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  1. Article ; Online: The role of SARS-CoV-2 antibody therapy in the treatment of COVID-19

    Fábián, Ákos

    Orvosi hetilap

    2021  Volume 162, Issue 51, Page(s) 2030–2039

    Abstract: Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta fertőzés és a COVID-19 elleni küzdelem egyik lehetősége a SARS-CoV-2-ellenes neutralizáló antitestekkel végzett passzív immunizáció. Az utóbbi időben számos készítmény jutott el a klinikai ... ...

    Title translation A SARS-CoV-2-ellenes antitestekkel végzett terápia helye a COVID-19 kezelésében.
    Abstract Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta fertőzés és a COVID-19 elleni küzdelem egyik lehetősége a SARS-CoV-2-ellenes neutralizáló antitestekkel végzett passzív immunizáció. Az utóbbi időben számos készítmény jutott el a klinikai kipróbálásig. Az alábbiakban áttekintjük ezen készítmények legfőbb tulajdonságait és az antitest-terápiával elért klinikai eredményeket. Ezek alapján elsősorban prehospitálisan, az állapotprogresszió szempontjából leginkább veszélyeztetett populációnál alkalmazva, e készítmények jelentősen csökkenthetik az állapotromlás esélyét és a kórházi ellátás igényét, ezáltal javíthatják a kimenetelt, és mérsékelhetik az egészségügyi ellátórendszer terhelését. Orv Hetil. 2021; 162(51): 2030-2039. Summary. Passive immunization is a therapeutic option in the fight against the infection caused by the novel coronavirus (SARS-CoV-2) and COVID-19. Significant advances have been made in the development of SARS-CoV-2 neutralizing antibodies. Here we discuss the antibodies under clinical trial and the published data regarding their clinical efficacy. Based on these, when given to non-hospitalized patients at high risk for disease progression, these antibodies can significantly reduce worsening of the disease and the need for hospitalization. This can improve the outcomes of patients and help reduce the burden on the healthcare system. Orv Hetil. 2021; 162(51): 2030-2039.
    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; SARS-CoV-2 ; Treatment Outcome
    Language Hungarian
    Publishing date 2021-12-19
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2021.32414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In memoriam Ferenc Schweitzer (1939–2023)

    Szabolcs Ákos Fábián / Gábor Varga / Dénes Lóczy

    Hungarian Geographical Bulletin, Vol 72, Iss 2, Pp 201-

    2023  Volume 202

    Abstract: ...

    Abstract -
    Keywords Geography (General) ; G1-922
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Channel-reach morphometric analysis on a headwater stream in a low-mountainous region

    Balázs Víg / Gábor Varga / Richárd Balogh / Dénes Lóczy / László Nagyváradi / Szabolcs Ákos Fábián

    Hungarian Geographical Bulletin, Vol 72, Iss 4, Pp 365-

    a case study from Mecsek Hills

    2024  Volume 381

    Abstract: Small catchments in mountainous regions affect downstream rivers as a primary source of sediment supply and also generate flash swasfloods, especially during extreme events. These floods have significantly shaped the catchments of small streams in the ... ...

    Abstract Small catchments in mountainous regions affect downstream rivers as a primary source of sediment supply and also generate flash swasfloods, especially during extreme events. These floods have significantly shaped the catchments of small streams in the Mecsek Hills and some rural areas over the past two decades. However, there has been no previous study examining the hydromorphology of headwater catchments in low mountain environments in Hungary. The present study was meant to investigate the fundamental hydrogeomorphological properties of a first-order catchment. A customary and detailed GIS survey of 50-metre sections was aimed at deciphering flash flood vulnerability and geomorphic interrelations within a micro watershed. We found moderate susceptibility to flash floods compared to the whole Mecsek Hills. Stable large woody debris jams were identified during the field survey as major geomorphic channel features functioning as natural barriers which drive channel evolution and reduce flood hazards.
    Keywords hydromorphometry ; large woody debris ; semi-natural ; stream reach ; field survey ; öreg-patak stream ; Geography (General) ; G1-922
    Subject code 910
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Morphological analysis of mineral grains from different sedimentary environments using automated static image analysis

    Gresina, Fruzsina / Farkas, Beáta / Fábián, Szabolcs Ákos / Szalai, Zoltán / Varga, György

    Sedimentary Geology. 2023 Aug. 07, p.106479-

    2023  , Page(s) 106479–

    Abstract: The properties of sediment grain shape provide valuable information about the transport mechanisms in different sedimentary and geomorphological environments. With the emergence of new, high-resolution analytical techniques, it has become possible to ... ...

