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Article ; Online: Intraocular Lymphoma.

Cunningham, Emmett T / Miserocchi, Elisabetta / Smith, Justine R / Gonzales, John A / Zierhut, Manfred

2021 Volume 29, Issue 3, Page(s) 425–429

MeSH term(s)	Eye Neoplasms/diagnosis ; Eye Neoplasms/therapy ; Humans ; Intraocular Lymphoma/diagnosis ; Intraocular Lymphoma/therapy ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/therapy
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Editorial
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2021.1941684
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Article ; Online: Development, validation, and pilot application of a high throughput molecular xenomonitoring assay to detect

Archer, John / Yeo, Shi Min / Gadd, Grace / Pennance, Tom / Cunningham, Lucas J / Juhàsz, Alexandra / Jones, Sam / Chammudzi, Priscilla / Kapira, Donales R / Lally, David / Namacha, Gladys / Mainga, Bright / Makaula, Peter / LaCourse, James E / Kayuni, Sekeleghe A / Musaya, Janelisa / Stothard, J Russell / Webster, Bonnie L

Current research in parasitology & vector-borne diseases

2024 Volume 5, Page(s) 100174

Abstract: Schistosomiasis is a neglected tropical disease (NTD) caused by infection with parasitic trematodes of the ... ...

Abstract	Schistosomiasis is a neglected tropical disease (NTD) caused by infection with parasitic trematodes of the genus
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	2667-114X
ISSN (online)	2667-114X
DOI	10.1016/j.crpvbd.2024.100174
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Article ; Online: THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS.

Ramtohul, Prithvi / Cicinelli, Maria Vittoria / Dolz-Marco, Rosa / Gal-Or, Orly / Mrejen, Sarah / García-Martínez, Jesús R / Goldberg, Alla / Cunha de Souza, Eduardo / Miserocchi, Elisabetta / Cunningham, Emmett T / Yannuzzi, Lawrence A / Freund, K Bailey / Tsui, Edmund

Retina (Philadelphia, Pa.)

2023 Volume 43, Issue 8, Page(s) 1377–1385

Abstract: Purpose: To describe the clinical characteristics and multimodal imaging features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey-yellow chorioretinal lesions surrounded by smaller satellite dots, a ... ...

Abstract	Purpose: To describe the clinical characteristics and multimodal imaging features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey-yellow chorioretinal lesions surrounded by smaller satellite dots, a presentation referred to as "chrysanthemum lesions." Methods: Retrospective, observational, multicenter case series of eyes with active iMFC and chrysanthemum lesions. Multimodal imaging features were reviewed and presented. Results: Twenty-five eyes from 20 patients (12 women and 8 men), with a mean age of 35.8 ± 17.0 years (range, 7-78 years) were included. Chrysanthemum lesions were equally located in the macula (48.0%) or the mid/far periphery (52.0%). The number of lesions per eye varied from 1 (16.0%) to more than 20 (56.0%). On optical coherence tomography, chrysanthemum lesions showed typical features of iMFC, including subretinal hyperreflective material splitting the retinal pigment epithelium/Bruch membrane. Chrysanthemum lesions were hypoautofluorescent on fundus autofluorescence imaging, hyperfluorescent on fluorescein angiography, hypofluorescent on indocyanine green angiography, and associated with choriocapillaris flow signal deficit on optical coherence tomography angiography. Conclusion: Active iMFC may present with findings resembling chrysanthemum lesions. The distinctive lesion morphology on ophthalmoscopic examination, the large number of lesions, and the high prevalence of exclusive midperipheral and far peripheral involvement may represent a distinctive phenotype of iMFC.
MeSH term(s)	Humans ; Multifocal Choroiditis ; Retrospective Studies ; Fundus Oculi ; Choroiditis/diagnosis ; Choroid/pathology ; Fluorescein Angiography/methods ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000003815
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Article ; Online: Whole genome sequencing identifies associations for nonsyndromic sagittal craniosynostosis with the intergenic region of BMP2 and noncoding RNA gene LINC01428.

