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Article: Multiparametric Radiogenomic Model to Predict Survival in Patients with Glioblastoma.

Mahmoudi, Keon / Kim, Daniel H / Tavakkol, Elham / Kihira, Shingo / Bauer, Adam / Tsankova, Nadejda / Khan, Fahad / Hormigo, Adilia / Yedavalli, Vivek / Nael, Kambiz

Cancers

2024 Volume 16, Issue 3

Abstract: Background: Clinical, histopathological, and imaging variables have been associated with prognosis in patients with glioblastoma (GBM). We aimed to develop a multiparametric radiogenomic model incorporating MRI texture features, demographic data, and ... ...

Abstract	Background: Clinical, histopathological, and imaging variables have been associated with prognosis in patients with glioblastoma (GBM). We aimed to develop a multiparametric radiogenomic model incorporating MRI texture features, demographic data, and histopathological tumor biomarkers to predict prognosis in patients with GBM. Methods: In this retrospective study, patients were included if they had confirmed diagnosis of GBM with histopathological biomarkers and pre-operative MRI. Tumor segmentation was performed, and texture features were extracted to develop a predictive radiomic model of survival (<18 months vs. ≥18 months) using multivariate analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regularization to reduce the risk of overfitting. This radiomic model in combination with clinical and histopathological data was inserted into a backward stepwise logistic regression model to assess survival. The diagnostic performance of this model was reported for the training and external validation sets. Results: A total of 116 patients were included for model development and 40 patients for external testing validation. The diagnostic performance (AUC/sensitivity/specificity) of the radiomic model generated from seven texture features in determination of ≥18 months survival was 0.71/69.0/70.3. Three variables remained as independent predictors of survival, including radiomics ( Conclusions: Results show that our radiogenomic model generated from radiomic features at baseline MRI, age, and
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spontaneous formation of a core–shell structure by a lithium ion conductive garnet-type oxide electrolyte for co-sintering with the cathode

Ohta, Shingo / Kihira, Yuki / Asaoka, Takahiko

Journal of materials chemistry A. 2021 Feb. 16, v. 9, no. 6

2021

Abstract: Solid-state batteries (SSBs) that use a lithium ion, conducting garnet-type oxide electrolyte, Li₇La₃Zr₂O₁₂ (LLZ), are currently gaining a lot of attention. As they are very safe and reliable, these batteries can be used in a range of wireless devices ... ...

Abstract	Solid-state batteries (SSBs) that use a lithium ion, conducting garnet-type oxide electrolyte, Li₇La₃Zr₂O₁₂ (LLZ), are currently gaining a lot of attention. As they are very safe and reliable, these batteries can be used in a range of wireless devices and sensors as part of the future internet of things. The major issue for realizing oxide-based SSBs is the chemical reaction between the cathode and electrolyte during the ceramic fabrication process. We developed an Sr-substituted LLZ that spontaneously formed a core–shell structure that suppressed the chemical reaction during high-temperature sintering. The formation of this core–shell structure was confirmed using substitution by Sr only. A model battery using Sr-substituted LLZ significantly improved the battery capacity from ∼10% to ∼85% of the theoretical capacity.
Keywords	Internet ; batteries ; cathodes ; ceramics ; chemical reactions ; electrolytes ; lithium
Language	English
Dates of publication	2021-0216
Size	p. 3353-3359.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d0ta10215f
Database	NAL-Catalogue (AGRICOLA)

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Article: Trans-synaptic degeneration of the optic radiation from optic nerve atrophy.

Kihira, Shingo / Arnold, Anthony C / Pawha, Puneet S / Villablanca, Pablo / Nael, Kambiz

Radiology case reports

2021 Volume 16, Issue 4, Page(s) 855–857

Abstract: Fourty-seven-year-old woman with 5-year history of progressive decreased left eye vision. Optical coherence tomography showed optic nerve atrophy (left > right) and brain MRI revealed T2 hyperintense signal along the course of left optic radiations. We ... ...

