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  1. Article ; Online: Interventional Pulmonology: Diagnostic and Therapeutic Advances in Bronchoscopy.

    Agrawal, Abhinav

    American journal of therapeutics

    2021  Volume 28, Issue 2, Page(s) e204–e216

    Abstract: Background: Interventional pulmonology is a rapidly evolving subspecialty of pulmonary medicine that offers advanced consultative and procedural services to patients with airway diseases, pleural diseases, as well as in the diagnosis and management of ... ...

    Abstract Background: Interventional pulmonology is a rapidly evolving subspecialty of pulmonary medicine that offers advanced consultative and procedural services to patients with airway diseases, pleural diseases, as well as in the diagnosis and management of patients with thoracic malignancy.
    Areas of uncertainty: The institution of lung cancer screening modalities as well as the search of additional minimally invasive diagnostic and treatment modalities for lung cancer and other chronic lung diseases has led to an increased focus on the field of interventional pulmonology. Rapid advancements in the field over the last 2 decades has led to development of various new minimally invasive bronchoscopic approaches and techniques for patients with cancer as well as for patients with chronic lung diseases.
    Data sources: A review of literature was performed using PubMed database to identify all articles published up till October 2020 relevant to the field of interventional pulmonology and bronchoscopy. The reference list of each article was searched to look for additional articles, and all relevant articles were included in the article.
    Therapeutic advances: Newer technologies are now available such navigation platforms to diagnose and possibly treat peripheral pulmonary nodules, endobronchial ultrasound in diagnosis of mediastinal and hilar adenopathy as well as cryobiopsy in the diagnosis of diffuse lung diseases. In addition, flexible and rigid bronchoscopy continues to provide new and expanding ability to manage patients with benign and malignant central airway obstruction. Interventions are also available for diseases such as asthma, chronic bronchitis, chronic obstructive pulmonary disease, and emphysema that were traditionally treated with medical management alone.
    Conclusions: With continued high quality research and an increasing body of evidence, interventional bronchoscopy has enormous potential to provide both safe and effective options for patients with a variety of lung diseases.
    MeSH term(s) Bronchoscopy ; Early Detection of Cancer ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/therapy ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Pulmonary Medicine
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1280786-2
    ISSN 1536-3686 ; 1075-2765
    ISSN (online) 1536-3686
    ISSN 1075-2765
    DOI 10.1097/MJT.0000000000001344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Comprehensive Review of the Immunomodulatory Effects of Vitamin D in Sepsis.

    Ahuja, Abhinav / Agrawal, Sachin / Acharya, Sourya / Kumar, Sunil

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53678

    Abstract: Sepsis remains a critical global health challenge characterised by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. This review examines the immunomodulatory effects of Vitamin D in sepsis, focusing on ... ...

    Abstract Sepsis remains a critical global health challenge characterised by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. This review examines the immunomodulatory effects of Vitamin D in sepsis, focusing on its regulation of immune cell function, modulation of cytokine production, and enhancement of antimicrobial responses. While the potential of Vitamin D as an adjunctive therapy in sepsis management is evident, challenges such as variability in Vitamin D status, uncertainties regarding optimal dosages and patient heterogeneity, and potential adverse effects require careful consideration. The review highlights the implications for future research and clinical practice, emphasising the need for standardised measurement protocols, elucidation of optimal supplementation strategies, and integration of Vitamin D assessments into routine care. Despite the complexities, Vitamin D emerges as a promising avenue for personalised interventions in sepsis, necessitating ongoing research collaboration and evidence-based guidelines to harness its full therapeutic potential and improve clinical outcomes.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unraveling Neurological Shades: Vitamin D Toxication and Central Pontine Myelinolysis Exposed.

    Ahuja, Abhinav / Agrawal, Sachin / Daiya, Varun / Batra, Nitish / Agarwal, Aaditi

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53806

    Abstract: This case report is about a middle-aged female who presented with complaints of pain in the abdomen with intractable vomiting for three months, pain and weakness in bilateral lower limbs for two months, and irritability for three days. She was previously ...

    Abstract This case report is about a middle-aged female who presented with complaints of pain in the abdomen with intractable vomiting for three months, pain and weakness in bilateral lower limbs for two months, and irritability for three days. She was previously treated for lumbar disc bulge and severe narrowing of the spinal cord whose treatment also included vitamin D supplements. After taking high doses of a vitamin D supplement daily for approximately four months, it resulted in vitamin D toxicity. The sodium level of the patient was in the normal range throughout the treatment. Her magnetic resonance imaging brain revealed features of central pontine myelinolysis. The development of central pontine myelinolysis due to vitamin D toxicity, with normal sodium levels, makes this a rare case for discussion.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Postoperative Evaluation of Pain and Disability in Patients Undergoing Spinal Discectomy.