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8533

Abstract: Craniosynostosis (CS) is a major birth defect resulting from premature fusion of cranial sutures. Nonsyndromic CS occurs more frequently than syndromic CS, with sagittal nonsyndromic craniosynostosis (sNCS) presenting as the most common CS phenotype. ... ...

Abstract	Craniosynostosis (CS) is a major birth defect resulting from premature fusion of cranial sutures. Nonsyndromic CS occurs more frequently than syndromic CS, with sagittal nonsyndromic craniosynostosis (sNCS) presenting as the most common CS phenotype. Previous genome-wide association and targeted sequencing analyses of sNCS have identified multiple associated loci, with the strongest association on chromosome 20. Herein, we report the first whole-genome sequencing study of sNCS using 63 proband-parent trios. Sequencing data for these trios were analyzed using the transmission disequilibrium test (TDT) and rare variant TDT (rvTDT) to identify high-risk rare gene variants. Sequencing data were also examined for copy number variants (CNVs) and de novo variants. TDT analysis identified a highly significant locus at 20p12.3, localized to the intergenic region between BMP2 and the noncoding RNA gene LINC01428. Three variants (rs6054763, rs6054764, rs932517) were identified as potential causal variants due to their probability of being transcription factor binding sites, deleterious combined annotation dependent depletion scores, and high minor allele enrichment in probands. Morphometric analysis of cranial vault shape in an unaffected cohort validated the effect of these three single nucleotide variants (SNVs) on dolichocephaly. No genome-wide significant rare variants, de novo loci, or CNVs were identified. Future efforts to identify risk variants for sNCS should include sequencing of larger and more diverse population samples and increased omics analyses, such as RNA-seq and ATAC-seq.
MeSH term(s)	Humans ; Alleles ; Bone Morphogenetic Protein 2/genetics ; Craniosynostoses/genetics ; DNA, Intergenic/genetics ; Genome-Wide Association Study ; Whole Genome Sequencing ; RNA, Long Noncoding
Chemical Substances	BMP2 protein, human ; Bone Morphogenetic Protein 2 ; DNA, Intergenic ; RNA, Long Noncoding
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58343-w
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Article ; Online: COVID-19 Vaccine Safety Technical (VaST) Work Group: Enhancing vaccine safety monitoring during the pandemic.

Markowitz, Lauri E / Hopkins, Robert H / Broder, Karen R / Lee, Grace M / Edwards, Kathryn M / Daley, Matthew F / Jackson, Lisa A / Nelson, Jennifer C / Riley, Laura E / McNally, Veronica V / Schechter, Robert / Whitley-Williams, Patricia N / Cunningham, Francesca / Clark, Matthew / Ryan, Margaret / Farizo, Karen M / Wong, Hui-Lee / Kelman, Jeffery / Beresnev, Tatiana /

Marshall, Valerie / Shay, David K / Gee, Julianne / Woo, Jared / McNeil, Michael M / Su, John R / Shimabukuro, Tom T / Wharton, Melinda / Keipp Talbot, H

Vaccine

2024

Abstract: During the COVID-19 pandemic, candidate COVID-19 vaccines were being developed for potential use in the United States on an unprecedented, accelerated schedule. It was anticipated that once available, under U.S. Food and Drug Administration (FDA) ... ...

