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  1. Article: Rôle des protéines HBe et HBc du virus de l’hépatite B dans l’hépatocarcinogenèse.

    Lefeuvre, Caroline / Ducancelle, Alexandra

    Virologie (Montrouge, France)

    2024  Volume 27, Issue 6, Page(s) 320–332

    Abstract: Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC). However, the pathogenesis of HBV-mediated hepatocarcinogenesis is not clearly defined. Persistence of HBV infection is associated ... ...

    Title translation Role of hepatitis B virus e protein and core protein in hepatocarcinogenesis.
    Abstract Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC). However, the pathogenesis of HBV-mediated hepatocarcinogenesis is not clearly defined. Persistence of HBV infection is associated with HCC pathogenesis, and various HBV proteins appear to be involved in promoting this persistence. Currently available data suggest that the core protein, a structural component of the viral nucleocapsid, and the HBe protein, a non-structural HBV protein that can act as both a tolerogen and an immunogen, play a potential role in the development of HCC. Research shows that both proteins are capable of disrupting various pathways involved in liver carcinogenesis, including the sustenance of proliferative signaling, resistance to cell death, tumor-promoting inflammation and avoid immune destruction. This review summarizes the various signaling pathways by which HBc and HBe proteins (and their precursors) can promote hepatocarcinogenesis.
    MeSH term(s) Humans ; Hepatitis B virus ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/etiology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Hepatitis B, Chronic/complications ; Carcinogenesis
    Language French
    Publishing date 2024-01-18
    Publishing country France
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2023.1025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nosocomial COVID-19, a risk illustrated by the first in-hospital transmission of B.1.1.7 variant of SARS-CoV-2 in a French University Hospital.

    Legeay, Clément / Lefeuvre, Caroline

    Journal of infection prevention

    2022  Volume 23, Issue 6, Page(s) 293–295

    Abstract: Objectives: In this short report, we describe the first nosocomial spread of B.1.1.7 variant (GR/20I/501Y.V1) in a French hospital, underlining the different aspects of in-hospital transmission of SARS-CoV-2.: Patients and methods: Retrospective ... ...

    Abstract Objectives: In this short report, we describe the first nosocomial spread of B.1.1.7 variant (GR/20I/501Y.V1) in a French hospital, underlining the different aspects of in-hospital transmission of SARS-CoV-2.
    Patients and methods: Retrospective study of a SARS-CoV-2 cluster investigation in January 2021. All cases were screened with RT-PCR.
    Results: First transmission occurred in a double room with a COVID-19 imported cases, undetected upon admission. Healthcare workers, their relatives and patients' relatives were screened. Eleven secondary cases were identified within a week, in and out of the hospital (in hospital attack rate: 3.1%). No severe COVID-19 was encountered.
    Conclusions: This report highlights several in-hospital chains of transmission involved with COVID-19 with rapid spread.
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774221127543
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  3. Article: Traitements de la sclérose en plaques : mise à jour.

    Uginet, Marjolaine / Lefeuvre, Lucie / Lerusse, Julien / Pot, Caroline / Du Pasquier, Renaud / Lalive, Patrice H

    Revue medicale suisse

    2024  Volume 20, Issue 871, Page(s) 837–842

    Abstract: The management of multiple sclerosis (MS) has undergone a veritable revolution in recent years, with the arrival of highly effective treatments. In some cases, therapeutic discussions even precede the first clinical signs of the disease. The aim of this ... ...

    Title translation Treatments for multiple sclerosis: update.
    Abstract The management of multiple sclerosis (MS) has undergone a veritable revolution in recent years, with the arrival of highly effective treatments. In some cases, therapeutic discussions even precede the first clinical signs of the disease. The aim of this review is to present the therapeutic arsenal of progression-preventing treatments available in 2024 for MS, with anti-CD20 antibodies taking pride of place, also available for certain progressive forms of MS. The use of these immunosuppressants requires in-depth knowledge of their mechanisms of action, in order to understand their risks, such as the occurrence of opportunistic infections.
    MeSH term(s) Humans ; Multiple Sclerosis/therapy ; Multiple Sclerosis/drug therapy ; Immunosuppressive Agents/therapeutic use ; Disease Progression
    Chemical Substances Immunosuppressive Agents
    Language French
    Publishing date 2024-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; English Abstract
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2024.20.871.837
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  4. Article ; Online: Corrigendum: Study Protocol: Randomised Controlled Trial Assessing the Efficacy of Strategies Involving Self-Sampling in Cervical Cancer Screening.

