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Article ; Online: Eating Event Recognition Using Accelerometer, Gyroscope, Piezoelectric, and Lung Volume Sensors.

Mevissen, Sigert J / Klaassen, Randy / van Beijnum, Bert-Jan F / Haarman, Juliet A M

2024 Volume 24, Issue 2

Abstract: In overcoming the worldwide problem of overweight and obesity, automatic dietary monitoring (ADM) is introduced as support in dieting practises. ADM aims to automatically, continuously, and objectively measure dimensions of food intake in a free-living ... ...

Abstract	In overcoming the worldwide problem of overweight and obesity, automatic dietary monitoring (ADM) is introduced as support in dieting practises. ADM aims to automatically, continuously, and objectively measure dimensions of food intake in a free-living environment. This could simplify the food registration process, thereby overcoming frequent memory, underestimation, and overestimation problems. In this study, an eating event detection sensor system was developed comprising a smartwatch worn on the wrist containing an accelerometer and gyroscope for eating gesture detection, a piezoelectric sensor worn on the jaw for chewing detection, and a respiratory inductance plethysmographic sensor consisting of two belts worn around the chest and abdomen for food swallowing detection. These sensors were combined to determine to what extent a combination of sensors focusing on different steps of the dietary cycle can improve eating event classification results. Six subjects participated in an experiment in a controlled setting consisting of both eating and non-eating events. Features were computed for each sensing measure to train a support vector machine model. This resulted in F1-scores of 0.82 for eating gestures, 0.94 for chewing food, and 0.58 for swallowing food.
MeSH term(s)	Humans ; Food Handling ; Gestures ; Mastication ; Obesity ; Accelerometry
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24020571
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Article ; Online: Extracellular vimentin as a versatile immune suppressive protein in cancer.

van Loon, Karlijn / van Breest Smallenburg, Mathilda E / Huijbers, Elisabeth J M / Griffioen, Arjan W / van Beijnum, Judy R

Biochimica et biophysica acta. Reviews on cancer

2023 Volume 1878, Issue 6, Page(s) 188985

Abstract: The interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the tumor-associated blood vessels are a promising target. We recently found that the intermediate filament ...

Abstract	The interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the tumor-associated blood vessels are a promising target. We recently found that the intermediate filament protein vimentin is externalized by endothelial cells of the tumor vasculature. Extracellular vimentin was shown to sustain angiogenesis by mimicking VEGF and supporting cell migration, as well as endothelial cell anergy, the unresponsiveness of the endothelium to proinflammatory cytokines. The latter hampers immune cell infiltration and subsequently provides escape from tumor immunity. Other studies showed that extracellular vimentin plays a role in sustained systemic and local inflammation. Here we will review the reported roles of extracellular vimentin with a particular emphasis on its involvement in the interactions between immune cells and the endothelium in the tumor microenvironment. To this end, we discuss the different ways by which extracellular vimentin modulates the immune system. Moreover, we review how this protein can alter immune cell-vessel wall adhesion by altering the expression of adhesion proteins, attenuating immune cell infiltration into the tumor parenchyma. Finally, we discuss how vimentin-targeting therapy can reverse endothelial cell anergy and promote immune infiltration, supporting anti-tumor immunity.
MeSH term(s)	Humans ; Vimentin ; Endothelial Cells/pathology ; Neoplasms/pathology ; Cell Adhesion ; Cytokines ; Tumor Microenvironment
Chemical Substances	Vimentin ; Cytokines
Language	English
Publishing date	2023-09-17
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2023.188985
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Article ; Online: Directing CAR T cells towards the tumor vasculature for the treatment of solid tumors.

Akbari, Parvin / Katsarou, Afroditi / Daghighian, Roxanna / van Mil, Lotte W H G / Huijbers, Elisabeth J M / Griffioen, Arjan W / van Beijnum, Judy R

Biochimica et biophysica acta. Reviews on cancer

2022 Volume 1877, Issue 3, Page(s) 188701

Abstract: For successful application of chimeric antigen receptor (CAR) T cell therapy in solid tumors, major hurdles have to be overcome. CAR T cells have to cross the vascular barrier, which is hampered by the anergic state of the tumor vasculature, ... ...

