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Article ; Online: (1)H, (13)C and (15)N resonance assignments for the response regulator CheY3 from Rhodobacter sphaeroides.

Varela, Lorena / Bell, Christian H / Armitage, Judith P / Redfield, Christina

2016 Volume 10, Issue 2, Page(s) 373–378

Abstract: ... in R. sphaeroides. Here we present the (1)H, (13)C and (15)N assignments for CheY3 in its active ...

Abstract	Rhodobacter sphaeroides has emerged as a model system for studies of the complex chemotaxis pathways that are a hallmark of many non-enteric bacteria. The genome of R. sphaeroides encodes two sets of flagellar genes, fla1 and fla2, that are controlled by three different operons. Each operon encodes homologues of most of the proteins required for the well-studied E. coli chemotaxis pathway. R. sphaeroides has six homologues of the response regulator CheY that are localized to and are regulated by different clusters of chemosensory proteins in the cell and have different effects on chemotaxis. CheY6 is the major CheY stopping the fla1 flagellar motor and associated with a cytoplasmically localised chemosensory pathway. CheY3 and CheY4 are associated with a membrane localised polar chemosensory cluster, and can bind to but not stop the motor. CheY6 and either CheY3 or CheY4 are required for chemotaxis. We are using NMR spectroscopy to characterise and compare the structure and dynamics of CheY3 and CheY6 in solution. We are interested in defining the conformational changes that occur upon activation of these two proteins and to identify differences in their properties that can explain the different functions they play in chemotaxis in R. sphaeroides. Here we present the (1)H, (13)C and (15)N assignments for CheY3 in its active, inactive and Mg(2+)-free apo form. These assignments provide the starting point for detailed investigations of the structure and function of CheY3.
MeSH term(s)	Apoproteins/chemistry ; Apoproteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Magnesium/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Rhodobacter sphaeroides
Chemical Substances	Apoproteins ; Bacterial Proteins ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2016-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2388861-1
ISSN	1874-270X ; 1874-2718
ISSN (online)	1874-270X
ISSN	1874-2718
DOI	10.1007/s12104-016-9703-x
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Article ; Online: Correction to: A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism.

Armitage, Michael N / Mughal, Aishah Z / Huntley, Christopher C / Lasserson, Daniel / Newnham, Michael

Journal of thrombosis and thrombolysis

2023 Volume 55, Issue 3, Page(s) 584

Language	English
Publishing date	2023-01-20
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-023-02771-4
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Article ; Online: Impacts of the COVID-19 public health emergency on healthcare professional delivery of opportunistic behaviour change interventions: a retrospective cohort study.

Keyworth, Chris / Conner, Mark / Johnson, Judith / Epton, Tracy / Vogt, Katharina S / Armitage, Christopher J

BMC health services research

2024 Volume 24, Issue 1, Page(s) 167

Abstract: ... change interventions, and (c) identify targets to increase healthcare professionals' delivery ... healthcare professionals working in the UK. In both surveys (July-September 2017; N = 1387, and February-March 2022; N ... 0%), and (c) they spent a lower proportion of the consultation time delivering interventions (26.5 ...

