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  1. Article: Mechanistic insights into fasting-induced autophagy in the aging heart.

    Parvaresh, Hannaneh / Paczek, Katarzyna / Al-Bari, Md Abdul Alim / Eid, Nabil

    World journal of cardiology

    2024  Volume 16, Issue 3, Page(s) 109–117

    Abstract: Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins, damaged organelles, and excessive lipids within mammalian cells. A growing body of data indicates that autophagy is reduced in aging cells. This reduction leads to ... ...

    Abstract Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins, damaged organelles, and excessive lipids within mammalian cells. A growing body of data indicates that autophagy is reduced in aging cells. This reduction leads to various diseases, such as myocardial hypertrophy, infarction, and atherosclerosis. Recent studies in animal models of an aging heart showed that fasting-induced autophagy improved cardiac function and longevity. This improvement is related to autophagic clearance of damaged cellular components
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v16.i3.109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Emerging mechanistic insights of selective and Nonselective Autophagy in liver and gut diseases and their treatment strategies in the era of COVID-19.

    Alim Al-Bari, Md Abdul / Menon, Manoj B / Eid, Nabil

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1206291

    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1206291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-19.

    Al-Bari, Abdul Alim

    Current drug targets

    2020  Volume 21, Issue 16, Page(s) 1703–1721

    Abstract: The emergence of coronavirus disease 2019 (COVID-19) is caused by the 2019 novel coronavirus (2019-nCoV). The 2019-nCoV first broke out in Wuhan and subsequently spread worldwide owing to its extreme transmission efficiency. The fact that the COVID-19 ... ...

    Abstract The emergence of coronavirus disease 2019 (COVID-19) is caused by the 2019 novel coronavirus (2019-nCoV). The 2019-nCoV first broke out in Wuhan and subsequently spread worldwide owing to its extreme transmission efficiency. The fact that the COVID-19 cases and mortalities are reported globally and the WHO has declared this outbreak as the pandemic, the international health authorities have focused on rapid diagnosis and isolation of patients as well as search for therapies able to counter the disease severity. Due to the lack of known specific, effective and proven therapies as well as the situation of public-health emergency, drug repurposing appears to be the best armour to find a therapeutic solution against 2019-nCoV infection. Repurposing anti-malarial drugs and chloroquine (CQ)/ hydroxychloroquine (HCQ) have shown efficacy to inhibit most coronaviruses, including SARS-CoV-1 coronavirus. These CQ analogues have shown potential efficacy to inhibit 2019-nCoV in vitro that leads to focus several future clinical trials. This review discusses the possible effective roles and mechanisms of CQ analogues for interfering with the 2019-nCoV replication cycle and infection.
    MeSH term(s) Aminoquinolines/pharmacology ; Aminoquinolines/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Clinical Trials as Topic ; Drug Repositioning ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Treatment Outcome ; Virulence/drug effects ; Virus Replication/drug effects
    Chemical Substances Aminoquinolines ; Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-12-17
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450121666200617133142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5578: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Current Scenario and Future Direction of Newborn Screening and Management Program for Phenylketonuria in Bangladesh

    Abdul Alim Al-Bari

    Journal of Inborn Errors of Metabolism and Screening, Vol

    2022  Volume 10

    Abstract: Abstract Phenylketonuria (PKU) is a correctable inborn error of metabolism which causes lethal intellectual delay and neurobehavioral anomalies. A screening package, especially for early recognition can support to regulate the PKU process of most ... ...

    Abstract Abstract Phenylketonuria (PKU) is a correctable inborn error of metabolism which causes lethal intellectual delay and neurobehavioral anomalies. A screening package, especially for early recognition can support to regulate the PKU process of most patients. New-born screening program in any country focuses at the earliest detection of inheritance deficiency disorders in order to avoid the most severe repercussion by appropriate medication. This screening program needs a concomitant diagnosis and involves additional clinical research. Strategies from developed countries recommend that new-born screening should be done as soon as possible after birth before hospital/clinic discharge because if detected later, it conveys to significantly increase in disability as well as morbidity. Although exact protocol differs among different countries, testing procedures for PKU should be followed universally recognized in the developed world. Unfortunately, new-born screening program in Bangladesh is in lying-in room or possibly in pilot study in particular hospital, because the health-care system is classically targeted mortality (like childbirth complications) and transmittable morbidities (such as COVID-19) but not inborn frailties. Although policies and management of childbirth complications have been successfully lowered infant and mother mortality rates, the number of disabled babies increased tremendously. The study aims to investigate the current status of new-born screening (NBS) program of PKU in the Rajshahi Division Bangladesh, and focus on future plans to manage with life-long treatment. The primary challenges such as financial support for newborn screening, publicity, should be identified and implemented for national PKU-NBS policy as a role model of Bangladesh for developing countries.
    Keywords Phenylketonuria ; new-born screening ; dried blood spot (DBS) cards ; Guthrie test ; Bangladesh ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher SciELO
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A current view of molecular dissection in autophagy machinery.

