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  1. Article ; Online: Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19: análisis de 52 casos.

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora

    Medicina clinica

    2020  Volume 155, Issue 8, Page(s) 360–361

    Title translation Risk factors and severity predictors in COVID-19 hospitalized patients: Analysis of 52 patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/etiology ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/etiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Prospective Studies ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Spain/epidemiology
    Keywords covid19
    Language Spanish
    Publishing date 2020-06-25
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk factors and severity predictors in COVID-19 hospitalized patients: Analysis of 52 patients:

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora

    Medicina clinica (English ed.)

    2020  Volume 155, Issue 8, Page(s) 360–361

    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country Spain
    Document type Case Reports
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2020.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fatal Guillain-Barre syndrome after infection with SARS-CoV-2.

    Marta-Enguita, J / Rubio-Baines, I / Gastón-Zubimendi, I

    Neurologia (Barcelona, Spain)

    2020  Volume 35, Issue 4, Page(s) 265–267

    Title translation Síndrome de Guillain-Barré fatal tras infección por el virus SARS-CoV-2.
    MeSH term(s) Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Female ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/physiopathology ; Guillain-Barre Syndrome/virology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language Spanish
    Publishing date 2020-04-18
    Document type Case Reports ; Letter
    ISSN 2173-5808
    ISSN (online) 2173-5808
    DOI 10.1016/j.nrl.2020.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies.

    Machado, Florencio J D M / Marta-Enguita, Juan / Gómez, Susan U / Rodriguez, Jose A / Páramo-Fernández, José Antonio / Herrera, María / Zandio, Beatriz / Aymerich, Nuria / Muñoz, Roberto / Bermejo, Rebeca / Marta-Moreno, Javier / López, Begoña / González, Arantxa / Roncal, Carmen / Orbe, Josune

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content of ... ...

    Abstract Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content of plasma extracellular vesicles (EVs) (
    MeSH term(s) Humans ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/genetics ; Biomarkers/blood ; Male ; Female ; Aged ; Thrombosis/metabolism ; Thrombosis/etiology ; Thrombosis/blood ; Ischemic Stroke/metabolism ; Ischemic Stroke/blood ; Ischemic Stroke/genetics ; Insulin-Like Growth Factor Binding Protein 2/genetics ; Insulin-Like Growth Factor Binding Protein 2/metabolism ; Insulin-Like Growth Factor Binding Protein 2/blood ; Middle Aged ; Gene Expression Profiling ; Transcriptome ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/genetics ; Atrial Fibrillation/complications ; Atrial Fibrillation/blood
    Chemical Substances Biomarkers ; Insulin-Like Growth Factor Binding Protein 2 ; IGFBP2 protein, human
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19: análisis de 52 casos./ Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19: análisis de 52 casos./ [Risk factors and severity predictors in COVID-19 hospitalized patients: Analysis of 52 patients]

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora

    Med Clin (Barc)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613823
    Database COVID19

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  6. Article: Risk factors and severity predictors in COVID-19 hospitalized patients: Analysis of 52 patients: [[es]]Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19: análisis de 52 casos

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #808928
    Database COVID19

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  7. Article ; Online: Risk factors and severity predictors in COVID-19 hospitalized patients

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora

    Medicina Clínica (English Edition)

    Analysis of 52 patients

    2020  Volume 155, Issue 8, Page(s) 360–361

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2387-0206
    DOI 10.1016/j.medcle.2020.06.018
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19

    Marta-Enguita, Juan / Corroza-Laviñeta, Jon / Ostolaza, Aiora

    Medicina Clínica

    análisis de 52 casos

    2020  Volume 155, Issue 8, Page(s) 360–361

    Keywords General Medicine ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.06.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Ua VI Zs.279: Show issues Location:
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  9. Article ; Online: The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis.

    Lopez-Pedrera, Chary / Oteros, Rafael / Ibáñez-Costa, Alejandro / Luque-Tévar, María / Muñoz-Barrera, Laura / Barbarroja, Nuria / Chicano-Gálvez, Eduardo / Marta-Enguita, Juan / Orbe, Josune / Velasco, Francisco / Perez-Sanchez, Carlos

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 10, Page(s) 2894–2907

    Abstract: Background: Nowadays little is known about the molecular profile of the occluding thrombus of patients with ischemic stroke.: Objectives: To analyze the proteomic profile of thrombi in patients who experienced an ischemic stroke in order to gain ... ...