Abstract	Fourty-seven-year-old woman with 5-year history of progressive decreased left eye vision. Optical coherence tomography showed optic nerve atrophy (left > right) and brain MRI revealed T2 hyperintense signal along the course of left optic radiations. We present a case of a trans-synaptic degeneration of the optic radiation in a patient with confirmed optic atrophy. Trans-synaptic degeneration of the optic radiation without associated infarct or inflammatory disease has not been reported before in patients with optic atrophy.
Language	English
Publishing date	2021-01-30
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.01.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fatal cerebral infarct in a child with COVID-19.

Kihira, Shingo / Morgenstern, Peter F / Raynes, Hillary / Naidich, Thomas P / Belani, Puneet

Pediatric radiology

2020 Volume 50, Issue 10, Page(s) 1479–1480

MeSH term(s)	Betacoronavirus ; COVID-19 ; Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/etiology ; Child, Preschool ; Coronavirus Infections/complications ; Fatal Outcome ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-020-04779-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Infundibulum at the origin of an accessory middle cerebral artery.

Kihira, Shingo / Fifi, Johanna T / Doshi, Amish H / Xuan, Dwight / Belani, Puneet

Clinical imaging

2020 Volume 72, Page(s) 19–21

Abstract: We present a case of an infundibular dilation at the origin of an accessory middle cerebral artery emanating from the distal A1 segment of the anterior cerebral artery. There was also partial vessel wall enhancement along this infundibulum. To our ... ...

Abstract	We present a case of an infundibular dilation at the origin of an accessory middle cerebral artery emanating from the distal A1 segment of the anterior cerebral artery. There was also partial vessel wall enhancement along this infundibulum. To our knowledge, this is the first case report with such findings.
MeSH term(s)	Anterior Cerebral Artery ; Cerebral Arteries/diagnostic imaging ; Humans ; Intracranial Aneurysm ; Middle Cerebral Artery/diagnostic imaging ; Pituitary Gland
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2020.11.015
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Article: Multi-Parametric Radiomic Model to Predict 1p/19q Co-Deletion in Patients with IDH-1 Mutant Glioma: Added Value to the T2-FLAIR Mismatch Sign.

Kihira, Shingo / Derakhshani, Ahrya / Leung, Michael / Mahmoudi, Keon / Bauer, Adam / Zhang, Haoyue / Polson, Jennifer / Arnold, Corey / Tsankova, Nadejda M / Hormigo, Adilia / Salehi, Banafsheh / Pham, Nancy / Ellingson, Benjamin M / Cloughesy, Timothy F / Nael, Kambiz

Cancers

2023 Volume 15, Issue 4

Abstract: Purpose: The T2-FLAIR mismatch sign has shown promise in determining IDH mutant 1p/19q non-co-deleted gliomas with a high specificity and modest sensitivity. To develop a multi-parametric radiomic model using MRI to predict 1p/19q co-deletion status in ... ...

Abstract	Purpose: The T2-FLAIR mismatch sign has shown promise in determining IDH mutant 1p/19q non-co-deleted gliomas with a high specificity and modest sensitivity. To develop a multi-parametric radiomic model using MRI to predict 1p/19q co-deletion status in patients with newly diagnosed IDH1 mutant glioma and to perform a comparative analysis to T2-FLAIR mismatch sign+. Methods: In this retrospective study, patients with diagnosis of IDH1 mutant gliomas with known 1p/19q status who had preoperative MRI were included. T2-FLAIR mismatch was evaluated independently by two board-certified neuroradiologists. Texture features were extracted from glioma segmentation of FLAIR images. eXtremeGradient Boosting (XGboost) classifiers were used for model development. Leave-one-out-cross-validation (LOOCV) and external validation performances were reported for both the training and external validation sets. Results: A total of 103 patients were included for model development and 18 patients for external testing validation. The diagnostic performance (sensitivity/specificity/accuracy) in the determination of the 1p/19q co-deletion status was 59%/83%/67% (training) and 62.5%/70.0%/66.3% (testing) for the T2-FLAIR mismatch sign. This was significantly improved ( Conclusion: The proposed radiomic model provides much needed sensitivity to the highly specific T2-FLAIR mismatch sign in the determination of the 1p/19q non-co-deletion status and improves the overall diagnostic performance of neuroradiologists when used as an assistive tool.
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041037
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Article ; Online: Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients: Impact of cancer and ventilatory support status.

