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  1. Article ; Online: Integrated UHPLC-QE/MS, transcriptomics and network pharmacology reveal the mechanisms via which Liang-Yan-Yi-Zhen-San promotes the browning of white adipose tissue.

    Yao, Dong / Xing, Bo / Li, Xiang / Xu, Zi-Hua / Liu, Qian / Liu, Xin / Wu, Qiong / Cui, Ya-Ling / Fan, Ying / Zhao, Qing-Chun

    Biomedical chromatography : BMC

    2023  Volume 37, Issue 12, Page(s) e5734

    Abstract: We have previously shown that Liang-Yan-Yi-Zhen-San (LYYZS), an ancient Chinese herbal formula ...

    Abstract We have previously shown that Liang-Yan-Yi-Zhen-San (LYYZS), an ancient Chinese herbal formula, can promote the browning of white adipose tissue. In this study, we sought to determine which active ingredients of LYYZS mediated its effects on the browning of white adipose tissue. Employing ultra-high performance liquid chromatography-Q-Exactive HF mass spectrometry, a total of 52 LYYZS ingredients were identified. On this basis, 1,560 ingredient-related targets of LYYZS were screened using the HERB databases. Meanwhile, RNA sequencing analysis of the inguinal white adipose tissue of mice produced a total of 3148 genes that were significantly differentially expressed following LYYZS treatment and differentially expressed genes regarded as browning-related targets. Through the network pharmacological analysis, a total of 136 intersection targets were obtained and an ingredient-target-pathway network was established. According to network pharmacology analysis, 10 ingredients containing trans-cinnamaldehyde, genistein, daidzein, calycosin, arginine, coumarin, oleic acid, isoleucine, palmitic acid and tyrosine were regarded as active ingredients of browning of white adipose tissue. Integrated evaluation using chemical analysis, transcriptomics and network pharmacology provides an efficient strategy for discovering the active ingredients involved in how LYYZS promotes the browning of white adipose tissue.
    MeSH term(s) Animals ; Mice ; Network Pharmacology ; Chromatography, High Pressure Liquid ; Transcriptome ; Adipose Tissue, Brown ; Gas Chromatography-Mass Spectrometry ; Adipose Tissue, White ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.5734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article: Gan-Dan-Liang-Yi-Tang alleviates p-chlorophenylalanine-induced insomnia through modification of the serotonergic and immune system.

    Hu, Yuan / Wang, Yu-Nin / Zhang, Gang-Qiang / Dong, Xian-Zhe / Liu, Wan-Wan / Liu, Ping

    Experimental and therapeutic medicine

    2016  Volume 12, Issue 5, Page(s) 3087–3092

    Abstract: Gan-Dan-Liang-Yi-Tang (GDLYT) is a Traditional Chinese Medicine that has been historically used ...

    Abstract Gan-Dan-Liang-Yi-Tang (GDLYT) is a Traditional Chinese Medicine that has been historically used for the treatment of insomnia. However, investigations into its pharmacological ingredients and the mechanism underlying its sedative and hypnotic effects remain limited. The present study reported the detailed mechanisms underlying the sedative and hypnotic effects of GDLYT. Kunming mice were administered GDLYT at various sub-hypnotic doses, which underwent sodium pentobarbital treatment test, pentetrazole induced convulsant studies and p-chlorophenylalanine (PCPA) induced insomnia model. Potentiated hypnotic and sedative effects in mice was studied, and also the changes in related neurotransmitter and immune factors were evaluated. The results suggested that GDLYT possessed weak sedative effects on pentetrazole-induced convulsive activity in normal mice at a dose of 1.3 mg/kg, with an increase in sleep onset in subhypnotic dose of sodium pentobarbital-treated mice. GDLYT was also able to alleviate insomnia induced by PCPA in the rodent models, and increased 5-hydroxytryptamine levels in the prefrontal cortex, hippocampus, hypothalamus and corpus striatum of PCPA-treated rats. Furthermore, the hypnotic effects of GDLYT were modified, which allowed for PCPA-induced immune system changes, including increased interleukin (IL)-1β, tumor necrosis factor-α and IL-2 expression levels. The results of the present study indicated that GDLYT induced sedative and hypnotic bioactivity by regulating serotonergic activity in the central nervous system and immune system.
    Language English
    Publishing date 2016-09-21
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2016.3737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Zhi bu liang yi hua huang qi