    Al-Bari, Md Abdul Alim

    Journal of physiology and biochemistry

    2020  Volume 76, Issue 3, Page(s) 357–372

    Abstract: Macroautophagy (hereafter called autophagy) is a highly conserved lysosomal pathway for catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential homeostatic process through which intracellular components are recycled for ... ...

    Abstract Macroautophagy (hereafter called autophagy) is a highly conserved lysosomal pathway for catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential homeostatic process through which intracellular components are recycled for reuse or energy production. The extremely regulated autophagy process begins with the formation of hallmarked double membrane bound organelles called autophagosomes which in turn fuse with lysosomes called autolysosomes and finally degrade the autophagic cargos. The multistages molecular machinery of autophagy is critically orchestrated by the action of a set of the autophagy proteins (Atg) and a supreme regulator, mTOR (mechanistic target of rapamycin). However, individual stages of autophagy are mechanistically complex and partially understood. In this review, the individual stages of autophagy are dissected, and the corresponding molecular regulation is discussed in view of current scientific knowledge of autophagy. This understanding of sequential events of autophagy machinery through this review may lead to great interest in the therapeutic potential for manipulating of autophagy in established diseases.
    MeSH term(s) Animals ; Autophagy ; Autophagy-Related Proteins/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Humans ; Lysosomes/metabolism ; Signal Transduction
    Chemical Substances Autophagy-Related Proteins
    Language English
    Publishing date 2020-05-25
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1325104-1
    ISSN 1877-8755 ; 0034-9402 ; 1138-7548
    ISSN (online) 1877-8755
    ISSN 0034-9402 ; 1138-7548
    DOI 10.1007/s13105-020-00746-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 198: Show issues Location:
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  6. Article ; Online: Co-targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics.

    Al-Bari, Md Abdul Alim

    Journal of cellular and molecular medicine

    2020  Volume 24, Issue 20, Page(s) 11667–11679

    Abstract: The catabolic autophagy eliminates cytoplasmic components and organelles via lysosomes. Non-selective bulk autophagy and selective autophagy (mitophagy) are linked in intracellular homeostasis both normal and cancer cells. Autophagy has complex and ... ...

    Abstract The catabolic autophagy eliminates cytoplasmic components and organelles via lysosomes. Non-selective bulk autophagy and selective autophagy (mitophagy) are linked in intracellular homeostasis both normal and cancer cells. Autophagy has complex and paradoxical dual role in cancers; it can play either tumour suppressor or tumour promoter depending on the tumour type, stage, microenvironment and genetic context. Cancer stem cells (CSCs) cause tumour recurrence and promote resistant to therapy for driving poor clinical consequences. Thus, new healing strategies are urgently needed to annihilate and eradicate CSCs. As chloroquine (CQ) analogues show positive clinical outcome in several clinical trials either standalone or combination with several chemotherapies. Moreover, CQ analogues are known to eliminate CSCs via altering DNA methylation. However, several obstacles such as higher concentrations and dose-dependent toxicity are noticeable in the treatment of cancers. As tumour cells predominantly rely on mitochondrial actions, mitochondrial targeting FDA-approved antibiotics are reported to effectively eradicate CSCs alone or combination with chemotherapy. However, antibiotics cause metabolic glycolytic shift in cancer cells for survival and repopulation. This review will provide a sketch of the inhibiting roles of current chloroquine analogues and antibiotic combination in CSC autophagy process and discuss the possibility that pre-clinical and clinical potential therapeutic strategy for anticancer therapy.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Autophagy/drug effects ; Chloroquine/analogs & derivatives ; Chloroquine/pharmacology ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mitophagy/drug effects ; Neoplastic Stem Cells/pathology
    Chemical Substances Anti-Bacterial Agents ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2020-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.15879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Enhanced autophagy and phagocytosis of apoptotic lymphocytes in splenic macrophages of acute ethanol-treated rats: Light and electron microscopic studies.

    Betsuyaku, Tsubasa / Ito, Yuko / Peake, Nicholas / Al-Bari, Abdul Alim / El-Akabawy, Gehan / Eid, Nabil

    Histology and histopathology

    2024  , Page(s) 18729

    Abstract: Autophagy is a prosurvival mechanism for the clearance of damaged cellular components, specifically upon exposure to various stressors. In lymphoid organs, excessive ethanol consumption increases lymphocyte apoptosis, resulting in immunosuppression. ... ...