McCarthy, Lily / Khegai, Oleksandr / Goldstein, Jonathan / Belani, Puneet / Pawha, Puneet / Kihira, Shingo / Mathew, Brian / Gururangan, Kapil / Hao, Qing / Singh, Anuradha / Navis, Allison / Delman, Bradley N / Jette, Nathalie / Balchandani, Priti

PloS one

2023 Volume 18, Issue 3, Page(s) e0283614

Abstract: Introduction: Coronavirus 2019 (COVID-19) is known to affect the central nervous system. Neurologic morbidity associated with COVID-19 is commonly attributed to sequelae of some combination of thrombotic and inflammatory processes. The aim of this ... ...

Abstract	Introduction: Coronavirus 2019 (COVID-19) is known to affect the central nervous system. Neurologic morbidity associated with COVID-19 is commonly attributed to sequelae of some combination of thrombotic and inflammatory processes. The aim of this retrospective observational study was to evaluate neuroimaging findings in hospitalized COVID-19 patients with neurological manifestations in cancer versus non-cancer patients, and in patients with versus without ventilatory support (with ventilatory support defined as including patients with intubation and noninvasive ventilation). Cancer patients are frequently in an immunocompromised or prothrombotic state with side effects from chemotherapy and radiation that may cause neurological issues and increase vulnerability to systemic illness. We wanted to determine whether neurological and/or neuroimaging findings differed between patients with and without cancer. Methods: Eighty adults (44 male, 36 female, 64.5 ±14 years) hospitalized in the Mount Sinai Health System in New York City between March 2020 and April 2021 with reverse-transcriptase polymerase chain reaction-confirmed COVID-19 underwent magnetic resonance imaging (MRI) during their admissions. The cohort consisted of four equal subgroups based on cancer and ventilatory support status. Clinical and imaging data were acquired and analyzed. Results: Neuroimaging findings included non-ischemic parenchymal T2/FLAIR signal hyperintensities (36.3%), acute/subacute infarcts (26.3%), chronic infarcts (25.0%), microhemorrhages (23.8%), chronic macrohemorrhages (10.0%), acute macrohemorrhages (7.5%), and encephalitis-like findings (7.5%). There were no significant differences in neuroimaging findings between cancer and non-cancer subgroups. Clinical neurological manifestations varied. The most common was encephalopathy (77.5%), followed by impaired responsiveness/coma (38.8%) and stroke (26.3%). There were significant differences between patients with versus without ventilatory support. Encephalopathy and impaired responsiveness/coma were more prevalent in patients with ventilatory support (p = 0.02). Focal weakness was more frequently seen in patients without ventilatory support (p = 0.01). Discussion: This study suggests COVID-19 is associated with neurological manifestations that may be visible with brain imaging techniques such as MRI. In our COVID-19 cohort, there was no association between cancer status and neuroimaging findings. Future studies might include more prospectively enrolled systematically characterized patients, allowing for more rigorous statistical analysis.
MeSH term(s)	Adult ; Humans ; Male ; Female ; COVID-19/complications ; COVID-19/diagnostic imaging ; Coma ; SARS-CoV-2 ; Neuroimaging/methods ; Stroke/etiology ; Neoplasms/complications ; Neoplasms/diagnostic imaging ; Neoplasms/therapy
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Addition of arterial spin-labelled MR perfusion to conventional brain MRI: clinical experience in a retrospective cohort study.

Belani, Puneet / Kihira, Shingo / Pacheco, Felipe / Pawha, Puneet / Cruciata, Giuseppe / Nael, Kambiz

BMJ open

2020 Volume 10, Issue 6, Page(s) e036785

Abstract: Objective: The usage of arterial spin labelling (ASL) perfusion has exponentially increased due to improved and faster acquisition time and ease of postprocessing. We aimed to report potential additional findings obtained by adding ASL to routine ... ...

