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  1. Article ; Online: Trainees' Experience of Family Presence during Intensive Care Unit Procedures.

    Harris, Benjamin R E / Butler, Allison / Hirshberg, Eliotte L / Hopkins, Ramona O / Butler, Jorie / Orme, James / Brown, Samuel M / Beesley, Sarah J

    ATS scholar

    2023  Volume 4, Issue 4, Page(s) 469–473

    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 2690-7097
    ISSN (online) 2690-7097
    DOI 10.34197/ats-scholar.2023-0065BR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cost of start-up activities to implement a community-level opioid overdose reduction intervention in the HEALing Communities Study.

    Montoya, Iván D / Watson, Colleen / Aldridge, Arnie / Ryan, Danielle / Murphy, Sean M / Amuchi, Brenda / McCollister, Kathryn E / Schackman, Bruce R / Bush, Joshua L / Speer, Drew / Harlow, Kristin / Orme, Stephen / Zarkin, Gary A / Castry, Mathieu / Seiber, Eric E / Barocas, Joshua A / Linas, Benjamin P / Starbird, Laura E

    Addiction science & clinical practice

    2024  Volume 19, Issue 1, Page(s) 23

    Abstract: ... investments of time and other expenditures (i.e., start-up costs). Despite the importance of these start-up ...

    Abstract Background: Communities That HEAL (CTH) is a novel, data-driven community-engaged intervention designed to reduce opioid overdose deaths by increasing community engagement, adoption of an integrated set of evidence-based practices, and delivering a communications campaign across healthcare, behavioral-health, criminal-legal, and other community-based settings. The implementation of such a complex initiative requires up-front investments of time and other expenditures (i.e., start-up costs). Despite the importance of these start-up costs in investment decisions to stakeholders, they are typically excluded from cost-effectiveness analyses. The objective of this study is to report a detailed analysis of CTH start-up costs pre-intervention implementation and to describe the relevance of these data for stakeholders to determine implementation feasibility.
    Methods: This study is guided by the community perspective, reflecting the investments that a real-world community would need to incur to implement the CTH intervention. We adopted an activity-based costing approach, in which resources related to hiring, training, purchasing, and community dashboard creation were identified through macro- and micro-costing techniques from 34 communities with high rates of fatal opioid overdoses, across four states-Kentucky, Massachusetts, New York, and Ohio. Resources were identified and assigned a unit cost using administrative and semi-structured-interview data. All cost estimates were reported in 2019 dollars.
    Results: State-level average and median start-up cost (representing 8-10 communities per state) were $268,657 and $175,683, respectively. Hiring and training represented 40%, equipment and infrastructure costs represented 24%, and dashboard creation represented 36% of the total average start-up cost. Comparatively, hiring and training represented 49%, purchasing costs represented 18%, and dashboard creation represented 34% of the total median start-up cost.
    Conclusion: We identified three distinct CTH hiring models that affected start-up costs: hospital-academic (Massachusetts), university-academic (Kentucky and Ohio), and community-leveraged (New York). Hiring, training, and purchasing start-up costs were lowest in New York due to existing local infrastructure. Community-based implementation similar to the New York model may have lower start-up costs due to leveraging of existing infrastructure, relationships, and support from local health departments.
    MeSH term(s) Humans ; Opiate Overdose ; Delivery of Health Care ; Massachusetts ; Evidence-Based Practice
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2492632-2
    ISSN 1940-0640 ; 1940-0640
    ISSN (online) 1940-0640
    ISSN 1940-0640
    DOI 10.1186/s13722-024-00454-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Monitoring cardiac output from the radial artery pressure waveform.

    Orme, R M L'E / Pigott, D W

    Anaesthesia

    2007  Volume 62, Issue 1, Page(s) 90–1; author reply 91

    MeSH term(s) Blood Pressure/physiology ; Cardiac Output/physiology ; Humans ; Monitoring, Physiologic/methods ; Radial Artery/physiology
    Language English
    Publishing date 2007-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/j.1365-2044.2006.04916_1.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Subcutaneous emphysema after percutaneous tracheostomy--time to dispense with fenestrated tubes?