    Abstract Autophagy is a prosurvival mechanism for the clearance of damaged cellular components, specifically upon exposure to various stressors. In lymphoid organs, excessive ethanol consumption increases lymphocyte apoptosis, resulting in immunosuppression. However, ethanol-induced autophagy and related phagocytosis of apoptotic lymphocytes in the spleen have not been studied yet. Adult male Wistar rats were injected intraperitoneally either with 5 g/kg ethanol or phosphate-buffered saline (as a control group) and then sacrificed 0, 3, 6, and 24 hours after injection. Light and transmission electron microscopy (TEM) findings indicated enhanced T cell apoptosis in the white pulps of ethanol-treated rats (ETRs) compared with the control group, which peaked at 6 h and was associated with the accumulation of tingible body macrophages (TBMs). These macrophages exhibited an upregulated autophagic response, as evidenced by enhanced LC3-II (a specific marker of autophagosomes) expression, which peaked at 24h. In addition, double labeling immunofluorescence of LC3-II with lysosomal markers revealed the enhanced formation of autolysosomes in TBMs of ETRs, which was associated with suppression of p62 immunostaining, indicating the enhanced autophagic flux. Interestingly, this elevated autophagic response in ETR TBMs was accompanied by evidence of LC3-associated phagocytosis (LAP) of apoptotic splenocytes. This is based on TUNEL/LC3-II double labeling and TEM observations of phagosomes containing apoptotic bodies, enclosed within phagosomal membranes adjacent to the autophagic vacuoles. It can be concluded that enhanced prosurvival autophagy in splenic TBMs of ETRs and clearing of apoptotic lymphocytes via LAP may contribute to preventing secondary necrosis and autoimmune diseases.
    Language English
    Publishing date 2024-03-05
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3013: Show issues Location:
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  8. Article ; Online: Retraction Note: Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation.

    Al Mamun, Md Abdullah / Hosen, Mohammad Jakir / Khatun, Amina / Alam, M Masihul / Al-Bari, Md Abdul Alim

    Biological research

    2023  Volume 56, Issue 1, Page(s) 37

    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 1138990-4
    ISSN 0717-6287 ; 0716-9760
    ISSN (online) 0717-6287
    ISSN 0716-9760
    DOI 10.1186/s40659-023-00450-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 671: Show issues Location:
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  9. Article ; Online: Current advances in regulation of bone homeostasis.

    Al-Bari, Abdul Alim / Al Mamun, Abdullah

    FASEB bioAdvances

    2020  Volume 2, Issue 11, Page(s) 668–679

    Abstract: Bone homeostasis is securely controlled by the dynamic well-balanced actions among osteoclasts, osteoblasts and osteocytes. Osteoclasts are large multinucleated cells that degrade bone matrix and involve in the bone remodelling in conjunction with other ... ...

    Abstract Bone homeostasis is securely controlled by the dynamic well-balanced actions among osteoclasts, osteoblasts and osteocytes. Osteoclasts are large multinucleated cells that degrade bone matrix and involve in the bone remodelling in conjunction with other bone cells, osteoblasts and osteocytes, the completely matured form of osteoblasts. Disruption of this controlling balance among these cells or any disparity in bone remodelling caused by a higher rate of resorption by osteoclasts over construction of bone by osteoblasts results in a reduction of bone matrix including bone mineral density (BMD) and bone marrow cells (BMCs). The dominating effect of osteoclasts results in advanced risk of bone crack and joint destruction in several diseases including osteoporosis and rheumatoid arthritis (RA). However, the boosted osteoblastic activity produces osteosclerotic phenotype and weakened its action primes to osteomalacia or rickets. On the other hand, senescent osteocytes predominately progress the senescence associated secretory phenotype (SASP) and may contribute to age related bone loss. Here, we discuss an advanced level work on newly identified cellular mechanisms controlling the remodelling of bone and crosstalk among bone cells as these relate to the therapeutic targeting of the skeleton.
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2020-00058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Emerging mechanistic insights of selective autophagy in hepatic diseases.

    Alim Al-Bari, Abdul / Ito, Yuko / Thomes, Paul G / Menon, Manoj B / García-Macia, Marina / Fadel, Raouf / Stadlin, Alfreda / Peake, Nicholas / Faris, MoezAlIslam Ezzat / Eid, Nabil / Klionsky, Daniel J

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1149809

    Abstract: Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading ... ...

    Abstract Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1149809
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