    Abstract Background: Nowadays little is known about the molecular profile of the occluding thrombus of patients with ischemic stroke.
    Objectives: To analyze the proteomic profile of thrombi in patients who experienced an ischemic stroke in order to gain insights into disease pathogenesis.
    Methods: Thrombi from an exploratory cohort of patients who experienced a stroke were obtained by thrombectomy and analyzed by sequential window acquisition of all theoretical spectra-mass spectrometry. Unsupervised k-means clustering analysis was performed to stratify patients who experienced a stroke. The proteomic profile was associated with both the neurological function (National Institute of Health Stroke Scale [NIHSS]) and the cerebral involvement (Alberta Stroke Program Early CT Score [ASPECTS]) prior to thrombectomy and the clinical status of patients at 3 months using the modified Rankin Scale. In an independent cohort of 210 patients who experienced a stroke, the potential role of neutrophils in stroke severity was interrogated.
    Results: Proteomic analysis identified 580 proteins in thrombi, which were stratified into 4 groups: hemostasis, proteasome and neurological diseases, structural proteins, and innate immune system and neutrophils. The thrombus proteome identified 3 clusters of patients with distinctive severity, prognosis, and etiology of the stroke. A protein signature clearly distinguished atherothrombotic and cardioembolic strokes. Several proteins were significantly correlated with the severity of the stroke (NIHSS and ASPECTS). Functional proteomic analysis highlighted the prominent role of neutrophils in stroke severity. This was in line with the association of neutrophil activation markers and count with NIHSS, ASPECTS, and the modified Rankin Scale score 90 days after the event.
    Conclusion: The use of sequential window acquisition of all theoretical spectra-mass spectrometry in thrombi from patients who experienced an ischemic stroke has provided new insights into pathways and players involved in its etiology, severity, and prognosis. The prominent role of the innate immune system identified might pave the way for the development of new biomarkers and therapeutic approaches in this disease.
    MeSH term(s) Humans ; Brain Ischemia/metabolism ; Ischemic Stroke ; Neutrophils/metabolism ; Prognosis ; Proteome ; Proteomics ; Retrospective Studies ; Stroke/etiology ; Thrombectomy ; Thrombosis/metabolism ; Treatment Outcome
    Chemical Substances Proteome
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of factor XIII in ischemic stroke: a key molecule promoting thrombus stabilization and resistance to lysis.

    Marta-Enguita, Juan / Navarro-Oviedo, Manuel / Machado, Florencio J D M / Bermejo, Rebeca / Aymerich, Nuria / Herrera, Maria / Zandio, Beatriz / Pagola, Jorge / Juega, Jesús / Marta-Moreno, Javier / Rodriguez, Jose-Antonio / Páramo, Jose-Antonio / Roncal, Carmen / Muñoz, Roberto / Orbe, Josune

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 4, Page(s) 1080–1093

    Abstract: Background: Active coagulation factor XIII (FXIII) catalyzing crosslinking of fibrin and other hemostatic factors plays a key role in clot stability and lysis.: Objectives: To evaluate the effect of FXIII inhibition in a mouse model of ischemic ... ...

    Abstract Background: Active coagulation factor XIII (FXIII) catalyzing crosslinking of fibrin and other hemostatic factors plays a key role in clot stability and lysis.
    Objectives: To evaluate the effect of FXIII inhibition in a mouse model of ischemic stroke (IS) and the role of activated FXIII (FXIIIa) in clot formation and lysis in patients with IS.
    Methods: A ferric chloride IS murine model was performed before and after administration of a FXIIIa inhibitor (FXIIIinh). Thromboelastometry in human and mice blood was used to evaluate thrombus stiffness and lysis with FXIIIinh. FXIIIa-dependent fibrin crosslinking and lysis with fibrinolytic drugs (tissue plasminogen activator and tenecteplase) were studied on fibrin plates and on thrombi and clotted plasma of patients with IS. Finally, circulating and thrombus FXIIIa were measured in 85 patients with IS.
    Results: FXIIIinh administration before stroke induction reduced infarct size, α2-antiplasmin (α2AP) crosslinking, and local microthrombosis, improving motor coordination and fibrinolysis without intracranial bleeds (24 hours). Interestingly, FXIII blockade after stroke also reduced brain damage and neurologic deficit. Thromboelastometry in human/mice blood with FXIIIinh showed delayed clot formation, reduced clot firmness, and shortened tissue plasminogen activator lysis time. FXIIIa fibrin crosslinking increased fibrin density and lysis resistance, which increased further after α2AP addition. FXIIIinh enhanced ex vivo lysis in stroke thrombi and fibrin plates. In patients with IS, thrombus FXIII and α2AP were associated with inflammatory and hemostatic components, and plasma FXIIIa correlated with thrombus α2AP and fibrin.
    Conclusion: Our results suggest a key role of FXIIIa in thrombus stabilization, α2AP crosslinking, and lysis resistance, with a protective effect of FXIIIinh in an IS experimental model.
    MeSH term(s) Humans ; Animals ; Mice ; Factor XIII ; Tissue Plasminogen Activator ; Ischemic Stroke ; Fibrinolysis/physiology ; Fibrin ; Antifibrinolytic Agents ; Thrombosis/drug therapy
    Chemical Substances Factor XIII (9013-56-3) ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrin (9001-31-4) ; Antifibrinolytic Agents
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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