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Article ; Online: Feasibility of Linear Irreversible Electroporation Ablation in the Coronary Sinus.

Buist, Thomas J / Groen, Marijn H A / Wittkampf, Fred H M / Loh, Peter / Doevendans, Pieter A F M / van Es, René / Elvan, Arif

Cardiovascular engineering and technology

2022 Volume 14, Issue 1, Page(s) 60–66

Abstract: Introduction: Previous studies demonstrated that the coronary sinus (CS) is an important target for ablation in persistent atrial fibrillation. However, radiofrequency ablation in the CS is associated with coronary vessel damage and tamponade. Animal ... ...

Abstract	Introduction: Previous studies demonstrated that the coronary sinus (CS) is an important target for ablation in persistent atrial fibrillation. However, radiofrequency ablation in the CS is associated with coronary vessel damage and tamponade. Animal data suggest irreversible electroporation (IRE) ablation can be a safe ablation modality in vicinity of coronary arteries. We investigated the feasibility of IRE in the CS in a porcine model. Methods: Ablation and pacing was performed in the CS in six pigs (weight 60-75 kg) using a modified 9-French steerable linear hexapolar Tip-Versatile Ablation Catheter. Pacing maneuvers were performed from distal to proximal segments of the CS to assess atrial capture thresholds before and after IRE application. IRE ablations were performed with 100 J IRE pulses. After 3-week survival animals were euthanized and histological sections from the CS were analyzed. Results: A total of 27 IRE applications in six animals were performed. Mean peak voltage was 1509 ± 36 V, with a mean peak current of 22.9 ± 1.0 A. No complications occurred during procedure and 3-week survival. At 30 min post ablation 100% isolation was achieved in all animals. At 3 weeks follow-up pacing thresholds were significant higher as compared to baseline. Histological analysis showed transmural ablation lesions in muscular sleeves surrounding the CS. Conclusion: IRE ablation of the musculature along the CS using a multi-electrode catheter is feasible in a porcine model.
MeSH term(s)	Swine ; Animals ; Coronary Sinus/surgery ; Electroporation/methods ; Feasibility Studies ; Atrial Fibrillation/surgery ; Coronary Vessels/surgery ; Catheter Ablation/adverse effects
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2543111-0
ISSN	1869-4098 ; 1869-408X
ISSN (online)	1869-4098
ISSN	1869-408X
DOI	10.1007/s13239-022-00633-3
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Article: Exotic biomodification of fatty acids.

Buist, Peter H

Natural product reports

2007 Volume 24, Issue 5, Page(s) 1110–1127

Abstract: Many biotransformations of mid- to long chain fatty acyl derivatives are intrinsically interesting because of their high selectivity and novel mechanisms. These include one carbon transfer, hydration, isomerization, hydrogenation, ladderane and ... ...

Abstract	Many biotransformations of mid- to long chain fatty acyl derivatives are intrinsically interesting because of their high selectivity and novel mechanisms. These include one carbon transfer, hydration, isomerization, hydrogenation, ladderane and hydrocarbon formation, thiolation and various oxidative transformations such as epoxidation, hydroxylation and desaturation. In addition, hydroperoxidation of polyunsaturated fatty acids leads to a diverse array of bioactive compounds. The bioorganic aspects of selected reactions will be highlighted in this review; 210 references are cited.
MeSH term(s)	Biotransformation ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Molecular Structure
Chemical Substances	Fatty Acids
Language	English
Publishing date	2007-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b508584p
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Article ; Online: Castor Stearoyl-ACP Desaturase Can Synthesize a Vicinal Diol by Dioxygenase Chemistry.

Whittle, Edward J / Cai, Yuanheng / Keereetaweep, Jantana / Chai, Jin / Buist, Peter H / Shanklin, John

Plant physiology

2019 Volume 182, Issue 2, Page(s) 730–738

Abstract: In previous work, we identified a triple mutant of the castor ( ...

