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  1. Article ; Online: Training the host organism to enhance anti-cancer immunity.

    Ferrer, Miriam / Janowitz, Tobias

    Cancer cell

    2022  Volume 40, Issue 7, Page(s) 703–705

    Abstract: In this issue of Cancer Cell, Kurz et al. demonstrate in an orthotopic pancreatic cancer model that low-intensity exercise improves tumor control and response to immunotherapy in an IL-15-dependent manner. Combination therapy, IL-15 super-agonist, anti- ... ...

    Abstract In this issue of Cancer Cell, Kurz et al. demonstrate in an orthotopic pancreatic cancer model that low-intensity exercise improves tumor control and response to immunotherapy in an IL-15-dependent manner. Combination therapy, IL-15 super-agonist, anti-PD-1 antibody and chemotherapy, strongly reduces tumor growth. Therefore, the study opens rich translational avenues.
    MeSH term(s) Cell Line, Tumor ; Combined Modality Therapy ; Humans ; Immunotherapy ; Interleukin-15/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.06.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
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  2. Article ; Online: Cancer: The Tumor-Driven Disease of the Host.

    Janowitz, Tobias

    Cell metabolism

    2018  Volume 28, Issue 1, Page(s) 5–6

    Abstract: Tumors interact reciprocally with their hosts' physiology and metabolism, making cancer a systemic disease. In this issue of Cell Metabolism, Borniger et al. (2018) demonstrate this phenomenon by linking the endocrine control of food intake with sleep ... ...

    Abstract Tumors interact reciprocally with their hosts' physiology and metabolism, making cancer a systemic disease. In this issue of Cell Metabolism, Borniger et al. (2018) demonstrate this phenomenon by linking the endocrine control of food intake with sleep behavior and liver metabolism in a mouse model of non-metastatic breast carcinoma.
    MeSH term(s) Animals ; Breast Neoplasms ; Disease Models, Animal ; Mice ; Orexins
    Chemical Substances Orexins
    Language English
    Publishing date 2018-06-19
    Publishing country United States
    Document type Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2018.06.016
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  3. Article ; Online: AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells.

    Fearon, Douglas T / Janowitz, Tobias

    British journal of cancer

    2021  Volume 125, Issue 2, Page(s) 149–151

    Abstract: A recent Phase 1 clinical study of the immunological effects of inhibiting the chemokine receptor, CXCR4, in patients with pancreatic ductal adenocarcinoma or colorectal cancer suggests that stimulation of CXCR4 on immune cells suppresses the ... ...

    Abstract A recent Phase 1 clinical study of the immunological effects of inhibiting the chemokine receptor, CXCR4, in patients with pancreatic ductal adenocarcinoma or colorectal cancer suggests that stimulation of CXCR4 on immune cells suppresses the intratumoural immune reaction. Here, we discuss how CXCR4 mediates this response, and how cancer cells elicit it.
    MeSH term(s) Benzylamines ; Chemokine CXCL12 ; Colorectal Neoplasms ; Cyclams ; Hematopoietic Stem Cell Mobilization ; Heterocyclic Compounds ; Humans ; Pancreatic Neoplasms ; Receptors, CXCR4
    Chemical Substances Benzylamines ; CXCL12 protein, human ; Chemokine CXCL12 ; Cyclams ; Heterocyclic Compounds ; Receptors, CXCR4 ; plerixafor (S915P5499N)
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01315-y
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  4. Article ; Online: The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research.

    Janowitz, Tobias / Tuveson, David A

    Cancer discovery

    2020  Volume 10, Issue 7, Page(s) 913–915

    Abstract: The coronavirus SARS-CoV-2 has created a global pandemic that has killed more than a quarter million people since December 2019, halted commerce, and disrupted our ability to research cancer in the laboratory and clinic and care for our patients. A ... ...

    Abstract The coronavirus SARS-CoV-2 has created a global pandemic that has killed more than a quarter million people since December 2019, halted commerce, and disrupted our ability to research cancer in the laboratory and clinic and care for our patients. A return to a functioning society can be facilitated by the active participation of cancer researchers to diagnose and treat SARS-CoV-2-infected patients, and the direct and indirect benefits of our involvement cannot be overstated.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Humans ; Neoplasms/drug therapy ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Letter
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-0657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6916: Show issues Location:
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  5. Article ; Online: Reconsidering Dexamethasone for Antiemesis when Combining Chemotherapy and Immunotherapy.

