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  1. Article ; Online: Resistance in Enteric Shigella and nontyphoidal Salmonella : emerging concepts.

    Yang, Chaojie / Xiang, Ying / Qiu, Shaofu

    Current opinion in infectious diseases

    2023  Volume 36, Issue 5, Page(s) 360–365

    Abstract: Purpose of review: The emergence of globally resistant enteric Shigella and nontyphoidal Salmonella strains (NTS) has limited the selection of effective drugs, which has become a major challenge for the treatment of infections. The purpose of this ... ...

    Abstract Purpose of review: The emergence of globally resistant enteric Shigella and nontyphoidal Salmonella strains (NTS) has limited the selection of effective drugs, which has become a major challenge for the treatment of infections. The purpose of this review is to provide the current opinion on the antimicrobial-resistant enteric Shigella and nontyphoidal Salmonella .
    Recent findings: Enteric Shigella and NTS are resistant to almost all classes of antimicrobials in recent years. Those with co-resistance to ciprofloxacin, azithromycin and ceftriaxone, the first-line antibiotics for the treatment of infectious diarrhoea have emerged worldwide. Some of them have caused interregional and international spread by travel, trade, MSM, and polluted water sources. Several strains have even developed resistance to colistin, the last-resort antibiotic used for treatment of multidrug-resistant Gram-negative bacteria infections.
    Summary: The drug resistance of enteric Shigella and NTS is largely driven by the use of antibiotics and horizontal gene transfer of mobile genetic elements. These two species show various drug resistance patterns in different regions and serotypes. Hence treatment decisions for Shigella and Salmonella infections need to take into consideration prevalent antimicrobial drug resistance patterns. It is worth noting that the resistance genes such as blaCTX,mph, ermB , qnr and mcr , which can cause resistance to ciprofloxacin, cephalosporin, azithromycin and colistin are widespread because of transmission by IncFII, IncI1, IncI2 and IncB/O/K/Z plasmids. Therefore, continuous global monitoring of resistance in Shigella and Salmonella is imperative.
    MeSH term(s) Humans ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; Colistin ; Shigella/genetics ; Salmonella/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use
    Chemical Substances Azithromycin (83905-01-5) ; Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of control measures for COVID-19 in Wuhan, China.

    Wang, Ligui / Chen, Hui / Qiu, Shaofu / Song, Hongbin

    The Journal of infection

    2020  Volume 81, Issue 2, Page(s) 318–356

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the

    Ge, Xin / Zhou, Yu / Jin, Hang / Liu, Kangkang / Zhu, Kunpeng / Yu, Yulong / Xue, Jingzhuang / Wang, Qi / Du, Xinying / Wang, Hui / Xiang, Ying / Li, Wenjun / Tian, Sai / Yan, Zhongqiang / Qiu, Shaofu

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1359340

    Abstract: Background: The escalating resistance of : Methods: This research compared the resistance phenotypes and genomic profiles of CRKP and Non-CRKP isolates in a Beijing hospital, focusing on high-risk : Results: The study revealed that among the 31 ... ...

    Abstract Background: The escalating resistance of
    Methods: This research compared the resistance phenotypes and genomic profiles of CRKP and Non-CRKP isolates in a Beijing hospital, focusing on high-risk
    Results: The study revealed that among the 31 CRKP isolates, ST11 is the most common sequence type, with K47 and OL101 being the dominant capsule types, primarily observed in the respiratory department. In terms of antimicrobial susceptibility: 87.5% of the isolates exhibited multidrug resistance (MDR), with a high resistance rate of 30% against tigecycline. All CRKP isolates demonstrated resistance to multiple drug classes (≥5 CLSI classes). Non-CRKP isolates also showed high resistance rates to minocycline and doxycycline (77.8%). the ST11-KL47-OL101 type emerged as the predominant clone among the CRKP isolates carrying the
    Conclusion: In summary, our study highlights the extensive spread of antibiotic-resistant
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1359340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid Identification and Source Tracing of a

    Lin, Yanfeng / Yang, Lang / Qiu, Shaofu / Yang, Chaojie / Wang, Kaiying / Li, Jinhui / Jia, Leili / Li, Peng / Song, Hongbin

    Foodborne pathogens and disease

    2022  Volume 19, Issue 4, Page(s) 259–265

    Abstract: ... ...

    Abstract Salmonella
    MeSH term(s) China/epidemiology ; Disease Outbreaks ; Electrophoresis, Gel, Pulsed-Field ; Salmonella typhimurium/genetics ; Whole Genome Sequencing
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2148479-X
    ISSN 1556-7125 ; 1535-3141
    ISSN (online) 1556-7125
    ISSN 1535-3141
    DOI 10.1089/fpd.2021.0072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A model study on predicting new COVID-19 cases in China based on social and news media.

    Lin, Mengxuan / Chen, Hui / Wang, Yuqi / Qiu, Shaofu / Yang, Mingjuan / Du, Xinying / Zheng, Tao / Song, Hongbin / Wang, Ligui

    The Journal of infection

    2022  Volume 84, Issue 4, Page(s) e1–e3

    MeSH term(s) COVID-19 ; China/epidemiology ; Humans ; Mass Media ; Social Media
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A novel humanized tri-receptor transgenic mouse model of HAdV infection and pathogenesis.