    Abhinav, Kumar / Jadhav, Dikpal / Agrawal, Arun Kumar / Agrawal, Rama / Agrawal, Ankita

    Cureus

    2023  Volume 15, Issue 12, Page(s) e49963

    Abstract: Background: A spinal discectomy surgery (SDS) is a common surgical procedure performed to treat lumbosacral radiculopathy.: Aim: To evaluate postoperative patterns of pain and disability in patients undergoing spinal discectomy.: Methods and ... ...

    Abstract Background: A spinal discectomy surgery (SDS) is a common surgical procedure performed to treat lumbosacral radiculopathy.
    Aim: To evaluate postoperative patterns of pain and disability in patients undergoing spinal discectomy.
    Methods and materials: This investigation was a retrospective longitudinal review of prospective information gathered from 543 enrolled patients for lumbar radiculoplasty. The study participants were divided into two categories: Category 1 (SDS) comprising patients of lumbar radiculoplasty managed with SDS (n=270) and Category 2 (non-SDS) comprising patients of lumbar radiculoplasty managed with therapy other than SDS (n=273). It included study participants taking medication for pain control including opioids and non-opioids and physiotherapy for strengthening lower back muscles. At baseline, three months, 12 months, and 24 months after surgery, patient-reported information was gathered. Leg pain magnitude, back pain magnitude, and pain-related impairment were the key outcome metrics of interest.
    Results: The mean postoperative visual analog scale (VAS) score for leg pain at three-month follow-up was 4.3±1.2 in study participants in SDS and 8.1±1.3 in the non-SDS category. The VAS score was lower in the SDS category showing greater reduction in postoperative pain with statistically meaningful results (p<0.001). The mean postoperative VAS score at 12-month follow-up was 2.8±1.1 in study participants in SDS and 7.9±1.5 in the non-SDS category. The VAS score was lower in the SDS category showing greater reduction in postoperative pain with statistically meaningful results (p<0.001). The mean postoperative VAS score at 24-month follow-up was 1.7±1.2 in study participants in SDS and 7.1±1.1 in the non-SDS category. The VAS score was lower in the SDS category showing greater reduction in postoperative pain with statistically meaningful results (p<0.001).
    Conclusion:  It was observed that after discectomy, patients suffering from lumbar radiculopathy have significant pain and disability recovery. According to these results, only a small percentage of individuals exhibit negative results at the level of impairment.
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hiding in Plain Sight: The Unaddressed Risk of Self-Harm With Alcohol-Based Hand Sanitizers.

    Agrawal, Abhinav / Mukhopadhyay, Sanchari

    Indian journal of psychological medicine

    2021  Volume 43, Issue 6, Page(s) 561–562

    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2622378-8
    ISSN 0975-1564 ; 0253-7176
    ISSN (online) 0975-1564
    ISSN 0253-7176
    DOI 10.1177/02537176211042197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proliferative Membranous Bronchial Webs: A Rare Complication of Lung Transplantation.

    Agrawal, Abhinav / Frye, Laura

    Journal of bronchology & interventional pulmonology

    2021  Volume 28, Issue 4, Page(s) e54–e57

    MeSH term(s) Bronchi/diagnostic imaging ; Humans ; Lung Transplantation/adverse effects
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: External Fixation of Upper Tracheal Stents in Complex Stenosis: Revising the "Hitch Stitch".

    Salguero, Bertin D / Song, Kimberly J / Agrawal, Abhinav / Chaddha, Udit

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 9, Page(s) 1353–1356

    MeSH term(s) Humans ; Constriction, Pathologic ; External Fixators ; Fracture Fixation
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202302-127CC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Cognitive behavioral therapy-based approach for management of persistent hallucinations in treatment-resistant schizophrenia.

    Agrawal, Abhinav / Kaur, Raman Deep / Sidana, Ajeet

    Industrial psychiatry journal

    2022  Volume 31, Issue 2, Page(s) 376–377

    Language English
    Publishing date 2022-08-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2580355-4
    ISSN 0976-2795 ; 0972-6748
    ISSN (online) 0976-2795
    ISSN 0972-6748
    DOI 10.4103/ipj.ipj_137_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Intrapleural Anticancer Therapy for Malignant Pleural Diseases: Facts or Fiction?