    Abstract The properties of sediment grain shape provide valuable information about the transport mechanisms in different sedimentary and geomorphological environments. With the emergence of new, high-resolution analytical techniques, it has become possible to quickly examine the grain shape properties of a large number of individual mineral grains. In this study, we used automated image analysis (Malvern Morphologi G3SE-ID) to investigate mineral particles of four sediment types from different depositional environments (sand sheet (1), floodplain (2) and fluvial channel deposits (3), Pleistocene infilling material of sand wedges (4), n = 20) in the Carpathian Basin (Central Europe). Our primary objective was to identify quantitative key variables that can help objectively distinguish certain geomorphological environments located in the Carpathian Basin. In our analysis and data processing (which included techniques such as hierarchical cluster analysis, Wilks' λ, Kruskal-Wallis, multivariate analysis of variance and principal component analysis) we focused on four variables related to grain shape: circularity (form), convexity (surface texture), solidity (roundness) and elongation (form). The form of sedimentary grains depends largely on the physical properties of their source area, while the roundness depends on the energy of the transport medium and the distant of transportation. Surface texture or convexity can change in a relatively short time in fluvial environment. The study revealed that distinguishing geomorphological environments can be achieved by analyzing the circularity, convexity and solidity parameters of the sediment grains. Based on the established grouping, the analyses carried out with hundred repetitions showed that HS circularity, convexity and solidity variables were the most effective attributes regarding Kruskal-Wallis test statistics it provided significant (p < 0.001) results between the analyzed sedimentary environments, while the elongation was not able to provide significant results between the grouped samples. Statistical analyses of the MANOVA test with hundredfold repetitions showed significant differences between the derived groups. Wilks' λ test statistics and PCA showed that convexity and HS circularity discriminate the groups. Separate analyses of aeolian and fluvial sediments have been carried out. The Kruskal-Wallis analysis of variance showed the significant differences considering all four variables, and differences were also significant in the case of MANOVA test. Wilks' λ test statistics and PCA showed that convexity, HS circularity and solidity discriminate the groups. According to our results, the circularity parameter can provide information about the transport distance, while the solidity parameter can indicate the transport energy. The convexity parameter can serve as an indicator of both transport distance, as well as post-depositional processes. Some infilling materials underwent multiple transport processes, including high energy aqueous, wind transport mechanisms, and post-depositional alteration process (frost weathering), while others originated from sand-sheet covered areas (active during Pleistocene glacials).The solidity parameter proved effective in separating sediments with similarly high convexity values (smooth surface), which were, in our case, from recent aeolian and fluvial environments. This result was due to the investigated fluvial sediments inherited their form and low level of roundness from their source area. Our research supports that aeolian transport is more effective in rounding the grains than the aqueous environment. Using automated static image analysis producing statistically stable results with hundreds of analyzed mineral grains provide useful indicators for paleogeographical reconstruction studies by investigating paleo and recent sediments.
    Keywords Pleistocene epoch ; automation ; basins ; cluster analysis ; energy ; floodplains ; frost ; image analysis ; multivariate analysis ; principal component analysis ; sand ; texture ; transportation ; wind ; Central European region ; Grain shape ; Sediment transport ; Micromorphology ; Paleoenvironment ; Granulometry ; Granulometric proxy
    Language English
    Dates of publication 2023-0807
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 216739-6
    ISSN 0037-0738
    ISSN 0037-0738
    DOI 10.1016/j.sedgeo.2023.106479
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Generation of a flood susceptibility map of evenly weighted conditioning factors for Hungary

    Sarkadi Noémi / Pirkhoffer Ervin / Lóczy Dénes / Balatonyi László B. / Geresdi István / Fábián Szabolcs Ákos / Varga Gábor / Balogh Richárd / Gradwohl-Valkay Alexandra / Halmai Ákos / Czigány Szabolcs

    Geographica Pannonica, Vol 26, Iss 3, Pp 200-

    2022  Volume 214

    Abstract: Over the past decades, in the mountainous, hilly and/or urban areas of Hungary several high-intensity storms were followed by severe flash flooding and other hydrologic consequences. The overall aim of this paper was to upgrade the national flash flood ... ...