    Orme, R M L'E / Welham, K L

    Anaesthesia

    2006  Volume 61, Issue 9, Page(s) 911–2; reply 912

    MeSH term(s) Aged ; Equipment Design ; Equipment Failure ; Humans ; Male ; Subcutaneous Emphysema/etiology ; Tracheostomy/adverse effects
    Language English
    Publishing date 2006-09
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/j.1365-2044.2006.04768_1.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Influence of body weight and body mass index on the chronic pharmacokinetic and pharmacodynamic responses to clinically available doses of ticagrelor in patients with chronic coronary syndromes.

    Parker, William A E / Angiolillo, Dominick J / Rollini, Fabiana / Franchi, Francesco / Bonaca, Marc P / Bhatt, Deepak L / Steg, Ph Gabriel / Orme, Rachel C / Thomas, Mark R / Judge, Heather M / Sabatine, Marc S / Storey, Robert F

    Vascular pharmacology

    2023  Volume 149, Page(s) 107145

    Abstract: ... pharmacokinetics (PK). We investigated the influence of body mass (range 53-172 kg, 20.8-46.9 kg/m ...

    Abstract Ticagrelor has multiple indications, including for some patients with chronic coronary syndromes (CCS) at high risk of ischaemic events. Body mass can potentially affect pharmacodynamics (PD) and pharmacokinetics (PK). We investigated the influence of body mass (range 53-172 kg, 20.8-46.9 kg/m
    MeSH term(s) Humans ; Ticagrelor/adverse effects ; Body Mass Index ; Purinergic P2Y Receptor Antagonists/adverse effects ; Purinergic P2Y Receptor Antagonists/pharmacokinetics ; Platelet Aggregation ; Adenosine/adverse effects ; Blood Platelets ; Body Weight ; Platelet Aggregation Inhibitors/adverse effects ; Treatment Outcome
    Chemical Substances Ticagrelor (GLH0314RVC) ; Purinergic P2Y Receptor Antagonists ; Adenosine (K72T3FS567) ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2023.107145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of echocardiography on patient management in the intensive care unit: an audit of district general hospital practice.

    Orme, R M L'E / Oram, M P / McKinstry, C E

    British journal of anaesthesia

    2009  Volume 102, Issue 3, Page(s) 340–344

    Abstract: Background: Echocardiography has been shown to positively impact on the management of the critically ill patient. However, many published studies have a significant bias towards inclusion of cardiothoracic patients. We present an audit of the impact of ... ...

    Abstract Background: Echocardiography has been shown to positively impact on the management of the critically ill patient. However, many published studies have a significant bias towards inclusion of cardiothoracic patients. We present an audit of the impact of echocardiography on the management of patients in a district general hospital intensive care unit (ICU).
    Methods: We conducted a prospective audit of all echocardiograms, both transthoracic (TTE) and transoesophageal (TOE), performed on our ICU between October 1, 2005, and December 31, 2007. In addition to patient characteristics, we recorded the indication for the echocardiogram, and any change in management that occurred as a result of the study.
    Results: Two hundred and fifty-eight echocardiograms were performed in 217 patients, of which 224 (86.8%) were performed by intensive care consultants. One hundred and eighty-seven studies (72.4%) were TTEs and 71 (27.8%) were TOEs. TTE provided diagnostic images in 91.3% of spontaneously breathing and 84.2% of mechanically ventilated patients. Management was changed directly as a result of information provided in 51.2% of studies. Changes included fluid administration, inotrope or drug therapy, and treatment limitation.
    Conclusions: Echocardiography may have a significant impact on the management of patients in the general ICU. We recommend that appropriate training in echocardiography should be incorporated into the intensive care curriculum in the UK.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Critical Care/methods ; Critical Illness/therapy ; Echocardiography/utilization ; Echocardiography, Transesophageal/utilization ; England ; Female ; Hospitals, District/statistics & numerical data ; Hospitals, General/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Medical Audit ; Middle Aged ; Professional Practice/statistics & numerical data ; Prospective Studies ; Young Adult
    Language English
    Publishing date 2009-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/aen378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Versatile microbial communities rapidly assimilate ammonium hydroxide-treated plastic waste.

