Result 1 - 10 of total 289
(Handbook of experimental pharmacology ...)
2014
| Author's details | Bernd Nilius ; Veit Flockerzi ed |
|---|---|
| Series title | Handbook of experimental pharmacology ... |
| Language | English |
| Dates of publication | 2014-2014 |
| Publisher | Springer |
| Publishing place | Heidelberg u.a. |
| Publishing country | Germany |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT018266688 |
| Database | Catalogue ZB MED Medicine, Health |
(Handbook of experimental pharmacology ; 223)
2014
| Author's details | Bernd Nilius ; Veit Flockerzi ed |
|---|---|
| Series title | Handbook of experimental pharmacology ; 223 Mammalian transient receptor potential (TRP) cation channels |
| Collection | Mammalian transient receptor potential (TRP) cation channels |
| Language | English |
| Size | XI S. , S. 730 - 1290 : Ill., graph. Darst. |
| Publisher | Springer |
| Publishing place | Heidelberg u.a. |
| Publishing country | Germany |
| Document type | Book |
| HBZ-ID | HT018336033 |
| ISBN | 978-3-319-05160-4 ; 9783319051611 ; 3-319-05160-1 ; 331905161X |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2014 A 2921 | available for loan (reading room) | Lesesaal EG |
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(Handbook of experimental pharmacology ; 222)
2014
| Author's details | Bernd Nilius ; Veit Flockerzi ed |
|---|---|
| Series title | Handbook of experimental pharmacology ; 222 Mammalian transient receptor potential (TRP) cation channels |
| Collection | Mammalian transient receptor potential (TRP) cation channels |
| Language | English |
| Size | XII, 726 S. : Ill., graph. Darst. |
| Publisher | Springer |
| Publishing place | Heidelberg u.a. |
| Publishing country | Germany |
| Document type | Book |
| HBZ-ID | HT018266721 |
| ISBN | 978-3-642-54214-5 ; 9783642542152 ; 3-642-54214-X ; 3642542158 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2014 A 2067 | available for loan (reading room) | Lesesaal EG |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Pflugers Archiv : European journal of physiology
2015 Volume 467, Issue 12, Page(s) 2399–2400
| MeSH term(s) | Periodicals as Topic ; Physiology |
|---|---|
| Language | English |
| Publishing date | 2015-12 |
| Publishing country | Germany |
| Document type | Editorial |
| ZDB-ID | 6380-0 |
| ISSN | 1432-2013 ; 0031-6768 |
| ISSN (online) | 1432-2013 |
| ISSN | 0031-6768 |
| DOI | 10.1007/s00424-015-1755-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.35: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Pflugers Archiv : European journal of physiology
2014 Volume 466, Issue 11, Page(s) 2019–2020
| MeSH term(s) | History, 20th Century ; Humans ; Nobel Prize ; Periodicals as Topic/history ; Physiology/history |
|---|---|
| Language | English |
| Publishing date | 2014-08-06 |
| Publishing country | Germany |
| Document type | Biography ; Editorial ; Historical Article |
| ZDB-ID | 6380-0 |
| ISSN | 1432-2013 ; 0031-6768 |
| ISSN (online) | 1432-2013 |
| ISSN | 0031-6768 |
| DOI | 10.1007/s00424-014-1567-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.35: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2024 Volume 32, Issue 4, Page(s) 413–422
Abstract: Background: Blocking Transient Receptor Potential Melastatin 4 (TRPM4) in rodents by our antibody M4P has shown to attenuate cerebral ischaemia-reperfusion injury. Since M4P does not interact with human TRPM4, the therapeutic potential of blocking human ...
| Abstract | Background: Blocking Transient Receptor Potential Melastatin 4 (TRPM4) in rodents by our antibody M4P has shown to attenuate cerebral ischaemia-reperfusion injury. Since M4P does not interact with human TRPM4, the therapeutic potential of blocking human TRPM4 remains unclear. We developed a monoclonal antibody M4M that inhibited human TRPM4 in cultured cells. However, M4M has no effect on stroke outcome in wild-type rats. Therefore, M4M needs to be evaluated on animal models expressing human TRPM4. Methods: We generated a humanised rat model using the CRISPR/Cas technique to knock-in (KI) the human TRPM4 antigen sequence. Results: In primary neurons from human TRPM4 KI rats, M4M binds to hypoxic neurons, but not normoxic nor wild-type neurons. Electrophysiological studies showed that M4M blocked ATP depletion-induced activation of TRPM4 and inhibited hypoxia-associated cell volume increase. In a stroke model, administration of M4M reduced infarct volume in KI rats. Rotarod test and Neurological deficit score revealed improvement following M4M treatment. Conclusion: M4M selectively binds and inhibits hypoxia-induced human TRPM4 channel activation in neurons from the humanised rat model, with no effect on healthy neurons. Use of M4M in stroke rats showed functional improvements, suggesting the potential for anti-human TRPM4 antibodies in treating acute ischaemic stroke patients. |
|---|---|
| MeSH term(s) | Rats ; Humans ; Animals ; Stroke/drug therapy ; Transient Receptor Potential Channels/therapeutic use ; Antibodies, Monoclonal/pharmacology ; Brain Ischemia/drug therapy ; TRPM Cation Channels/metabolism ; Reperfusion Injury/drug therapy ; Hypoxia |
| Chemical Substances | Transient Receptor Potential Channels ; Antibodies, Monoclonal ; TRPM Cation Channels ; TRPM4 protein, human ; TRPM4 protein, rat |
| Language | English |
| Publishing date | 2024-02-12 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1187110-6 |
| ISSN | 1029-2330 ; 1061-186X |
| ISSN (online) | 1029-2330 |
| ISSN | 1061-186X |
| DOI | 10.1080/1061186X.2024.2313522 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4481: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 Volume 191, Page(s) 106408
Abstract: Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists ...