    Abstract Over the past decades, in the mountainous, hilly and/or urban areas of Hungary several high-intensity storms were followed by severe flash flooding and other hydrologic consequences. The overall aim of this paper was to upgrade the national flash flood susceptibility map of Hungary first published by Czigány et al. (2011). One elementary watershed level (FFSIws) and three settlement level flash flood susceptibility maps (FFSIs) were constructed using 13 environmental factors that influence flash flood generation. FFSI maps were verified by 2,677 documented flash flood events. In total, 5,458 watersheds were delineated. Almost exactly 10% of all delineated watersheds were included into the category of extreme susceptibility. While the number of the mean-based FFSIs demonstrated a normal quasi-Gaussian distribution with very low percentages in the quintile of low and extreme categories, the maximum-based FFSIs overemphasized the proportion of settlements of high and extreme susceptibility. These two categories combined accounted for more than 50% of all settlements. The highest accuracy at 59.02% for class 5 (highest susceptibility) was found for the majority based FFSIs. The current map has been improved compared to the former one in terms of (i) a higher number of conditional factors considered, (ii) higher resolution, (iii) being settlement-based and (iv) a higher number of events used for verification.
    Keywords flood potential ; flash flood ; susceptibility ; arcgis ; ffsi ; conditional factors ; Geography (General) ; G1-922
    Subject code 910
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher University of Novi Sad, Department of Geography, Tourism and Hotel Management
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Impact of Agricultural Land Use Types on Soil Moisture Retention of Loamy Soils

    Szabolcs Czigány / Noémi Sarkadi / Dénes Lóczy / Anikó Cséplő / Richárd Balogh / Szabolcs Ákos Fábián / Rok Ciglič / Mateja Ferk / Gábor Pirisi / Marcell Imre / Gábor Nagy / Ervin Pirkhoffer

    Sustainability, Vol 15, Iss 4925, p

    2023  Volume 4925

    Abstract: Increasingly severe hydrological extremes are predicted for the Pannonian Basin as one of the consequences of climate change. The challenges of extreme droughts require the adaptation of agriculture especially during the intense growth phase of crops. ... ...

    Abstract Increasingly severe hydrological extremes are predicted for the Pannonian Basin as one of the consequences of climate change. The challenges of extreme droughts require the adaptation of agriculture especially during the intense growth phase of crops. For dryland farming, the selections of the optimal land use type and sustainable agricultural land management are potential adaptation tools for facing the challenges posed by increased aridity. To this end, it is indispensable to understand soil moisture (SM) dynamics under different land use types over drought-affected periods. Within the framework of a Slovenian–Hungarian project, soil moisture, matric potential and rainfall time series have been collected at three pilot sites of different land use types (pasture, orchards and a ploughland) in SW Hungary since September 2018. Experiments were carried out in soils of silt, silt loam and clay loam texture. In the summers (June 1 to August 31) of 2019 and 2022, we identified normal and dry conditions, respectively, with regard to differences in water balance. Our results demonstrated that soil moisture is closely controlled by land use. Marked differences of the moisture regime were revealed among the three land use types based on statistical analyses. Soils under pasture had the most balanced regime, whereas ploughland soils indicated the highest amplitude of moisture dynamics. The orchard, however, showed responses to weather conditions in sharp contrast with the other two sites. Our results are applicable for loamy soils under humid and subhumid temperate climates and for periods of extreme droughts, a condition which is expected to be the norm for the future.
    Keywords drought ; ecosystem services ; land use ; soil moisture dynamics ; water stress ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 550
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Organ replacement therapy and life-supporting treatment modalities in critically ill COVID-19 patients

    Berhés, Mariann / Fábián, Ákos / László, István / Végh, Tamás / Molnár, Csilla / Fülesdi, Béla / Koszta, György

    Orvosi hetilap

    2020  Volume 161, Issue 17, Page(s) 704–709

    Abstract: In critically ill COVID-19 patients, the failure of the cardiorespiratory system can be due to one of the following: (1) cytokine storm, haemophagocytosis – septic shock, (2) unmanageable hypoxemia, (3) isolated organ failure or as part of multi-organ ... ...