    Wang, Yawei / Wang, Min / Bao, Renlong / Wang, Ligui / Du, Xinying / Qiu, Shaofu / Yang, Chaojie / Song, Hongbin

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e29026

    Abstract: Human adenovirus (HAdV) is a highly virulent respiratory pathogen that poses clinical challenges in terms of diagnostics and treatment. Currently, no effective therapeutic drugs or prophylactic vaccines are available for HAdV infections. One factor ... ...

    Abstract Human adenovirus (HAdV) is a highly virulent respiratory pathogen that poses clinical challenges in terms of diagnostics and treatment. Currently, no effective therapeutic drugs or prophylactic vaccines are available for HAdV infections. One factor contributing to this deficiency is that existing animal models, including wild-type and single-receptor transgenic mice, are unsuitable for HAdV proliferation and pathology testing. In this study, a tri-receptor transgenic mouse model expressing the three best-characterized human cellular receptors for HAdV (hCAR, hCD46, and hDSG2) was generated and validated via analysis of transgene insertion, receptor mRNA expression, and protein abundance distribution. Following HAdV-7 infection, the tri-receptor mice exhibited high transcription levels at the early and late stages of the HAdV gene, as well as viral protein expression. Furthermore, the tri-receptor mice infected with HAdV exhibited dysregulated cytokine responses and multiple tissue lesions. This transgenic mouse model represents human HAdV infection and pathogenesis with more accuracy than any other reported animal model. As such, this model facilitates the comprehensive investigation of HAdV pathogenesis as well as the evaluation of potential vaccines and therapeutic modalities for HAdV.
    MeSH term(s) Mice ; Animals ; Humans ; Mice, Transgenic ; Adenovirus Infections, Human ; Adenoviridae Infections ; Protein Processing, Post-Translational ; Gene Expression ; Disease Models, Animal ; Adenoviruses, Human/physiology
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29026
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  8. Article ; Online: Evaluation of control measures for COVID-19 in Wuhan, China

    Wang, Ligui / Chen, Hui / Qiu, Shaofu / Song, Hongbin

    Journal of Infection

    2020  Volume 81, Issue 2, Page(s) 318–356

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.043
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  9. Article ; Online: Indirubin-3'-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo.

    Wang, Junyu / Yang, Chaojie / Liang, Zhixin / Sun, Junping / Zhang, Mingyue / Qiu, Shaofu / Du, Xinying / He, Xi / Pang, Xiaoying / Ma, Xidong / Xie, Mei / Han, Xinjie / Fan, Ru / Zhou, Enlu / Yu, Hairong / She, Danyang / Song, Hongbin / Wang, Jianxin

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 174, Page(s) 116558

    Abstract: Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor ... ...

    Abstract Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3'-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM. Quantitative real-time polymerase chain reaction (qPCR), quantitative reverse transcription PCR (qRT-PCR), and western blotting were used to assess the effects of IM on HAdV DNA replication, transcription, and protein expression, respectively. IM significantly inhibited HAdV DNA replication as well as E1A and Hexon transcription, in addition to significantly suppressing the phosphorylation of the RNA polymerase II C-terminal domain (CTD). IM mitigated body weight loss, reduced viral burden, and lung injury, decreasing cytokine and chemokine secretion to a greater extent than cidofovir. Altogether, IM inhibits HAdV replication by downregulating CTD phosphorylation to suppress viral infection and corresponding innate immune reactions as a promising therapeutic agent.
    MeSH term(s) Indoles/pharmacology ; Animals ; Oximes/pharmacology ; Humans ; Antiviral Agents/pharmacology ; Adenoviruses, Human/drug effects ; Virus Replication/drug effects ; Anti-Inflammatory Agents/pharmacology ; Mice ; Mice, Transgenic ; Adenovirus Infections, Human/drug therapy ; Adenovirus Infections, Human/virology ; A549 Cells ; Cytokines/metabolism ; Phosphorylation/drug effects
    Chemical Substances Indoles ; Oximes ; Antiviral Agents ; Anti-Inflammatory Agents ; indirubin-3'-monoxime ; Cytokines
    Language English
    Publishing date 2024-04-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantitative analysis of the impact of various urban socioeconomic indicators on search-engine-based estimation of COVID-19 prevalence.

    Wang, Ligui / Lin, Mengxuan / Wang, Jiaojiao / Chen, Hui / Yang, Mingjuan / Qiu, Shaofu / Zheng, Tao / Li, Zhenjun / Song, Hongbin

    Infectious Disease Modelling

    2022  Volume 7, Issue 2, Page(s) 117–126

    Abstract: Numerous studies have proposed search engine-based estimation of COVID-19 prevalence during the COVID-19 pandemic; however, their estimation models do not consider the impact of various urban socioeconomic indicators (USIs). This study quantitatively ... ...

    Abstract Numerous studies have proposed search engine-based estimation of COVID-19 prevalence during the COVID-19 pandemic; however, their estimation models do not consider the impact of various urban socioeconomic indicators (USIs). This study quantitatively analysed the impact of various USIs on search engine-based estimation of COVID-19 prevalence using 15 USIs (including total population, gross regional product (GRP), and population density) from 369 cities in China. The results suggested that 13 USIs affected either the correlation (SC-corr) or time lag (SC-lag) between search engine query volume and new COVID-19 cases (
    Language English
    Publishing date 2022-04-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 3015225-2
    ISSN 2468-0427 ; 2468-2152
    ISSN (online) 2468-0427
    ISSN 2468-2152
    DOI 10.1016/j.idm.2022.04.003
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