Abstract	For successful application of chimeric antigen receptor (CAR) T cell therapy in solid tumors, major hurdles have to be overcome. CAR T cells have to cross the vascular barrier, which is hampered by the anergic state of the tumor vasculature, characterized by suppressed levels of leukocyte adhesion molecules on the endothelium. Additional immunosuppressive mechanisms in the solid tumor microenvironment can affect infiltration, activity and persistence of CAR T cells. Redirecting CAR T cells towards the tumor vasculature poses a possible solution, as molecular targets of tumor endothelial cells can be directly engaged from within the blood. In this review, we discuss recent advances in CAR T cell therapy against solid tumors, with a focus on targeting the tumor vasculature. Furthermore, we discuss opportunities to overcome challenges and barriers through engineering of CAR T cells to enhance trafficking, safety and efficacy.
MeSH term(s)	Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Immunotherapy, Adoptive ; Neoplasms/pathology ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes ; Tumor Microenvironment
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2022-02-22
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2022.188701
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Article: Vaccination against Extracellular Vimentin for Treatment of Urothelial Cancer of the Bladder in Client-Owned Dogs.

Engbersen, Diederik J M / van Beijnum, Judy R / Roos, Arno / van Beelen, Marit / de Haan, Jan David / Grinwis, Guy C M / Schalken, Jack A / Witjes, J Alfred / Griffioen, Arjan W / Huijbers, Elisabeth J M

Cancers

2023 Volume 15, Issue 15

Abstract: It was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine ... ...

Abstract	It was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine targeting eVim in combination with COX-2 inhibition. This was a single-arm prospective phase 1/2 study with CVx1 in 20 client-owned dogs with spontaneous UC which involved four subcutaneous vaccinations with CVx1 at 2-week intervals for induction of antibody titers, followed by maintenance vaccinations at 2-month intervals. Additionally, daily cyclooxygenase (COX)-2 inhibition with meloxicam was given. The response was assessed by antibody titers, physical condition, abdominal ultrasound and thorax X-ray. The primary endpoints were the development of antibody titers, as well as overall survival compared to a historical control group receiving carboplatin and COX-2 inhibition with piroxicam. Kaplan-Meier survival analysis was performed. All dogs developed antibodies against eVim. Titers were adequately maintained for the duration of this study. A median overall survival of 374 days was observed, which was 196 days for the historical control group (
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15153958
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Article ; Online: Requirements for home-based upper extremity rehabilitation using wearable motion sensors for stroke patients: a user-centred approach.

Langerak, A J / Regterschot, G R H / Selles, R W / Meskers, C G M / Evers, M / Ribbers, G M / van Beijnum, B J F / Bussmann, J B J

Disability and rehabilitation. Assistive technology

2023 , Page(s) 1–13

Abstract: Purpose: Telerehabilitation systems have the potential to enable therapists to monitor and assist stroke patients in achieving high-intensity upper extremity exercise in the home environment. We adopted an iterative user-centred approach, including ... ...

Abstract	Purpose: Telerehabilitation systems have the potential to enable therapists to monitor and assist stroke patients in achieving high-intensity upper extremity exercise in the home environment. We adopted an iterative user-centred approach, including multiple data sources and meetings with end-users and stakeholders to define the user requirements for home-based upper extremity rehabilitation using wearable motion sensors for subacute stroke patients. Methods: We performed a requirement analysis consisting of the following steps: 1) context & groundwork; 2) eliciting requirements; 3) modelling & analysis; 4) agreeing requirements. During these steps, a pragmatic literature search, interviews and focus groups with stroke patients, physiotherapists and occupational therapists were performed. The results were systematically analysed and prioritised into "must-haves", "should-haves", and "could-haves". Results: We formulated 33 functional requirements: eighteen must-have requirements related to blended care (2), exercise principles (7), exercise delivery (3), exercise evaluation (4), and usability (2); ten should-haves; and five could-haves. Six movement components, including twelve exercises and five combination exercises, are required. For each exercise, appropriate exercise measures were defined. Conclusion: This study provides an overview of functional requirements, required exercises, and required exercise measures for home-based upper extremity rehabilitation using wearable motion sensors for stroke patients, which can be used to develop home-based upper extremity rehabilitation interventions. Moreover, the comprehensive and systematic requirement analysis used in this study can be applied by other researchers and developers when extracting requirements for designing a system or intervention in a medical context.
Language	English
Publishing date	2023-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.1080/17483107.2023.2183993
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Article ; Online: A Sensor-Based Feedback Device Stimulating Daily Life Upper Extremity Activity in Stroke Patients: A Feasibility Study.