    Lefeuvre, Caroline / De Pauw, Hélène / Le Duc Banaszuk, Anne-Sophie / Pivert, Adeline / Ducancelle, Alexandra / Rexand-Galais, Franck / Arbyn, Marc

    International journal of public health

    2024  Volume 69, Page(s) 1607299

    Abstract: This corrects the article DOI: 10.3389/ijph.2022.1604284.]. ...

    Abstract [This corrects the article DOI: 10.3389/ijph.2022.1604284.].
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2024.1607299
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  5. Article ; Online: A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis.

    Lefeuvre, Caroline / Le Guillou-Guillemette, Hélène / Ducancelle, Alexandra

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated ... ...

    Abstract Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated hepatocarcinogenesis is unclear. Evidence currently available suggests that the HBV core protein (HBc) plays a potential role in the development of HCC, such as the HBV X protein. The core protein, which is the structural component of the viral nucleocapsid, contributes to almost every stage of the HBV life cycle and occupies diverse roles in HBV replication and pathogenesis. Recent studies have shown that HBc was able to disrupt various pathways involved in liver carcinogenesis: the signaling pathways implicated in migration and proliferation of hepatoma cells, apoptosis pathways, and cell metabolic pathways inducing the development of HCC; and the immune system, through the expression and production of proinflammatory cytokines. In addition, HBc can modulate normal functions of hepatocytes through disrupting human host gene expression by binding to promoter regions. This HBV protein also promotes HCC metastasis through epigenetic alterations, such as micro-RNA. This review focuses on the molecular pathogenesis of the HBc protein in HBV-induced HCC.
    MeSH term(s) Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/virology ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Hepatitis B virus/metabolism ; Hepatitis B virus/pathogenicity ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/virology ; Promoter Regions, Genetic ; Viral Core Proteins/metabolism ; Virus Replication
    Chemical Substances Viral Core Proteins
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413651
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  6. Article: Aspects virologiques et diagnostic du coronavirus Sars-CoV-2.

    Lefeuvre, Caroline / Przyrowski, Émilie / Apaire-Marchais, Véronique

    Actualites pharmaceutiques

    2020  Volume 59, Issue 599, Page(s) 18–23

    Abstract: Since the emergence of the new Sars-CoV-2 coronavirus in China at the end of December 2019 and its spread around the world, the scientific community has been mobilized to study its phylogeny, virological aspects, and to understand viral and immune ... ...

    Title translation Virological aspects and diagnosis of SARS-CoV-2 coronavirus.
    Abstract Since the emergence of the new Sars-CoV-2 coronavirus in China at the end of December 2019 and its spread around the world, the scientific community has been mobilized to study its phylogeny, virological aspects, and to understand viral and immune kinetics. In order to propose the best diagnosis, the use of direct diagnosis, by reverse transcriptase-polymerase chain reaction, or indirect diagnosis, by serology, needs to be clarified.
    Keywords covid19
    Language French
    Publishing date 2020-08-21
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 885063-x
    ISSN 0515-3700
    ISSN 0515-3700
    DOI 10.1016/j.actpha.2020.08.005
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  7. Article ; Online: A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis

    Caroline Lefeuvre / Hélène Le Guillou-Guillemette / Alexandra Ducancelle

    International Journal of Molecular Sciences, Vol 22, Iss 13651, p

    2021  Volume 13651

    Abstract: Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated ... ...