    Title translation [Emelt szintű szervtámogató és életfenntartó kezelések kritikus állapotú COVID–19-fertőzött betegeken]
    Abstract In critically ill COVID-19 patients, the failure of the cardiorespiratory system can be due to one of the following: (1) cytokine storm, haemophagocytosis – septic shock, (2) unmanageable hypoxemia, (3) isolated organ failure or as part of multi-organ failure. Herein we give an overview of the therapeutic options for treating or preventing these disease states. In recent years, CytoSorb-haemoperfusion to remove cytokines has shown promising results in the treatment of septic shock. Inhalational nitric oxide (iNO), inhalational epoprostenol and veno-venous extracorporeal membrane oxygenation (ECMO) are options in severe hypoxemia that is unresponsive to conventional mechanical ventilation. Renal failure is a frequent component of the multi-organ failure usually seen with disease progression and necessitates starting one of the available continuous renal replacement modalities. Orv Hetil. 2020; 161(17): 704–709.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Critical Care ; Critical Illness ; Cytokines/metabolism ; Extracorporeal Membrane Oxygenation ; Hemoperfusion ; Humans ; Hypoxia/etiology ; Hypoxia/therapy ; Nitric Oxide/administration & dosage ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Renal Replacement Therapy ; SARS-CoV-2
    Chemical Substances Cytokines ; Nitric Oxide (31C4KY9ESH)
    Keywords covid19
    Language Hungarian
    Publishing date 2020-04-01
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2020.31813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study.

    Fábián, Ákos I / Tassonyi, Edömér / Csernoch, Vera / Fedor, Marianna / Sohajda, Tamás / Szente, Lajos / Fülesdi, Béla

    BMC anesthesiology

    2021  Volume 21, Issue 1, Page(s) 206

    Abstract: Background: Residual neuromuscular block at the end of surgery may compromise the patient's safety. The risk of airway complications can be minimized through monitoring of neuromuscular function and reversal of neuromuscular block if needed. Effective ... ...

    Abstract Background: Residual neuromuscular block at the end of surgery may compromise the patient's safety. The risk of airway complications can be minimized through monitoring of neuromuscular function and reversal of neuromuscular block if needed. Effective reversal can be achieved with selective relaxant binding agents, however, sugammadex is the only clinically approved drug in this group. We investigated the concentration-response properties of a novel selective relaxant binding agent, carboxymethyl-γ-cyclodextrin for the reversal of neuromuscular block. We evaluated the hypothesis that it is equally potent for reversing neuromuscular block as sugammadex.
    Methods: Phrenic nerve - hemidiaphragm tissue preparations were isolated from male Wistar rats and suspended in a tissue holder allowing electrical stimulation of the nerve and monitoring of muscle contraction force. Concentration-response relationships were constructed for the neuromuscular blocking agents rocuronium, pipecuronium, and vecuronium. The half-effective concentrations of sugammadex and carboxymethyl-γ-cyclodextrin for reversal of neuromuscular block were determined.
    Results: The half effective concentrations (95% confidence interval, CI) were 7.50 (6.93-8.12) μM for rocuronium, 1.38 (1.33-1.42) μM for pipecuronium, and 3.69 (3.59-3.80) μM for vecuronium. The half effective concentrations (95% CI) of carboxymethyl-γ-cyclodextrin and sugammadex were 35.89 (32.67-39.41) μM and 3.67 (3.43-3.92) μM, respectively, for the reversal of rocuronium-induced block; 10.14 (9.61-10.70) μM and 0.67 (0.62-0.74) μM, respectively, for the reversal of pipecuronium-induced block; and 376.1 (341.9-413.8) μM and 1.45 (1.35-1.56) μM, respectively, for the reversal of vecuronium-induced block.
    Conclusions: Carboxymethyl-γ-cyclodextrin is an effective, but less potent agent for reversal of neuromuscular block than sugammadex.
    MeSH term(s) Animals ; Neuromuscular Blockade ; Neuromuscular Blocking Agents/antagonists & inhibitors ; Rats, Wistar ; gamma-Cyclodextrins/pharmacology ; Rats
    Chemical Substances Neuromuscular Blocking Agents ; carboxymethyl-gamma-cyclodextrin ; gamma-Cyclodextrins
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-021-01424-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study.