    Liu, Lichang

    (Lü se sheng huo jian kang tong dao)

    2002  

    Title translation A word about astragalus membranaceus, effective for therapy and nutrition.
    Title variant Huang qi
    Author's details Liu Lichang bian zhu
    Series title Lü se sheng huo jian kang tong dao
    MeSH term(s) Astragalus membranaceus ; Phytotherapy/methods ; Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 1, 4, 282 p. :, ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Jilin ke xue ji shu chu ban she
    Publishing place Changchun
    Document type Book
    ISBN 9787538424041 ; 7538424040
    Database Catalogue of the US National Library of Medicine (NLM)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book: Guo yue jin liang. Di yi ce

    Liu, Yizhi

    Guo yue qian shuo

    (Taibeishi Zhongguo min zu yin yue yan jiu xue hui, Zhongguo nü zi guo yue tuan cong shu ; 臺北市中國民族音樂研究學會中國女子國樂團叢書)

    1967  

    Author's details Liu Yizhi bianzhu
    Series title Taibeishi Zhongguo min zu yin yue yan jiu xue hui, Zhongguo nü zi guo yue tuan cong shu
    臺北市中國民族音樂研究學會中國女子國樂團叢書
    Language Chinese
    Size 4, 104 S., Ill.
    Edition Chu ban
    Publisher Da Zhongguo tushu gongsi
    Publishing place Taibei
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  5. Article ; Online: Freeze-thaw cycles drove chemical weathering and enriched sulfates in the Burns formation at Meridiani, Mars.

    Liu, Jiacheng / Michalski, Joseph R / Gao, Wenyuan / Schröder, Christian / Li, Yi-Liang

    Science advances

    2024  Volume 10, Issue 3, Page(s) eadi1805

    Abstract: Sulfate-rich sedimentary rocks explored by the Opportunity rover during its 14-year surface mission at Meridiani Planum provide an invaluable window into the thousands of sulfate deposits detected on Mars via remote sensing. Existing models explaining ... ...

    Abstract Sulfate-rich sedimentary rocks explored by the Opportunity rover during its 14-year surface mission at Meridiani Planum provide an invaluable window into the thousands of sulfate deposits detected on Mars via remote sensing. Existing models explaining the formation of martian sulfates can be generally described as either bottom-up, groundwater-driven playa settings or top-down icy chemical weathering environments. Here, we propose a hybrid model involving both bottom-up and top-down processes driven by freeze-thaw cycles. Freezing leads to cryo-concentration of acidic fluids from precipitations at the surface, facilitating rapid chemical weathering despite low temperatures. Cryosuction causes the upward migration of vadose water and even groundwater with dissolved ions, resulting in the accumulation of ions in near-surface environments. Evaporation precipitates salts, but leaching separates chlorides from sulfates during the thawing period. Freeze-thaw cycles, therefore, can enrich sulfates at the surface. While freeze-thaw is more commonly understood as a mechanism of physical weathering, we suggest that it is a fundamental aspect of chemical weathering on Mars.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi1805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: C

    Zhang, Meifang / Liang, Xiangfei / Gao, Yang / Liu, Yi

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 5

    Abstract: The inherent properties of ... ...

    Abstract The inherent properties of TiO
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17051206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Response to correspondence on "Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances".

    Xie, Meng-Yi / Liu, Liang-Ying

    Journal of hazardous materials

    2024  , Page(s) 134071

    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sustainable youth employment quality management: The impact of robotization in China.

    Liang, Fucheng / Liu, Yi

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0298081

    Abstract: Robotization has caused widespread concern about job losses, but few scholars have paid attention to changes in employment quality. This study provides supplementary evidences on the impact of robotization on youth employment quality and compares the ... ...

    Abstract Robotization has caused widespread concern about job losses, but few scholars have paid attention to changes in employment quality. This study provides supplementary evidences on the impact of robotization on youth employment quality and compares the effectiveness of various measures. Using data about individual employment and robot usage in China, this study finds that robotization reduces youth employment quality, especially for males and the middle-educated, aged 26 to 35, and in regions with insufficient workers. The substitution effect, skill preparation effect, and productivity effect play important roles in this process. Besides the common strategy of education, the mitigating capabilities of skill training has been demonstrated, but self-entrepreneurship has not. This study suggests that the exploration of various youth self-development measures, such as skill training, is warranted to improve employment quality.
    MeSH term(s) Humans ; China ; Male ; Employment ; Adult ; Female ; Robotics ; Young Adult ; Adolescent
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Testing of two SNP array-based genealogy algorithms using extended Han Chinese pedigrees and recommendations for improved performances in forensic practice.