Abstract	During the COVID-19 pandemic, candidate COVID-19 vaccines were being developed for potential use in the United States on an unprecedented, accelerated schedule. It was anticipated that once available, under U.S. Food and Drug Administration (FDA) Emergency Use Authorization (EUA) or FDA approval, COVID-19 vaccines would be broadly used and potentially administered to millions of individuals in a short period of time. Intensive monitoring in the post-EUA/licensure period would be necessary for timely detection and assessment of potential safety concerns. To address this, the Centers for Disease Control and Prevention (CDC) convened an Advisory Committee on Immunization Practices (ACIP) work group focused solely on COVID-19 vaccine safety, consisting of independent vaccine safety experts and representatives from federal agencies - the ACIP COVID-19 Vaccine Safety Technical Work Group (VaST). This report provides an overview of the organization and activities of VaST, summarizes data reviewed as part of the comprehensive effort to monitor vaccine safety during the COVID-19 pandemic, and highlights selected actions taken by CDC, ACIP, and FDA in response to accumulating post-authorization safety data. VaST convened regular meetings over the course of 29 months, from November 2020 through April 2023; through March 2023 FDA issued EUAs for six COVID-19 vaccines from four different manufacturers and subsequently licensed two of these COVID-19 vaccines. The independent vaccine safety experts collaborated with federal agencies to ensure timely assessment of vaccine safety data during this time. VaST worked closely with the ACIP COVID-19 Vaccines Work Group; that work group used safety data and VaST's assessments for benefit-risk assessments and guidance for COVID-19 vaccination policy. Safety topics reviewed by VaST included those identified in safety monitoring systems and other topics of scientific or public interest. VaST provided guidance to CDC's COVID-19 vaccine safety monitoring efforts, provided a forum for review of data from several U.S. government vaccine safety systems, and assured that a diverse group of scientists and clinicians, external to the federal government, promptly reviewed vaccine safety data. In the event of a future pandemic or other biological public health emergency, the VaST model could be used to strengthen vaccine safety monitoring, enhance public confidence, and increase transparency through incorporation of independent, non-government safety experts into the monitoring process, and through strong collaboration among federal and other partners.
Language	English
Publishing date	2024-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.12.059
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Zs.MO 458: Show issues

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Article ; Online: Overview of U.S. COVID-19 vaccine safety surveillance systems.

Gee, Julianne / Shimabukuro, Tom T / Su, John R / Shay, David / Ryan, Margaret / Basavaraju, Sridhar V / Broder, Karen R / Clark, Matthew / Buddy Creech, C / Cunningham, Francesca / Goddard, Kristin / Guy, Harrison / Edwards, Kathryn M / Forshee, Richard / Hamburger, Tanya / Hause, Anne M / Klein, Nicola P / Kracalik, Ian / Lamer, Chris /

Loran, David A / McNeil, Michael M / Montgomery, Jay / Moro, Pedro / Myers, Tanya R / Olson, Christine / Oster, Matthew E / Sharma, Andrea J / Schupbach, Ryan / Weintraub, Eric / Whitehead, Brett / Anderson, Steven

Vaccine

2024

Abstract: The U.S. COVID-19 vaccination program, which commenced in December 2020, has been instrumental in preventing morbidity and mortality from COVID-19 disease. Safety monitoring has been an essential component of the program. The federal government undertook ...

Abstract	The U.S. COVID-19 vaccination program, which commenced in December 2020, has been instrumental in preventing morbidity and mortality from COVID-19 disease. Safety monitoring has been an essential component of the program. The federal government undertook a comprehensive and coordinated approach to implement complementary safety monitoring systems and to communicate findings in a timely and transparent way to healthcare providers, policymakers, and the public. Monitoring involved both well-established and newly developed systems that relied on both spontaneous (passive) and active surveillance methods. Clinical consultation for individual cases of adverse events following vaccination was performed, and monitoring of special populations, such as pregnant persons, was conducted. This report describes the U.S. government's COVID-19 vaccine safety monitoring systems and programs used by the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the Department of Defense, the Department of Veterans Affairs, and the Indian Health Service. Using the adverse event of myocarditis following mRNA COVID-19 vaccination as a model, we demonstrate how the multiple, complementary monitoring systems worked to rapidly detect, assess, and verify a vaccine safety signal. In addition, longer-term follow-up was conducted to evaluate the recovery status of myocarditis cases following vaccination. Finally, the process for timely and transparent communication and dissemination of COVID-19 vaccine safety data is described, highlighting the responsiveness and robustness of the U.S. vaccine safety monitoring infrastructure during the national COVID-19 vaccination program.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.065
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Zs.MO 458: Show issues

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Article ; Online: Electromagnetic power of lightning superbolts from Earth to space.