    Fábián, Ákos I / Csernoch, Vera / Tassonyi, Edömér / Fedor, Marianna / Fülesdi, Béla

    BMC anesthesiology

    2019  Volume 19, Issue 1, Page(s) 64

    Abstract: Background: Magnesium dose-dependently potentiates the effect of non-depolarizing neuromuscular blocking agents. We investigated whether the potentiation of rocuronium-induced blockade by magnesium reduces the effect of sugammadex in an ex-vivo ... ...

    Abstract Background: Magnesium dose-dependently potentiates the effect of non-depolarizing neuromuscular blocking agents. We investigated whether the potentiation of rocuronium-induced blockade by magnesium reduces the effect of sugammadex in an ex-vivo environment and how this influences the safety margin of reversal.
    Methods: Phrenic nerve - hemidiaphragm tissue preparations were isolated from male Wistar rats. The specimens were suspended in a tissue holder that allowed registering muscle contraction amplitude following electrical stimulation of the nerve. Concentration-response relationships were elucidated for magnesium, as well as for rocuronium and sugammadex.
    Results: The mean (95% confidence interval [CI]) half effective concentrations (EC
    Conclusions: Magnesium potentiates the neuromuscular effect of rocuronium and shifts the concentration-response curve to the left. Magnesium decreases the safety margin of reversal of rocuronium-induced neuromuscular block with sugammadex.
    MeSH term(s) Animals ; Diaphragm/drug effects ; Diaphragm/innervation ; Diaphragm/physiology ; Dose-Response Relationship, Drug ; Magnesium/pharmacology ; Male ; Neuromuscular Blockade/methods ; Neuromuscular Nondepolarizing Agents/pharmacology ; Organ Culture Techniques ; Rats ; Rats, Wistar ; Rocuronium/pharmacology ; Sugammadex/pharmacology ; Treatment Outcome
    Chemical Substances Neuromuscular Nondepolarizing Agents ; Sugammadex (361LPM2T56) ; Magnesium (I38ZP9992A) ; Rocuronium (WRE554RFEZ)
    Language English
    Publishing date 2019-05-01
    Publishing country England
    Document type Journal Article
    ISSN 1471-2253
    ISSN (online) 1471-2253
    DOI 10.1186/s12871-019-0734-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Assessment of adrenocortical reserve capacity and inflammatory parameters in critically ill dogs.

    Csöndes, Judit / Fábián, Ibolya / Szabó, Bernadett / Máthé, Ákos / Vajdovich, Péter

    Acta veterinaria Hungarica

    2017  Volume 65, Issue 4, Page(s) 475–486

    Abstract: Inflammatory markers and adrenocorticotropic hormone (ACTH) stimulation test results may help us recognise critically ill dogs with poor disease outcome. Systemic inflammatory response syndrome (SIRS) criteria, the fast version of the Acute Patient ... ...

    Abstract Inflammatory markers and adrenocorticotropic hormone (ACTH) stimulation test results may help us recognise critically ill dogs with poor disease outcome. Systemic inflammatory response syndrome (SIRS) criteria, the fast version of the Acute Patient Physiologic and Laboratory Evaluation Score (APPLE
    MeSH term(s) Adrenocorticotropic Hormone/blood ; Adrenocorticotropic Hormone/metabolism ; Animals ; Biomarkers/blood ; Critical Illness ; Dog Diseases/metabolism ; Dogs ; Female ; Hydrocortisone/blood ; Hydrocortisone/metabolism ; Inflammation/blood ; Inflammation/metabolism ; Inflammation/veterinary ; Male ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/metabolism ; Systemic Inflammatory Response Syndrome/veterinary
    Chemical Substances Biomarkers ; Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2017
    Publishing country Hungary
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605742-1
    ISSN 1588-2705 ; 0236-6290 ; 0365-8198
    ISSN (online) 1588-2705
    ISSN 0236-6290 ; 0365-8198
    DOI 10.1556/004.2017.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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