Abstract	In previous work, we identified a triple mutant of the castor (
MeSH term(s)	Castor Oil/chemistry ; Catalysis ; Dioxygenases/chemistry ; Dioxygenases/metabolism ; Gas Chromatography-Mass Spectrometry ; Mixed Function Oxygenases/chemistry ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Mutation ; Oleic Acid/chemistry ; Oleic Acid/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Propanols/metabolism ; Ricinus/enzymology ; Ricinus/genetics ; Ricinus/metabolism ; Stearic Acids/chemistry ; Stearic Acids/metabolism
Chemical Substances	Propanols ; Stearic Acids ; 9,10-dihydroxystearic acid (120-87-6) ; Oleic Acid (2UMI9U37CP) ; allyl alcohol (3W678R12M0) ; Castor Oil (8001-79-4) ; Mixed Function Oxygenases (EC 1.-) ; Dioxygenases (EC 1.13.11.-) ; acyl-(acyl-carrier-protein)desaturase (EC 1.14.19.2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2019-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.19.01111
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Article ; Online: Derivation of safe exposure levels for potential migration of formaldehyde into food.

Gelbke, Heinz-Peter / Buist, Harrie / Eisert, Ralf / Leibold, Edgar / Sherman, James H

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2019 Volume 132, Page(s) 110598

Abstract: Polyoxymethylene (POM) is a polymer of formaldehyde used inter alia for kitchenware and food processing machines. By migration into food, consumers may be exposed to small additional amounts of formaldehyde in food. In order to address such potential ... ...

Abstract	Polyoxymethylene (POM) is a polymer of formaldehyde used inter alia for kitchenware and food processing machines. By migration into food, consumers may be exposed to small additional amounts of formaldehyde in food. In order to address such potential exposures, Specific Migration Limits are derived using all studies with oral exposure in mammals and birds. The assessment is not only based on local irritation observed in a 2-year rat study that has previously served to calculate acceptable exposure levels, but also on systemic effects, namely on effects on the kidney in adult rats and testes in birds before sexual maturity. At the relatively high oral exposure levels (up to 2000 ppm in drinking water) long-term effects caused by formic acid, the first step metabolite of formaldehyde, such as acidosis, cannot be excluded. The lowest Specific Migration Limit of 2.74 mg/dm
MeSH term(s)	Administration, Oral ; Animals ; Chickens ; Dietary Exposure/standards ; Dogs ; Food Contamination ; Formaldehyde/metabolism ; Formaldehyde/standards ; Formaldehyde/toxicity ; Kidney/drug effects ; Leukocyte Count ; Male ; No-Observed-Adverse-Effect Level ; Quail ; Rats, Sprague-Dawley ; Rats, Wistar ; Resins, Synthetic/chemistry ; Risk Assessment ; Species Specificity ; Stomach/drug effects ; Testis/drug effects
Chemical Substances	Resins, Synthetic ; Formaldehyde (1HG84L3525) ; delrin (9085-38-5)
Language	English
Publishing date	2019-06-19
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2019.110598
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Article: Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange

Shields, Samuel W. J. / Buist, Peter H. / Manthorpe, Jeffrey M.

SynOpen

2018 Volume 02, Issue 02, Page(s) 168–175

Abstract: The total synthesis of isotopically labelled (9 R,10 S )-dihydrosterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey–Chaykovsky reaction was employed to ... ...

Abstract	The total synthesis of isotopically labelled (9 R,10 S )-dihydrosterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey–Chaykovsky reaction was employed to form the cyclopropane ring. Rapid quenching of a lithium-sulfoxide exchange was required to achieve the requisite high levels of deuterium incorporation.
Keywords	lithium-sulfoxide exchange ; deuterium labelling ; asymmetric Corey–Chaykovsky cyclopropanation ; cyclopropane fatty acids ; mechanistic probes ; fatty acid desaturation
Language	English
Publishing date	2018-04-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2509-9396
ISSN (online)	2509-9396
DOI	10.1055/s-0036-1591976
Database	Thieme publisher's database

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Article ; Online: Efficacy of multi-electrode linear irreversible electroporation.