    Schaerer, Laura G / Wood, Emily / Aloba, Sulihat / Byrne, Emily / Bashir, M Aamir / Baruah, Kaushik / Schumann, Elizabeth / Umlor, Libby / Wu, Ruochen / Lee, Hyeonseok / Orme, Christopher J / Wilson, Aaron D / Lacey, Jeffrey A / Ong, Rebecca G / Techtmann, Stephen M

    Journal of industrial microbiology & biotechnology

    2023  Volume 50, Issue 1

    Abstract: Waste plastic presently accumulates in landfills or the environment. While natural microbial metabolisms can degrade plastic polymers, biodegradation of plastic is very slow. This study demonstrates that chemical deconstruction of polyethylene ... ...

    Abstract Waste plastic presently accumulates in landfills or the environment. While natural microbial metabolisms can degrade plastic polymers, biodegradation of plastic is very slow. This study demonstrates that chemical deconstruction of polyethylene terephthalate (PET) with ammonium hydroxide can replace the rate limiting step (depolymerization) and by producing plastic-derived terephthalic acid and terephthalic acid monoamide. The deconstructed PET (DCPET) is neutralized with phosphoric acid prior to bioprocessing, resulting in a product containing biologically accessible nitrogen and phosphorus from the process reactants. Three microbial consortia obtained from compost and sediment degraded DCPET in ultrapure water and scavenged river water without addition of nutrients. No statistically significant difference was observed in growth rate compared to communities grown on DCPET in minimal culture medium. The consortia were dominated by Rhodococcus spp., Hydrogenophaga spp., and many lower abundance genera. All taxa were related to species known to degrade aromatic compounds. Microbial consortia are known to confer flexibility in processing diverse substrates. To highlight this, we also demonstrate that two microbial consortia can grow on similarly deconstructed polyesters, polyamides, and polyurethanes in water instead of medium. Our findings suggest that microbial communities may enable flexible bioprocessing of mixed plastic wastes when coupled with chemical deconstruction.
    MeSH term(s) Plastics/metabolism ; Ammonium Hydroxide ; Microbiota ; Biodegradation, Environmental ; Water
    Chemical Substances Plastics ; terephthalic acid (6S7NKZ40BQ) ; Ammonium Hydroxide (5138Q19F1X) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1093/jimb/kuad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Snap evaporation of droplets on smooth topographies.

    Wells, Gary G / Ruiz-Gutiérrez, Élfego / Le Lirzin, Youen / Nourry, Anthony / Orme, Bethany V / Pradas, Marc / Ledesma-Aguilar, Rodrigo

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 1380

    Abstract: Droplet evaporation on solid surfaces is important in many applications including printing, micro-patterning and cooling. While seemingly simple, the configuration of evaporating droplets on solids is difficult to predict and control. This is because ... ...

    Abstract Droplet evaporation on solid surfaces is important in many applications including printing, micro-patterning and cooling. While seemingly simple, the configuration of evaporating droplets on solids is difficult to predict and control. This is because evaporation typically proceeds as a "stick-slip" sequence-a combination of pinning and de-pinning events dominated by static friction or "pinning", caused by microscopic surface roughness. Here we show how smooth, pinning-free, solid surfaces of non-planar topography promote a different process called snap evaporation. During snap evaporation a droplet follows a reproducible sequence of configurations, consisting of a quasi-static phase-change controlled by mass diffusion interrupted by out-of-equilibrium snaps. Snaps are triggered by bifurcations of the equilibrium droplet shape mediated by the underlying non-planar solid. Because the evolution of droplets during snap evaporation is controlled by a smooth topography, and not by surface roughness, our ideas can inspire programmable surfaces that manage liquids in heat- and mass-transfer applications.
    Language English
    Publishing date 2018-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-03840-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The 'swoosh' test--an evaluation of a modified 'whoosh' test in children.