Langerak, Anthonia J / Regterschot, Gerrit Ruben Hendrik / Evers, Marc / van Beijnum, Bert-Jan F / Meskers, Carel G M / Selles, Ruud W / Ribbers, Gerard M / Bussmann, Johannes B J

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 13

Abstract: This study aims to evaluate the feasibility and explore the efficacy of the Arm Activity Tracker (AAT). The AAT is a device based on wrist-worn accelerometers that provides visual and tactile feedback to stimulate daily life upper extremity (UE) activity ...

Abstract	This study aims to evaluate the feasibility and explore the efficacy of the Arm Activity Tracker (AAT). The AAT is a device based on wrist-worn accelerometers that provides visual and tactile feedback to stimulate daily life upper extremity (UE) activity in stroke patients. Methods: A randomised, crossover within-subject study was conducted in sub-acute stroke patients admitted to a rehabilitation centre. Feasibility encompassed (1) adherence: the dropout rate and the number of participants with insufficient AAT data collection; (2) acceptance: the technology acceptance model (range: 7-112) and (3) usability: the system usability scale (range: 0-100). A two-way ANOVA was used to estimate the difference between the baseline, intervention and control conditions for (1) paretic UE activity and (2) UE activity ratio. Results: Seventeen stroke patients were included. A 29% dropout rate was observed, and two participants had insufficient data collection. Participants who adhered to the study reported good acceptance (median (IQR): 94 (77-111)) and usability (median (IQR): 77.5 (75-78.5)-). We found small to medium effect sizes favouring the intervention condition for paretic UE activity (η Conclusion: Participants who adhered to the study showed good acceptance and usability of the AAT and increased paretic UE activity. Dropouts should be further evaluated, and a sufficiently powered trial should be performed to analyse efficacy.
MeSH term(s)	Humans ; Feasibility Studies ; Feedback ; Stroke Rehabilitation ; Upper Extremity ; Stroke ; Recovery of Function
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23135868
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Article ; Online: The association of tumor-expressed REG4, SPINK4 and alpha-1 antitrypsin with cancer-associated thrombosis in colorectal cancer.

Buijs, Jeroen T / van Beijnum, Robin / Anijs, Rayna J S / Laghmani, El Houari / Sensuk, Lily / Minderhoud, Cas / Ünlü, Betül / Klok, Frederikus A / Kuppen, Peter J K / Cannegieter, Suzanne C / Versteeg, Henri H

Journal of thrombosis and thrombolysis

2023 Volume 57, Issue 3, Page(s) 370–380

Abstract: Novel biomarkers are needed to improve current imperfect risk prediction models for cancer-associated thrombosis (CAT). We recently identified an RNA-sequencing profile that associates with CAT in colorectal cancer (CRC) patients, with REG4, SPINK4, and ... ...

Abstract	Novel biomarkers are needed to improve current imperfect risk prediction models for cancer-associated thrombosis (CAT). We recently identified an RNA-sequencing profile that associates with CAT in colorectal cancer (CRC) patients, with REG4, SPINK4, and SERPINA1 as the top-3 upregulated genes at mRNA level. In the current study, we investigated whether protein expression of REG4, SPINK4 and alpha-1 antitrypsin (A1AT, encoded by SERPINA1) in the tumor associated with CAT in an independent cohort of CRC patients. From 418 patients with resected CRC, 18 patients who developed CAT were age, sex, and tumor stage-matched to 18 CRC patients without CAT. Protein expression was detected by immunohistochemical staining and scored blindly by assessing the H-score (percentage positive cells*scoring intensity). The association with CAT was assessed by means of logistic regression, using patients with an H-score below 33 as reference group. The odds ratios (ORs) for developing CAT for patients with A1AT
MeSH term(s)	Humans ; Case-Control Studies ; Anticoagulants ; Venous Thromboembolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Biomarkers ; Pancreatitis-Associated Proteins ; Serine Peptidase Inhibitors, Kazal Type
Chemical Substances	Anticoagulants ; Biomarkers ; REG4 protein, human ; Pancreatitis-Associated Proteins ; SPINK4 protein, human ; Serine Peptidase Inhibitors, Kazal Type
Language	English
Publishing date	2023-12-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-023-02907-6
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Article ; Online: Foot progression angle estimation using a single foot-worn inertial sensor.