Abstract	Background: The public health policy "Making Every Contact Count" (MECC) compels healthcare professionals to deliver health behaviour change interventions during routine consultations. As healthcare systems continue their recovery from the impacts of the COVID-19 public health emergency, supporting people to modify health behaviours is more important now than when the policy was introduced. The present study aims to: (a) examine changes in healthcare professionals' awareness of, and engagement with the policy over a five-year period, (b) examine the psychosocial drivers associated with delivering behaviour change interventions, and (c) identify targets to increase healthcare professionals' delivery of interventions. Methods: Comparison of data from two independent representative surveys of NHS healthcare professionals working in the UK. In both surveys (July-September 2017; N = 1387, and February-March 2022; N = 1008), participants were asked to report: (1) awareness of the MECC policy, (2) the prevalence of MECC-related practice (perceived patient benefit, how often interventions were delivered, and time spent delivering interventions), and (3) perceptions of capabilities, opportunities and motivations to deliver behaviour change interventions. T- tests (independent-samples), MANOVA, multiple linear regression, and chi-square analyses were used to generate comparisons between the surveys. Results: Awareness of the policy increased from 2017 (31.4%) to 2022 (52.0%). However, in 2022 compared with 2017, healthcare professionals reported (a) fewer patients would benefit from behaviour change interventions (49.1% versus 55.9%), (b) they delivered behaviour change interventions to a lower proportion of patients (38.0% versus 50.0%), and (c) they spent a lower proportion of the consultation time delivering interventions (26.5% versus 35.3%). Further, in 2022, compared with 2017, healthcare professionals reported fewer physical opportunities, fewer social opportunities, and fewer psychological capabilities to deliver behaviour change interventions. In the 2022 survey, perceptions of patient benefit and delivery of interventions was associated with greater perceptions of opportunities and motivations. Conclusions: Health behaviour change interventions remain an important part of routine healthcare in the continued recovery from COVID-19 public health emergency, however reported engagement with MECC-related practices appears to have reduced over time. Future research should consider how healthcare professionals identify patients who might benefit from opportunistic behaviour change interventions, and to increase capabilities, opportunities, and motivations to deliver interventions during routine consultations.
MeSH term(s)	Humans ; Public Health ; Retrospective Studies ; COVID-19/epidemiology ; Health Personnel/psychology ; Delivery of Health Care
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-10522-7
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Article ; Online: Periodontal Diagnosis and Treatment in the Coming Decades.

Armitage, Gary C

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)

2017 Volume 38, Issue 8 Suppl, Page(s) 34–36

Abstract: The purpose of this article is to review the dominant paradigms and thinking behind periodontal diagnosis and treatment over the last 150 years, including the clinical characteristics paradigm, the classical pathology paradigm, and the infection/ host ... ...

Abstract	The purpose of this article is to review the dominant paradigms and thinking behind periodontal diagnosis and treatment over the last 150 years, including the clinical characteristics paradigm, the classical pathology paradigm, and the infection/ host response paradigm, and to predict what changes may occur in the next 50 years, such as the molecular ecology paradigm.
MeSH term(s)	Forecasting ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Periodontal Diseases/diagnosis ; Periodontal Diseases/history ; Periodontal Diseases/microbiology ; Periodontal Diseases/therapy ; Periodontics/history ; Periodontics/trends
Language	English
Publishing date	2017-12-11
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	632569-5
ISSN	2158-1797 ; 0734-0338
ISSN (online)	2158-1797
ISSN	0734-0338
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Article: Implementation of national guidance for self-harm among general practice nurses: a qualitative exploration using the capabilities, opportunities, and motivations model of behaviour change (COM-B) and the theoretical domains framework.

Leather, Jessica Z / Keyworth, Chris / Kapur, Nav / Campbell, Stephen M / Armitage, Christopher J

BMC nursing

2023 Volume 22, Issue 1, Page(s) 452

Abstract: Background: Patients who self-harm may consult with primary care nurses, who have a safeguarding responsibility to recognise and respond to self-harm. However, the responses of nursing staff to self-harm are poorly understood, and opportunities to ... ...

Abstract	Background: Patients who self-harm may consult with primary care nurses, who have a safeguarding responsibility to recognise and respond to self-harm. However, the responses of nursing staff to self-harm are poorly understood, and opportunities to identify self-harm and signpost towards treatment may be missed. It is unclear how to support nursing staff to implement national guidelines. Aims: Among primary care nursing staff to: [1] Examine reported barriers and enablers to nurses' use of, and adherence to, national guidance for self-harm; and [2] Recommend potential intervention strategies to improve implementation of the NICE guidelines. Methods: Twelve telephone interviews partly structured around the capabilities, opportunities and motivations model of behaviour change (COM-B) were conducted with primary care nurses in the United Kingdom. The Theoretical Domains Framework was used as an analytical framework, while the Behaviour Change Wheel was used to identify exemplar behaviour change techniques and intervention functions. Results: Nursing staff identified a need to learn more about risk factors (knowledge), and strategies to initiate sensitive conversations about self-harm (cognitive and interpersonal skills) to support their professional competencies (professional role and identity). Prompts may support recall of the guidance and support a patient centred approach to self-harm within practices (memory, attention, and decision making). GPs, and other practice nurses offer guidance and support (social influences), which helps nurses to navigate referrals and restricted appointment lengths (environmental context and influences). Conclusions: Two converging sets of themes relating to information delivery and resource availability need to be targeted. Nine groups of behaviour change techniques, and five intervention functions offer candidate solutions for future intervention design. Key targets for change include practical training to redress conversational skill gaps about self-harm, the integration of national guidance with local resources and practice-level protocols to support decision-making, and creating opportunities for team-based mentoring.
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-023-01360-3
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Article ; Online: Re-evaluating how sweet-liking and PROP-tasting are related.