    Janowitz, Tobias / Kleeman, Sam / Vonderheide, Robert H

    The oncologist

    2021  Volume 26, Issue 4, Page(s) 269–273

    Abstract: Whether the immune suppressive action of glucocorticoid steroids, such as dexamethasone, might reduce the benefits of cancer immunotherapy has long been a concern. Observations that established tumor regressions in response to immune checkpoint ... ...

    Abstract Whether the immune suppressive action of glucocorticoid steroids, such as dexamethasone, might reduce the benefits of cancer immunotherapy has long been a concern. Observations that established tumor regressions in response to immune checkpoint inhibitors (ICIs) often persist, despite the use of steroids to mitigate ICI-related autoimmune breakthrough, are not sufficiently reassuring, because these observations do not address the potential blunting of immune priming at the initiation of ICI therapy. With increasing indications for ICI in combination with chemotherapy, this issue merits reconsideration. Professional society guidance advises that dexamethasone should be used as first-line prophylaxis for nausea and vomiting in patients receiving ICI and highly emetogenic chemotherapy combination regimens. Here, we review the availability of data on this subject and propose an alternative approach focused on the adoption of steroid minimization or sparing for prophylaxis of nausea until the underlying immune biology is better understood.
    MeSH term(s) Antiemetics/therapeutic use ; Antineoplastic Agents/therapeutic use ; Dexamethasone/therapeutic use ; Humans ; Immunotherapy/adverse effects ; Nausea/drug therapy ; Neoplasms/drug therapy ; Vomiting/drug therapy
    Chemical Substances Antiemetics ; Antineoplastic Agents ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1002/onco.13680
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    Zs.A 4845: Show issues Location:
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    Zs.MO 494: Show issues

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  6. Article ; Online: Analysis and Optimization of Equitable US Cancer Clinical Trial Center Access by Travel Time.

    Lee, Hassal / Bates, Alexander Shakeel / Callier, Shawneequa / Chan, Michael / Chambwe, Nyasha / Marshall, Andrea / Terry, Mary Beth / Winkfield, Karen / Janowitz, Tobias

    JAMA oncology

    2024  

    Abstract: Importance: Racially minoritized and socioeconomically disadvantaged populations are currently underrepresented in clinical trials. Data-driven, quantitative analyses and strategies are required to help address this inequity.: Objective: To ... ...

    Abstract Importance: Racially minoritized and socioeconomically disadvantaged populations are currently underrepresented in clinical trials. Data-driven, quantitative analyses and strategies are required to help address this inequity.
    Objective: To systematically analyze the geographical distribution of self-identified racial and socioeconomic demographics within commuting distance to cancer clinical trial centers and other hospitals in the US.
    Design, setting, and participants: This longitudinal quantitative study used data from the US Census 2020 Decennial and American community survey (which collects data from all US residents), OpenStreetMap, National Cancer Institute-designated Cancer Centers list, Nature Index of Cancer Research Health Institutions, National Trial registry, and National Homeland Infrastructure Foundation-Level Data. Statistical analyses were performed on data collected between 2006 and 2020.
    Main outcomes and measures: Population distributions of socioeconomic deprivation indices and self-identified race within 30-, 60-, and 120-minute 1-way driving commute times from US cancer trial sites. Map overlay of high deprivation index and high diversity areas with existing hospitals, existing major cancer trial centers, and commuting distance to the closest cancer trial center.
    Results: The 78 major US cancer trial centers that are involved in 94% of all US cancer trials and included in this study were found to be located in areas with socioeconomically more affluent populations with higher proportions of self-identified White individuals (+10.1% unpaired mean difference; 95% CI, +6.8% to +13.7%) compared with the national average. The top 10th percentile of all US hospitals has catchment populations with a range of absolute sum difference from 2.4% to 35% from one-third each of Asian/multiracial/other (Asian alone, American Indian or Alaska Native alone, Native Hawaiian or Other Pacific Islander alone, some other race alone, population of 2 or more races), Black or African American, and White populations. Currently available data are sufficient to identify diverse census tracks within preset commuting times (30, 60, or 120 minutes) from all hospitals in the US (N = 7623). Maps are presented for each US city above 500 000 inhabitants, which display all prospective hospitals and major cancer trial sites within commutable distance to racially diverse and socioeconomically disadvantaged populations.
    Conclusion and relevance: This study identified biases in the sociodemographics of populations living within commuting distance to US-based cancer trial sites and enables the determination of more equitably commutable prospective satellite hospital sites that could be mobilized for enhanced racial and socioeconomic representation in clinical trials. The maps generated in this work may inform the design of future clinical trials or investigations in enrollment and retention strategies for clinical trials; however, other recruitment barriers still need to be addressed to ensure racial and socioeconomic demographics within the geographical vicinity of a clinical site can translate to equitable trial participant representation.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.7314
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  7. Article: Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia.