Ripoll, J-F / Farges, T / Malaspina, D M / Cunningham, G S / Lay, E H / Hospodarsky, G B / Kletzing, C A / Wygant, J R / Pédeboy, S

Nature communications

2021 Volume 12, Issue 1, Page(s) 3553

Abstract: Lightning superbolts are the most powerful and rare lightning events with intense optical emission, first identified from space. Superbolt events occurred in 2010-2018 could be localized by extracting the high energy tail of the lightning stroke signals ... ...

Abstract	Lightning superbolts are the most powerful and rare lightning events with intense optical emission, first identified from space. Superbolt events occurred in 2010-2018 could be localized by extracting the high energy tail of the lightning stroke signals measured by the very low frequency ground stations of the World-Wide Lightning Location Network. Here, we report electromagnetic observations of superbolts from space using Van Allen Probes satellite measurements, and ground measurements, and with two events measured both from ground and space. From burst-triggered measurements, we compute electric and magnetic power spectral density for very low frequency waves driven by superbolts, both on Earth and transmitted into space, demonstrating that superbolts transmit 10-1000 times more powerful very low frequency waves into space than typical strokes and revealing that their extreme nature is observed in space. We find several properties of superbolts that notably differ from most lightning flashes; a more symmetric first ground-wave peak due to a longer rise time, larger peak current, weaker decay of electromagnetic power density in space with distance, and a power mostly confined in the very low frequency range. Their signal is absent in space during day times and is received with a long-time delay on the Van Allen Probes. These results have implications for our understanding of lightning and superbolts, for ionosphere-magnetosphere wave transmission, wave propagation in space, and remote sensing of extreme events.
Language	English
Publishing date	2021-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-23740-6
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Article ; Online: National British Orthodontic Society (BOS) Orthognathic Audit 2017-2018.

Ireland, Anthony J / Atack, Nicola E / Cunningham, Susan J / House, Kate / Cobourne, Martyn T / Hunt, Nigel P / Sherriff, Martyn / Sandy, Jonathan R

Journal of orthodontics

2019 Volume 46, Issue 4, Page(s) 287–296

Abstract: Objective: To carry out a UK national clinical audit of orthognathic acceptance criteria and information provided to orthognathic patients before treatment.: Design: National clinical audit.: Setting: Data collected using Bristol Online Surveys.!## ...

Abstract	Objective: To carry out a UK national clinical audit of orthognathic acceptance criteria and information provided to orthognathic patients before treatment. Design: National clinical audit. Setting: Data collected using Bristol Online Surveys. Participants: Sixty-nine UK hospital orthodontic departments submitted data. Methods: Data were collected at two time points using Bristol Online Surveys over a period of 12 months. These were before treatment at the first multidisciplinary clinic (MDT) and immediately after surgery. The data collected included: Index of Orthognathic Functional Treatment Need (IOFTN); Index of Orthodontic Treatment Need (IOTN); age; previous orthodontic treatment; attendance at an MDT; treatment times; and information provision. Results: Eighty-five units agreed to take part in the audit with 69 submitting data, giving a response rate of 81%. The data from 3404 patients were uploaded, 2263 before treatment and 1141 immediately after surgery. Of patients, 91.07% had an IOFTN score of 4 or 5 and 88.73% had an IOTN score of 4 or 5. The mean age at the first MDT was 22 years in the first cohort and 21 years and 4 months in the second immediate post-surgery cohort. Of patients, 37.93% had undergone some form of previous orthodontic treatment, but only 0.28% had undergone previous orthognathic treatment; 96.93% had an MDT confirm that orthodontic treatment by itself was insufficient to adequately correct their functional symptoms. The average treatment time from bond up to surgery was 2 years and 6 months. With respect to information provision, patients received information from a number of sources, principally the British Orthodontic Society (BOS) patient information leaflets and the BOS website Your Jaw Surgery. Conclusions: In the UK, the majority of orthognathic cases fulfil the criteria for acceptance for NHS-funded orthognathic treatment, as outlined by the Chief Dental Officer's interim guidance on orthognathic treatment. This suggests any prior approval process would not be a good use of NHS resources in the commissioning of orthognathic treatment.
MeSH term(s)	Adult ; Ethnic Groups ; Humans ; Index of Orthodontic Treatment Need ; Orthognathic Surgical Procedures ; Societies, Dental ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2011954-9
ISSN	1465-3133 ; 0301-228X ; 1465-3125
ISSN (online)	1465-3133
ISSN	0301-228X ; 1465-3125
DOI	10.1177/1465312519879934
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Article ; Online: Correction: The One Health High-Level Expert Panel (OHHLEP).

