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  1. Article ; Online: Estimating the Effect of Discontinuing Universal Screening of Donated Blood for Zika Virus in the 50 U.S. States.

    Russell, W Alton

    Annals of internal medicine

    2021  Volume 174, Issue 5, Page(s) 728–730

    MeSH term(s) Blood/virology ; Blood Donors ; Humans ; Mass Screening ; RNA, Viral/blood ; United States/epidemiology ; United States Food and Drug Administration ; Viral Load ; Zika Virus/isolation & purification ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-6879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Racial and Ethnic Disparities in Buprenorphine Treatment Duration in the US.

    Dong, Huiru / Stringfellow, Erin J / Russell, W Alton / Jalali, Mohammad S

    JAMA psychiatry

    2022  Volume 80, Issue 1, Page(s) 93–95

    MeSH term(s) Humans ; United States ; Buprenorphine/therapeutic use ; Duration of Therapy ; Racial Groups ; Ethnicity ; Opioid-Related Disorders/drug therapy ; Health Status Disparities
    Chemical Substances Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2022.3673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of COVID-19 Pandemic on Colonoscopy Wait Times by Procedure Indication

    Thibault, Melina / Barkun, Alan / Martel, Myriam / Russell, Alton W.

    medRxiv

    Abstract: Background: Patients are referred for colonoscopy for symptom assessment, screening, and surveillance. Public health measures to mitigate the spread of the COVID−19 pandemic disrupted services and increased patient delays for colonoscopy services in ... ...

    Abstract Background: Patients are referred for colonoscopy for symptom assessment, screening, and surveillance. Public health measures to mitigate the spread of the COVID−19 pandemic disrupted services and increased patient delays for colonoscopy services in Quebec. The differential impact of these interruptions by colonoscopy indication is largely unknown. Methods: Using 2018−2022 retrospective clinical data from two high-volume Montreal endoscopy centres and provincial administrative data, we characterized changes in colonoscopy wait times and the proportion of waitlisted patients who were delayed (wait time exceeded provincial guidelines) by procedure indication and demographics. We used regression to examine patient characteristics associated with delayed procedures during pre- and intra−COVID−19 periods. We used time series analysis to characterize trends in the proportion of waitlisted patients delayed. Results: The COVID-19−related public health measures resulted in record-high delays (median increase in wait times of 34−159% across indications). While older patients experienced longer wait times pre-pandemic, intra−COVID−19 wait times increased disproportionately for patients younger than 50. The proportion of waitlisted patients delayed peaked mid−2020 (56.9% for screening; 56.0% for symptom assessment patients). By early 2022, the proportion delayed had fallen to 37.3% for screening patients but remained at 53.8% for symptom assessment patients. Conclusions: In Quebec, intra-COVID-19 colonoscopy delays disproportionately impacted symptom assessment procedures and younger patients. Additional capacity or improved triaging may be needed to address persistent delays. Understanding the effects of the pandemic on colonoscopy services can help inform strategies to mitigate harms from on-going delays in Quebec.
    Keywords covid19
    Language English
    Publishing date 2024-03-21
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.03.20.24304332
    Database COVID19

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  4. Article ; Online: Impact of COVID-19 Pandemic on Colonoscopy Wait Times by Procedure Indication in Quebec

    Thibault, Melina / Barkun, Alan / Martel, Myriam / Russell, W. Alton

    medRxiv

    Abstract: Background: Patients are referred for colonoscopy for symptom assessment, screening, and surveillance. Public health measures to mitigate the spread of the COVID−19 pandemic disrupted services and increased patient delays for colonoscopy services in ... ...