    Abstract Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated hepatocarcinogenesis is unclear. Evidence currently available suggests that the HBV core protein (HBc) plays a potential role in the development of HCC, such as the HBV X protein. The core protein, which is the structural component of the viral nucleocapsid, contributes to almost every stage of the HBV life cycle and occupies diverse roles in HBV replication and pathogenesis. Recent studies have shown that HBc was able to disrupt various pathways involved in liver carcinogenesis: the signaling pathways implicated in migration and proliferation of hepatoma cells, apoptosis pathways, and cell metabolic pathways inducing the development of HCC; and the immune system, through the expression and production of proinflammatory cytokines. In addition, HBc can modulate normal functions of hepatocytes through disrupting human host gene expression by binding to promoter regions. This HBV protein also promotes HCC metastasis through epigenetic alterations, such as micro-RNA. This review focuses on the molecular pathogenesis of the HBc protein in HBV-induced HCC.
    Keywords hepatitis B virus ; hepatitis B virus core protein ; hepatocellular carcinoma ; hepatocarcinogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  8. Article ; Online: Adenovirus F41 infection and liver cytolysis in adult hematopoietic stem cell transplant recipients.

    Lefeuvre, Caroline / Thepot, Sylvain / Mercier-Delarue, Séverine / Bouille, Tiffany / Michonneau, David / Le Goff, Jérôme / Salmona, Maud

    Journal of medical virology

    2023  Volume 95, Issue 7, Page(s) e28922

    Abstract: Human adenoviruses (HAdVs) of the F species are commonly responsible for acute gastroenteritis. A few cases of systemic infections have been described in adults or children who have received a hematopoietic stem cell transplant (HSCT), but with no report ...

    Abstract Human adenoviruses (HAdVs) of the F species are commonly responsible for acute gastroenteritis. A few cases of systemic infections have been described in adults or children who have received a hematopoietic stem cell transplant (HSCT), but with no report of liver cytolysis. Since January 2022, several countries have reported an increase in cases of acute hepatitis of unknown cause in children. Adenovirus species F type 41 (HAdV-F41) infection was predominantly identified. The objective of this study is to describe HAdV-F41 infections diagnosed since January 2022 in adult HSCT recipients in two French hospitals. All four patients had diarrhea and liver cytolysis at the time of diagnosis of infection. HAdV viremia was observed in three patients (#1, #3, and #4), but no disseminated disease was reported. HAdV whole genome sequencing and metagenomics characterization were performed on stool and blood samples. The complete HAdV-F41 genome sequence was obtained for three patients and phylogenetic analysis showed that the strains consisted of similar lineage (2b). We did not identify any new HAdV-F41 strains. Metagenomics analysis found adeno-associated virus 2 and torque-teno virus infection in patient #1 and Epstein-Barr virus in patient #4. This is the first case series reporting liver cytolysis during HAdV-F41 infection in adult HSCT patients.
    MeSH term(s) Child ; Adult ; Humans ; Epstein-Barr Virus Infections ; Phylogeny ; Herpesvirus 4, Human ; Adenoviruses, Human ; Adenoviridae Infections ; Hematopoietic Stem Cell Transplantation/adverse effects ; Liver
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28922
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  9. Article ; Online: Study Protocol: Randomised Controlled Trial Assessing the Efficacy of Strategies Involving Self-Sampling in Cervical Cancer Screening.

    Lefeuvre, Caroline / De Pauw, Hélène / Le Duc Banaszuk, Anne-Sophie / Pivert, Adeline / Ducancelle, Alexandra / Rexand-Galais, Franck / Arbyn, Marc

    International journal of public health

    2022  Volume 67, Page(s) 1604284

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Adult ; Aged ; Early Detection of Cancer ; Female ; Humans ; Middle Aged ; Randomized Controlled Trials as Topic ; Self Care ; Specimen Handling ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control ; Vaginal Smears
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2022.1604284
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  10. Article ; Online: Aspects virologiques et diagnostic du coronavirus Sars-CoV-2

    Lefeuvre, Caroline / Przyrowski, Émilie / Apaire-Marchais, Véronique

    Actualités Pharmaceutiques

    2020  Volume 59, Issue 599, Page(s) 18–23

    Keywords Pharmacology (medical) ; Pharmacology ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 885063-x
    ISSN 0515-3700
    ISSN 0515-3700
    DOI 10.1016/j.actpha.2020.08.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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