    Agrawal, Abhinav / Chaddha, Udit / Shojaee, Samira / Maldonado, Fabien

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 4, Page(s) 462–467

    Abstract: Malignant pleural diseases involves both primary pleural malignancies (e.g., mesothelioma) as well as metastatic disease involving the pleura. The management of primary pleural malignancies remains a challenge, given their limited response to ... ...

    Abstract Malignant pleural diseases involves both primary pleural malignancies (e.g., mesothelioma) as well as metastatic disease involving the pleura. The management of primary pleural malignancies remains a challenge, given their limited response to conventional treatments such as surgery, systemic chemotherapy, and immunotherapy. In this article, we aimed to review the management of primary pleural malignancy as well as malignant pleural effusion and assess the current state of intrapleural anticancer therapies. We review the role intrapleural chemotherapy, immunotherapy, and immunogene therapy, as well as oncolytic viral, therapy and intrapleural drug device combination. We further discuss that while the pleural space offers a unique opportunity for local therapy as an adjuvant option to systemic therapy and may help decrease some of the systemic side effects, further patient outcome-oriented research is needed to determine the exact role of these treatments within the armamentarium of currently available options.
    MeSH term(s) Humans ; Mesothelioma, Malignant ; Pleural Neoplasms/therapy ; Pleural Neoplasms/pathology ; Pleural Effusion, Malignant/therapy ; Pleural Effusion, Malignant/pathology ; Mesothelioma/therapy ; Mesothelioma/pathology ; Pleura/pathology
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1769094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Management of Post-craniotomy Pain in Elective Cases: A Randomized Controlled Trial.

    Abhinav, Kumar / Jadhav, Dikpal / Andar, Uday B / Karmarkar, Vikram / Agrawal, Rama / Agrawal, Ankita

    Cureus

    2023  Volume 15, Issue 9, Page(s) e46189

    Abstract: Background:  : Aim:  The aim of this study is to prospectively assess the effectiveness of an ERAS protocol for neurosurgery in the treatment of postoperative pain following elective craniotomies.: Methods and materials:  A total of 128 patients ... ...

    Abstract Background:  
    Aim:  The aim of this study is to prospectively assess the effectiveness of an ERAS protocol for neurosurgery in the treatment of postoperative pain following elective craniotomies.
    Methods and materials:  A total of 128 patients were assigned to the ERAS group and received care in accordance with the neurosurgical ERAS regulations, while 130 other participants were assigned to the control group and received traditional postoperative assistance. The participants' postoperative pain ratings using the numerical rating scale (NRS) were this study's main outcome of interest. The verbal NRS uses the numbers 0 to 10, with 0 indicating no sensation of pain and 10 indicating the most severe pain. On postoperative day (POD) 1, the patients' postoperative pain level at the surgical site was evaluated using the NRS. This was repeated every day until the patient either reported feeling no sensation of pain or was discharged home.
    Results:  The mean value of pain on the day of surgery was 4.43 ± 0.43 and 4.72 ± 0.68 for patients in the ERAS and control groups, respectively. The pain values were higher in the control group compared to the ERAS group. However, the difference was not statistically significant (p = 0.478). The mean value of pain on POD1 was 3.13 ± 0.21 and 4.45 ± 0.95 for patients in the ERAS and control groups, respectively. These pain values were higher in the control group compared to the ERAS group, and the difference was statistically significant (p = 0.011). The mean value of pain on POD2 was 2.86 ± 0.3 and 4.33 ± 0.37 for patients in the ERAS and control groups, respectively. The values of pain were higher in the control group compared to the ERAS group, and the difference was statistically significant (p = 0.003). The mean value of pain on POD3 was 2.33 ± 0.52 and 4.04 ± 0.15 for patients in the ERAS and control groups, respectively. The pain values were higher in the control group compared to the ERAS group. The difference was meaningful statistically (p < 0.001). The mean value of pain on POD4 was 2.26 ± 0.9 and 2.84 ± 0.13 for the ERAS and control groups, respectively. However, the difference was not statistically significant (p = 0.274). The ERAS group had a significantly higher proportion of participants rating their pain between 1 and 3 (68.9%) and a lower proportion rating their pain between 4 and 7 (28.2%), compared to the control group (p < 0.001). Differences in the highest pain ratings (8-10) between the groups were not statistically significant. The duration of hospital stay, beginning from surgery to discharge, was lesser among study participants in the ERAS group, and this finding was statistically significant (p < 0.001).
    Conclusion:
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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