Yeomans, Martin R / Vi, Chi / Mohammed, Narmeen / Armitage, Rhiannon M

Physiology & behavior

2022 Volume 246, Page(s) 113702

Abstract: ... liking are a manifestation of the more widely known differences in sensitivity to the bitter tastant 6-n ...

Abstract	Past research has identified distinct phenotypic differences in responses to sweet taste, although the origins of these differences remain unclear. One possibility is that these individual differences in sweet-liking are a manifestation of the more widely known differences in sensitivity to the bitter tastant 6-n-propylthiouracil (PROP), which has been related to wider differences in food liking and preference. However, previous studies exploring the relationship between sweet-liking and PROP-tasting have had mixed outcomes. This is possibly due to older studies using a more simplistic dichotic characterisation of sweet likers, whereas recent research suggests three sweet-liking phenotypes (extreme sweet likers, ESL; moderate sweet likers, MSL; and sweet dislikers, SD). To re-assess how sweet-liking and PROP tasting are inter-related, 236 volunteers evaluated their liking for 1.0 M sucrose and the intensity of three concentrations of each NaCl and PROP. Using three different methods for classifying PROP taster status, our analysis confirmed that all three sweet-liking phenotypes were represented in all three PROP taster groups (super-tasters, ST; medium tasters, MT; and non-tasters, NT), but relatively few ESL were classified as ST, or SD as NT. Overall, these data suggest that while PROP tasting and sweet-liking are not causally related, the SD phenotype may partly be explained by a broader tendency for anhedonia.
MeSH term(s)	Emotions ; Food Preferences/physiology ; Humans ; Propylthiouracil ; Sodium Chloride ; Sucrose ; Taste/physiology
Chemical Substances	Sodium Chloride (451W47IQ8X) ; Sucrose (57-50-1) ; Propylthiouracil (721M9407IY)
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2022.113702
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Article ; Online: A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism.

Armitage, Michael N / Mughal, Aishah Z / Huntley, Christopher C / Lasserson, Daniel / Newnham, Michael

Journal of thrombosis and thrombolysis

2022 Volume 55, Issue 1, Page(s) 126–133

Abstract: Background: The incidence of subsegmental pulmonary embolism (SSPE) has increased with improvements in imaging technology. There is clinical equipoise for SSPE treatment, with conflicting evidence of improved mortality or reduced venous thromboembolism ... ...

Abstract	Background: The incidence of subsegmental pulmonary embolism (SSPE) has increased with improvements in imaging technology. There is clinical equipoise for SSPE treatment, with conflicting evidence of improved mortality or reduced venous thromboembolism recurrence with anticoagulation. SSPE studies have significant heterogeneity and often lack adequately matched disease comparator groups. Objectives: To determine the prevalence, management, and outcomes of SSPE and compare them to patients with main, lobar, segmental, and no pulmonary embolism (PE). Patients/methods: All adult patients undergoing CT pulmonary angiography (CTPA) between 2013 and 2019, at 3 UK hospitals were included in the study. CTPA reports were text mined for language relating to PE, and then further manually screened for the presence and anatomical location of PE. Patient groups were propensity matched by age, sex, and year of CTPA prior to analysis. 3-month outcomes of major bleeding, VTE recurrence, and death were recorded. Results: 79 (3.8%) SSPEs were identified from 2,055 diagnoses of PE, and 14,300 CTPA reports. 44 (56%) of SSPEs were single artery emboli, 25 (32%) were multiple unilateral emboli, and 10 (13%) were multiple bilateral emboli. Mortality, VTE recurrence and major bleeding were similar at 3 months across all groups. 87.3% of SSPE imaging reports had an additional radiological diagnosis, with pleural effusion (30%), consolidation (19%), and cardiomegaly (19%) being the most common. Conclusion: The prevalence of SSPE was 3.8% of all PEs and there were a substantial number of additional radiological findings in the SSPE group that may have accounted for their symptoms.
MeSH term(s)	Adult ; Humans ; Venous Thromboembolism/diagnostic imaging ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology ; Prevalence ; Subacute Sclerosing Panencephalitis/drug therapy ; Anticoagulants/therapeutic use ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Hemorrhage/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-11-07
Publishing country	Netherlands
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-022-02714-5
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Article ; Online: The Trichoptera of Panama XXIV. Fifteen new species and two new country records of the caddisfly genus Neotrichia (Trichoptera, Hydroptilidae), with a key to all known Panamanian species