Buist, Thomas J / Groen, Marijn H A / Wittkampf, Fred H M / Loh, Peter / Doevendans, Pieter A F M / van Es, René / Elvan, Arif

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2020 Volume 23, Issue 3, Page(s) 464–468

Abstract: Aims: We investigated the efficacy of linear multi-electrode irreversible electroporation (IRE) ablation in a porcine model.: Methods and results: The study was performed in six pigs (weight 60-75 kg). After median sternotomy and opening of the ... ...

Abstract	Aims: We investigated the efficacy of linear multi-electrode irreversible electroporation (IRE) ablation in a porcine model. Methods and results: The study was performed in six pigs (weight 60-75 kg). After median sternotomy and opening of the pericardium, a pericardial cradle was formed and filled with blood. A linear seven polar 7-Fr electrode catheter with 2.5 mm electrodes and 2.5 mm inter-electrode spacing was placed in good contact with epicardial tissue. A single IRE application was delivered using 50 J at one site and 100 J at two other sites, in random sequence, using a standard monophasic defibrillator connected to all seven electrodes connected in parallel. The pericardium and thorax were closed and after 3 weeks survival animals were euthanized. A total of 82 histological sections from all 18 electroporation lesions were analysed. A total of seven 50 J and fourteen 100 J epicardial IRE applications were performed. Mean peak voltages at 50 and 100 J were 1079.2 V ± 81.1 and 1609.5 V ± 56.8, with a mean peak current of 15.4 A ± 2.3 and 20.2 A ± 1.7, respectively. Median depth of the 50 and 100 J lesions were 3.2 mm [interquartile range (IQR) 3.1-3.6] and 5.5 mm (IQR 4.6-6.6) (P < 0.001), respectively. Median lesion width of the 50 and 100 J lesions was 3.9 mm (IQR 3.7-4.8) and 5.4 mm (IQR 5.0-6.3), respectively (P < 0.001). Longitudinal sections showed continuous lesions for 100 J applications. Conclusion: Epicardial multi-electrode linear application of IRE pulses is effective in creating continuous deep lesions.
MeSH term(s)	Animals ; Catheter Ablation ; Catheters ; Electrodes ; Electroporation ; Pericardium/surgery ; Swine
Language	English
Publishing date	2020-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euaa280
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Zs.A 5434: Show issues

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Article ; Online: Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R,10S)-Dihydrosterculic Acid

Samuel W. J. Shields / Peter H. Buist / Jeffrey M. Manthorpe

SynOpen, Vol 02, Iss 02, Pp 0168-

Overcoming Spontaneous Protonation During Lithium-Sulfoxide Exchange

2018 Volume 0175

Abstract: Abstract The total synthesis of isotopically labelled (9R,10S)-dihydrosterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey–Chaykovsky reaction was ... ...

Abstract	Abstract The total synthesis of isotopically labelled (9R,10S)-dihydrosterculic acid, a usual cyclopropane fatty acid with biologically relevant toxicity upon desaturation in vivo, is reported. A diastereoselective Corey–Chaykovsky reaction was employed to form the cyclopropane ring. Rapid quenching of a lithium-sulfoxide exchange was required to achieve the requisite high levels of deuterium incorporation.
Keywords	lithium-sulfoxide exchange ; deuterium labelling ; asymmetric corey–chaykovsky cyclopropanation ; cyclopropane fatty acids ; mechanistic probes ; fatty acid desaturation ; Chemistry ; QD1-999
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Georg Thieme Verlag KG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Commentary on F.E. Gomez et al., "Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes".

