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  1. Article ; Online: Improving the Efficacy of Regulatory T Cell Therapy.

    Baeten, Paulien / Van Zeebroeck, Lauren / Kleinewietfeld, Markus / Hellings, Niels / Broux, Bieke

    Clinical reviews in allergy & immunology

    2021  Volume 62, Issue 2, Page(s) 363–381

    Abstract: Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-specific to system disorders. Patients with autoimmune diseases are commonly treated with broad-acting immunomodulatory drugs, with the risk of severe side effects. ... ...

    Abstract Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-specific to system disorders. Patients with autoimmune diseases are commonly treated with broad-acting immunomodulatory drugs, with the risk of severe side effects. Regulatory T cells (Tregs) have the inherent capacity to induce peripheral tolerance as well as tissue regeneration and are therefore a prime candidate to use as cell therapy in patients with autoimmune disorders. (Pre)clinical studies using Treg therapy have already established safety and feasibility, and some show clinical benefits. However, Tregs are known to be functionally impaired in autoimmune diseases. Therefore, ex vivo manipulation to boost and stably maintain their suppressive function is necessary when considering autologous transplantation. Similar to autoimmunity, severe coronavirus disease 2019 (COVID-19) is characterized by an exaggerated immune reaction and altered Treg responses. In light of this, Treg-based therapies are currently under investigation to treat severe COVID-19. This review provides a detailed overview of the current progress and clinical challenges of Treg therapy for autoimmune and hyperinflammatory diseases, with a focus on recent successes of ex vivo Treg manipulation.
    MeSH term(s) Autoimmune Diseases/therapy ; Autoimmunity ; COVID-19/therapy ; Humans ; Immunotherapy, Adoptive ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2021-07-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-021-08866-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1844: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fast and Efficient Genome Editing of Human FOXP3

    Van Zeebroeck, Lauren / Arroyo Hornero, Rebeca / Côrte-Real, Beatriz F / Hamad, Ibrahim / Meissner, Torsten B / Kleinewietfeld, Markus

    Frontiers in immunology

    2021  Volume 12, Page(s) 655122

    Abstract: ... ...

    Abstract FOXP3
    MeSH term(s) Blood Buffy Coat/cytology ; CRISPR-Cas Systems/genetics ; Forkhead Transcription Factors/metabolism ; Gene Editing/methods ; Gene Knockdown Techniques ; HEK293 Cells ; Healthy Volunteers ; Humans ; Immunotherapy, Adoptive/methods ; Interleukin-2 Receptor alpha Subunit/genetics ; Primary Cell Culture ; RNA, Guide, CRISPR-Cas Systems/genetics ; Receptors, Interleukin-6/genetics ; T-Lymphocytes, Regulatory/metabolism ; Time Factors
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; IL2RA protein, human ; IL6R protein, human ; Interleukin-2 Receptor alpha Subunit ; RNA, Guide, CRISPR-Cas Systems ; Receptors, Interleukin-6
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.655122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.

    Côrte-Real, Beatriz F / Hamad, Ibrahim / Arroyo Hornero, Rebeca / Geisberger, Sabrina / Roels, Joris / Van Zeebroeck, Lauren / Dyczko, Aleksandra / van Gisbergen, Marike W / Kurniawan, Henry / Wagner, Allon / Yosef, Nir / Weiss, Susanne N Y / Schmetterer, Klaus G / Schröder, Agnes / Krampert, Luka / Haase, Stefanie / Bartolomaeus, Hendrik / Hellings, Niels / Saeys, Yvan /
    Dubois, Ludwig J / Brenner, Dirk / Kempa, Stefan / Hafler, David A / Stegbauer, Johannes / Linker, Ralf A / Jantsch, Jonathan / Müller, Dominik N / Kleinewietfeld, Markus

    Cell metabolism

    2023  Volume 35, Issue 2, Page(s) 299–315.e8

    Abstract: ... ...

    Abstract FOXP3
    MeSH term(s) Humans ; Sodium/metabolism ; T-Lymphocytes, Regulatory ; Autoimmunity ; Forkhead Transcription Factors/metabolism
    Chemical Substances Sodium (9NEZ333N27) ; Forkhead Transcription Factors
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity.

    Willebrand, Ralf / Hamad, Ibrahim / Van Zeebroeck, Lauren / Kiss, Máté / Bruderek, Kirsten / Geuzens, Anneleen / Swinnen, Dries / Côrte-Real, Beatriz Fernandes / Markó, Lajos / Lebegge, Els / Laoui, Damya / Kemna, Josephine / Kammertoens, Thomas / Brandau, Sven / Van Ginderachter, Jo A / Kleinewietfeld, Markus

    Frontiers in immunology

    2019  Volume 10, Page(s) 1141

    Abstract: Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on ... ...

    Abstract Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on tumor growth in mice. Here we show that high salt significantly inhibited tumor growth in two independent murine tumor transplantation models. Although high salt fed tumor-bearing mice showed alterations in T cell populations, the effect seemed to be largely independent of adaptive immune cells. In contrast, depletion of myeloid-derived suppressor cells (MDSCs) significantly reverted the inhibitory effect on tumor growth. In line with this, high salt conditions almost completely blocked murine MDSC function
    MeSH term(s) Animals ; Apoptosis ; Biomarkers ; Disease Models, Animal ; Disease Progression ; Heterografts ; Humans ; Immunity ; Immunohistochemistry ; Mice ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Sodium Chloride, Dietary/metabolism
    Chemical Substances Biomarkers ; Sodium Chloride, Dietary
    Language English
    Publishing date 2019-06-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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