Steven C. Harris / Brian J. Armitage / Tomás A. Ríos González

ZooKeys, Vol 1188, Iss , Pp 47-

2024 Volume 90

Abstract: ... Ross, 1944. Finally, the male of N. vibrans is re-illustrated, the female is illustrated and ...

Abstract	In this paper, 15 new species of microcaddisflies in the genus Neotrichia Morton, 1905 (Trichoptera, Hydroptilidae) from Panama are described and illustrated: Neotrichia abrebotella sp. nov.; Neotrichia candela sp. nov.; Neotrichia codaza sp. nov.; Neotrichia embera sp. nov.; Neotrichia flennikeni sp. nov.; Neotrichia honda sp. nov.; Neotrichia landisae sp. nov.; Neotrichia lenati sp. nov.; Neotrichia mindyae sp. nov.; Neotrichia panamensis sp. nov.; Neotrichia parajarochita sp. nov.; Neotrichia paraxicana sp. nov.; Neotrichia snixae sp. nov.; Neotrichia spangleri sp. nov.; Neotrichia veraguasensis sp. nov. In addition, two new country records are presented: Neotrichia minutisimella (Chambers, 1873) and Neotrichia vibrans Ross, 1944. Finally, the male of N. vibrans is re-illustrated, the female is illustrated and descriptive information given, and a key is provided to the males of all current Neotrichia species in Panama. There are now 45 species of Neotrichia and a total of 525 Trichoptera species recorded from Panama.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: A magnetic continuum in the cobalt-based honeycomb magnet BaCo

Zhang, Xinshu / Xu, Yuanyuan / Halloran, T / Zhong, Ruidan / Broholm, C / Cava, R J / Drichko, N / Armitage, N P

Nature materials

2022

Abstract: Quantum spin liquids (QSLs) are topologically ordered states of matter that host fractionalized excitations. A particular route towards a QSL is via strongly bond-dependent interactions on the hexagonal lattice. A number of Ru- and Ir-based candidate ... ...

Abstract	Quantum spin liquids (QSLs) are topologically ordered states of matter that host fractionalized excitations. A particular route towards a QSL is via strongly bond-dependent interactions on the hexagonal lattice. A number of Ru- and Ir-based candidate Kitaev QSL materials have been pursued, but all have appreciable non-Kitaev interactions. Using time-domain terahertz spectroscopy, we observed a broad magnetic continuum over a wide range of temperatures and fields in the honeycomb cobalt-based magnet BaCo
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2088679-2
ISSN	1476-4660 ; 1476-1122
ISSN (online)	1476-4660
ISSN	1476-1122
DOI	10.1038/s41563-022-01403-1
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Article ; Online: The Plecoptera of Panama. III. The genus Anacroneuria (Plecoptera: Perlidae) in Panama's national parks: 2017 survey results.

Kondratieff, Boris C / Armitage, Brian J

Zootaxa

2019 Volume 4565, Issue 3, Page(s) zootaxa.4565.3.7

Abstract: Two new species of Anacroneuria are described. Anacroneuria bandido sp. n. is described from Coclé ... and Veraguas provinces of central Panama, and A. tuberculata sp. n. is proposed to provide a new name ...

Abstract	Two new species of Anacroneuria are described. Anacroneuria bandido sp. n. is described from Coclé and Veraguas provinces of central Panama, and A. tuberculata sp. n. is proposed to provide a new name for a species previously identified from Costa Rica as A. magnirufa Jewett, 1958. New locality records are presented for eight species previously reported from Panama. The female of one species from Bocas del Toro province is described under an informal designation. There are now 26 recognized species of Plecoptera known from Panama.
MeSH term(s)	Animals ; Costa Rica ; Female ; Insecta ; Panama ; Parks, Recreational
Language	English
Publishing date	2019-03-11
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4565.3.7
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