Buist, Peter H

Biochemical and biophysical research communications

2005 Volume 332, Issue 2, Page(s) 319–320

MeSH term(s)	3T3 Cells ; Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/enzymology ; Animals ; Blotting, Northern ; Blotting, Western ; Cell Differentiation ; Cell Size ; Cyclopropanes/chemistry ; Cyclopropanes/classification ; Cyclopropanes/metabolism ; Cyclopropanes/pharmacology ; Deoxyglucose/metabolism ; Fatty Acids/analysis ; Fatty Acids, Monounsaturated/chemistry ; Fatty Acids, Monounsaturated/classification ; Fatty Acids, Monounsaturated/metabolism ; Fatty Acids, Monounsaturated/pharmacology ; Flow Cytometry ; Insulin/pharmacology ; Isomerism ; Mice ; Stearoyl-CoA Desaturase/genetics ; Stearoyl-CoA Desaturase/metabolism ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/enzymology
Chemical Substances	Cyclopropanes ; Fatty Acids ; Fatty Acids, Monounsaturated ; Insulin ; Deoxyglucose (9G2MP84A8W) ; Stearoyl-CoA Desaturase (EC 1.14.19.1) ; sterculic acid (MXV06G5ROK)
Language	English
Publishing date	2005-07-01
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2005.03.081
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Article: Fatty acid desaturases: selecting the dehydrogenation channel.

Buist, Peter H

Natural product reports

2004 Volume 21, Issue 2, Page(s) 249–262

MeSH term(s)	Catalysis ; Fatty Acid Desaturases/metabolism ; Fatty Acids/metabolism ; Hydrogen ; Molecular Structure ; Oxidation-Reduction
Chemical Substances	Fatty Acids ; Hydrogen (7YNJ3PO35Z) ; Fatty Acid Desaturases (EC 1.14.19.-)
Language	English
Publishing date	2004-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b302094k
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Article ; Online: Differential effects of oleate on vascular endothelial and liver sinusoidal endothelial cells reveal its toxic features in vitro.

Geng, Yana / Arroyave-Ospina, Johanna C / Buist-Homan, Manon / Plantinga, Josée / Olinga, Peter / Reijngoud, Dirk-Jan / Van Vilsteren, Frederike G I / Blokzijl, Hans / Kamps, Jan A A M / Moshage, Han

The Journal of nutritional biochemistry

2023 Volume 114, Page(s) 109255

Abstract: Several fatty acids, in particular saturated fatty acids like palmitic acid, cause lipotoxicity in the context of non-alcoholic fatty liver disease . Unsaturated fatty acids (e.g. oleic acid) protect against lipotoxicity in hepatocytes. However, the ... ...

Abstract	Several fatty acids, in particular saturated fatty acids like palmitic acid, cause lipotoxicity in the context of non-alcoholic fatty liver disease . Unsaturated fatty acids (e.g. oleic acid) protect against lipotoxicity in hepatocytes. However, the effect of oleic acid on other liver cell types, in particular liver sinusoidal endothelial cells (LSECs), is unknown. Human umbilical vein endothelial cells (HUVECs) are often used as a substitute for LSECs, however, because of the unique phenotype of LSECs, HUVECs cannot represent the same biological features as LSECs. In this study, we investigate the effects of oleate and palmitate (the sodium salts of oleic acid and palmitic acid) on primary rat LSECs in comparison to their effects on HUVECs. Oleate induces necrotic cell death in LSECs, but not in HUVECs. Necrotic cell death of LSECs can be prevented by supplementation of 2-stearoylglycerol, which promotes cellular triglyceride (TG) synthesis. Repressing TG synthesis, by knocking down DGAT1 renders HUVECs sensitive to oleate-induced necrotic death. Mechanistically, oleate causes a sharp drop of intracellular ATP level and impairs mitochondrial respiration in LSECs. The combination of oleate and palmitate reverses the toxic effect of oleate in both LSECs and HUVECs. These results indicate that oleate is toxic and its toxicity can be attenuated by stimulating TG synthesis. The toxicity of oleate is characterized by mitochondrial dysfunction and necrotic cell death. Moreover, HUVECs are not suitable as a substitute model for LSECs.
MeSH term(s)	Rats ; Animals ; Humans ; Oleic Acid/pharmacology ; Oleic Acid/metabolism ; Hepatocytes/metabolism ; Fatty Acids/metabolism ; Palmitic Acid/toxicity ; Palmitic Acid/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Liver/metabolism ; Palmitates/toxicity ; Palmitates/metabolism
Chemical Substances	Oleic Acid (2UMI9U37CP) ; Fatty Acids ; Palmitic Acid (2V16EO95H1) ; Palmitates
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.109255
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