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  1. Article: Magnetite Nanoparticles Functionalized with Therapeutic Agents for Enhanced ENT Antimicrobial Properties.

    Caciandone, Mara / Niculescu, Adelina-Gabriela / Grumezescu, Valentina / Bîrcă, Alexandra Cătălina / Ghica, Ionuț Cosmin / Vasile, Bogdan Ștefan / Oprea, Ovidiu / Nica, Ionela Cristina / Stan, Miruna Silvia / Holban, Alina Maria / Grumezescu, Alexandru Mihai / Anghel, Ion / Anghel, Alina Georgiana

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: In the context of inefficient antibiotics, antibacterial alternatives are urgently needed to stop the increasing resistance rates in pathogens. This study reports the fabrication and characterization of four promising magnetite-based antibiotic delivery ... ...

    Abstract In the context of inefficient antibiotics, antibacterial alternatives are urgently needed to stop the increasing resistance rates in pathogens. This study reports the fabrication and characterization of four promising magnetite-based antibiotic delivery systems for ENT (ear, nose and throat) applications. Magnetite nanoparticles were functionalized with streptomycin and neomycin and some were entrapped in polymeric spheres. The obtained nanomaterials are stable, with spherical morphology, their size ranging from ~2.8 to ~4.7 nm for antibiotic-coated magnetite nanoparticles, and from submicron sizes up to several microns for polymer-coated magnetite-antibiotic composites. Cell viability and antimicrobial tests demonstrated their biocompatibility on human diploid cells and their antibacterial effect against Gram-negative (
    Language English
    Publishing date 2022-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11050623
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  2. Article: Pathologic Response After Weekly Paclitaxel versus Docetaxel in Operable Breast Cancer.

    Bacinschi, Xenia Elena / Anghel, Rodica Maricela / Toma, Paula Iuliana / Safta, Inga / Ilie, Alis / Ilie, Silvia Mihaela

    Cancer management and research

    2020  Volume 12, Page(s) 1419–1426

    Abstract: Introduction: Weekly paclitaxel (Ptx) and q3w docetaxel (Dtx) are equivalent in adjuvant breast cancer treatment. Weekly Ptx is better tolerated than q3w Dtx and became the first choice in daily practice, even preoperatively.: Methods: To compare the ...

    Abstract Introduction: Weekly paclitaxel (Ptx) and q3w docetaxel (Dtx) are equivalent in adjuvant breast cancer treatment. Weekly Ptx is better tolerated than q3w Dtx and became the first choice in daily practice, even preoperatively.
    Methods: To compare the efficacy and safety of the two regimens, a retrospective analysis was performed in breast cancer patients (pts) referred for neoadjuvant, sequential, taxane-containing chemotherapy to the Institute of Oncology and Oncofort Clinic, Bucharest, between 2008 and 2017.
    Results: Forty-seven cases were eligible, median age was 56 years (34-73 years), mainly stage IIIA-B (53.2%, 25 pts) and ductal invasive (70.2%, 33 pts) of which 24 pts (51%) received q3w Dtx and 23 pts (48.9%) weekly Ptx. The histological response rates were 62.5% (15 pts) and 73.7% (17 pts) (p=0.47), average dose-intensity was 87.7% and 96.7% (p=0.002) and grade III-IV toxicity rate was 12.5% and 13% (p=0.64), respectively. Pathologic response was correlated with immunophenotype, PgR expression, tumor size and backbone chemotherapy (p<0.05).
    Discussion: Our study showed an improved efficacy of taxane's weekly administration, probably due to a better tolerance and a lower rate of dose-impairing toxicities.
    Language English
    Publishing date 2020-02-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S234527
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  3. Article: PEG-Functionalized Magnetite Nanoparticles for Modulation of Microbial Biofilms on Voice Prosthesis.

    Caciandone, Mara / Niculescu, Adelina-Gabriela / Roșu, Aurelian Radu / Grumezescu, Valentina / Negut, Irina / Holban, Alina Maria / Oprea, Ovidiu / Vasile, Bogdan Ștefan / Bîrcă, Alexandra Cătălina / Grumezescu, Alexandru Mihai / Stan, Miruna Silvia / Anghel, Alina Georgiana / Anghel, Ion

    Antibiotics (Basel, Switzerland)

    2021  Volume 11, Issue 1

    Abstract: This study reports the fabrication of nanostructured coatings based on magnetite, polyethyleneglycol, and biologically active molecule (polymyxin B-PM) for producing biofilm-resistant surfaces (voice prosthesis). Magnetite nanoparticles (MNPs) have been ... ...

