Article: Triple-Therapy of Peritoneal Metastasis-Partial-Dehydration under Hyperthermic Condition Combined with Chemotherapy: The First Preliminary In-Vitro Results.
Pharmaceuticals (Basel, Switzerland)
2023 Volume 16, Issue 5
Abstract: A newly introduced combination of intraperitoneal dehydration and hyperthermia has recently been shown to be feasible and cytotoxic for colon cancer cells in vivo. For the first time, our study now aims to evaluate dehydration under hyperthermic ... ...
| Abstract | A newly introduced combination of intraperitoneal dehydration and hyperthermia has recently been shown to be feasible and cytotoxic for colon cancer cells in vivo. For the first time, our study now aims to evaluate dehydration under hyperthermic conditions combined with chemotherapy for potential use in the clinical setting. In this study, in vitro colon cancer cells (HT-29) were subjected to single or several cycles of partial dehydration under hyperthermic conditions (45 °C), followed by chemotherapy (triple exposure) with oxaliplatin or doxorubicin in various configurations. The viability, cytotoxicity, and proliferation of cells after the proposed protocols were assessed. Intracellular doxorubicin uptake was measured via flow cytometry. After one cycle of triple exposure, the viability of HT-29 cells was significantly reduced versus the untreated control (65.11 ± 5%, |
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| Language | English |
| Publishing date | 2023-05-18 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2193542-7 |
| ISSN | 1424-8247 |
| ISSN | 1424-8247 |
| DOI | 10.3390/ph16050763 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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