    Abstract Background: Patients are referred for colonoscopy for symptom assessment, screening, and surveillance. Public health measures to mitigate the spread of the COVID−19 pandemic disrupted services and increased patient delays for colonoscopy services in Quebec. The differential impact of these interruptions by colonoscopy indication is largely unknown. Methods: Using 2018−2022 retrospective clinical data from two high-volume Montreal endoscopy centres and provincial administrative data, we characterized changes in colonoscopy wait times and the proportion of waitlisted patients who were delayed (wait time exceeded provincial guidelines) by procedure indication and demographics. We used regression to examine patient characteristics associated with delayed procedures during pre- and intra−COVID−19 periods. We used time series analysis to characterize trends in the proportion of waitlisted patients delayed. Results: The COVID-19−related public health measures resulted in record-high delays (median increase in wait times of 34−159% across indications). While older patients experienced longer wait times pre-pandemic, intra−COVID−19 wait times increased disproportionately for patients younger than 50. The proportion of waitlisted patients delayed peaked mid−2020 (56.9% for screening; 56.0% for symptom assessment patients). By early 2022, the proportion delayed had fallen to 37.3% for screening patients but remained at 53.8% for symptom assessment patients. Conclusions: In Quebec, intra-COVID-19 colonoscopy delays disproportionately impacted symptom assessment procedures and younger patients. Additional capacity or improved triaging may be needed to address persistent delays. Understanding the effects of the pandemic on colonoscopy services can help inform strategies to mitigate harms from on-going delays in Quebec.
    Keywords covid19
    Language English
    Publishing date 2024-03-21
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.03.20.24304332
    Database COVID19

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  5. Article ; Online: Factors Associated With Abrupt Discontinuation of Long-Term High-Dose Opioid Treatment.

    Vivas-Valencia, Carolina / Dong, Huiru / Stringfellow, Erin J / Russell, W Alton / Morgan, Jake R / Tadrous, Mina / Jalali, Mohammad S

    JAMA network open

    2023  Volume 6, Issue 11, Page(s) e2341416

    MeSH term(s) Humans ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Long-Term Care
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.41416
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  6. Book ; Online: Code and data repository for modeling effectiveness of quarantine and testing to prevent COVID-19 transmission from arriving travelers

    W. Alton Russell / David L. Buckeridge

    2020  

    Abstract: Code and data to accompany manuscript "Effectiveness of quarantine and testing to prevent COVID-19 transmission from arriving travelers". ...

    Abstract Code and data to accompany manuscript "Effectiveness of quarantine and testing to prevent COVID-19 transmission from arriving travelers".
    Keywords covid19
    Publishing date 2020-10-19
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: COVID-19 Convalescent Plasma Model

    Eduard Grebe / Alton W. Russell / Brian Custer

    2020  

    Abstract: This release was an error and does not contain the manuscript code and data it was intended to include. It is unchanged from version 0.5-alpha. ...

    Abstract This release was an error and does not contain the manuscript code and data it was intended to include. It is unchanged from version 0.5-alpha.
    Keywords covid19
    Publishing date 2020-10-26
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Factors driving availability of COVID-19 convalescent plasma: Insights from a demand, production, and supply model.

    Russell, W Alton / Grebe, Eduard / Custer, Brian

    Transfusion

    2021  Volume 61, Issue 5, Page(s) 1370–1376

    Abstract: Background: COVID-19 Convalescent Plasma (CCP) is a promising treatment for COVID-19. Blood collectors have rapidly scaled up collection and distribution programs.: Methods: We developed a detailed simulation model of CCP donor recruitment, ... ...

    Abstract Background: COVID-19 Convalescent Plasma (CCP) is a promising treatment for COVID-19. Blood collectors have rapidly scaled up collection and distribution programs.
    Methods: We developed a detailed simulation model of CCP donor recruitment, collection, production, and distribution processes. We ran our model using varying epidemic trajectories from 11 U.S. states and with key input parameters drawn from wide ranges of plausible values to identify key drivers of ability to scale collections capacity and meet demand for CCP.
    Results: Utilization of available CCP collections capacity followed increases in COVID-19 hospital discharges with a lag. Utilization never exceeded 75% of available capacity in most simulations. Demand was met for most of the simulation period in most simulations, but a substantial portion of demand went unmet during early, sharp increases in hospitalizations. For epidemic trajectories that included multiple epidemic peaks, second wave demand could generally be met due to stockpiles established during the decline from an earlier peak. Apheresis machine capacity (number of machines) and probability that COVID-19 recovered individuals are willing to donate were the most important supply-side drivers of ability to meet demand. Recruitment capacity was important in states with early peaks.
    Conclusions: Epidemic trajectory was the most important determinant of ability to meet demand for CCP, although our simulations revealed several contributing operational drivers of CCP program success.
    MeSH term(s) Antibodies, Viral/blood ; Antibodies, Viral/therapeutic use ; Blood Donors ; COVID-19/blood ; COVID-19/therapy ; Convalescence ; Humans ; Immunization, Passive ; Models, Biological ; SARS-CoV-2/metabolism
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16317
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    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Optimal portfolios of blood safety interventions: test, defer or modify?