Abstract	Objective: The usage of arterial spin labelling (ASL) perfusion has exponentially increased due to improved and faster acquisition time and ease of postprocessing. We aimed to report potential additional findings obtained by adding ASL to routine unenhanced brain MRI for patients being scanned in a hospital setting for various neurological indications. Design: Retrospective. Setting: Large tertiary hospital. Participants: 676 patients. Primary outcome: Additional findings from ASL sequence compared with conventional MRI. Results: Our patient cohorts consisted of 676 patients with 257 with acute infarcts and 419 without an infarct. Additional findings from ASL were observed in 13.9% (94/676) of patients. In the non-infarct group, additional findings from ASL were observed in 7.4% (31/419) of patients, whereas in patients with an acute infarct, supplemental information was obtained in 24.5% (63/257) of patients. Conclusion: The addition of an ASL sequence to routine brain MRI in a hospital setting provides additional findings compared with conventional brain MRI in about 7.4% of patients with additional supplementary information in 24.5% of patients with acute infarct.
MeSH term(s)	Cerebral Infarction/diagnostic imaging ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Retrospective Studies ; Spin Labels
Chemical Substances	Spin Labels
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-036785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fatal cerebral infarct in a child with COVID-19

Kihira, Shingo / Morgenstern, Peter F / Raynes, Hillary / Naidich, Thomas P / Belani, Puneet

Pediatr Radiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #670755
Database	COVID19

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Article ; Online: Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients

Lily McCarthy / Oleksandr Khegai / Jonathan Goldstein / Puneet Belani / Puneet Pawha / Shingo Kihira / Brian Mathew / Kapil Gururangan / Qing Hao / Anuradha Singh / Allison Navis / Bradley N Delman / Nathalie Jette / Priti Balchandani

PLoS ONE, Vol 18, Iss 3, p e

Impact of cancer and ventilatory support status.

2023 Volume 0283614

Abstract: Introduction Coronavirus 2019 (COVID-19) is known to affect the central nervous system. Neurologic morbidity associated with COVID-19 is commonly attributed to sequelae of some combination of thrombotic and inflammatory processes. The aim of this ... ...

Abstract	Introduction Coronavirus 2019 (COVID-19) is known to affect the central nervous system. Neurologic morbidity associated with COVID-19 is commonly attributed to sequelae of some combination of thrombotic and inflammatory processes. The aim of this retrospective observational study was to evaluate neuroimaging findings in hospitalized COVID-19 patients with neurological manifestations in cancer versus non-cancer patients, and in patients with versus without ventilatory support (with ventilatory support defined as including patients with intubation and noninvasive ventilation). Cancer patients are frequently in an immunocompromised or prothrombotic state with side effects from chemotherapy and radiation that may cause neurological issues and increase vulnerability to systemic illness. We wanted to determine whether neurological and/or neuroimaging findings differed between patients with and without cancer. Methods Eighty adults (44 male, 36 female, 64.5 ±14 years) hospitalized in the Mount Sinai Health System in New York City between March 2020 and April 2021 with reverse-transcriptase polymerase chain reaction-confirmed COVID-19 underwent magnetic resonance imaging (MRI) during their admissions. The cohort consisted of four equal subgroups based on cancer and ventilatory support status. Clinical and imaging data were acquired and analyzed. Results Neuroimaging findings included non-ischemic parenchymal T2/FLAIR signal hyperintensities (36.3%), acute/subacute infarcts (26.3%), chronic infarcts (25.0%), microhemorrhages (23.8%), chronic macrohemorrhages (10.0%), acute macrohemorrhages (7.5%), and encephalitis-like findings (7.5%). There were no significant differences in neuroimaging findings between cancer and non-cancer subgroups. Clinical neurological manifestations varied. The most common was encephalopathy (77.5%), followed by impaired responsiveness/coma (38.8%) and stroke (26.3%). There were significant differences between patients with versus without ventilatory support. Encephalopathy and impaired ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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