    Abstract This study reports the fabrication of nanostructured coatings based on magnetite, polyethyleneglycol, and biologically active molecule (polymyxin B-PM) for producing biofilm-resistant surfaces (voice prosthesis). Magnetite nanoparticles (MNPs) have been synthesized and functionalized using a co-precipitation method and were further deposited into thin coatings using the matrix-assisted pulsed laser evaporation (MAPLE) technique. The obtained nanoparticles and coatings were characterized by X-ray diffraction (XRD), thermogravimetric analysis with differential scanning calorimetry (TGA-DSC), scanning electron microscopy (SEM), transmission electron microscopy with selected area electron diffraction (TEM-SAED), Fourier-transform infrared spectroscopy (FT-IR), and infrared microscopy (IRM). Their antibiofilm activity was tested against relevant
    Language English
    Publishing date 2021-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11010039
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  4. Article: Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis.

    Ilie, Silvia Mihaela / Bacinschi, Xenia Elena / Botnariuc, Inga / Anghel, Rodica Maricela

    Breast cancer (Dove Medical Press)

    2018  Volume 10, Page(s) 177–194

    Abstract: Background: Triple-negative breast cancer (TNBC) has a poor prognosis, even in its early stages. In the absence of postoperative targeted treatments, intensive adjuvant chemotherapy regimens are proposed. For those favorable histologies, such as ... ...

    Abstract Background: Triple-negative breast cancer (TNBC) has a poor prognosis, even in its early stages. In the absence of postoperative targeted treatments, intensive adjuvant chemotherapy regimens are proposed. For those favorable histologies, such as apocrine and adenoid cystic carcinoma, which frequently belong to TNBC, aggressive treatments are unnecessary.
    Patients and methods: We retrospectively analyzed 631 cases of breast cancer, primary operated curatively, and followed up at our institution for at least 36 months to identify the bio-markers assessable by immunohistochemistry, to be proposed as prognostic score for tailoring adjuvant treatment to TNBC patients.
    Results: The triple-negative phenotype was found in 85 patients (13.5%). Over a mean followup of 55.7 months, relapses occurred in 106 patients (16.8%), of which 18 (2.8%) were TNBC. Recurrence was directly correlated with Ki67 and cytokeratin 5/6 (CK5/6) immunoreactivity in all breast cancer patients (
    Conclusion: These preliminary results suggest that CK5/6 and E-cad are possible core biomarkers for a cost-effective prognostic evaluation of primary operable TNBC patients.
    Language English
    Publishing date 2018-11-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S175556
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  5. Article ; Online: LEADERS’ CHARACTERISTICS

    ANGHEL - VLAD SILVIA

    Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, Vol 1, Iss 3, Pp 41-

    2018  Volume 47

    Abstract: Leadership is not perceived only as an individual quality of a certain person but also as a decisive condition of culture; this means that leadership is the result of some specific actions well planned by one or more leaders who want to create a strong ... ...

    Abstract Leadership is not perceived only as an individual quality of a certain person but also as a decisive condition of culture; this means that leadership is the result of some specific actions well planned by one or more leaders who want to create a strong managerial culture characterized by intern harmony of a vision, of some values that they have and manage to transfer to their supporters. Henry Mintzberg said that the leader merges the needs of the company with the needs of the people under his command and the leader position is given to you by the people that you lead, you have to gain their respect. In this study I showed the characteristics of a leader in a company and how he manages to combine the individual needs of the employees under his command with the needs of the company and how he managed to gain their respect. Following an interview with leader D.I. obtained some conclusions presented in this article.
    Keywords leadership ; leader ; characteristics ; abilities ; managerial culture ; Commercial geography. Economic geography ; HF1021-1027 ; Economics as a science ; HB71-74
    Subject code 650
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Academica Brâncuşi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Therapeutic challenges of psoriasis in the HIV-infected patient: A case report.

    Arbune, Manuela / Arbune, Anca-Adriana / Niculet, Elena / Anghel, Lucretia / Fotea, Silvia / Tatu, Alin Laurentiu

    Experimental and therapeutic medicine

    2021  Volume 23, Issue 2, Page(s) 175

    Abstract: Psoriasis can be paradoxically associated with human immunodeficiency virus (HIV) infection, having a prevalence similar to the general population but with a more severe evolution. In the genetically predisposed patients with the ... ...

    Abstract Psoriasis can be paradoxically associated with human immunodeficiency virus (HIV) infection, having a prevalence similar to the general population but with a more severe evolution. In the genetically predisposed patients with the CW
    Language English
    Publishing date 2021-12-28
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.11098
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  7. Article ; Online: COMPARATIVE ANALYSIS REGARDING THE HUMAN RESOURCES MOTIVATION IN THE HOTEL INDUSTRY

    ANGHEL-VLAD SILVIA

    Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, Vol 1, Iss 3, Pp 5-

    2017  Volume 11

    Abstract: Motivation has an essential role in the employees rewarding. According to Milkovich and Newman, motivation represents „all forms of financial returns and tangible services and benefits employees receive as part of an employment relationship” [1] „ ... ...