    Liu, Jing / Wei, Yi-Liang / Yang, Lan / Jiang, Li / Zhao, Wen-Ting / Li, Cai-Xia

    Electrophoresis

    2023  Volume 44, Issue 17-18, Page(s) 1435–1445

    Abstract: Distant genetic relatives can be linked to a crime scene sample by computing identity-by-state (IBS) and identity-by-descent (IBD) shared by individuals. To test the methods of genetic genealogy estimation and optimal the parameters for forensic ... ...

    Abstract Distant genetic relatives can be linked to a crime scene sample by computing identity-by-state (IBS) and identity-by-descent (IBD) shared by individuals. To test the methods of genetic genealogy estimation and optimal the parameters for forensic investigation, a family-based genetic genealogy analysis was performed using a dataset of 262 Han Chinese individuals from 11 families. The dataset covered relative pairs from 1st- to 14th degrees. But the 7th-degree relative is the most distant kinship to be fully investigated, and each individual has ∼200 relatives within the 7th degree. The KING algorithm by calculating IBS and IBD statistics can correctly discriminate the first-degree relationships of monozygotic twin, parent-offspring and full sibling. The inferred relationship was reliable within the fifth-degree, false positive rate <1.8%. The IBD segment algorithm, GERMLINE + ERSA, could provide reliable inference result prolonged to eighth degree. Analysis of IBD segments produced obviously false negative estimations (<27.4%) rather than false positives (0%) within the eighth-degree inferences. We studied different minimum IBD segment threshold settings (changed from >0 to 6 cM); the inferred results did not make much difference. In distant relative analysis, genetically undetectable relationships begin to occur from the sixth degree (second cousin once removed), which means the offspring after seven meiotic divisions may share no ancestor IBD segment at all. Application of KING and GERMLINE + ERSA worked complementarily to ensure accurate inference from first degree to eighth degree. Using simulated low call rate data, the KING algorithm shows better tolerance to marker decrease compared with the GERMLINE + ERSA segment algorithm.
    MeSH term(s) Humans ; Algorithms ; East Asian People ; Pedigree ; Polymorphism, Single Nucleotide ; Forensic Genetics
    Language English
    Publishing date 2023-07-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619001-7
    ISSN 1522-2683 ; 0173-0835
    ISSN (online) 1522-2683
    ISSN 0173-0835
    DOI 10.1002/elps.202200237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1868: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Robotic Hysterectomy with Ureter Identification and Uterine Artery Ligation for Benign Gynecological Conditions: An Early-Year Single-Center Experience.

    Lee, Yi-Liang / Chiang, Kai-Jo / Lin, Chi-Kung / Chao, Tai-Kuang / Yu, Mu-Hsien / Liu, Yung-Liang / Wang, Yu-Chi

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 10

    Abstract: The use and application of robotic systems with a high-definition, three-dimensional vision system and advanced EndoWrist technology have become widespread. We sought to share our clinical experience with ureter identification and preventive uterine ... ...

    Abstract The use and application of robotic systems with a high-definition, three-dimensional vision system and advanced EndoWrist technology have become widespread. We sought to share our clinical experience with ureter identification and preventive uterine artery ligation in robotic hysterectomy. The records of patients undergoing robotic hysterectomy between May 2014 and December 2015, including patient preoperative characteristics, operative time, and postoperative outcomes, were analyzed. We evaluated the feasibility and safety of using early ureteral identification and preventive uterine artery ligation in robotic hysterectomy in patients with benign gynecological conditions. Overall, 49 patients diagnosed with benign gynecological conditions were evaluated. The mean age of the patients and mean uterine weight were 46.2 ± 5.3 years and 348.7 ± 311.8 g, respectively. Robotic hysterectomy achieved satisfactory results, including a short postoperative hospital stay (2.7 ± 0.8 days), low conversion rate (n = 0), and low complication rate (n = 1; 2%). The average estimated blood loss was 109 ± 107.2 mL. Our results suggest that robotic hysterectomy using early ureteral identification and preventive uterine artery ligation is feasible and safe in patients with benign gynecological conditions.
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13101809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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