Mettenleiter, Thomas C / Markotter, Wanda / Charron, Dominique F / Adisasmito, Wiku B / Almuhairi, Salama / Behravesh, Casey Barton / Bilivogui, Pépé / Bukachi, Salome A / Casas, Natalia / Becerra, Natalia Cediel / Chaudhary, Abhishek / Ciacci Zanella, Janice R / Cunningham, Andrew A / Dar, Osman / Debnath, Nitish / Dungu, Baptiste / Farag, Elmoubasher / Gao, George F / Hayman, David T S /

Khaitsa, Margaret / Koopmans, Marion P G / Machalaba, Catherine / Mackenzie, John S / Morand, Serge / Smolenskiy, Vyacheslav / Zhou, Lei

One health outlook

2024 Volume 6, Issue 1, Page(s) 6

Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Published Erratum
ISSN	2524-4655
ISSN (online)	2524-4655
DOI	10.1186/s42522-024-00096-7
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Article ; Online: Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.

Nason, Shelly R / Antipenko, Jessica / Presedo, Natalie / Cunningham, Stephen E / Pierre, Tanya H / Kim, Teayoun / Paul, Jodi R / Holleman, Cassie / Young, Martin E / Gamble, Karen L / Finan, Brian / DiMarchi, Richard / Hunter, Chad S / Kharitonenkov, Alexei / Habegger, Kirk M

JCI insight

2021 Volume 6, Issue 4

Abstract: Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully elucidated. We ... ...

Abstract	Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully elucidated. We previously identified that hepatic GCGR signaling increases circulating fibroblast growth factor 21 (FGF21), a potent regulator of energy balance. We reported that mice deficient for liver Fgf21 are partially resistant to GCGR-mediated weight loss, implicating FGF21 as a regulator of glucagon's weight loss effects. FGF21 signaling requires an obligate coreceptor (β-Klotho, KLB), with expression limited to adipose tissue, liver, pancreas, and brain. We hypothesized that the GCGR-FGF21 system mediates weight loss through a central mechanism. Mice deficient for neuronal Klb exhibited a partial reduction in body weight with chronic GCGR agonism (via IUB288) compared with controls, supporting a role for central FGF21 signaling in GCGR-mediated weight loss. Substantiating these results, mice with central KLB inhibition via a pharmacological KLB antagonist, 1153, also displayed partial weight loss. Central KLB, however, is dispensable for GCGR-mediated improvements in plasma cholesterol and liver triglycerides. Together, these data suggest GCGR agonism mediates part of its weight loss properties through central KLB and has implications for future treatments of obesity and metabolic syndrome.
MeSH term(s)	Animals ; Body Weight ; Eating ; Fibroblast Growth Factors/genetics ; Gene Expression ; Glucagon/metabolism ; Glucose/metabolism ; Homeostasis ; Klotho Proteins/genetics ; Klotho Proteins/metabolism ; Lipid Metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/metabolism ; Peptides ; Receptors, Glucagon/metabolism ; Signal Transduction ; Weight Loss
Chemical Substances	IUB288 ; Klb protein, mouse ; Peptides ; Receptors, Glucagon ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; Glucagon (9007-92-5) ; Klotho Proteins (EC 3.2.1.31) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.141323
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