| Abstract | Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists have been examined for their efficacy in mitigating excitotoxicity, but failed to generate beneficial outcome due to their side effects on healthy neurons where glutamate receptors are also blocked. In this study, we found that during chronic hypoxia there is upregulation and activation of a nonselective cation channel TRPM4 that contributes to the depolarized neuronal membrane potential and enhanced glutamate-induced calcium entry. TRPM4 is involved in modulating neuronal membrane excitability and calcium signaling, with a complex and multifaceted role in the brain. Here, we inhibited TRPM4 using a newly developed blocking antibody M4P, which could repolarize the resting membrane potential and ameliorate calcium influx upon glutamate stimulation. Importantly, M4P did not affect the functions of healthy neurons as the activity of TRPM4 channel is not upregulated under normoxia. Using a rat model of chronic hypoxia with both common carotid arteries occluded, we found that M4P treatment could reduce apoptosis in the neurons within the hippocampus, attenuate long-term potentiation impairment and improve the functions of learning and memory in this rat model. With specificity to hypoxic neurons, TRPM4 blocking antibody can be a novel way of controlling excitotoxicity with minimal side effects that are common among direct blockers of glutamate receptors. |
|---|---|
| MeSH term(s) | Rats ; Animals ; Glutamic Acid/metabolism ; Calcium/metabolism ; Receptors, Glutamate/metabolism ; Neurons/metabolism ; Hypoxia/metabolism ; TRPM Cation Channels/metabolism |
| Chemical Substances | Glutamic Acid (3KX376GY7L) ; Calcium (SY7Q814VUP) ; Receptors, Glutamate ; TRPM4 protein, rat ; TRPM Cation Channels |
| Language | English |
| Publishing date | 2024-01-09 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1211786-9 |
| ISSN | 1095-953X ; 0969-9961 |
| ISSN (online) | 1095-953X |
| ISSN | 0969-9961 |
| DOI | 10.1016/j.nbd.2024.106408 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4444: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Current topics in medicinal chemistry
2013 Volume 13, Issue 3, Page(s) 244–246
| MeSH term(s) | Animals ; Disease ; Drug Design ; Humans ; Molecular Targeted Therapy ; Pharmaceutical Preparations ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/metabolism |
|---|---|
| Chemical Substances | Pharmaceutical Preparations ; Transient Receptor Potential Channels |
| Language | English |
| Publishing date | 2013-02-27 |
| Publishing country | United Arab Emirates |
| Document type | Introductory Journal Article |
| ZDB-ID | 2064823-6 |
| ISSN | 1873-4294 ; 1568-0266 |
| ISSN (online) | 1873-4294 |
| ISSN | 1568-0266 |
| DOI | 10.2174/1568026611313030002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5572: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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funktionelle Eigenschaften und Modulation myokardialer Natrium-Kanäle
(Sitzungsberichte der Akademie der Wissenschaften der DDR : N, Mathematik, Naturwissenschaften, Technik ; Jg. 1989, Nr. 6)
1989
| Author's details | Bernd Nilius |
|---|---|
| Series title | Sitzungsberichte der Akademie der Wissenschaften der DDR : N, Mathematik, Naturwissenschaften, Technik ; Jg. 1989, Nr. 6 Sitzungsberichte der Akademie der Wissenschaften der DDR Sitzungsberichte der Akademie der Wissenschaften der DDR ; N, Mathematik, Naturwissenschaften, Technik |
| Collection | Sitzungsberichte der Akademie der Wissenschaften der DDR Sitzungsberichte der Akademie der Wissenschaften der DDR ; N, Mathematik, Naturwissenschaften, Technik |
| Keywords | Ion Channels ; Herzmuskelzelle ; Erregungsbildung |
| Subject | Kardiomyozyt ; Kardialer Myozyt ; Herzmuskelzellen |
| Language | German |
| Size | 27 S. : Ill., graph. Darst. |
| Publisher | Akad.-Verl |
| Publishing place | Berlin |
| Publishing country | XA-DDDE |
| Document type | Book |
| HBZ-ID | HT003559279 |
| ISBN | 3-05-500529-5 ; 978-3-05-500529-9 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 1991 B 1049 | order for loan | Magazin |
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Biochimica et biophysica acta. Molecular basis of disease
2024 Volume 1870, Issue 3, Page(s) 167030
| MeSH term(s) | Cell Line ; Calcium Channels/metabolism |
|---|---|
| Chemical Substances | Calcium Channels |
| Language | English |
| Publishing date | 2024-01-23 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 60-7 |
| ISSN | 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| ISSN (online) | 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 |
| ISSN | 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| DOI | 10.1016/j.bbadis.2024.167030 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.247: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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