Wouda, Frank J / Jaspar, Stephan L J O / Harlaar, Jaap / van Beijnum, Bert-Jan F / Veltink, Peter H

Journal of neuroengineering and rehabilitation

2021 Volume 18, Issue 1, Page(s) 37

Abstract: Background: The foot progression angle is an important measure used to help patients reduce their knee adduction moment. Current measurement systems are either lab-bounded or do not function in all environments (e.g., magnetically distorted). This work ... ...

Abstract	Background: The foot progression angle is an important measure used to help patients reduce their knee adduction moment. Current measurement systems are either lab-bounded or do not function in all environments (e.g., magnetically distorted). This work proposes a novel approach to estimate foot progression angle using a single foot-worn inertial sensor (accelerometer and gyroscope). Methods: The approach uses a dynamic step frame that is recalculated for the stance phase of each step to calculate the foot trajectory relative to that frame, to minimize effects of drift and to eliminate the need for a magnetometer. The foot progression angle (FPA) is then calculated as the angle between walking direction and the dynamic step frame. This approach was validated by gait measurements with five subjects walking with three gait types (normal, toe-in and toe-out). Results: The FPA was estimated with a maximum mean error of ~ 2.6° over all gait conditions. Additionally, the proposed inertial approach can significantly differentiate between the three different gait types. Conclusion: The proposed approach can effectively estimate differences in FPA without requiring a heading reference (magnetometer). This work enables feedback applications on FPA for patients with gait disorders that function in any environment, i.e. outside of a gait lab or in magnetically distorted environments.
MeSH term(s)	Accelerometry/instrumentation ; Adult ; Biomechanical Phenomena ; Foot/physiopathology ; Gait Analysis/instrumentation ; Humans ; Male ; Wearable Electronic Devices
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1743-0003
ISSN (online)	1743-0003
DOI	10.1186/s12984-021-00816-4
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Article ; Online: Corrigendum to "An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature" [Vaccine 36(21) 3054-3060].

Huijbers, Elisabeth J M / van Beijnum, Judy R / Lê, Chung T / Langman, Sophia / Nowak-Sliwinska, Patrycja / Mayo, Kevin H / Griffioen, Arjan W

Vaccine

2019 Volume 37, Issue 30, Page(s) 4231–4232

Language	English
Publishing date	2019-06-13
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2019.06.010
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Anti-angiogenic agents - overcoming tumour endothelial cell anergy and improving immunotherapy outcomes.

Huinen, Zowi R / Huijbers, Elisabeth J M / van Beijnum, Judy R / Nowak-Sliwinska, Patrycja / Griffioen, Arjan W

Nature reviews. Clinical oncology

2021 Volume 18, Issue 8, Page(s) 527–540

Abstract: Immune checkpoint inhibitors have revolutionized medical oncology, although currently only a subset of patients has a response to such treatment. A compelling body of evidence indicates that anti-angiogenic therapy has the capacity to ameliorate ... ...

Abstract	Immune checkpoint inhibitors have revolutionized medical oncology, although currently only a subset of patients has a response to such treatment. A compelling body of evidence indicates that anti-angiogenic therapy has the capacity to ameliorate antitumour immunity owing to the inhibition of various immunosuppressive features of angiogenesis. Hence, combinations of anti-angiogenic agents and immunotherapy are currently being tested in >90 clinical trials and 5 such combinations have been approved by the FDA in the past few years. In this Perspective, we describe how the angiogenesis-induced endothelial immune cell barrier hampers antitumour immunity and the role of endothelial cell anergy as the vascular counterpart of immune checkpoints. We review the antitumour immunity-promoting effects of anti-angiogenic agents and provide an update on the current clinical successes achieved when these agents are combined with immune checkpoint inhibitors. Finally, we propose that anti-angiogenic agents are immunotherapies - and vice versa - and discuss future research priorities.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Animals ; Clonal Anergy/drug effects ; Combined Modality Therapy ; Drug Resistance, Neoplasm/immunology ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Treatment Outcome ; Tumor Escape/drug effects ; Tumor Escape/physiology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2021-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2491410-1
ISSN	1759-4782 ; 1759-4774
ISSN (online)	1759-4782
ISSN	1759-4774
DOI	10.1038/s41571-021-00496-y
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