p8op-lacZ, and screened on plates of Gal/Raf his- trp- ura- leu- and Gal/Raf his- trp- ura-X-gal. The clones with galactose dependent leu+ and lacZ+ were isolated; their library plasmids were rescued by means of transforming E.coli KC8. These library plasmids were transformed into the yeast again to re-screen. The remaining positive clones were analyzed by PCR and restriction endonuclease. Finally two kinds of target DNA fragments were obtained. Results: The specificity testing indicated that the two target proteins could specially bind GK domain of hCASK. After DNA sequencing and BLASTn analysis on NCBI, it was shown that the two target DNA fragments, 732 and 683 bp, had high sequence similarity with human inhibitors of differentiation 1(Id1) mRNA, with identities of 97%(630/645) and 98%(656/666), respectively. Conclusion: GK domain of hCASK could specially interact with Id1 in yeast. Id1 might be a downstream signal molecule of hCASK, which might involve in regulation of cell differentiation.
MeSH term(s)	Base Sequence ; Calcium-Calmodulin-Dependent Protein Kinases ; Guanylate Kinases ; Helminth Proteins/genetics ; Helminth Proteins/physiology ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Molecular Sequence Data ; Nucleoside-Phosphate Kinase/physiology ; Signal Transduction
Chemical Substances	Helminth Proteins ; Lin-2 protein, C elegans ; Membrane Proteins ; CASK kinases (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; Nucleoside-Phosphate Kinase (EC 2.7.4.4) ; Guanylate Kinases (EC 2.7.4.8)
Language	Chinese
Publishing date	2000-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1003-9406
ISSN	1003-9406
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Book: Zhong yi zang xiang yu lin chuang

Yang, Fuguo / Qi, Nan

2001

Title translation	Clinical viscera manifestation theory in Chinese traditional medicine.
Author's details	zhu bian Yang Fuguo, Qi Nan
MeSH term(s)	Medicine, Chinese Traditional ; Viscera/physiopathology
Keywords	China
Language	Chinese
Size	13, 688 p. ;, 27 cm.
Edition	Di 1 ban.
Publisher	Zhong yi gu ji chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787800139291 ; 7800139298
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Wang Qi lin chuang yi xue cong shu

Wang, Qi

2003

Title translation	Wang Qi's medical collection.
Author's details	Wang Qi zhu bian
MeSH term(s)	Medicine, Chinese Traditional
Keywords	China
Language	Chinese
Size	2 v. (2, 2, 3, 1628 p.) ;, 27 cm.
Edition	Di 1 ban.
Publisher	Ren min wei sheng chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787117054997 ; 7117054999
Database	Catalogue of the US National Library of Medicine (NLM)

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