    Orme, R M L'E / Berg, S J

    British journal of anaesthesia

    2003  Volume 90, Issue 1, Page(s) 62–65

    Abstract: Background: Caudal analgesia is widely used in paediatric anaesthetic practice. In adults, the 'whoosh' test has been recommended as a guide to successful needle insertion, but it has not been extensively studied in paediatric patients. We have ... ...

    Abstract Background: Caudal analgesia is widely used in paediatric anaesthetic practice. In adults, the 'whoosh' test has been recommended as a guide to successful needle insertion, but it has not been extensively studied in paediatric patients. We have investigated a modification of the 'whoosh' test, which we have christened the 'swoosh' test. It avoids the injection of air by performing auscultation during injection of the local anaesthetic solution. We have compared it with clinical judgement of correct placement.
    Methods: We studied 113 children undergoing elective surgery. During insertion of the caudal block, a stethoscope was placed over the lower lumbar spine and the presence or absence of an audible 'swoosh' noted. The operator's clinical impression of successful insertion was also recorded.
    Results: The overall success rate of caudal anaesthesia was 95.6%. Of the 108 patients with a successful block, 98 had a positive 'swoosh' test. There were no false positive results. Calculations show the 'swoosh' test to have a sensitivity of 91%, a specificity of 100% and a positive predictive value of 100%.
    Conclusions: The 'swoosh' test is a simple and accurate test to confirm successful caudal insertion in children, and is especially useful as a teaching aid for anaesthetists new to the technique.
    MeSH term(s) Adolescent ; Anesthesia, Caudal/methods ; Anesthetics, Local/administration & dosage ; Auscultation ; Bupivacaine/administration & dosage ; Child ; Child, Preschool ; Clinical Competence ; Female ; Humans ; Infant ; Infant, Newborn ; Injections, Intradermal ; Male ; Needles ; Nerve Block/methods
    Chemical Substances Anesthetics, Local ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2003-01
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Fatal cardiac tamponade as a result of a peripherally inserted central venous catheter: a case report and review of the literature.

    Orme, R M L'E / McSwiney, M M / Chamberlain-Webber, R F O

    British journal of anaesthesia

    2007  Volume 99, Issue 3, Page(s) 384–388

    Abstract: We present a case of fatal cardiac tamponade that occurred in association with a peripherally inserted central catheter (PICC) inserted from the right antecubital fossa. Migration of the catheter from the right atrium within 24 h of insertion lead to the ...

    Abstract We present a case of fatal cardiac tamponade that occurred in association with a peripherally inserted central catheter (PICC) inserted from the right antecubital fossa. Migration of the catheter from the right atrium within 24 h of insertion lead to the administration of a potassium-enriched sodium chloride solution into the pericardial space with the development of ST-segment elevation and progression to pulseless electrical activity and, subsequently, ventricular fibrillation. Although signs of tamponade were seen on echocardiography, we propose that myocardial hyperkalaemia from the diffusion of potassium through the epicardium accounted for some of the clinical picture. PICC lines carry a greater risk of migration because of the tip movement associated with arm abduction and, therefore, care must be taken to ensure that the catheter tip is correctly positioned to reduce this risk. When such catheters are used for intra-operative central venous access, we believe chest radiography is mandatory before fluid administration through the catheter, but that this is unnecessary when the catheter is being used solely for central venous pressure monitoring. The use of softer catheters may reduce the risk of vessel perforation. Once tamponade is suspected, all drugs and infusions administered via the catheter should be reviewed, the catheter aspirated and echocardiography performed urgently. This may be facilitated by the greater availability of limited bedside echocardiography within critical care units and theatre complexes.
    MeSH term(s) Adult ; Cardiac Tamponade/etiology ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Fatal Outcome ; Female ; Fluid Therapy/adverse effects ; Fluid Therapy/methods ; Foreign-Body Migration/complications ; Humans ; Hyperkalemia/etiology ; Postoperative Complications
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/aem181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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