    Sun, Qingtao / van de Lisdonk, Daniëlle / Ferrer, Miriam / Gegenhuber, Bruno / Wu, Melody / Tollkuhn, Jessica / Janowitz, Tobias / Li, Bo

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Interleukin-6 (IL-6) has been long considered a key player in cancer-associated ... ...

    Abstract Interleukin-6 (IL-6) has been long considered a key player in cancer-associated cachexia
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.12.523716
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  8. Article ; Online: Sensitive, non-immunogenic

    Merrill, Joseph R / Inguscio, Alessandra / Chung, Taemoon / Demestichas, Breanna / Garcia, Libia A / Habel, Jill / Lewis, David Y / Janowitz, Tobias / Lyons, Scott K

    Cell stress

    2023  Volume 7, Issue 8, Page(s) 59–68

    Abstract: Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to ... ...

    Abstract Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to therapy
    Language English
    Publishing date 2023-08-14
    Publishing country Austria
    Document type Journal Article
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2023.08.288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research

    Janowitz, Tobias / Tuveson, David A

    Cancer Discov

    Abstract: The coronavirus SARS-CoV-2 has created a global pandemic that has killed more than a quarter million people since December 2019, halted commerce, and disrupted our ability to research cancer in the laboratory and clinic and care for our patients. A ... ...

    Abstract The coronavirus SARS-CoV-2 has created a global pandemic that has killed more than a quarter million people since December 2019, halted commerce, and disrupted our ability to research cancer in the laboratory and clinic and care for our patients. A return to a functioning society can be facilitated by the active participation of cancer researchers to diagnose and treat SARS-CoV-2-infected patients, and the direct and indirect benefits of our involvement cannot be overstated.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #260346
    Database COVID19

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  10. Article ; Online: Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.

    Yang, Wen-Hsuan / Qiu, Yijian / Stamatatos, Olivia / Janowitz, Tobias / Lukey, Michael J

    Trends in cancer

    2021  Volume 7, Issue 8, Page(s) 790–804

    Abstract: Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as a promising target for cancer therapy. However, efforts to drug this process are confounded by the intrinsic metabolic heterogeneity and flexibility of tumors, as well ...

    Abstract Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as a promising target for cancer therapy. However, efforts to drug this process are confounded by the intrinsic metabolic heterogeneity and flexibility of tumors, as well as the risk of adverse effects on the anticancer immune response. Recent research has yielded important insights into the mechanisms that determine the tumor and the host immune responses to pharmacological perturbation of glutamine metabolism. Here, we discuss these findings and suggest that, collectively, they point toward patient stratification and drug combination strategies to maximize the efficacy of glutamine metabolism inhibitors as cancer therapeutics.
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzeneacetamides/pharmacology ; Benzeneacetamides/therapeutic use ; Carcinogenesis/drug effects ; Carcinogenesis/immunology ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Clinical Trials as Topic ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Glutaminase/antagonists & inhibitors ; Glutaminase/metabolism ; Glutamine/antagonists & inhibitors ; Glutamine/metabolism ; Humans ; NF-E2-Related Factor 2/metabolism ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidative Stress/drug effects ; Thiadiazoles/pharmacology ; Thiadiazoles/therapeutic use ; Tumor Escape/drug effects ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
    Chemical Substances Antimetabolites, Antineoplastic ; Benzeneacetamides ; CB-839 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Thiadiazoles ; Glutamine (0RH81L854J) ; GLS protein, human (EC 3.5.1.2) ; GLS2 protein, human (EC 3.5.1.2) ; Glutaminase (EC 3.5.1.2)
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.04.003
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