    Abstract Motivation has an essential role in the employees rewarding. According to Milkovich and Newman, motivation represents „all forms of financial returns and tangible services and benefits employees receive as part of an employment relationship” [1] „Financial returns” refers to the payment, while „services and benefits” refers to benefits such as medical assurance, paid vacation, pension and discounts for employees.
    Keywords motivation ; feedback ; professional satisfaction ; employee participation ; Commercial geography. Economic geography ; HF1021-1027 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Academica Brâncuşi
    Document type Article ; Online
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  8. Article ; Online: Good Prognosis Went Badly: Fulminant Evolution of a 29-Year-Old Patient with Verrucous Carcinoma of the Cervix.

    Anghel, Rodica M / Trifanescu, Oana G / Mitrica, Radu I / Curea, Fabiana G / Botnariuc, Inga / Herghelegiu, Catalin G / Orlov, Cristina M / Ilie, Silvia M

    Journal of adolescent and young adult oncology

    2017  Volume 6, Issue 3, Page(s) 499–502

    Abstract: Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent ... ...

    Abstract Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Treatment of choice in VC is surgery, because of the risk of anaplastic transformation under irradiation, raising the chances of distant spread and converting this rather benign-like type of cancer to an aggressive cancer.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2607978-1
    ISSN 2156-535X ; 2156-5333
    ISSN (online) 2156-535X
    ISSN 2156-5333
    DOI 10.1089/jayao.2017.0009
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  9. Article ; Online: Rare Pelvic Malignant Tumors in Adults: Treatment Features and Clinical Outcome in Nonmetastatic Disease (Single Institution Experience).

    Bacinschi, Xenia E / Ilie, Silvia M / Trifanescu, Oana G / Serbanescu, Georgia-Luiza / Botnariuc, Inga / Curea, Fabiana / Orlov, Cristina / Anghel, Rodica M

    Cancer biotherapy & radiopharmaceuticals

    2018  Volume 34, Issue 1, Page(s) 56–66

    Abstract: Background: Nearly 200 cancers repertories are rare, and more than 20% are pelvic neoplasia. Diagnosis and treatment are challenging, even in reference centers, and survival is influenced by the aggressiveness of certain histologies and absence of a ... ...

    Abstract Background: Nearly 200 cancers repertories are rare, and more than 20% are pelvic neoplasia. Diagnosis and treatment are challenging, even in reference centers, and survival is influenced by the aggressiveness of certain histologies and absence of a standard of care.
    Patients and methods: The authors report the results of a retrospective analysis of patients that attended the Institute of Oncology, Bucharest, between 2004 and 2015, for nonmetastatic pelvic malignant tumor treatment and follow-up. The outcomes are compared between the rare and common histology groups.
    Results: Of the 60 cases analyzed, 17 patients (28.33%) bore a rare tumor, 33 (55%) were women, and the median age was 59 years. The majority was concerned by bladder (41.66%, 25 patients) and cervix (23.33%, 14 patients) neoplasms. For a median follow-up of 27.5 months, relapse was registered in 27 patients (45%), of whom 9 (33.33%) were from the rare group (53% of this subpopulation). The highest relapse rates were recorded in patients with rare bladder tumors (66.7%, 4 patients) compared with 42.1% (8 patients) in the common group (p = 0.294) and in prostate localization (66.7%, 2 patients) compared with 16.7% (1 patient) (p = 0.134). Estimated median relapse-free survival (RFS) was 60, 12 months in the rare group and 67 months for common tumors.
    Conclusions: In nonmetastatic rare pelvic tumor patients, the outcome was found to be poorer than in those concerned by common histologies stratified by organ. A higher rate of relapse and the lowest median RFS were observed in bladder and prostatic cancers.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Pelvic Neoplasms/diagnosis ; Pelvic Neoplasms/pathology ; Pelvic Neoplasms/therapy ; Treatment Outcome
    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2018.2535
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1896: Show issues Location:
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  10. Article ; Online: Fat poetry: a kingdom for PPAR gamma.

    Anghel, Silvia I / Wahli, Walter

    Cell research

    2007  Volume 17, Issue 6, Page(s) 486–511

    Abstract: Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it ...

    Abstract Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma), which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARgamma agonists are therapeutic agents used in the treatment of type 2 diabetes.This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARgamma in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARgamma modulators.
    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue/physiology ; Animals ; Energy Metabolism/physiology ; Homeostasis/physiology ; Humans ; Obesity/metabolism ; PPAR gamma/metabolism ; PPAR gamma/physiology
    Chemical Substances PPAR gamma
    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/cr.2007.48
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