    Russell, W Alton / Custer, Brian / Brandeau, Margaret L

    Health care management science

    2021  Volume 24, Issue 3, Page(s) 551–568

    Abstract: A safe supply of blood for transfusion is a critical component of the healthcare system in all countries. Most health systems manage the risk of transfusion-transmissible infections (TTIs) through a portfolio of blood safety interventions. These ... ...

    Abstract A safe supply of blood for transfusion is a critical component of the healthcare system in all countries. Most health systems manage the risk of transfusion-transmissible infections (TTIs) through a portfolio of blood safety interventions. These portfolios must be updated periodically to reflect shifting epidemiological conditions, emerging infectious diseases, and new technologies. However, the number of available blood safety portfolios grows exponentially with the number of available interventions, making it impossible for policymakers to evaluate all feasible portfolios without the assistance of a computer model. We develop a novel optimization model for evaluating blood safety portfolios that enables systematic comparison of all feasible portfolios of deferral, testing, and modification interventions to identify the portfolio that is preferred from a cost-utility perspective. We present structural properties that reduce the state space and required computation time in certain cases, and we develop a linear approximation of the model. We apply the model to retrospectively evaluate U.S. blood safety policies for Zika and West Nile virus for the years 2017, 2018, and 2019, defining donor groups based on season and geography. We leverage structural properties to efficiently find an optimal solution. We find that the optimal portfolio varies geographically, seasonally, and over time. Additionally, we show that for this problem the approximated model yields the same optimal solution as the exact model. Our method enables systematic identification of the optimal blood safety portfolio in any setting and any time period, thereby supporting decision makers in efforts to ensure the safety of the blood supply.
    MeSH term(s) Blood Safety ; Computer Simulation ; Humans ; Retrospective Studies ; Zika Virus ; Zika Virus Infection
    Language English
    Publishing date 2021-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1469148-6
    ISSN 1572-9389 ; 1386-9620
    ISSN (online) 1572-9389
    ISSN 1386-9620
    DOI 10.1007/s10729-021-09557-1
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    Zs.A 5158: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors.

    Russell, W Alton / Scheinker, David / Custer, Brian

    Transfusion

    2021  Volume 62, Issue 1, Page(s) 116–124

    Abstract: Background: Despite a fingerstick hemoglobin requirement and 56-day minimum donation interval, repeat blood donation continues to cause and exacerbate iron deficiency.: Study design and methods: Using data from the REDS-II Donor Iron Status ... ...

    Abstract Background: Despite a fingerstick hemoglobin requirement and 56-day minimum donation interval, repeat blood donation continues to cause and exacerbate iron deficiency.
    Study design and methods: Using data from the REDS-II Donor Iron Status Evaluation study, we developed multiclass prediction models to estimate the competing risk of hemoglobin deferral and collecting blood from a donor with sufficient hemoglobin but low or absent underlying iron stores. We compared models developed with and without two biomarkers not routinely measured in most blood centers: ferritin and soluble transferrin receptor. We generated and analyzed "individual risk trajectories": estimates of how each donors' risk developed as a function of the time interval until their next donation attempt.
    Results: With standard biomarkers, the top model had a multiclass area under the receiver operator characteristic curve (AUC) of 77.6% (95% CI [77.3%-77.8%]). With extra biomarkers, multiclass AUC increased to 82.8% (95% CI [82.5%-83.1%]). In the extra biomarkers model, ferritin was the single most important variable, followed by the donation interval. We identified three risk archetypes: "fast recoverers" (<10% risk of any adverse outcome on post-donation day 56), "slow recoverers" (>60% adverse outcome risk on day 56 that declines to <35% by day 250), and "chronic high-risk" (>85% risk of the adverse outcome on day 250).
    Discussion: A longer donation interval reduced the estimated risk of iron-related adverse outcomesfor most donors, but risk remained high for some. Tailoring safeguards to individual risk estimates could reduce blood collections from donors with low or absent iron stores.
    MeSH term(s) Blood Donors ; Ferritins ; Hemoglobins ; Humans ; Iron ; Receptors, Transferrin
    Chemical Substances Hemoglobins ; Receptors, Transferrin ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16740
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    Zs.A 284: Show issues Location:
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